
SCIENCE . ORG {
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Title:
Act1, a U-box E3 Ubiquitin Ligase for IL-17 Signaling | Science Signaling
Description:
Interleukin-17 (IL-17), a proinflammatory cytokine mainly produced by cells of the T helper 17 (TH17) lineage, is required for host defense against bacterial and fungal infections and plays a criti...
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science, crossref, web, google, scholar, pubmed, signaling, act, ubiquitin, article, cleveland, view, research, news, traf, protein, usa, access, department, articles, ubox, author, ligase, immunology, chen, factor, aaas, institute, liu, information, receptor, activation, cells, interleukin, lerner, clinic, euclid, avenue, qian, nfκb, free, immunol, cell, molecular, role, authors, family, ubiquitination, essential, service,
Topics {✒️}
reviewers librarians manage act1/traf6/tak1-dependent nf-κb activation ubc13-uev1a ubiquitin-conjugating enzyme disease–linked lrrk2-mutant mice genome-wide rna sequences authors information k63-linked polyubiquitin chains jak-mediated pi3k signaling mediate il-17–induced activation advances partner ubc13-uev1a e2 complex underwent lys63-mediated ubiquitination restore il-17–dependent signaling full text authors contributed equally il-17–mediated signaling pathways tab2-related protein tab3 long-lived plasma cells science google scholar chaperoned ubiquitylation—crystal structures chip-ubc13-uev1a complex journals efficient act1-mediated ubiquitination transcription factor nf-κb support il-17–mediated activation nf-κb-activating protein science news social media facebook il-17–dependent inflammatory response scholarly commentary science family account member current issue u-box domains e3 ubiquitin ligase lysine-63–linked ubiquitination u-box family il-17–mediated signaling nf-κb signaling latest news interleukin 17-dependent signaling request permissions acknowledgments contents advertisement sign il-17 receptor signaling factor 6 auto-ubiquitination e3 ubiquitin ligases traf-binding sites il-23/il-17 axis commentary permissions toc alerts
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