We are analyzing https://link.springer.com/article/10.1007/s00018-025-05617-9.

Title:
Dysregulation of cholesterol homeostasis in cancer pathogenesis | Cellular and Molecular Life Sciences
Description:
Cholesterol is a unique lipid for all mammalian cells, with important functions in membrane biogenesis and maintenance of proper membrane integrity and fluidity. Therefore, it plays an important role in cellular homeostasis. Dysregulation of cholesterol homeostasis is associated with various diseases in humans, including cardiovascular diseases, inflammatory diseases, neurodegenerative disorders, and cancers. In the tumor microenvironment, intrinsic and extrinsic cellular factors reprogram cholesterol metabolism and consequently promote tumorigenesis. Here, we summarize the current knowledge on molecular mechanisms and functional roles of cholesterol homeostasis and its dysregulation in regard to cancer pathogenesis. We also discuss the interplay of cholesterol metabolism and the ATP-binding cassette (ABC) proteins, highly conserved cellular transmembrane lipid transporters. An emerging role of lipid ABC transporters as potential prognostic tools for cancer progression and invasiveness is emphasized. Targeting both cholesterol metabolism and proteins associated with membrane cholesterol holds promise as a novel therapeutic strategy for cancer treatment.
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Keywords {🔍}

cholesterol, pubmed, cancer, article, google, scholar, cas, abca, cell, central, cells, lipid, tumor, membrane, metabolism, signaling, expression, efflux, role, breast, receptor, homeostasis, progression, levels, cellular, protein, transporters, plasma, pathway, abc, growth, abcg, biol, proliferation, increased, res, proteins, mol, dysregulation, rafts, high, transport, nat, macrophages, biosynthesis, mechanisms, colorectal, survival, activation, cancers,

Topics {✒️}

wnt/β-catenin signaling coalesce klf5/mir-27a/fbxw7 pathway atp-binding cassette a1 pdz-scaffold protein nherf1/ebp50 ifn-γ-induced anti-tumor effects altered lipid profiles lipid atp-binding cassette glycosylation-dependent ifn-γr partitioning ewa błaszczak modulating mir-33a-pim3 pathway acat1-/- cd8 + t-cells raises tumor-fighting anti-tumor phenotype wnt/β-catenin signaling wnt/β-catenin pathway niemann-pick type c2 article download pdf grégory verdeil atp-binding cassette rassf1c regulates mir-33a anti-inflammatory/pro-tumor functions [155] hypoxia-inducible factor-1α 3-hydroxy-methylglutaryl-coa reductase 3-hydroxy-3-methylglutaryl-coa reductase bulk rna-sequencing reveals myc-mediated de-repression blocking srebp-1-mediated lipogenesis author information authors specific small-molecule inhibitor conserved cholesterol-responsive motifs g-protein coupled receptor current view distinct membrane meso-domains article mordzińska-rak cholesterol-esterifying enzyme acat1 sterol-o-acyl transferase 1 t-cell immune responses triple-negative breast cancer mitogen-activated protein kinase niemann-pick c1 enzyme sterol-o-acyltransferase 1 disturb detergent-resistant domains t-cell killing compared stronger t-cell receptor macrophage-derived foam cells interferon-gamma-mediated downregulation erk/fra-1/zeb1 pathway reduces cancer-related mortality targeting human acyl-coa pro-inflammatory/anti-tumor mouse low-grade gliomas

Questions {❓}

Attard G, Cooper CS, de Bono JS (2009) Steroid hormone receptors in prostate cancer: a hard habit to break?
Ben Hassen C, Goupille C, Vigor C et al (2023) Is cholesterol a risk factor for breast cancer incidence and outcome?
He X, Lan H, Jin K, Liu F (2023) Cholesterol in colorectal cancer: an essential but tumorigenic precursor?
Lewis BS (2023) First-in-human trial of PCSK9 gene editing therapy for lowering cholesterol: a new frontier in cardiovascular pharmacotherapy?
Phillips MC (2018) Is ABCA1 a lipid transfer protein?
Ruzzi F, Cappello C, Semprini MS et al (2024) Lipid rafts, caveolae, and epidermal growth factor receptor family: friends or foes?
Vishwa R, BharathwajChetty B, Girisa S et al (2024) Lipid metabolism and its implications in tumor cell plasticity and drug resistance: what we learned thus far?
Wu A, Wojtowicz K, Savary S et al (2020) Do ABC transporters regulate plasma membrane organization?

Schema {🗺️}

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         description:Cholesterol is a unique lipid for all mammalian cells, with important functions in membrane biogenesis and maintenance of proper membrane integrity and fluidity. Therefore, it plays an important role in cellular homeostasis. Dysregulation of cholesterol homeostasis is associated with various diseases in humans, including cardiovascular diseases, inflammatory diseases, neurodegenerative disorders, and cancers. In the tumor microenvironment, intrinsic and extrinsic cellular factors reprogram cholesterol metabolism and consequently promote tumorigenesis. Here, we summarize the current knowledge on molecular mechanisms and functional roles of cholesterol homeostasis and its dysregulation in regard to cancer pathogenesis. We also discuss the interplay of cholesterol metabolism and the ATP-binding cassette (ABC) proteins, highly conserved cellular transmembrane lipid transporters. An emerging role of lipid ABC transporters as potential prognostic tools for cancer progression and invasiveness is emphasized. Targeting both cholesterol metabolism and proteins associated with membrane cholesterol holds promise as a novel therapeutic strategy for cancer treatment.
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            Cancer
            Cancer progression
            Tumor microenvironment
            ATP-binding cassette transporters
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            Biomedicine
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            Biochemistry
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      headline:Dysregulation of cholesterol homeostasis in cancer pathogenesis
      description:Cholesterol is a unique lipid for all mammalian cells, with important functions in membrane biogenesis and maintenance of proper membrane integrity and fluidity. Therefore, it plays an important role in cellular homeostasis. Dysregulation of cholesterol homeostasis is associated with various diseases in humans, including cardiovascular diseases, inflammatory diseases, neurodegenerative disorders, and cancers. In the tumor microenvironment, intrinsic and extrinsic cellular factors reprogram cholesterol metabolism and consequently promote tumorigenesis. Here, we summarize the current knowledge on molecular mechanisms and functional roles of cholesterol homeostasis and its dysregulation in regard to cancer pathogenesis. We also discuss the interplay of cholesterol metabolism and the ATP-binding cassette (ABC) proteins, highly conserved cellular transmembrane lipid transporters. An emerging role of lipid ABC transporters as potential prognostic tools for cancer progression and invasiveness is emphasized. Targeting both cholesterol metabolism and proteins associated with membrane cholesterol holds promise as a novel therapeutic strategy for cancer treatment.
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         Membrane cholesterol
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         Cancer
         Cancer progression
         Tumor microenvironment
         ATP-binding cassette transporters
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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               type:PostalAddress
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      name:Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France
      name:Department of Biochemistry and Molecular Biology, Faculty of Medical Sciences, Medical University of Lublin, Lublin, Poland
      name:Department of Biochemistry and Molecular Biology, Faculty of Medical Sciences, Medical University of Lublin, Lublin, Poland

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