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Title:
Waldenström macroglobulinemia: a review of pathogenesis, current treatment, and future prospects | Annals of Hematology
Description:
Waldenström macroglobulinemia (WM) is a chronic B-cell lymphoproliferative disorder characterized by lymphoplasmacytic cell overgrowth in the bone marrow and increased secretion of IgM immunoglobulins into the serum. Patients with WM have a variety of clinical outcomes, including long-term survival but inevitable recurrence. Recent advances in disease knowledge, including molecular and genetic principles with the discovery of MYD88 and CXCR4 mutations, have rapidly increased patient-tolerable treatment options. WM patients may benefit from chemotherapy regimens that include rituximab-based regimens, alkylating drugs, proteasome inhibitors, monoclonal antibodies, and drugs targeting Bruton tyrosine kinase inhibitors. In light of these advancements, patients can now receive treatment customized to their specific clinical characteristics, focusing on enhancing the depth and durability of their response while limiting the adverse effects. Despite the rapidly developing therapeutic armament against WM, a lack of high-quality evidence from extensive phase 3 trials remains a significant challenge in the research. We believe clinical outcomes will keep improving when new medicines are introduced while preserving efficacy and minimizing toxicity.
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pubmed, article, google, scholar, macroglobulinemia, cas, waldenström, patients, clin, rituximab, treatment, central, oncol, waldenströms, blood, lymphoma, treon, phase, study, httpsdoiorgjco, writing, therapy, review, httpsdoiorgblood, waldenstroms, cancer, trial, methodology, original, draft, ghafoor, clinical, ibrutinib, usa, data, research, myd, waldenstrom, castillo, leuk, nature, springer, dimopoulos, transplantation, privacy, cookies, content, hameed, cell, outcomes,
Topics {✒️}
month download article/chapter proteasome inhibitors autologous stem-cell transplantation proteasome inhibitor therapy alkylating drugs lymphoplasmacytic cell overgrowth maha hameed hafiza huda akhtar hassan min allah mohammad mohsin arshad include rituximab-based regimens hodgkin lymphoma full article pdf dimopoulos ma large population-based study including long-term survival kyle ra treon sp ghobrial im high-dose therapy lymphoplasmacytic lymphoma cxcr4-mutated waldenström macroglobulinemia muhammad husnain privacy choices/manage cookies mantle-cell lymphomas chemotherapy regimens marginal zone lymphoma 1007/s00277-018-3311 lymphoma working party springer international publishing cxcr4 antagonist ulocuplumab valley royal hospital population-based study shameera shaik masthan high-quality evidence immune-related factors article ghafoor castillo jj myd88 l265p mutation type ii cryoglobulinaemia faiz anwer accepted manuscript version article annals extended rituximab therapy check access additional information publisher instant access received research funding prospectively randomized trial phase ii study
Questions {❓}
- Kristinsson SY, Landgren O (2011) What causes Waldenström’s macroglobulinemia: genetic or immune-related factors, or a combination?
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headline:Waldenström macroglobulinemia: a review of pathogenesis, current treatment, and future prospects
description:Waldenström macroglobulinemia (WM) is a chronic B-cell lymphoproliferative disorder characterized by lymphoplasmacytic cell overgrowth in the bone marrow and increased secretion of IgM immunoglobulins into the serum. Patients with WM have a variety of clinical outcomes, including long-term survival but inevitable recurrence. Recent advances in disease knowledge, including molecular and genetic principles with the discovery of MYD88 and CXCR4 mutations, have rapidly increased patient-tolerable treatment options. WM patients may benefit from chemotherapy regimens that include rituximab-based regimens, alkylating drugs, proteasome inhibitors, monoclonal antibodies, and drugs targeting Bruton tyrosine kinase inhibitors. In light of these advancements, patients can now receive treatment customized to their specific clinical characteristics, focusing on enhancing the depth and durability of their response while limiting the adverse effects. Despite the rapidly developing therapeutic armament against WM, a lack of high-quality evidence from extensive phase 3 trials remains a significant challenge in the research. We believe clinical outcomes will keep improving when new medicines are introduced while preserving efficacy and minimizing toxicity.
datePublished:2023-07-06T00:00:00Z
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Waldemström macroglobulinemia
Lymphoplasmacytic lymphoma
Rituximab
Alkylating agents
Proteasome inhibitors
BTK inhibitors
Hematology
Oncology
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headline:Waldenström macroglobulinemia: a review of pathogenesis, current treatment, and future prospects
description:Waldenström macroglobulinemia (WM) is a chronic B-cell lymphoproliferative disorder characterized by lymphoplasmacytic cell overgrowth in the bone marrow and increased secretion of IgM immunoglobulins into the serum. Patients with WM have a variety of clinical outcomes, including long-term survival but inevitable recurrence. Recent advances in disease knowledge, including molecular and genetic principles with the discovery of MYD88 and CXCR4 mutations, have rapidly increased patient-tolerable treatment options. WM patients may benefit from chemotherapy regimens that include rituximab-based regimens, alkylating drugs, proteasome inhibitors, monoclonal antibodies, and drugs targeting Bruton tyrosine kinase inhibitors. In light of these advancements, patients can now receive treatment customized to their specific clinical characteristics, focusing on enhancing the depth and durability of their response while limiting the adverse effects. Despite the rapidly developing therapeutic armament against WM, a lack of high-quality evidence from extensive phase 3 trials remains a significant challenge in the research. We believe clinical outcomes will keep improving when new medicines are introduced while preserving efficacy and minimizing toxicity.
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Waldemström macroglobulinemia
Lymphoplasmacytic lymphoma
Rituximab
Alkylating agents
Proteasome inhibitors
BTK inhibitors
Hematology
Oncology
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