
NCBI . NLM . NIH . GOV {
}
Title[redir]:
T Cell Dysfunction in Cancer - PMC
Description:
Therapeutic reinvigoration of tumor-specific T cells has greatly improved clinical outcome in cancer. Nevertheless, many patients still do not achieve durable benefit. Recent evidence from studies in murine and human cancer suggest that intratumoral ...
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Keywords {🔍}
doi, cells, cell, pubmed, google, scholar, pmc, article, free, cancer, tumor, expression, chronic, infection, blockade, dysfunction, immune, dysfunctional, melanoma, immunol, inhibitory, exhausted, effector, patients, state, exhaustion, receptors, single, metabolic, intratumoral, states, human, immunity, tumors, viral, murine, tcr, nature, function, analysis, model, activation, nat, wherry, responses, med, van, functional, observed, therapy,
Topics {✒️}
tumor-infiltrating ny-eso-1-specific cd8+ wnt-b-catenin signaling pathway anti-pd-1/anti-pd-l1 therapy neoantigen-reactive t-cell receptors tumor-reactive t-cell repertoire transcription factor t-bet melan-a-specific til population antibodies targeting pd-1/pd-l1 anti-programmed-death-receptor-1 treatment pd-1+ ny-eso-1-specific cxcr5+pd-1int subset migrates lcmv-specific cxcr5+ pd-1int pd-1/pd-l1 signaling suppresses t-bethi pd-1int pmc beta search single-cell rna-seq multifunctional t-cell analyses zinc-finger transcription factors incorporate tumor-specific epitopes advanced renal-cell carcinoma fak family-interacting protein cytolytic t-cell responses melan-a-specific tils sustaining ca2+-nfat signaling reversing t-cell dysfunction adoptive t-cell therapy eomeshi pd-1hi progeny paired single-cell analyses randomised dose-comparison cohort adoptively transferred tumor-reactive high bio-energetic demands bio-energetic alterations include follicular t-helper cells pd-1/ pd-l1 axis pd-1/pd-l1 axis murine late-stage tils tumor-derived lactic acid peripheral t-cell tolerance inducing t-cell apoptosis anti-pd-1/pd-l1 anti-pd-l1 therapy sustains virus-specific cd8+ t-cell-dependent mechanism hypoxia-inducible factors enhance cd8 t-cell exhaustion activation-independent exhaustion program pd-l2 expressing macrophages small-cell lung cancer pd-1/pd-l1 blockade mass spectrometry-based detection
Questions {❓}
- Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?
- The aryl hydrocarbon receptor meets immunology: friend or foe?
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- https://scholar.google.com/scholar_lookup?journal=Immunity&title=Dynamic%20changes%20in%20chromatin%20accessibility%20occur%20in%20CD8(+)%20T%20cells%20responding%20to%20viral%20infection&author=JP%20Scott-Browne&author=IF%20Lopez-Moyado&author=S%20Trifari&author=V%20Wong&author=L%20Chavez&volume=45&publication_year=2016&pages=1327-1340&pmid=27939672&doi=10.1016/j.immuni.2016.10.028&'s total income per month
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- https://doi.org/10.1172/jci.insight.93411's revenue stream
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- Monthly income for https://scholar.google.com/scholar_lookup?journal=Blood&title=CMV-specific%20CD8+%20T-cell%20function%20is%20not%20impaired%20in%20chronic%20lymphocytic%20leukemia&author=GD%20te%20Raa&author=MF%20Pascutti&author=JJ%20Garcia-Vallejo&author=E%20Reinen&author=EB%20Remmerswaal&volume=123&publication_year=2014&pages=717-724&pmid=24246502&doi=10.1182/blood-2013-08-518183&
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- How much does https://doi.org/10.1158/2326-6066.CIR-15-0097 earn?
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- Income figures for https://scholar.google.com/scholar_lookup?journal=Nat%20Med&title=Upregulation%20of%20PD-1%20expression%20on%20HIV-specific%20CD8+%20T%20cells%20leads%20to%20reversible%20immune%20dysfunction&author=L%20Trautmann&author=L%20Janbazian&author=N%20Chomont&author=EA%20Said&author=S%20Gimmig&volume=12&publication_year=2006&pages=1198-1202&pmid=16917489&doi=10.1038/nm1482&
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