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Title[redir]:
Iron promotes protein insolubility and aging in C. elegans - PubMed
Description:
Many late-onset proteotoxic diseases are accompanied by a disruption in homeostasis of metals (metallostasis) including iron, copper and zinc. Although aging is the most prominent risk factor for these disorders, the impact of aging on metallostasis and its role in proteotoxic disease remain poorly …
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Keywords {🔍}
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Topics {✒️}
united states government caenorhabditis elegans age-related protein aggregation insoluble proteins age-related accumulation promotes protein homeostasis hhs longevity ofcaenorhabditis elegans protein homeostasis elegans ida main page content funding linkout elegans mesh keyword insoluble protein aggregation long-lived species mediates effects late-onset proteotoxic diseases impaired iron recycling insoluble protein data-independent acquisition workflow brain iron accumulation dietary iron age similar articles cited including iron llc pubmed central heavy-metal transport medical clinics extramural research support homeostasis iron manganese levels increase resources aging extended normal lifespan metal storage disorders high dietary carbohydrate prominent risk factor phosphorus levels tend curr pharm des elevated metallothionein expression amyotrophic lateral sclerosis anti-aggregation properties health 100689 abstract specific metals attenuated authors interest statement conflict cellular transport
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