We are analyzing https://link.springer.com/article/10.1007/s00011-024-01853-0.

Title:
Tricarboxylic acid cycle metabolites: new players in macrophage | Inflammation Research
Description:
Metabolic remodeling is a key feature of macrophage activation and polarization. Recent studies have demonstrated the role of tricarboxylic acid (TCA) cycle metabolites in the innate immune system. In the current review, we summarize recent advances in the metabolic reprogramming of the TCA cycle during macrophage activation and polarization and address the effects of these metabolites in modulating macrophage function. Deciphering the crosstalk between the TCA cycle and the immune response might provide novel potential targets for the intervention of immune reactions and favor the development of new strategies for the treatment of infection, inflammation, and cancer.
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Keywords {🔍}

pubmed, article, google, scholar, cas, macrophage, central, cell, metabolic, cycle, acid, wang, macrophages, inflammation, metabolism, immunol, nat, zhang, activation, succinate, mol, nature, china, data, tricarboxylic, metabolites, manuscript, polarization, reprogramming, access, cells, immunity, inflammatory, biol, traditional, chinese, medicine, privacy, cookies, function, content, research, ying, yang, jingyi, tca, potential, author, dendritic, res,

Topics {✒️}

xbp-1/cctalpha-mediated phospholipid accumulation orphan g-protein-coupled receptors 2/ep4-camp-epac-dependent pathway month download article/chapter ri-ran zhu kinases tbk1-ikkvarepsilon supports cardiac energy metabolism impairs energy metabolism paraquat-induced pulmonary fibrosis jing-yi wang google scholar full article pdf cheng-yong zhang mitochondrial membrane potential alpha-ketoglutarate accelerates mitochondrial citrate carrier induces il-1beta atp-citrate lyase di noia ma cell stem cell promotes histone acetylation sucnr1-mediated chemotaxis mammalian metabolite induced klein geltink ri van teijlingen bn tricarboxylic acid privacy choices/manage cookies krebs cycle rewired cycle metabolites gm-csf bing-bing cui pro-il-1beta john di battista article yang macrophage metabolic remodeling modulating macrophage function mtorc1/p70s6k pathway itaconate links inhibition inhibiting atp synthase annu rev pathol annu rev physiol lipids health dis alpha-ketoglutarate m2 macrophage differentiation inhibits isocitrate dehydrogenase prostaglandin e2 holds exclusive rights sirt3 diminishes inflammation dendritic cell activation xiao-tong wei

Schema {🗺️}

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         Allergology
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         Neurology
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