We are analyzing https://link.springer.com/article/10.1007/s00018-021-03839-1.

Title:
Follicular helper T cells: potential therapeutic targets in rheumatoid arthritis | Cellular and Molecular Life Sciences
Description:
Rheumatoid arthritis (RA) is a chronic autoimmune disease with joint and systemic inflammation that is accompanied by the production of autoantibodies, such as rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies. Follicular helper T (Tfh) cells, which are a subset of CD4+ T cells, facilitate germinal center (GC) reactions by providing signals required for high-affinity antibody production and the generation of long-lived antibody-secreting plasma cells. Uncontrolled expansion of Tfh cells is observed in various systemic autoimmune diseases. Particularly, the frequencies of circulating Tfh-like (cTfh-like) cells, their subtypes and synovial-infiltrated T helper cells correlate with disease activity in RA patients. Therefore, reducing autoantibody production and restricting excessive Tfh cell responses are ideal ways to control RA pathogenesis. The present review summarizes current knowledge of the involvement of Tfh cells in RA pathogenesis and highlights the potential of these cells as therapeutic targets.
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Keywords {🔍}

pubmed, article, google, scholar, cas, arthritis, cells, rheumatoid, central, cell, follicular, helper, patients, immunol, rheum, germinal, disease, dis, tfh, circulating, httpsdoiorgs, ann, med, immunity, httpsdoiorgannrheumdis, interleukin, autoimmune, center, rheumatol, res, ther, development, nat, clin, therapeutic, wang, antibody, responses, rev, httpsdoiorgjimmuni, subsets, human, study, regulatory, function, systemic, activity, differentiation, lupus, httpsdoiorgart,

Topics {✒️}

t-follicular regulatory cells month download article/chapter disease-modifying anti-rheumatic drugs randomised saril-ra-mobility part long-lived plasma cells t-cell platelet-derived membrane vesicles tetraspanin-enriched microdomains reveals anti-il-6 receptor nanobody® natural single-domain antibodies anti-cyclic citrullinated peptide dendritic cells stimulates tcr/cd3/zeta complex integrating single-cell transcriptomics antagonistic anti-cd40 antibody anti-il-21 monoclonal antibody high-affinity antibody production anti-cd40 ligand antibody circulating tfr/tfh ratio full article pdf lloyd cm germinal center reaction high-dimensional analysis follicular helper cells dendritic cells nurieva ri germinal center formation rao da pd-1 controls follicular follicular helper lymphocytes helper cells correlate helper cells synthesize privacy choices/manage cookies circulating follicular helper circulating follicular helper facilitate germinal center germinal center suppression soluble interleukin-6 receptor pathogenic cellular networks cxcl13-producing helper antigen-driven selection helper cell positioning sanchez-hernandez pe plasma cell differentiation circulating follicullar helper follicular helper expansion article lu il-10 receptor signaling germinal center response anti-tnf therapy

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         description:Rheumatoid arthritis (RA) is a chronic autoimmune disease with joint and systemic inflammation that is accompanied by the production of autoantibodies, such as rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies. Follicular helper T (Tfh) cells, which are a subset of CD4+ T cells, facilitate germinal center (GC) reactions by providing signals required for high-affinity antibody production and the generation of long-lived antibody-secreting plasma cells. Uncontrolled expansion of Tfh cells is observed in various systemic autoimmune diseases. Particularly, the frequencies of circulating Tfh-like (cTfh-like) cells, their subtypes and synovial-infiltrated T helper cells correlate with disease activity in RA patients. Therefore, reducing autoantibody production and restricting excessive Tfh cell responses are ideal ways to control RA pathogenesis. The present review summarizes current knowledge of the involvement of Tfh cells in RA pathogenesis and highlights the potential of these cells as therapeutic targets.
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      headline:Follicular helper T cells: potential therapeutic targets in rheumatoid arthritis
      description:Rheumatoid arthritis (RA) is a chronic autoimmune disease with joint and systemic inflammation that is accompanied by the production of autoantibodies, such as rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies. Follicular helper T (Tfh) cells, which are a subset of CD4+ T cells, facilitate germinal center (GC) reactions by providing signals required for high-affinity antibody production and the generation of long-lived antibody-secreting plasma cells. Uncontrolled expansion of Tfh cells is observed in various systemic autoimmune diseases. Particularly, the frequencies of circulating Tfh-like (cTfh-like) cells, their subtypes and synovial-infiltrated T helper cells correlate with disease activity in RA patients. Therefore, reducing autoantibody production and restricting excessive Tfh cell responses are ideal ways to control RA pathogenesis. The present review summarizes current knowledge of the involvement of Tfh cells in RA pathogenesis and highlights the potential of these cells as therapeutic targets.
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         Biochemistry
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