We are analyzing https://link.springer.com/article/10.1007/s00018-018-2940-7.

Title:
Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression | Cellular and Molecular Life Sciences
Description:
MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that participate in a majority of biological processes via regulating target gene expression. The post-transcriptional repression through miRNA seed region binding to 3′ UTR of target mRNA is considered as the canonical mode of miRNA-mediated gene regulation. However, emerging evidence suggests that other regulatory modes exist beyond the canonical mechanism. In particular, the function of intranuclear miRNA in gene transcriptional regulation is gradually revealed, with evidence showing their contribution to gene silencing or activating. Therefore, miRNA-mediated regulation of gene transcription not only expands our understanding of the molecular mechanism underlying miRNA regulatory function, but also provides new evidence to explain its ability in the sophisticated regulation of many bioprocesses. In this review, mechanisms of miRNA-mediated gene transcriptional and post-transcriptional regulation are summarized, and the synergistic effects among these actions which form a regulatory network of a miRNA on its target are particularly elaborated. With these discussions, we aim to emphasize the importance of miRNA regulatory network on target gene regulation and further highlight the potential application of the network mode in the achievement of a more effective and stable modulation of the target gene expression.
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Keywords {🔍}

pubmed, article, google, scholar, cas, central, gene, microrna, cell, mirna, transcriptional, target, regulatory, mol, zhang, regulation, expression, silencing, biol, chen, wang, rna, micrornas, utr, nature, nat, science, cells, human, res, transcription, nuclear, kim, nucleic, plos, function, posttranscriptional, ren, mirnas, genes, mammalian, acids, analysis, network, rnas, bartel, targets, sci, cancer, zhao,

Topics {✒️}

month download article/chapter tgf-beta-responsive colon carcinoma mir-196b-mediated translation regulation swi/snf-related matrix mirna-mediated gene regulation mirna-mediated gene transcriptional post-transcriptional gene silencing seed region-dependent silencing gene-specific transcriptional upregulation diversifying microrna sequence monocyte/macrophage cell line chi sw full article pdf article cellular rnase iii enzymes mirna regulatory network gene transcriptional regulation mirna-mediated regulation transcriptional gene silencing mirnas regulates transcriptional younger st regulatory modes exist bidirectional transcription directs related small rnas transcriptional gene activation target gene regulation post-transcriptional regulation microrna-directed cleavage privacy choices/manage cookies open reading frame ribosomal protein mrnas related subjects target gene expression article pu igf2 fetal promoters state key laboratory target gene promoters post-transcriptional repression complementary promoter sequences mir-24 regulates apoptosis mir-155 downregulates erbb2 microprocessor complex mediates gregory ri multidrug resistance microrna-373 induces expression mirna effector complexes modulate mirna activity microrna target recognition microrna-target recognition natural antisense transcripts

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         description:MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that participate in a majority of biological processes via regulating target gene expression. The post-transcriptional repression through miRNA seed region binding to 3′ UTR of target mRNA is considered as the canonical mode of miRNA-mediated gene regulation. However, emerging evidence suggests that other regulatory modes exist beyond the canonical mechanism. In particular, the function of intranuclear miRNA in gene transcriptional regulation is gradually revealed, with evidence showing their contribution to gene silencing or activating. Therefore, miRNA-mediated regulation of gene transcription not only expands our understanding of the molecular mechanism underlying miRNA regulatory function, but also provides new evidence to explain its ability in the sophisticated regulation of many bioprocesses. In this review, mechanisms of miRNA-mediated gene transcriptional and post-transcriptional regulation are summarized, and the synergistic effects among these actions which form a regulatory network of a miRNA on its target are particularly elaborated. With these discussions, we aim to emphasize the importance of miRNA regulatory network on target gene regulation and further highlight the potential application of the network mode in the achievement of a more effective and stable modulation of the target gene expression.
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            miRNA-related nucleic acid drugs
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            Biochemistry
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         miRNA non-seed sequence function
         miRNA cellular distribution
         miRNA-related nucleic acid drugs
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         Biomedicine
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         Biochemistry
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