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pubmed, google, scholar, article, cas, development, dev, genes, ear, expression, irx, iroquois, gene, biol, central, otic, specification, homeobox, developing, cell, patterns, chick, hidalgosánchez, mech, gómezskarmeta, patterning, signaling, drosophila, mouse, cheng, early, fgf, required, neural, formation, function, transcription, regulation, res, hui, zebrafish, grant, sponsor, brain, sánchezguardado, puelles, vertebrate, hindbrain, int, modolell,

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junta-de-extremadura predoctoral fellowship de la calle-mustienes month download article/chapter luis óscar sánchez-guardado sánchez-guardado lo acoustic–vestibular ganglionic neuroblasts rubén corral-san-miguel luis puelles & pilar aroca martínez-de-la-torre meso-isthmo-cerebellar region díez-del-corral article cardeña-núñez matías hidalgo-sánchez central nervous system kuroski-de bold ml dorsal/ventral boundary established article brain structure fgf8/map kinase cascade chamber-specific gene expression zinc-finger genes fez fgf10/fgf8 regulatory loop full article pdf springer science + business media feijóo cg corral-san-miguel lucía rodríguez-gallardo gómez-skarmeta jl normal mid/hindbrain organizer terminal nephron differentiation c-irx2 expression reveals mouse otic vesicle wing-body wall subdivision privacy choices/manage cookies junta de extremadura midbrain-hindbrain boundary formation related subjects bürglin tr de bold aj de celis jf posterior semicircular canal otic vesicle stage retinoic acid repression iroquois homeobox gene homeodomain iroquois proteins iroquois homeodomain proteins body wall identity homeobox gene irx1a iroquois3 homeobox gene sensory organ generation avda de elvas

Questions {❓}

• Brigande JV, Kiernan AE, Gao X, Iten LE, Fekete DM (2000) Molecular genetics of pattern formation in the inner ear: do compartment boundaries play a role?

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      headline:Expression patterns of Irx genes in the developing chick inner ear
      description:The vertebrate inner ear is a complex three-dimensional sensorial structure with auditory and vestibular functions. The molecular patterning of the developing otic epithelium creates various positional identities, consequently leading to the stereotyped specification of each neurosensory and non-sensory element of the membranous labyrinth. The Iroquois (Iro/Irx) genes, clustered in two groups (A: Irx1, Irx2, and Irx4; and B: Irx3, Irx5, and Irx6), encode for transcriptional factors involved directly in numerous patterning processes of embryonic tissues in many phyla. This work presents a detailed study of the expression patterns of these six Irx genes during chick inner ear development, paying particular attention to the axial specification of the otic anlagen. The Irx genes seem to play different roles at different embryonic periods. At the otic vesicle stage (HH18), all the genes of each cluster are expressed identically. Both clusters A and B seem involved in the specification of the lateral and posterior portions of the otic anlagen. Cluster B seems to regulate a larger area than cluster A, including the presumptive territory of the endolymphatic apparatus. Both clusters seem also to be involved in neurogenic events. At stages HH24/25-HH27, combinations of IrxA and IrxB genes participate in the specification of most sensory patches and some non-sensory components of the otic epithelium. At stage HH34, the six Irx genes show divergent patterns of expression, leading to the final specification of the membranous labyrinth, as well as to cell differentiation.
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