We are analyzing https://link.springer.com/article/10.1007/s00281-014-0470-4.

Title:
Innate lymphoid cells, possible interaction with microbiota | Seminars in Immunopathology
Description:
Recent studies have identified novel lymphocyte subsets named innate lymphoid cells (ILCs) lacking antigen-specific receptors. ILCs are present in a wide variety of epithelial compartments and occupy an intermediate position between acquired immune cells and myeloid cells. ILCs are now classified into three groups: group 1 ILC, group 2 ILC, and group 3 ILC based on their cytokine production patterns that correspond to the helper T cell subsets Th1, Th2, and Th17, respectively. ILCs play important roles in protection against various invading microbes including multicellular parasites, and in the maintenance of homeostasis and repair of epithelial layers. Excessive activation of ILCs, however, leads to various inflammatory disease conditions. ILCs have thus attracted interests of many researchers in the fields of infectious immunity, inflammatory diseases, and allergic diseases. Because epithelial cells sense alterations in environmental cues, it is important to understand the functional interaction between epithelial cells, ILCs, and environmental factors such as commensal microbiota. We discuss in this review developmental pathways of ILCs, their functions, and contribution of commensal microbiota to the differentiation and function of ILCs.
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Keywords {🔍}

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Topics {✒️}

lin−id2+il-7rα+cd25−α4β7+flt3− progenitor cells lin−id2+il-7rα+cd25−α4β7+flt3− chilp capable lin−id2+il-7rα+cd25−α4β7+flt3− progenitor population lin−id2+il-7rα+cd25−α4β7+ flt3−cells [7 lin−id2+il-7rα+cd25−α4β7+flt3− derived lin−plzfhighil-7rα+c-kit+α4β7high cells falc lin−c-kit+sca-1+ cells lin−c-kit+sca-1+ phenotype ��c-kitintsca-1+il-7rα+ phenotype il-15-responsive ifn-gamma-producing cells lin−sca-1hiid2higata3hi cell rorγt+ ifn-γ-producing cells nkp46+il-7rα+ ilc lineage ifn-γ-producing ilc1 cells article download pdf c-type lectin receptors rorgammat + innate lymphoid cells high nucleus/cytoplasm ratio tissue-resident memory cd8 antigen receptor-expressing lymphocytes interleukin-1beta selectively expands express c-kit lymphocyte-lacking antigen receptors t-bet gradient controls innate il-5-producing cells ifn-γ-producing ilc1 adult rara-deficient mice lacking antigen-specific receptors cd4+cd3−ltβ+ cells c-kit gene [69] oliveira-dos-santos aj rorc + cd127+ natural killer aryl hydrocarbon receptor transcription factor t-bet interleukin-7 receptor alpha identified cd4+cd3− lti anti-helminth innate immunity cytotoxic ifnγ-producing cells promote oral tolerance earliest nk-cell precursor fate-mapping experiments showed transcription factor id2 innate immune cells innate lymphoid cells innate lymphoid cells intestinal mononuclear phagocytes gm-csf production produce ifn-γ lymphoid tissue inducer th2 cell-type cytokines

Schema {🗺️}

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         headline:Innate lymphoid cells, possible interaction with microbiota
         description:Recent studies have identified novel lymphocyte subsets named innate lymphoid cells (ILCs) lacking antigen-specific receptors. ILCs are present in a wide variety of epithelial compartments and occupy an intermediate position between acquired immune cells and myeloid cells. ILCs are now classified into three groups: group 1 ILC, group 2 ILC, and group 3 ILC based on their cytokine production patterns that correspond to the helper T cell subsets Th1, Th2, and Th17, respectively. ILCs play important roles in protection against various invading microbes including multicellular parasites, and in the maintenance of homeostasis and repair of epithelial layers. Excessive activation of ILCs, however, leads to various inflammatory disease conditions. ILCs have thus attracted interests of many researchers in the fields of infectious immunity, inflammatory diseases, and allergic diseases. Because epithelial cells sense alterations in environmental cues, it is important to understand the functional interaction between epithelial cells, ILCs, and environmental factors such as commensal microbiota. We discuss in this review developmental pathways of ILCs, their functions, and contribution of commensal microbiota to the differentiation and function of ILCs.
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      headline:Innate lymphoid cells, possible interaction with microbiota
      description:Recent studies have identified novel lymphocyte subsets named innate lymphoid cells (ILCs) lacking antigen-specific receptors. ILCs are present in a wide variety of epithelial compartments and occupy an intermediate position between acquired immune cells and myeloid cells. ILCs are now classified into three groups: group 1 ILC, group 2 ILC, and group 3 ILC based on their cytokine production patterns that correspond to the helper T cell subsets Th1, Th2, and Th17, respectively. ILCs play important roles in protection against various invading microbes including multicellular parasites, and in the maintenance of homeostasis and repair of epithelial layers. Excessive activation of ILCs, however, leads to various inflammatory disease conditions. ILCs have thus attracted interests of many researchers in the fields of infectious immunity, inflammatory diseases, and allergic diseases. Because epithelial cells sense alterations in environmental cues, it is important to understand the functional interaction between epithelial cells, ILCs, and environmental factors such as commensal microbiota. We discuss in this review developmental pathways of ILCs, their functions, and contribution of commensal microbiota to the differentiation and function of ILCs.
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         Infection
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               type:PostalAddress
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               type:PostalAddress
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