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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
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  13. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s00018-023-05054-6.

Title:
Biophysical control of plasticity and patterning in regeneration and cancer | Cellular and Molecular Life Sciences
Description:
Cells and tissues display a remarkable range of plasticity and tissue-patterning activities that are emergent of complex signaling dynamics within their microenvironments. These properties, which when operating normally guide embryogenesis and regeneration, become highly disordered in diseases such as cancer. While morphogens and other molecular factors help determine the shapes of tissues and their patterned cellular organization, the parallel contributions of biophysical control mechanisms must be considered to accurately predict and model important processes such as growth, maturation, injury, repair, and senescence. We now know that mechanical, optical, electric, and electromagnetic signals are integral to cellular plasticity and tissue patterning. Because biophysical modalities underly interactions between cells and their extracellular matrices, including cell cycle, metabolism, migration, and differentiation, their applications as tuning dials for regenerative and anti-cancer therapies are being rapidly exploited. Despite this, the importance of cellular communication through biophysical signaling remains disproportionately underrepresented in the literature. Here, we provide a review of biophysical signaling modalities and known mechanisms that initiate, modulate, or inhibit plasticity and tissue patterning in models of regeneration and cancer. We also discuss current approaches in biomedical engineering that harness biophysical control mechanisms to model, characterize, diagnose, and treat disease states.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

pubmed, google, scholar, article, cas, cells, cancer, cell, central, regeneration, tissue, plasticity, fields, tumor, ecm, biophysical, tissues, channels, stem, patterning, signaling, growth, including, biol, electric, differentiation, effects, sci, cellular, ion, stiffness, light, signals, magnetic, potential, mechanisms, microenvironment, bioelectric, wound, migration, expression, healing, control, mechanical, field, photobiomodulation, molecular, proliferation, vitro, wang,

Topics {✒️}

bone-marrow-derived progenitor cells n-methyl-d-aspartate receptors akt/hypoxia inducible factor-1α article download pdf time-varying magnetic fields long-term structural stability voltage-gated calcium channel silver-wired electrodes coupled mechanostimulus-driven cancer therapeutics voltage-gated proton channel population-based case–control study mitogen-activated protein kinase enhances gap-junction communication voltage-sensitive ion channels low-level laser irradiation g-protein coupled receptors methicillin-resistant staphylococcus aureus low-level laser light wavelength-specific light exposures voltage-gated calcium channels dielectrophoresis based-cell patterning phototherapy-induced antitumor immunity artificial sunlight irradiation ultra-weak photon emission flow-induced shear stress central nervous system low-level light therapy oncogene-induced tumorigenesis dmba-induced mammary carcinogenesis light-gated ion channels mechanoresponsive epha2/lyn complex long-range tissue polarity el-hayek yh transforming growth factor-β1 ion channel-dependent mechanisms nanosecond-pulsed electric fields gj-mediated depolarizing waves microtubule-organizing center location cell–extracellular matrix mechanotransduction meso-scale tissue polarity send long-distance signals potential light-based therapies α1β1 integrin-dependent process low-intensity currents delivered long-range tissue dynamics endogenous em-related signals calcium-activated potassium channels cell–cell interactions present gap-junction-mediated ecm ligand type

Questions {❓}

  • Bhargava A, Saha S (2019) T-Type voltage gated calcium channels: a target in breast cancer?
  • Can electromagnetic factors influence cancer?
  • Cunningham JE, Jurj AL, Oman L, Stonerock AE, Nitcheva DK, Cupples TE (2006) Is risk of axillary lymph node metastasis associated with proximity of breast cancer to the skin?
  • Hamblin MR, Nelson ST, Strahan JR (2018) Photobiomodulation and cancer: what is the truth?
  • Havas M (2017) When theory and observation collide: can non-ionizing radiation cause cancer?
  • How do multicellular systems determine which individual cells should proliferate, specialize, or die in service of the group?
  • Moro C, Liebert A, Hamilton C, Pasqual N, Jeffery G, Stone J, Mitrofanis J (2022) The code of light: do neurons generate light to communicate and repair?
  • Novel questions can now be addressed: Are long-range bioelectric signals impacted by the polarization of ECM polymers?
  • Pahor M, Guralnik JM, Salive ME, Corti MC, Carbonin P, Havlik RJ (1996) Do calcium channel blockers increase the risk of cancer?
  • Pomerantz JH, Blau HM (2013) Tumor suppressors: enhancers or suppressors of regeneration?
  • Zarkeshian P, Kumar S, Tuszynski J, Barclay P, Simon C (2017) Are there optical communication channels in the brain?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Biophysical control of plasticity and patterning in regeneration and cancer
         description:Cells and tissues display a remarkable range of plasticity and tissue-patterning activities that are emergent of complex signaling dynamics within their microenvironments. These properties, which when operating normally guide embryogenesis and regeneration, become highly disordered in diseases such as cancer. While morphogens and other molecular factors help determine the shapes of tissues and their patterned cellular organization, the parallel contributions of biophysical control mechanisms must be considered to accurately predict and model important processes such as growth, maturation, injury, repair, and senescence. We now know that mechanical, optical, electric, and electromagnetic signals are integral to cellular plasticity and tissue patterning. Because biophysical modalities underly interactions between cells and their extracellular matrices, including cell cycle, metabolism, migration, and differentiation, their applications as tuning dials for regenerative and anti-cancer therapies are being rapidly exploited. Despite this, the importance of cellular communication through biophysical signaling remains disproportionately underrepresented in the literature. Here, we provide a review of biophysical signaling modalities and known mechanisms that initiate, modulate, or inhibit plasticity and tissue patterning in models of regeneration and cancer. We also discuss current approaches in biomedical engineering that harness biophysical control mechanisms to model, characterize, diagnose, and treat disease states.
         datePublished:2023-12-15T00:00:00Z
         dateModified:2023-12-15T00:00:00Z
         pageStart:1
         pageEnd:26
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s00018-023-05054-6
         keywords:
            Plasticity
            Patterning
            Biophysics
            Cancer
            Regeneration
            Cell Biology
            Biomedicine
            general
            Life Sciences
            Biochemistry
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            issn:
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ScholarlyArticle:
      headline:Biophysical control of plasticity and patterning in regeneration and cancer
      description:Cells and tissues display a remarkable range of plasticity and tissue-patterning activities that are emergent of complex signaling dynamics within their microenvironments. These properties, which when operating normally guide embryogenesis and regeneration, become highly disordered in diseases such as cancer. While morphogens and other molecular factors help determine the shapes of tissues and their patterned cellular organization, the parallel contributions of biophysical control mechanisms must be considered to accurately predict and model important processes such as growth, maturation, injury, repair, and senescence. We now know that mechanical, optical, electric, and electromagnetic signals are integral to cellular plasticity and tissue patterning. Because biophysical modalities underly interactions between cells and their extracellular matrices, including cell cycle, metabolism, migration, and differentiation, their applications as tuning dials for regenerative and anti-cancer therapies are being rapidly exploited. Despite this, the importance of cellular communication through biophysical signaling remains disproportionately underrepresented in the literature. Here, we provide a review of biophysical signaling modalities and known mechanisms that initiate, modulate, or inhibit plasticity and tissue patterning in models of regeneration and cancer. We also discuss current approaches in biomedical engineering that harness biophysical control mechanisms to model, characterize, diagnose, and treat disease states.
      datePublished:2023-12-15T00:00:00Z
      dateModified:2023-12-15T00:00:00Z
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      pageEnd:26
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s00018-023-05054-6
      keywords:
         Plasticity
         Patterning
         Biophysics
         Cancer
         Regeneration
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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         name:Springer International Publishing
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            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
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      author:
            name:Nirosha J. Murugan
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                     name:Department of Health Sciences, Wilfrid Laurier University, Waterloo, Canada
                     type:PostalAddress
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                     name:Department of Health Sciences, Wilfrid Laurier University, Waterloo, Canada
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                  name:Wilfrid Laurier University
                  address:
                     name:Department of Health Sciences, Wilfrid Laurier University, Waterloo, Canada
                     type:PostalAddress
                  type:Organization
                  name:Tufts University
                  address:
                     name:Allen Discovery Center, Tufts University, Medford, USA
                     type:PostalAddress
                  type:Organization
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                     name:Department of Biomedical Engineering, Tufts University, Medford, USA
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         name:Allen Discovery Center, Tufts University, Medford, USA
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         name:Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Canada
         type:PostalAddress
      name:Wilfrid Laurier University
      address:
         name:Department of Health Sciences, Wilfrid Laurier University, Waterloo, Canada
         type:PostalAddress
      name:Wilfrid Laurier University
      address:
         name:Department of Health Sciences, Wilfrid Laurier University, Waterloo, Canada
         type:PostalAddress
      name:Tufts University
      address:
         name:Allen Discovery Center, Tufts University, Medford, USA
         type:PostalAddress
      name:Tufts University
      address:
         name:Department of Biomedical Engineering, Tufts University, Medford, USA
         type:PostalAddress
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      affiliation:
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            address:
               name:Department of Health Sciences, Wilfrid Laurier University, Waterloo, Canada
               type:PostalAddress
            type:Organization
            name:Tufts University
            address:
               name:Allen Discovery Center, Tufts University, Medford, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Solsa Cariba
      affiliation:
            name:University of Guelph
            address:
               name:Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Canada
               type:PostalAddress
            type:Organization
      name:Sawith Abeygunawardena
      affiliation:
            name:Wilfrid Laurier University
            address:
               name:Department of Health Sciences, Wilfrid Laurier University, Waterloo, Canada
               type:PostalAddress
            type:Organization
      name:Nicolas Rouleau
      affiliation:
            name:Wilfrid Laurier University
            address:
               name:Department of Health Sciences, Wilfrid Laurier University, Waterloo, Canada
               type:PostalAddress
            type:Organization
            name:Tufts University
            address:
               name:Allen Discovery Center, Tufts University, Medford, USA
               type:PostalAddress
            type:Organization
            name:Tufts University
            address:
               name:Department of Biomedical Engineering, Tufts University, Medford, USA
               type:PostalAddress
            type:Organization
      name:Samantha L. Payne
      affiliation:
            name:University of Guelph
            address:
               name:Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Canada
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Health Sciences, Wilfrid Laurier University, Waterloo, Canada
      name:Allen Discovery Center, Tufts University, Medford, USA
      name:Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Canada
      name:Department of Health Sciences, Wilfrid Laurier University, Waterloo, Canada
      name:Department of Health Sciences, Wilfrid Laurier University, Waterloo, Canada
      name:Allen Discovery Center, Tufts University, Medford, USA
      name:Department of Biomedical Engineering, Tufts University, Medford, USA
      name:Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Canada

External Links {🔗}(986)

Analytics and Tracking {📊}

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Libraries {📚}

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