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Title[redir]:
A randomized phase 3 trial of zanubrutinib vs ibrutinib in symptomatic Waldenström macroglobulinemia: the ASPEN study - PMC
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There is a Blood Commentary on this article in this issue.
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Keywords {🔍}
patients, ibrutinib, zanubrutinib, treatment, study, median, google, scholar, janssen, doi, pubmed, response, receives, atrial, months, grade, disease, macroglobulinemia, patient, beigene, fibrillation, table, higher, incidence, reported, roche, btk, vgpr, data, consults, neutropenia, rates, arms, blood, arm, research, waldenström, supplemental, igm, pmc, article, pfs, baseline, rate, major, mutations, estimated, hypertension, aes, funding,
Topics {✒️}
repeated-measures mixed-effect model hierarchical fixed-sequence procedure 18-month event-free rates contrast-enhanced computed tomography supplementary material adp-mediated platelet aggregation 18-mo event-free rate drug-induced liver injury pmc beta search adequate end-organ function age-matched controlled population ibrutinib inhibits collagen-mediated key points central nervous system bristol-myers squibb company supplementary materials included exploratory end points cochran-mantel-haenszel test receiving single-agent zanubrutinib median progression-free survival log-transformed igm levels exposure-adjusted incidence rates blood web site key baseline characteristics high-risk prognostic category irc-assessed efficacy outcomes mantel-haenszel risk difference ibrutinib-treated patients presenting event-free rates page charge payment investigator-assessed efficacy outcomes selected time points authorship contribution supplementary materials click study comparing outcomes footnotes presented stem cell reports receptor signaling complexes exposure-adjusted basis primary end point license information pmcid local prescribing information ibrutinib-treated patients assessed progression-free survival including minor bleeding/bruising applicable regulatory requirements computed tomography evidence open-label substudy assumed cr/vgpr rate β-2 microglobulin levels
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