NCBI . NLM . NIH . GOV {
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Title[redir]:
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor - PMC
Description:
Histone deacetylases (HDACs) are a family of enzymes involved in the regulation of gene expression, DNA repair, and stress response. These processes often are altered in tumors, and HDAC inhibitors have had pronounced antitumor activity with ...
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Keywords {🔍}
hdac, site, fig, residues, gif, structure, inhibitor, doi, hdacs, pubmed, google, scholar, inhibitors, data, ions, class, hdlp, protein, human, oxygen, active, cell, open, shown, asp, hydroxamic, acid, tsa, supporting, group, molecules, compound, materials, sites, presence, interactions, inhibition, ion, region, yellow, drawn, representation, potassiumbinding, pnasspacergif, pmc, nlm, information, activity, observed, selective,
Topics {✒️}
sitting-drop vapor-diffusion technique quantitative rt-pcr analysis single α/β domain stranded parallel β-sheet main-chain carbonyl oxygens pmc beta search zinc–metalloprotease–hydroxamate complexes mock-transfected negative control eukaryotic zinc-dependent hdac main-chain carbonyl oxygen carbon-long aliphatic chain zinc-dependent hdacs suggests additional meta substituents supplementary materials included zinc-dependent hydrolases single-bond character twisted β-sheet hydroxamic acid group metal-binding domain pronounced antitumor activity variations give rise license information pmcid yeast rpd3 deacetylase yeast hda1 deacetylase protein data bank small molecules relies mounting evidence suggests yeast sir2 homologs 5-pyridin-2-yl-2-thienyl sulfonyl]amino}benzamide glycyl-glycyl-glycine short interfering rnas acute myeloid leukemia [14c]thymidine incorporation twofold axis relating size-exclusion chromatography beamline id14-h3 short interfering rna side-chain oxygens filled violet circles zinc-dependent hdacs strong positive peaks long extended loop long extended linker hydroxamic acid inhibitor pnas web site extensive hydrophobic sandwich central β-sheet generate docking sites distinct inhibition pattern
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