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Title[redir]:
The American Journal of Surgical Pathology
Description:
e aims of the present study were: (1) to investigate the relationship between Foxp3+ Tregs and histologic differentiation, Edmondson-Steiner (ES) nuclear grade, vascular invasion, and pathologic stage of HCC in patients undergoing surgery for their disease; and (2) to evaluate any Foxp3+ Treg-defined difference in the risk for tumor recurrence or death. The study sample included 131 histologic sections of HCC. The number of tumor-infiltrating CD3, CD8, and Foxp3+ lymphocytes was assessed by immunohistochemistry. An increased Foxp3:CD3 ratio was associated with more poorly differentiated HCC (P=0.0016) and higher ES nuclear grade (P=0.0407). An increased Foxp3:CD8 ratio was also associated with poorer differentiation (P=0.0044), higher ES nuclear grade (P=0.0179), recurrence (P=0.0183), decreased overall survival (hazard ratio=1.153; 95% confidence interval, 1.019-1.304; P=0.0235), and decreased disease-free survival (hazard ratio=1.138; 95% confidence interval, 1.016-1.273; P=0.0249). Tumor size and type of surgery (surgical resection) were associated with decreased disease-free survival on univariate analysis but not on multivariate analysis. In conclusion, a higher concentration of tumor-infiltrating Foxp3+ Tregs in HCC is associated with higher grade and poorly differentiated tumors and signifies an unfavorable prognosis....
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Keywords {🔍}
journal, foxp, hcc, issue, tregs, grade, ratio, higher, access, subscribe, alerts, articles, authors, abstract, tumorinfiltrating, histologic, carcinoma, nuclear, tumor, decreased, survival, log, register, logo, issues, role, foxppositive, lymphocytes, hepatocellular, surgical, buy, patients, study, differentiation, surgery, recurrence, increased, foxpcd, poorly, differentiated, hazard, confidence, interval, diseasefree, analysis, tumors, copyright, wolters, kluwer, health,
Topics {✒️}
foxp3-positive tumor-infiltrating lymphocytes foxp3+ treg-defined difference decreased disease-free survival tumor-infiltrating foxp3+ tregs 0b013e31824e9b7c buy abstract journal authors submit full text access foxp3-positive regulatory tumor-infiltrating cd3 antitumoral immune response specific clinicopathologic characteristics poorly differentiated tumors read immunohistochemical expression large-cell change clonal cellular proliferation benign fibromatous tumors artificial intelligence training prostatic carcinoma subsequent etoc alerts alka mary md service request 800-638-3030 poorly differentiated hcc register subscribe patients undergoing surgery individual subscribers log american journal journal tables nuclear grade foxp3+ lymphocytes higher grade issue present study foxp3+ tregs hepatocellular carcinoma histologic features histologic differentiation tumor size higher concentration desmoid tumor website subscribe increased foxp3 journal tumor recurrence cd3 ratio center submit clinical outcomes surgical pathology 36 edmondson-steiner vascular invasion pathologic stage
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