We are analyzing https://link.springer.com/article/10.1007/s00018-021-04109-w.

Title:
The key players of parthanatos: opportunities for targeting multiple levels in the therapy of parthanatos-based pathogenesis | Cellular and Molecular Life Sciences
Description:
Cellular and Molecular Life Sciences - Parthanatos is a form of regulated cell death involved in the pathogenesis of many diseases, particularly neurodegenerative disorders, such as Parkinson
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Keywords {🔍}

pubmed, article, google, scholar, cas, central, cell, death, dawson, factor, polyadpribose, wang, biol, parp, apoptosisinducing, parthanatos, mol, sci, dna, disease, aif, lee, polymerase, mitochondrial, med, liu, migration, inhibitory, mechanisms, science, macrophage, cancer, molecular, key, par, therapeutic, poirier, acad, httpsdoiorg, nat, nuclear, mif, andrabi, proc, natl, httpsdoiorgpnas, activation, chem, therapy, diseases,

Topics {✒️}

month download article/chapter caspase-independent programmed necrosis n-methyl-d-aspartate receptors underlying molecular mechanisms macrophage migration-inhibitory factor cd74-dependent manner regulates disease-related rna-binding proteins oxidant-induced cell death induce aif-mediated apoptosis apoptosis-inducing factor triggered apoptosis-inducing factor substitutes apoptosis-inducing factor due apoptosis-inducing factor leads polymer-induced cell death adp-ribosyl-acceptor hydrolase 3 peroxynitrite-induced thymocyte apoptosis polymerase-1-dependent cell death polymerase-dependent cell death dna-independent parp-1 activation fast signal-induced activation aif-mediated dna damage mitochondrial apoptosis-inducing factor redox-linked conformational dynamics hydrogen peroxide-induced poly cell death mechanisms bax-independent mechanisms full article pdf cell death mediated jinmin gao & ruoxi wang rna-binding protein hur aif/cypa complex protects neuronal cell death dependent cell death treating parthanatos-based pathogenesis analog-sensitive parp mutants prevents brain injury muscle-specific loss involves poly apoptosis-inducing factor aif-independent parthanatos mitochondrial-linked mechanisms chronic lung diseases privacy choices/manage cookies cell death subroutines necrotic cell death autophagic cell death nuclear adp-ribosylation reactions amyotrophic lateral sclerosis kam ti parp1-erk2 synergism

Questions {❓}

Hassa PO, Haenni SS, Elser M, Hottiger MO (2006) Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?

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         description:Parthanatos is a form of regulated cell death involved in the pathogenesis of many diseases, particularly neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, Huntington’s disease, and amyotrophic lateral sclerosis. Parthanatos is a multistep cell death pathway cascade that involves poly (ADP-ribose) polymerase 1 (PARP-1) overactivation, PAR accumulation, PAR binding to apoptosis-inducing factor (AIF), AIF release from the mitochondria, nuclear translocation of the AIF/macrophage migration inhibitory factor (MIF) complex, and MIF-mediated large-scale DNA fragmentation. All the key players in the parthanatos pathway are pleiotropic proteins with diverse functions. An in-depth understanding of the structure-based activity of the key factors, and the biochemical mechanisms of parthanatos, is crucial for the development of drugs and therapeutic strategies. In this review, we delve into the key players of the parthanatos pathway and reveal the multiple levels of therapeutic opportunities for treating parthanatos-based pathogenesis.
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      description:Parthanatos is a form of regulated cell death involved in the pathogenesis of many diseases, particularly neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, Huntington’s disease, and amyotrophic lateral sclerosis. Parthanatos is a multistep cell death pathway cascade that involves poly (ADP-ribose) polymerase 1 (PARP-1) overactivation, PAR accumulation, PAR binding to apoptosis-inducing factor (AIF), AIF release from the mitochondria, nuclear translocation of the AIF/macrophage migration inhibitory factor (MIF) complex, and MIF-mediated large-scale DNA fragmentation. All the key players in the parthanatos pathway are pleiotropic proteins with diverse functions. An in-depth understanding of the structure-based activity of the key factors, and the biochemical mechanisms of parthanatos, is crucial for the development of drugs and therapeutic strategies. In this review, we delve into the key players of the parthanatos pathway and reveal the multiple levels of therapeutic opportunities for treating parthanatos-based pathogenesis.
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         Life Sciences
         Biochemistry
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