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5′-gga-cta-cca-ggg-tat-cta-atc-ctg-tt-3′ 5′-tcc-tac-ggg-agg-cag-cag-t-3′ nature portfolio microglia/macrophage-specific calcium-binding protein privacy policy open-reference otu picking abx-treated appswe/ps1δe9 mice x60 z-stack images mini-beadbeater-8k cell disrupter long-term abx treatment author information authors advertising disease research center aging research unit plaque-localized gfap-positive astrocytes male appswe/ps1δe9 mice appswe/ps1δe9 mice treated female appswe/ps1δe9 mice regional variation psychiatry research 203 appswe/ps1δe9 mice leads microbiome-derived pro-inflammatory factors plaque-localized neuro-inflammation tlr2-mediated cd39 signalling z-stack images 0/ reprints gfap+ve positive somas nature communications 6 nature communications 5 nature genetics 41 nature genetics 43 nature methods 7 genome-wide association study nature medicine 18 aβ plaque-localized microglia nature neuroscience 18 16s rrna gene 16s rrna gene antibiotic-perturbed-microbiome shabana antibiotic treatment regime mouse monoclonal anti-aβ microglial-based innate immunity sterile micro-isolator cages display pro-inflammatory influenced neuro-inflammatory responses beneficial neuro-inflammation state cns neuro-inflammatory responses ice-cold heparinized pbs anti-inflammatory il-10 leads anti-aβ mab 3d6

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• Was it through the loss of microbiome-derived pro-inflammatory factors, or through the gain of disease-preventing factors from a new steady state community development of gut microbiota?

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      name:Joseph F. Ward
      affiliation:
            name:Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital
            address:
               name:Department of Neurology, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, USA
               type:PostalAddress
            type:Organization
      name:David M. Holtzman
      affiliation:
            name:Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine
            address:
               name:Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, USA
               type:PostalAddress
            type:Organization
      name:Eugene B. Chang
      affiliation:
            name:The Microbiome Center, The University of Chicago
            address:
               name:The Microbiome Center, The University of Chicago, Chicago, USA
               type:PostalAddress
            type:Organization
            name:The University of Chicago
            address:
               name:Department of Medicine, The University of Chicago, Chicago, USA
               type:PostalAddress
            type:Organization
      name:Rudolph E. Tanzi
      affiliation:
            name:Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital
            address:
               name:Department of Neurology, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, USA
               type:PostalAddress
            type:Organization
      name:Sangram S. Sisodia
      affiliation:
            name:The University of Chicago
            address:
               name:Department of Neurobiology, The University of Chicago, Chicago, USA
               type:PostalAddress
            type:Organization
            name:The Microbiome Center, The University of Chicago
            address:
               name:The Microbiome Center, The University of Chicago, Chicago, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Neurobiology, The University of Chicago, Chicago, USA
      name:The Microbiome Center, The University of Chicago, Chicago, USA
      name:Department of Neurology, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, USA
      name:The Microbiome Center, The University of Chicago, Chicago, USA
      name:Department of Medicine, The University of Chicago, Chicago, USA
      name:The Microbiome Center, The University of Chicago, Chicago, USA
      name:Department of Medicine, The University of Chicago, Chicago, USA
      name:Department of Neurobiology, The University of Chicago, Chicago, USA
      name:Department of Neurobiology, The University of Chicago, Chicago, USA
      name:The Microbiome Center, The University of Chicago, Chicago, USA
      name:Department of Medicine, The University of Chicago, Chicago, USA
      name:Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, USA
      name:Department of Neurology, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, USA
      name:Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, USA
      name:The Microbiome Center, The University of Chicago, Chicago, USA
      name:Department of Medicine, The University of Chicago, Chicago, USA
      name:Department of Neurology, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, USA
      name:Department of Neurobiology, The University of Chicago, Chicago, USA
      name:The Microbiome Center, The University of Chicago, Chicago, USA

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