We are analyzing https://link.springer.com/article/10.1007/s00424-024-02943-y.

Title:
Role of pH-sensing receptors in colitis | Pflügers Archiv - European Journal of Physiology
Description:
Low pH in the gut is associated with severe inflammation, fibrosis, and colorectal cancer (CRC) and is a hallmark of active inflammatory bowel disease (IBD). Subsequently, pH-sensing mechanisms are of interest for the understanding of IBD pathophysiology. Tissue hypoxia and acidosis—two contributing factors to disease pathophysiology—are linked to IBD, and understanding their interplay is highly relevant for the development of new therapeutic options. One member of the proton-sensing G protein-coupled receptor (GPCR) family, GPR65 (T-cell death-associated gene 8, TDAG8), was identified as a susceptibility gene for IBD in a large genome-wide association study. In response to acidic extracellular pH, GPR65 induces an anti-inflammatory response, whereas the two other proton-sensing receptors, GPR4 and GPR68 (ovarian cancer G protein-coupled receptor 1, OGR1), mediate pro-inflammatory responses. Here, we review the current knowledge on the role of these proton-sensing receptors in IBD and IBD-associated fibrosis and cancer, as well as colitis-associated cancer (CAC). We also describe emerging small molecule modulators of these receptors as therapeutic opportunities for the treatment of IBD.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

pubmed, article, google, scholar, cas, gpr, ogr, intestinal, central, inflammation, expression, cells, fibrosis, cell, inflammatory, tdag, ibd, colitis, receptor, disease, tissue, cancer, role, receptors, hypoxia, fibroblasts, phsensing, bowel, activation, increased, patients, human, factor, protonsensing, tumor, function, extracellular, murine, proteincoupled, signaling, physiol, model, immune, mice, factors, response, proinflammatory, crohns, endothelial, ecs,

Topics {✒️}

psychosine-sensitive g-protein-coupled receptor lysolipid-sensitive g-protein-coupled receptors proton-sensing g-protein-coupled receptors c-jun n-terminal kinase genome-wide meta-analysis increases tgf-beta-induced endothelial-mesenchymal transition /ca2+/extracellular signal-regulated kinases article download pdf large-scale meta-analysis identified pro-inflammatory ph-sensing receptors x-box binding protein protein-coupled receptor gpr65 imenez silva ph hypoxia-inducible factor-2alpha mediates protein-coupled receptor ogr1 proton-sensing receptors consists mitogen-activated protein kinase proton-sensing receptor gpr65 single-cell rna sequencing calcineurin-dependent nuclear factor ph-dependent nucleolar sequestration proton-sensing receptor ogr1 single-cell transcriptomic profiling specific ph-sensing receptors proton-sensing ogr1 receptors ogr1 small-molecule inhibitor ph-sensing receptor gpr4 ph-sensing receptor ogr1 protein-coupled receptor protein-coupled receptor 1 nf-κb-mediated mechanism [22 nf-κb-mediated mechanism [135] epithelial hypoxia-inducible factor-1 ph-sensing receptors constitute pro-inflammatory ogr1 exhibits hypoxia inducible factor-1alpha copd-asthma overlap syndrome protein-coupled receptors ph-sensing receptor tdag8 mediate pro-inflammatory responses autocrine fibronectin-induced migration galpha12/13-rho-rac1 pathway anti-inflammatory tdag8 emerged rs8005161-ct alleles present open public repositories nuclear factor-kappab proton sensing receptor inhibited vegf-induced angiogenesis lipid receptor g2a/gpr132 pro-inflammatory gene expression

Questions {❓}

Seuwen K, Ludwig MG, Wolf RM (2006) Receptors for protons or lipid messengers or both?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Role of pH-sensing receptors in colitis
         description:Low pH in the gut is associated with severe inflammation, fibrosis, and colorectal cancer (CRC) and is a hallmark of active inflammatory bowel disease (IBD). Subsequently, pH-sensing mechanisms are of interest for the understanding of IBD pathophysiology. Tissue hypoxia and acidosis—two contributing factors to disease pathophysiology—are linked to IBD, and understanding their interplay is highly relevant for the development of new therapeutic options. One member of the proton-sensing G protein-coupled receptor (GPCR) family, GPR65 (T-cell death-associated gene 8, TDAG8), was identified as a susceptibility gene for IBD in a large genome-wide association study. In response to acidic extracellular pH, GPR65 induces an anti-inflammatory response, whereas the two other proton-sensing receptors, GPR4 and GPR68 (ovarian cancer G protein-coupled receptor 1, OGR1), mediate pro-inflammatory responses. Here, we review the current knowledge on the role of these proton-sensing receptors in IBD and IBD-associated fibrosis and cancer, as well as colitis-associated cancer (CAC). We also describe emerging small molecule modulators of these receptors as therapeutic opportunities for the treatment of IBD.
         datePublished:2024-03-22T00:00:00Z
         dateModified:2024-03-22T00:00:00Z
         pageStart:611
         pageEnd:622
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s00424-024-02943-y
         keywords:
            Inflammatory bowel disease
            pH-sensing G protein-coupled receptors
            GPR65
            TDAG8
            GPR4
            GPR68
            OGR1
            Fibrosis
            Colitis-associated cancer
            EndoMT
            Hypoxia
            Human Physiology
            Molecular Medicine
            Neurosciences
            Cell Biology
            Receptors
         image:
         isPartOf:
            name:Pflügers Archiv - European Journal of Physiology
            issn:
               1432-2013
               0031-6768
            volumeNumber:476
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Martin Hausmann
               affiliation:
                     name:University Hospital Zurich, University of Zurich
                     address:
                        name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Klaus Seuwen
               affiliation:
                     name:University Hospital Zurich, University of Zurich
                     address:
                        name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Cheryl de Vallière
               affiliation:
                     name:University Hospital Zurich, University of Zurich
                     address:
                        name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Moana Busch
               affiliation:
                     name:University Hospital Zurich, University of Zurich
                     address:
                        name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pedro A. Ruiz
               affiliation:
                     name:University Hospital Zurich, University of Zurich
                     address:
                        name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gerhard Rogler
               affiliation:
                     name:University Hospital Zurich, University of Zurich
                     address:
                        name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Role of pH-sensing receptors in colitis
      description:Low pH in the gut is associated with severe inflammation, fibrosis, and colorectal cancer (CRC) and is a hallmark of active inflammatory bowel disease (IBD). Subsequently, pH-sensing mechanisms are of interest for the understanding of IBD pathophysiology. Tissue hypoxia and acidosis—two contributing factors to disease pathophysiology—are linked to IBD, and understanding their interplay is highly relevant for the development of new therapeutic options. One member of the proton-sensing G protein-coupled receptor (GPCR) family, GPR65 (T-cell death-associated gene 8, TDAG8), was identified as a susceptibility gene for IBD in a large genome-wide association study. In response to acidic extracellular pH, GPR65 induces an anti-inflammatory response, whereas the two other proton-sensing receptors, GPR4 and GPR68 (ovarian cancer G protein-coupled receptor 1, OGR1), mediate pro-inflammatory responses. Here, we review the current knowledge on the role of these proton-sensing receptors in IBD and IBD-associated fibrosis and cancer, as well as colitis-associated cancer (CAC). We also describe emerging small molecule modulators of these receptors as therapeutic opportunities for the treatment of IBD.
      datePublished:2024-03-22T00:00:00Z
      dateModified:2024-03-22T00:00:00Z
      pageStart:611
      pageEnd:622
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s00424-024-02943-y
      keywords:
         Inflammatory bowel disease
         pH-sensing G protein-coupled receptors
         GPR65
         TDAG8
         GPR4
         GPR68
         OGR1
         Fibrosis
         Colitis-associated cancer
         EndoMT
         Hypoxia
         Human Physiology
         Molecular Medicine
         Neurosciences
         Cell Biology
         Receptors
      image:
      isPartOf:
         name:Pflügers Archiv - European Journal of Physiology
         issn:
            1432-2013
            0031-6768
         volumeNumber:476
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Martin Hausmann
            affiliation:
                  name:University Hospital Zurich, University of Zurich
                  address:
                     name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Klaus Seuwen
            affiliation:
                  name:University Hospital Zurich, University of Zurich
                  address:
                     name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Cheryl de Vallière
            affiliation:
                  name:University Hospital Zurich, University of Zurich
                  address:
                     name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Moana Busch
            affiliation:
                  name:University Hospital Zurich, University of Zurich
                  address:
                     name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pedro A. Ruiz
            affiliation:
                  name:University Hospital Zurich, University of Zurich
                  address:
                     name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gerhard Rogler
            affiliation:
                  name:University Hospital Zurich, University of Zurich
                  address:
                     name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Pflügers Archiv - European Journal of Physiology
      issn:
         1432-2013
         0031-6768
      volumeNumber:476
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University Hospital Zurich, University of Zurich
      address:
         name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
         type:PostalAddress
      name:University Hospital Zurich, University of Zurich
      address:
         name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
         type:PostalAddress
      name:University Hospital Zurich, University of Zurich
      address:
         name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
         type:PostalAddress
      name:University Hospital Zurich, University of Zurich
      address:
         name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
         type:PostalAddress
      name:University Hospital Zurich, University of Zurich
      address:
         name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
         type:PostalAddress
      name:University Hospital Zurich, University of Zurich
      address:
         name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Martin Hausmann
      affiliation:
            name:University Hospital Zurich, University of Zurich
            address:
               name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Klaus Seuwen
      affiliation:
            name:University Hospital Zurich, University of Zurich
            address:
               name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
               type:PostalAddress
            type:Organization
      name:Cheryl de Vallière
      affiliation:
            name:University Hospital Zurich, University of Zurich
            address:
               name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
               type:PostalAddress
            type:Organization
      name:Moana Busch
      affiliation:
            name:University Hospital Zurich, University of Zurich
            address:
               name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
               type:PostalAddress
            type:Organization
      name:Pedro A. Ruiz
      affiliation:
            name:University Hospital Zurich, University of Zurich
            address:
               name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
               type:PostalAddress
            type:Organization
      name:Gerhard Rogler
      affiliation:
            name:University Hospital Zurich, University of Zurich
            address:
               name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
      name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
      name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
      name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
      name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
      name:Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

External Links {🔗}(534)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.99s.

LINK . SPRINGER . COM {}