We are analyzing https://link.springer.com/article/10.1007/s00262-013-1491-x.

Title:
Critical role of spatial interaction between CD8+ and Foxp3+ cells in human gastric cancer: the distance matters | Cancer Immunology, Immunotherapy
Description:
In various cancer types, an abundance of FoxP3+ regulatory T cells (Treg) has been associated with an unfavorable outcome. Yet, the role of Treg on cancer immunity has been shown to be complex. In single cell marker technique, other tumor-infiltrating lymphocytes (TILs) such as cytotoxic CD8+ T cells (CTL) also influenced prognosis. This study for the first time investigates the concurrent spatial distribution pattern of CD8+ and FoxP3+ TILs and their prognostic impact in human gastric cancer. Tumor tissue microarrays of 50 patients with surgically treated adenocarcinoma of the cardia were studied. An immunohistochemical double staining of CD8+ and FoxP3+ TILs was performed. Cell counts and cell-to-cell distances in tumor epithelium and stroma were evaluated with image-processing software. Metastasis-free survival, no-evidence-of-disease survival, and overall survival were investigated (mean follow-up time 6.9 years). High intraepithelial infiltration of CD8+ and FoxP3+ TIL was associated with the improved 10-year metastasis-free survival (83 vs. 54 %, p = 0.04 and 85 vs. 59 %, p = 0.09, respectively). Considering cell-to-cell distance and comparing patients with functional (30–110 μm) versus nonfunctional distances of CD8+ and FoxP3+ TILs, 10-year survival rates differed between 89 and 55 % (p = 0.009), respectively. Prognostic influence of tumor-infiltrating immune cells in gastric cancer critically depends on their cell-to-cell distance. FoxP3+ TILs must be located within a distance between 30 and 110 μm of CD8+ T cells to positively impact on prognosis.
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Keywords {🔍}

cancer, article, pubmed, google, scholar, gastric, cells, cas, foxp, regulatory, tumorinfiltrating, prognosis, central, lymphocytes, survival, immunol, human, haas, distel, tils, prognostic, patients, access, privacy, cookies, content, role, distance, cell, dois, information, publish, search, immunology, feichtenbeiner, grabenbauer, treg, tumor, cardia, infiltration, carcinoma, clin, wang, oncol, fujii, immunother, data, log, journal, research,

Topics {✒️}

naturally occurring cd4+ cd25+ regulatory long-term disease-free survival foxp3-positive tumor-infiltrating lymphocytes cd8-alpha t-cell infiltration month download article/chapter tumor-infiltrating immune cells cd4+ cd25high regulatory t-cells advanced gastric carcinoma intra-tumoral infiltrating macrophages potent anti-tumor killer tumor-draining lymph nodes article cancer immunology increased tumor-infiltrating cd8 stromal regulatory t-cells sentinel lymph-node metastasis related subjects intratumoural foxp3-positive regulatory tumour-infiltrating lymphocytes tumor-infiltrating lymphocytes full article pdf tumor-infiltrating foxp3+ metastasis-free survival privacy choices/manage cookies sentinel lymph node ten-year survival intratumoral foxp3+rorγt+ gastric cancer progression human gastric cancer article feichtenbeiner gastric cancer prevention resectable gastric cancer improved patient prognosis european economic area immunohistochemical double staining cox-2-dependent manner postoperative adjuvant chemotherapy common public hospital cancerous hla class excellent technical assistance independent prognostic factor conditions privacy policy check access instant access colorectal cancer differs surgically treated adenocarcinoma versus nonfunctional distances cancers cd8-positive electronic supplementary material article log accepting optional cookies

Questions {❓}

Haas M, Buttner M, Rau TT, Fietkau R, Grabenbauer GG, Distel LV (2011) Inflammation in gastric adenocarcinoma of the cardia: how do EBV infection, Her2 amplification and cancer progression influence tumor-infiltrating lymphocytes?

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         description:In various cancer types, an abundance of FoxP3+ regulatory T cells (Treg) has been associated with an unfavorable outcome. Yet, the role of Treg on cancer immunity has been shown to be complex. In single cell marker technique, other tumor-infiltrating lymphocytes (TILs) such as cytotoxic CD8+ T cells (CTL) also influenced prognosis. This study for the first time investigates the concurrent spatial distribution pattern of CD8+ and FoxP3+ TILs and their prognostic impact in human gastric cancer. Tumor tissue microarrays of 50 patients with surgically treated adenocarcinoma of the cardia were studied. An immunohistochemical double staining of CD8+ and FoxP3+ TILs was performed. Cell counts and cell-to-cell distances in tumor epithelium and stroma were evaluated with image-processing software. Metastasis-free survival, no-evidence-of-disease survival, and overall survival were investigated (mean follow-up time 6.9 years). High intraepithelial infiltration of CD8+ and FoxP3+ TIL was associated with the improved 10-year metastasis-free survival (83 vs. 54 %, p = 0.04 and 85 vs. 59 %, p = 0.09, respectively). Considering cell-to-cell distance and comparing patients with functional (30–110 μm) versus nonfunctional distances of CD8+ and FoxP3+ TILs, 10-year survival rates differed between 89 and 55 % (p = 0.009), respectively. Prognostic influence of tumor-infiltrating immune cells in gastric cancer critically depends on their cell-to-cell distance. FoxP3+ TILs must be located within a distance between 30 and 110 μm of CD8+ T cells to positively impact on prognosis.
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      headline:Critical role of spatial interaction between CD8+ and Foxp3+ cells in human gastric cancer: the distance matters
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