We are analyzing https://link.springer.com/article/10.1007/s10238-025-01659-2.

Title:
Exosome-based immunotherapy in hepatocellular carcinoma | Clinical and Experimental Medicine
Description:
Hepatocellular carcinoma (HCC) is a significant global health concern and ranks as the third leading cause of cancer-associated mortality. Systemic therapy faces the emergence of resistance, which hinders the clinical benefits. Recent evidence suggests that exosomes, measuring between 30 and 150 nm in size, which impact the antitumor immune responses, making them a promising candidate for cancer immunotherapy. Owing to their unique physical and chemical characteristics, exosomes can be tailored and engineered for a range of therapeutic objectives. In the present review, we outline the immunomodulatory functions of exosomes in the tumor microenvironment (TME) of HCC, aiming to decipher the underlying mechanisms of exosomes in remodeling suppressive TME. Moreover, we provide detailed and intuitive resource for leveraging the potential of exosomes in immunotherapy, presenting valuable strategies to improve and optimize HCC treatment. Despite the huge therapeutic potential of exosomes, significant challenges persist, including the need for standardization in exosome production, optimization of cargo loading techniques, and the assurance of safety and effectiveness in clinical applications. Addressing these challenges may pave the way for exosome-based immunotherapy for HCC patients.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, article, google, scholar, exosomes, cas, cells, cancer, hcc, central, immune, tumor, cell, exosomal, immunotherapy, pdl, carcinoma, hepatocellular, tme, exosome, httpsdoiorgs, macrophages, therapeutic, treatment, zhang, immunosuppressive, tams, wang, therapy, expression, microenvironment, mechanisms, drug, pathway, essential, resistance, role, chen, clinical, responses, potential, polarization, progression, delivery, function, liu, additionally, sci, research, leading,

Topics {✒️}

pten/akt/nf-κb/pd-l1 pathway tnf-α/nf-κb/pu1 axis pten/akt/nf-κb pathway [52] sall4/mir-146a-5p interaction release exosomal mir-23a-3p tumor-derived exosomal pd-l1 exosomal mir-200b-3p sponging hsa-mir-194-5p synergistic tumor-targeted photo-immunotherapy targeted sp1/dnmt1 axis dynamic cd73/pd-l1 pathway tumour-derived extracellular vesicles exosomal mir-21-5p facilitated exosomal pd-l1 derived article download pdf hcc-derived exosomes represents targeted klf5/galectin-3 axis exosomal pd-l1 secreted exosomal circuhrf1 derived exosomal pd-l1 inhibited exosomal pd-l1 levels mir-301b/creb1 signals exosome-mediated genetic reprogramming exosomal pd-l1 serves targeted xct-mediated ferroptosis mir-146a-5p myeloid-derived suppressor cells exosomal pd-l1 contributes atp-adenosine metabolism reprogramming employ single-cell sequencing express pd-l1 enter soluble pd-1/pd-l1 cytosolic rna-binding proteins mir-147a/arid3a axis anti-pd-l1 antibodies exosome-derived noncoding rnas exosomal mir-124 derived tam-derived exosomes enhanced hypoxia-inducible factor-1α mir-23a-3p enhanced tumor-suppressive activity regulating pd-l1 expression adenosine-a2ar signaling pathway anti-pd-1/l1 response increased pd-l1 levels multidimensional anti-tumor therapies exosomal lncrna neat1 cell-dependent immune responses small-cell lung cancer innovative exosome-based method

Questions {❓}

Could intratumoural microbiota be key to unlocking treatment responses in hepatocellular carcinoma?

Schema {🗺️}

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         headline:Exosome-based immunotherapy in hepatocellular carcinoma
         description:Hepatocellular carcinoma (HCC) is a significant global health concern and ranks as the third leading cause of cancer-associated mortality. Systemic therapy faces the emergence of resistance, which hinders the clinical benefits. Recent evidence suggests that exosomes, measuring between 30 and 150 nm in size, which impact the antitumor immune responses, making them a promising candidate for cancer immunotherapy. Owing to their unique physical and chemical characteristics, exosomes can be tailored and engineered for a range of therapeutic objectives. In the present review, we outline the immunomodulatory functions of exosomes in the tumor microenvironment (TME) of HCC, aiming to decipher the underlying mechanisms of exosomes in remodeling suppressive TME. Moreover, we provide detailed and intuitive resource for leveraging the potential of exosomes in immunotherapy, presenting valuable strategies to improve and optimize HCC treatment. Despite the huge therapeutic potential of exosomes, significant challenges persist, including the need for standardization in exosome production, optimization of cargo loading techniques, and the assurance of safety and effectiveness in clinical applications. Addressing these challenges may pave the way for exosome-based immunotherapy for HCC patients.
         datePublished:2025-04-24T00:00:00Z
         dateModified:2025-04-24T00:00:00Z
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            Oncology
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      headline:Exosome-based immunotherapy in hepatocellular carcinoma
      description:Hepatocellular carcinoma (HCC) is a significant global health concern and ranks as the third leading cause of cancer-associated mortality. Systemic therapy faces the emergence of resistance, which hinders the clinical benefits. Recent evidence suggests that exosomes, measuring between 30 and 150 nm in size, which impact the antitumor immune responses, making them a promising candidate for cancer immunotherapy. Owing to their unique physical and chemical characteristics, exosomes can be tailored and engineered for a range of therapeutic objectives. In the present review, we outline the immunomodulatory functions of exosomes in the tumor microenvironment (TME) of HCC, aiming to decipher the underlying mechanisms of exosomes in remodeling suppressive TME. Moreover, we provide detailed and intuitive resource for leveraging the potential of exosomes in immunotherapy, presenting valuable strategies to improve and optimize HCC treatment. Despite the huge therapeutic potential of exosomes, significant challenges persist, including the need for standardization in exosome production, optimization of cargo loading techniques, and the assurance of safety and effectiveness in clinical applications. Addressing these challenges may pave the way for exosome-based immunotherapy for HCC patients.
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      dateModified:2025-04-24T00:00:00Z
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         Exosomes
         Hepatocellular carcinoma
         Tumor microenvironment
         Immunotherapy
         Tumor vaccine
         Internal Medicine
         Hematology
         Oncology
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      name:Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China
      name:Xixi Hospital Biobank, Xixi Hospital of Hangzhou, Hangzhou, China
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