We are analyzing https://link.springer.com/article/10.1007/s00775-024-02060-2.

Title:
A commentary on studies of brain iron accumulation during ageing | JBIC Journal of Biological Inorganic Chemistry
Description:
Brain iron content is widely reported to increase during “ageing”, across multiple species from nematodes, rodents (mice and rats) and humans. Given the redox-active properties of iron, there has been a large research focus on iron-mediated oxidative stress as a contributor to tissue damage during natural ageing, and also as a risk factor for neurodegenerative disease. Surprisingly, however, the majority of published studies have not investigated brain iron homeostasis during the biological time period of senescence, and thus knowledge of how brain homeostasis changes during this critical stage of life largely remains unknown. This commentary examines the literature published on the topic of brain iron homeostasis during ageing, providing a critique on limitations of currently used experimental designs. The commentary also aims to highlight that although much research attention has been given to iron accumulation or iron overload as a pathological feature of ageing, there is evidence to support functional iron deficiency may exist, and this should not be overlooked in studies of ageing or neurodegenerative disease. Graphical abstract
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

brain, pubmed, article, google, scholar, cas, iron, ageing, senescence, adulthood, content, mice, disease, central, studies, deficiency, cells, neurons, accumulation, neurodegenerative, distribution, literature, alzheimers, hippocampus, months, homeostasis, bush, rats, tissue, aging, published, period, life, functional, hippocampal, neurosci, increase, metal, role, cell, transferrin, ferritin, xray, mapping, relative, senescent, function, hackett, elemental, res,

Topics {✒️}

x-ray fluorescence microscopy synchrotron x-ray fluorescence disease amyloid-β opposes pixel” x-ray absorption x-ray fluorescence imaging micro-x-ray absorption article download pdf quantitative susceptibility mapping metal-protein coordination environments central nervous system app/ps1 mouse model pro-inflammatory cytokines blood-brain barrier breakdown transferrin receptor-mediated internalisation low-molecular-weight complexes tumour necrosis factor-α micro-dissected tissue region cerebral protein synthesis tausted super-resolution imaging main fe-transport protein cellular iron-sulfur proteins free radical-mitochondrial theory paraffin-embedded brain tissue urrutia pj iron-deficient anemic rats iron-mediated oxidative stress levine sm cortex-derived hepcidin expression privacy choices/manage cookies aging c57bl/6j mice switzer rc 3rd leskovjan ac synchrotron access grants multiple research groups developing iron-deficient rats pilocarpine-induced epilepsy age-related fe increase xfm elemental mapping early-life iron deficiency hippocampal zn deficiency low-molecular-weight article hackett blood–brain barrier blood-brain barrier australian research council blood stream bound biochim biophys acta main force driving fe content appears iron regulatory elements

Questions {❓}

Functional Fe deficiency during ageing?
Gerlach M, Ben-Shachar D, Riederer P, Youdim MBH (1994) Altered brain metabolism of iron as a cause of neurodegenerative diseases?
Is elevated Fe in the senescent brain the result of Fe accumulation during senescence or Fe accumulation during adulthood?
What is meant by “ageing”, “aged” and “senescence”?
What is the role of Fe in the brain and how do we detect it?
Where is brain Fe located?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:A commentary on studies of brain iron accumulation during ageing
         description:Brain iron content is widely reported to increase during “ageing”, across multiple species from nematodes, rodents (mice and rats) and humans. Given the redox-active properties of iron, there has been a large research focus on iron-mediated oxidative stress as a contributor to tissue damage during natural ageing, and also as a risk factor for neurodegenerative disease. Surprisingly, however, the majority of published studies have not investigated brain iron homeostasis during the biological time period of senescence, and thus knowledge of how brain homeostasis changes during this critical stage of life largely remains unknown. This commentary examines the literature published on the topic of brain iron homeostasis during ageing, providing a critique on limitations of currently used experimental designs. The commentary also aims to highlight that although much research attention has been given to iron accumulation or iron overload as a pathological feature of ageing, there is evidence to support functional iron deficiency may exist, and this should not be overlooked in studies of ageing or neurodegenerative disease.
         datePublished:2024-05-12T00:00:00Z
         dateModified:2024-05-12T00:00:00Z
         pageStart:385
         pageEnd:394
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s00775-024-02060-2
         keywords:
            Metallomics
            Senescence
            X-ray fluorescence
            XFM
            Brain rust
            Biochemistry
            general
            Microbiology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00775-024-02060-2/MediaObjects/775_2024_2060_Figa_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00775-024-02060-2/MediaObjects/775_2024_2060_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00775-024-02060-2/MediaObjects/775_2024_2060_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00775-024-02060-2/MediaObjects/775_2024_2060_Fig3_HTML.png
         isPartOf:
            name:JBIC Journal of Biological Inorganic Chemistry
            issn:
               1432-1327
            volumeNumber:29
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer International Publishing
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Mark J. Hackett
               url:http://orcid.org/0000-0002-3296-7270
               affiliation:
                     name:Curtin University
                     address:
                        name:School of Molecular and Life Sciences, Curtin University, Perth, Australia
                        type:PostalAddress
                     type:Organization
                     name:Curtin University
                     address:
                        name:Curtin Health Innovation Research Institute, Curtin University, Perth, Australia
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A commentary on studies of brain iron accumulation during ageing
      description:Brain iron content is widely reported to increase during “ageing”, across multiple species from nematodes, rodents (mice and rats) and humans. Given the redox-active properties of iron, there has been a large research focus on iron-mediated oxidative stress as a contributor to tissue damage during natural ageing, and also as a risk factor for neurodegenerative disease. Surprisingly, however, the majority of published studies have not investigated brain iron homeostasis during the biological time period of senescence, and thus knowledge of how brain homeostasis changes during this critical stage of life largely remains unknown. This commentary examines the literature published on the topic of brain iron homeostasis during ageing, providing a critique on limitations of currently used experimental designs. The commentary also aims to highlight that although much research attention has been given to iron accumulation or iron overload as a pathological feature of ageing, there is evidence to support functional iron deficiency may exist, and this should not be overlooked in studies of ageing or neurodegenerative disease.
      datePublished:2024-05-12T00:00:00Z
      dateModified:2024-05-12T00:00:00Z
      pageStart:385
      pageEnd:394
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s00775-024-02060-2
      keywords:
         Metallomics
         Senescence
         X-ray fluorescence
         XFM
         Brain rust
         Biochemistry
         general
         Microbiology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00775-024-02060-2/MediaObjects/775_2024_2060_Figa_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00775-024-02060-2/MediaObjects/775_2024_2060_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00775-024-02060-2/MediaObjects/775_2024_2060_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00775-024-02060-2/MediaObjects/775_2024_2060_Fig3_HTML.png
      isPartOf:
         name:JBIC Journal of Biological Inorganic Chemistry
         issn:
            1432-1327
         volumeNumber:29
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Mark J. Hackett
            url:http://orcid.org/0000-0002-3296-7270
            affiliation:
                  name:Curtin University
                  address:
                     name:School of Molecular and Life Sciences, Curtin University, Perth, Australia
                     type:PostalAddress
                  type:Organization
                  name:Curtin University
                  address:
                     name:Curtin Health Innovation Research Institute, Curtin University, Perth, Australia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:JBIC Journal of Biological Inorganic Chemistry
      issn:
         1432-1327
      volumeNumber:29
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Curtin University
      address:
         name:School of Molecular and Life Sciences, Curtin University, Perth, Australia
         type:PostalAddress
      name:Curtin University
      address:
         name:Curtin Health Innovation Research Institute, Curtin University, Perth, Australia
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Mark J. Hackett
      url:http://orcid.org/0000-0002-3296-7270
      affiliation:
            name:Curtin University
            address:
               name:School of Molecular and Life Sciences, Curtin University, Perth, Australia
               type:PostalAddress
            type:Organization
            name:Curtin University
            address:
               name:Curtin Health Innovation Research Institute, Curtin University, Perth, Australia
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:School of Molecular and Life Sciences, Curtin University, Perth, Australia
      name:Curtin Health Innovation Research Institute, Curtin University, Perth, Australia

External Links {🔗}(376)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.42s.

LINK . SPRINGER . COM {}