We are analyzing https://link.springer.com/article/10.1007/s00253-007-0911-2.

Title:
Histone deacetylases—an important class of cellular regulators with a variety of functions | Applied Microbiology and Biotechnology
Description:
The elucidation of mechanisms of chromatin remodeling, particular transcriptional activation, and repression by histone acetylation and deacetylation has shed light on the role of histone deacetylases (HDAC) as a new kind of therapeutic target for human cancer treatment. HDACs, in general, act as components of large corepressor complexes that prevent the transcription of several tumor suppression genes. In addition, they appear to be also involved in the deacetylation of nonhistone proteins. This paper reviews the most recent insights into the diverse biological roles of HDACs as well as the evolution of this important protein family.
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

Blanchard F, Chipoy C (2005) Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases?
Kouzarides T (2000) Acetylation: a regulatory modification to rival phosphorylation?
Margueron R, Trojer P, Reinberg D (2005) The key to development: interpreting the histone code?
Nusinzon I, Horvath CM (2005) Histone deacetylases as transcriptional activators?
Pazin MJ, Kadonaga JT (1997) What’s up and down with histone deacetylation and transcription?

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