NATURE . COM {}

Matching Content Categories {📚}

• Video & Online Content
• Technology & Computing
• Books & Literature

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$63,100 per month
Our calculations suggest that Nature.com earns between $42,042 and $115,616 monthly online from display advertisements.

Keywords {🔍}

pneumolysin, domain, article, structure, membrane, residues, google, scholar, toxin, cas, binding, prepore, activity, crystal, fig, pore, mutations, interface, monomers, nature, fluorescence, packing, data, structures, domains, formation, arg, cell, protein, hemolytic, form, wildtype, mutants, membranebinding, surface, complex, contacts, interactions, molecular, pneumoniae, loop, adjacent, argala, gluala, streptococcus, cells, intermolecular, cdc, tryptophanrich, table,

Topics {✒️}

nature portfolio privacy policy high-resolution x-ray structures model-building tools advertising nature 0/ reprints middle c-terminal membrane-binding domain n-terminal his6 tag comprehensive python-based system large beta-barrel pore7 high-resolution data means human acute-phase protein extended beta-hairpins penetrating tryptophan-rich flips outwards social media otitis media bacterial cholesterol-dependent cytolysin chilled phosphate-buffered saline stable protein-protein complexes23 membrane-surface bound pre-pore maltose-binding protein fusion ring-shaped pre-pore pore-forming toxins putative membrane-binding conformation thermo scientific permissions membrane-spanning β-hairpins pre-pore complex jamie access mutant toxins bind monomer/monomer interface leads putative carbohydrate-binding residues cholesterol-dependent cytolysins pneumolysin red blood cells pore-forming protein toxin protein crystallography reveals molecular details full-length pneumolysin structure full size image wild-type toxin lead double mutant glu434ala + tyr461ala privacy glu434ala + arg437ala double mutant host cells involving pore-forming toxin intermedilysin threonine-leucine pair phosphate-buffered saline competing financial interests

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The Crystal Structure of Pneumolysin at 2.0 Å Resolution Reveals the Molecular Packing of the Pre-pore Complex
         description:Pneumolysin is a cholesterol-dependent cytolysin (CDC) and virulence factor of Streptococcus pneumoniae. It kills cells by forming pores assembled from oligomeric rings in cholesterol-containing membranes. Cryo-EM has revealed the structures of the membrane-surface bound pre-pore and inserted-pore oligomers, however the molecular contacts that mediate these oligomers are unknown because high-resolution information is not available. Here we have determined the crystal structure of full-length pneumolysin at 1.98 Å resolution. In the structure, crystal contacts demonstrate the likely interactions that enable polymerisation on the cell membrane and the molecular packing of the pre-pore complex. The hemolytic activity is abrogated in mutants that disrupt these intermolecular contacts, highlighting their importance during pore formation. An additional crystal structure of the membrane-binding domain alone suggests that changes in the conformation of a tryptophan rich-loop at the base of the toxin promote monomer-monomer interactions upon membrane binding by creating new contacts. Notably, residues at the interface are conserved in other members of the CDC family, suggesting a common mechanism for pore and pre-pore assembly.
         datePublished:2015-09-03T00:00:00Z
         dateModified:2015-09-03T00:00:00Z
         pageStart:1
         pageEnd:11
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/srep13293
         keywords:
            Bacterial toxins
            Biophysical chemistry
            X-ray crystallography
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep13293/MediaObjects/41598_2015_Article_BFsrep13293_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep13293/MediaObjects/41598_2015_Article_BFsrep13293_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep13293/MediaObjects/41598_2015_Article_BFsrep13293_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep13293/MediaObjects/41598_2015_Article_BFsrep13293_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep13293/MediaObjects/41598_2015_Article_BFsrep13293_Fig5_HTML.jpg
         isPartOf:
            name:Scientific Reports
            issn:
               2045-2322
            volumeNumber:5
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Jamie E. Marshall
               affiliation:
                     name:Immunity and Inflammation, University of Leicester
                     address:
                        name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bayan H. A. Faraj
               affiliation:
                     name:Immunity and Inflammation, University of Leicester
                     address:
                        name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alexandre R. Gingras
               affiliation:
                     name:University of Leicester
                     address:
                        name:Department of Biochemistry, University of Leicester, Leicester, UK
                        type:PostalAddress
                     type:Organization
                     name:University of California
                     address:
                        name:Department of Medicine, University of California, San Diego, La Jolla, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rana Lonnen
               affiliation:
                     name:Immunity and Inflammation, University of Leicester
                     address:
                        name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Md. Arif Sheikh
               affiliation:
                     name:Immunity and Inflammation, University of Leicester
                     address:
                        name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Sussex
                     address:
                        name:Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, United Kingdom
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mohammed El-Mezgueldi
               affiliation:
                     name:University of Leicester
                     address:
                        name:Department of Biochemistry, University of Leicester, Leicester, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Peter C. E. Moody
               affiliation:
                     name:University of Leicester
                     address:
                        name:Department of Biochemistry, University of Leicester, Leicester, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Peter W. Andrew
               affiliation:
                     name:Immunity and Inflammation, University of Leicester
                     address:
                        name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Russell Wallis
               affiliation:
                     name:Immunity and Inflammation, University of Leicester
                     address:
                        name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Leicester
                     address:
                        name:Department of Biochemistry, University of Leicester, Leicester, UK
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The Crystal Structure of Pneumolysin at 2.0 Å Resolution Reveals the Molecular Packing of the Pre-pore Complex
      description:Pneumolysin is a cholesterol-dependent cytolysin (CDC) and virulence factor of Streptococcus pneumoniae. It kills cells by forming pores assembled from oligomeric rings in cholesterol-containing membranes. Cryo-EM has revealed the structures of the membrane-surface bound pre-pore and inserted-pore oligomers, however the molecular contacts that mediate these oligomers are unknown because high-resolution information is not available. Here we have determined the crystal structure of full-length pneumolysin at 1.98 Å resolution. In the structure, crystal contacts demonstrate the likely interactions that enable polymerisation on the cell membrane and the molecular packing of the pre-pore complex. The hemolytic activity is abrogated in mutants that disrupt these intermolecular contacts, highlighting their importance during pore formation. An additional crystal structure of the membrane-binding domain alone suggests that changes in the conformation of a tryptophan rich-loop at the base of the toxin promote monomer-monomer interactions upon membrane binding by creating new contacts. Notably, residues at the interface are conserved in other members of the CDC family, suggesting a common mechanism for pore and pre-pore assembly.
      datePublished:2015-09-03T00:00:00Z
      dateModified:2015-09-03T00:00:00Z
      pageStart:1
      pageEnd:11
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/srep13293
      keywords:
         Bacterial toxins
         Biophysical chemistry
         X-ray crystallography
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep13293/MediaObjects/41598_2015_Article_BFsrep13293_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep13293/MediaObjects/41598_2015_Article_BFsrep13293_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep13293/MediaObjects/41598_2015_Article_BFsrep13293_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep13293/MediaObjects/41598_2015_Article_BFsrep13293_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep13293/MediaObjects/41598_2015_Article_BFsrep13293_Fig5_HTML.jpg
      isPartOf:
         name:Scientific Reports
         issn:
            2045-2322
         volumeNumber:5
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jamie E. Marshall
            affiliation:
                  name:Immunity and Inflammation, University of Leicester
                  address:
                     name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bayan H. A. Faraj
            affiliation:
                  name:Immunity and Inflammation, University of Leicester
                  address:
                     name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alexandre R. Gingras
            affiliation:
                  name:University of Leicester
                  address:
                     name:Department of Biochemistry, University of Leicester, Leicester, UK
                     type:PostalAddress
                  type:Organization
                  name:University of California
                  address:
                     name:Department of Medicine, University of California, San Diego, La Jolla, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rana Lonnen
            affiliation:
                  name:Immunity and Inflammation, University of Leicester
                  address:
                     name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Md. Arif Sheikh
            affiliation:
                  name:Immunity and Inflammation, University of Leicester
                  address:
                     name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Sussex
                  address:
                     name:Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, United Kingdom
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mohammed El-Mezgueldi
            affiliation:
                  name:University of Leicester
                  address:
                     name:Department of Biochemistry, University of Leicester, Leicester, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Peter C. E. Moody
            affiliation:
                  name:University of Leicester
                  address:
                     name:Department of Biochemistry, University of Leicester, Leicester, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Peter W. Andrew
            affiliation:
                  name:Immunity and Inflammation, University of Leicester
                  address:
                     name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Russell Wallis
            affiliation:
                  name:Immunity and Inflammation, University of Leicester
                  address:
                     name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Leicester
                  address:
                     name:Department of Biochemistry, University of Leicester, Leicester, UK
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Scientific Reports
      issn:
         2045-2322
      volumeNumber:5
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Immunity and Inflammation, University of Leicester
      address:
         name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
         type:PostalAddress
      name:Immunity and Inflammation, University of Leicester
      address:
         name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
         type:PostalAddress
      name:University of Leicester
      address:
         name:Department of Biochemistry, University of Leicester, Leicester, UK
         type:PostalAddress
      name:University of California
      address:
         name:Department of Medicine, University of California, San Diego, La Jolla, USA
         type:PostalAddress
      name:Immunity and Inflammation, University of Leicester
      address:
         name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
         type:PostalAddress
      name:Immunity and Inflammation, University of Leicester
      address:
         name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
         type:PostalAddress
      name:University of Sussex
      address:
         name:Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, United Kingdom
         type:PostalAddress
      name:University of Leicester
      address:
         name:Department of Biochemistry, University of Leicester, Leicester, UK
         type:PostalAddress
      name:University of Leicester
      address:
         name:Department of Biochemistry, University of Leicester, Leicester, UK
         type:PostalAddress
      name:Immunity and Inflammation, University of Leicester
      address:
         name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
         type:PostalAddress
      name:Immunity and Inflammation, University of Leicester
      address:
         name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
         type:PostalAddress
      name:University of Leicester
      address:
         name:Department of Biochemistry, University of Leicester, Leicester, UK
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Jamie E. Marshall
      affiliation:
            name:Immunity and Inflammation, University of Leicester
            address:
               name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
               type:PostalAddress
            type:Organization
      name:Bayan H. A. Faraj
      affiliation:
            name:Immunity and Inflammation, University of Leicester
            address:
               name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
               type:PostalAddress
            type:Organization
      name:Alexandre R. Gingras
      affiliation:
            name:University of Leicester
            address:
               name:Department of Biochemistry, University of Leicester, Leicester, UK
               type:PostalAddress
            type:Organization
            name:University of California
            address:
               name:Department of Medicine, University of California, San Diego, La Jolla, USA
               type:PostalAddress
            type:Organization
      name:Rana Lonnen
      affiliation:
            name:Immunity and Inflammation, University of Leicester
            address:
               name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
               type:PostalAddress
            type:Organization
      name:Md. Arif Sheikh
      affiliation:
            name:Immunity and Inflammation, University of Leicester
            address:
               name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
               type:PostalAddress
            type:Organization
            name:University of Sussex
            address:
               name:Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, United Kingdom
               type:PostalAddress
            type:Organization
      name:Mohammed El-Mezgueldi
      affiliation:
            name:University of Leicester
            address:
               name:Department of Biochemistry, University of Leicester, Leicester, UK
               type:PostalAddress
            type:Organization
      name:Peter C. E. Moody
      affiliation:
            name:University of Leicester
            address:
               name:Department of Biochemistry, University of Leicester, Leicester, UK
               type:PostalAddress
            type:Organization
      name:Peter W. Andrew
      affiliation:
            name:Immunity and Inflammation, University of Leicester
            address:
               name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
               type:PostalAddress
            type:Organization
      name:Russell Wallis
      affiliation:
            name:Immunity and Inflammation, University of Leicester
            address:
               name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
               type:PostalAddress
            type:Organization
            name:University of Leicester
            address:
               name:Department of Biochemistry, University of Leicester, Leicester, UK
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
      name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
      name:Department of Biochemistry, University of Leicester, Leicester, UK
      name:Department of Medicine, University of California, San Diego, La Jolla, USA
      name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
      name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
      name:Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, United Kingdom
      name:Department of Biochemistry, University of Leicester, Leicester, UK
      name:Department of Biochemistry, University of Leicester, Leicester, UK
      name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
      name:Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
      name:Department of Biochemistry, University of Leicester, Leicester, UK

Social Networks {👍}(2)

• https://www.facebook.com/scientificreports
• https://twitter.com/SciReports

External Links {🔗}(94)

• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=3552992 gross monthly?
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC260488's total income per month
• How much profit does http://scholar.google.com/scholar_lookup?&title=Molecular%20cloning%2C%20characterization%20and%20complete%20nucleotide%20sequence%20of%20the%20gene%20for%20pneumolysin%2C%20the%20sulfhydryl-activated%20toxin%20of%20Streptococcus%20pneumoniae&journal=Infect%20Immun&volume=55&pages=1184-9&publication_year=1987&author=Walker%2CJA&author=Allen%2CRL&author=Falmagne%2CP&author=Johnson%2CMK&author=Boulnois%2CGJ make?
• How much money does https://doi.org/10.1038%2Fnrmicro1871 generate?
• How much does http://scholar.google.com/scholar_lookup?&title=The%20role%20of%20Streptococcus%20pneumoniae%20virulence%20factors%20in%20host%20respiratory%20colonization%20and%20disease&journal=Nat%20Rev%20Microbiol&doi=10.1038%2Fnrmicro1871&volume=6&pages=288-301&publication_year=2008&author=Kadioglu%2CA&author=Weiser%2CJN&author=Paton%2CJC&author=Andrew%2CPW pull in?
• Discover the revenue of https://doi.org/10.2174%2F156652408785747924
• http://scholar.google.com/scholar_lookup?&title=Pneumolysin%3A%20a%20double-edged%20sword%20during%20the%20host-pathogen%20interaction&journal=Curr%20Mol%20Med&doi=10.2174%2F156652408785747924&volume=8&pages=497-509&publication_year=2008&author=Marriott%2CHM&author=Mitchell%2CTJ&author=Dockrell%2CDH income
• Check the income stats for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9916120
• What's http://www.ncbi.nlm.nih.gov/pmc/articles/PMC96416's gross income?
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Comparative%20virulence%20of%20Streptococcus%20pneumoniae%20strains%20with%20insertion-duplication%2C%20point%20and%20deletion%20mutations%20in%20the%20pneumolysin%20gene&journal=Infect%20Immun&volume=67&pages=981-5&publication_year=1999&author=Berry%2CAM&author=Ogunniyi%2CAD&author=Miller%2CDC&author=Paton%2CJC
• Learn about the earnings of https://doi.org/10.1093%2Finfdis%2F172.1.119
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=The%20role%20of%20pneumolysin%20and%20autolysin%20in%20the%20pathology%20of%20pneumonia%20and%20septicemia%20in%20mice%20infected%20with%20a%20type%202%20pneumococcus&journal=J%20Infect%20Dis&doi=10.1093%2Finfdis%2F172.1.119&volume=172&pages=119-23&publication_year=1995&author=Canvin%2CJR?
• How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=6840851 generate?
• What's the monthly income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC264890?
• Earnings of http://scholar.google.com/scholar_lookup?&title=Effect%20of%20immunization%20with%20pneumolysin%20on%20survival%20time%20of%20mice%20challenged%20with%20Streptococcus%20pneumoniae&journal=Infect%20Immun&volume=40&pages=548-52&publication_year=1983&author=Paton%2CJC&author=Lock%2CRA&author=Hansman%2CDJ
• Find out how much https://doi.org/10.1016%2Fj.cell.2005.02.033 earns monthly
• How much money does http://scholar.google.com/scholar_lookup?&title=Structural%20basis%20of%20pore%20formation%20by%20the%20bacterial%20toxin%20pneumolysin&journal=Cell&doi=10.1016%2Fj.cell.2005.02.033&volume=121&pages=247-56&publication_year=2005&author=Tilley%2CSJ&author=Orlova%2CEV&author=Gilbert%2CRJ&author=Andrew%2CPW&author=Saibil%2CHR make?
• What are the earnings of https://doi.org/10.1016%2FS1438-4221%2800%2980039-9?
• What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Cholesterol-binding%20cytolytic%20protein%20toxins&journal=Int%20J%20Med%20Microbiol&doi=10.1016%2FS1438-4221%2800%2980039-9&volume=290&pages=351-6&publication_year=2000&author=Alouf%2CJE?
• What's the income of https://link.springer.com/doi/10.1007/s00018-002-8471-1?
• Get to know http://scholar.google.com/scholar_lookup?&title=Pore-forming%20toxins&journal=Cell%20Mol%20Life%20Sci&doi=10.1007%2Fs00018-002-8471-1&volume=59&pages=832-44&publication_year=2002&author=Gilbert%2CRJ's earnings
• Revenue of https://doi.org/10.1016%2FS0041-0101%2801%2900155-6
• How much does http://scholar.google.com/scholar_lookup?&title=The%20family%20of%20thiol-activated%2C%20cholesterol-binding%20cytolysins&journal=Toxicon&doi=10.1016%2FS0041-0101%2801%2900155-6&volume=39&pages=1681-9&publication_year=2001&author=Palmer%2CM generate monthly?
• What are the earnings of https://doi.org/10.1073%2Fpnas.0911581107?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2010PNAS..107.4341F bring in each month?
• How much money does http://scholar.google.com/scholar_lookup?&title=Only%20two%20amino%20acids%20are%20essential%20for%20cytolytic%20toxin%20recognition%20of%20cholesterol%20at%20the%20membrane%20surface&journal=Proc%20Natl%20Acad%20Sci%20USA&doi=10.1073%2Fpnas.0911581107&volume=107&pages=4341-6&publication_year=2010&author=Farrand%2CAJ&author=LaChapelle%2CS&author=Hotze%2CEM&author=Johnson%2CAE&author=Tweten%2CRK generate?
• What are the earnings of https://doi.org/10.1016%2FS0092-8674%2800%2980251-2?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Structure%20of%20a%20cholesterol-binding%2C%20thiol-activated%20cytolysin%20and%20a%20model%20of%20its%20membrane%20form&journal=Cell&doi=10.1016%2FS0092-8674%2800%2980251-2&volume=89&pages=685-92&publication_year=1997&author=Rossjohn%2CJ&author=Feil%2CSC&author=McKinstry%2CWJ&author=Tweten%2CRK&author=Parker%2CMW produce monthly?
• How much profit does https://doi.org/10.1042%2Fbj3290571 make?
• How much money does http://scholar.google.com/scholar_lookup?&title=A%20conserved%20tryptophan%20in%20pneumolysin%20is%20a%20determinant%20of%20the%20characteristics%20of%20channels%20formed%20by%20pneumolysin%20in%20cells%20and%20planar%20lipid%20bilayers&journal=Biochem%20J&doi=10.1042%2Fbj3290571&volume=329&pages=571-7&publication_year=1998&author=Korchev%2CYE make?
• How much profit is https://doi.org/10.1111%2Fj.1432-1033.1996.00941.x making per month?
• Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Contribution%20of%20individual%20tryptophan%20residues%20to%20the%20structure%20and%20activity%20of%20theta-toxin%20%28perfringolysin%20O%29%2C%20a%20cholesterol-binding%20cytolysin&journal=Eur%20J%20Biochem&doi=10.1111%2Fj.1432-1033.1996.00941.x&volume=241&pages=941-7&publication_year=1996&author=Sekino-Suzuki%2CN&author=Nakamura%2CM&author=Mitsui%2CKI&author=Ohno-Iwashita%2CY
• How much profit does https://doi.org/10.7554%2FeLife.04247 make?
• How much profit does http://scholar.google.com/scholar_lookup?&title=Stepwise%20visualization%20of%20membrane%20pore%20formation%20by%20suilysin%2C%20a%20bacterial%20cholesterol-dependent%20cytolysin&journal=Elife&doi=10.7554%2FeLife.04247&volume=3&publication_year=2014&author=Leung%2CC generate?
• How much does https://doi.org/10.1111%2Fj.1365-2958.1991.tb00812.x earn?
• What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Complement%20activation%20and%20antibody%20binding%20by%20pneumolysin%20via%20a%20region%20of%20the%20toxin%20homologous%20to%20a%20human%20acute-phase%20protein&journal=Mol%20Microbiol&doi=10.1111%2Fj.1365-2958.1991.tb00812.x&volume=5&pages=1883-8&publication_year=1991&author=Mitchell%2CTJ&author=Andrew%2CPW&author=Saunders%2CFK&author=Smith%2CAN&author=Boulnois%2CGJ?
• What's the income generated by http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2744861 each month?
• How much revenue does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC313484 bring in?
• How much does http://scholar.google.com/scholar_lookup?&title=Pneumolysin%2C%20the%20thiol-activated%20toxin%20of%20Streptococcus%20pneumoniae%2C%20does%20not%20require%20a%20thiol%20group%20for%20in%20vitro%20activity&journal=Infect%20Immun&volume=57&pages=2547-52&publication_year=1989&author=Saunders%2CFK&author=Mitchell%2CTJ&author=Walker%2CJA&author=Andrew%2CPW&author=Boulnois%2CGJ rake in every month?
• How much does https://doi.org/10.1073%2Fpnas.0403229101 pull in?
• What's the income of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2005PNAS..102..600P?
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Insights%20into%20the%20action%20of%20the%20superfamily%20of%20cholesterol-dependent%20cytolysins%20from%20studies%20of%20intermedilysin&journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&doi=10.1073%2Fpnas.0403229101&volume=102&pages=600-5&publication_year=2005&author=Polekhina%2CG&author=Giddings%2CKS&author=Tweten%2CRK&author=Parker%2CMW?
• How much income does https://doi.org/10.1016%2Fj.celrep.2013.04.029 have?
• Financial intake of http://scholar.google.com/scholar_lookup?&title=Structural%20basis%20for%20recognition%20of%20the%20pore-forming%20toxin%20intermedilysin%20by%20human%20complement%20receptor%20CD59&journal=Cell%20Rep&doi=10.1016%2Fj.celrep.2013.04.029&volume=3&pages=1369-77&publication_year=2013&author=Johnson%2CS&author=Brooks%2CNJ&author=Smith%2CRA&author=Lea%2CSM&author=Bubeck%2CD
• Income figures for https://doi.org/10.1038%2Fncomms4690
• Discover the revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2014NatCo...5.3690K
• How much does http://scholar.google.com/scholar_lookup?&title=Crystal%20structure%20of%20listeriolysin%20O%20reveals%20molecular%20details%20of%20oligomerization%20and%20pore%20formation&journal=Nat%20Commun&doi=10.1038%2Fncomms4690&volume=5&publication_year=2014&author=Koster%2CS make?
• How much revenue does https://doi.org/10.1016%2FS0092-8674%2800%2980775-8 bring in?
• How much income is http://scholar.google.com/scholar_lookup?&title=Two%20structural%20transitions%20in%20membrane%20pore%20formation%20by%20pneumolysin%2C%20the%20pore-forming%20toxin%20of%20Streptococcus%20pneumoniae&journal=Cell&doi=10.1016%2FS0092-8674%2800%2980775-8&volume=97&pages=647-55&publication_year=1999&author=Gilbert%2CRJ earning monthly?
• What's the income generated by https://doi.org/10.1006%2Fjmbi.1998.2258 each month?
• How much does http://scholar.google.com/scholar_lookup?&title=Self-interaction%20of%20pneumolysin%2C%20the%20pore-forming%20protein%20toxin%20of%20Streptococcus%20pneumoniae&journal=J%20Mol%20Biol&doi=10.1006%2Fjmbi.1998.2258&volume=284&pages=1223-37&publication_year=1998&author=Gilbert%2CRJ generate monthly?
• Profit of https://link.springer.com/doi/10.1007/s10930-007-9108-x
• How much profit is http://scholar.google.com/scholar_lookup?&title=Characterization%20of%20protein-protein%20interfaces&journal=Protein%20J&doi=10.1007%2Fs10930-007-9108-x&volume=27&pages=59-70&publication_year=2008&author=Yan%2CC&author=Wu%2CF&author=Jernigan%2CRL&author=Dobbs%2CD&author=Honavar%2CV making per month?
• How much money does https://doi.org/10.1073%2Fpnas.1412703111 generate?
• What is the earnings of http://scholar.google.com/scholar_lookup?&title=The%20cholesterol-dependent%20cytolysins%20pneumolysin%20and%20streptolysin%20O%20require%20binding%20to%20red%20blood%20cell%20glycans%20for%20hemolytic%20activity&journal=Proc%20Natl%20Acad%20Sci%20USA&doi=10.1073%2Fpnas.1412703111&volume=111&pages=E5312-20&publication_year=2014&author=Shewell%2CLK?
• Income figures for https://doi.org/10.1107%2FS0907444910048675
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=iMOSFLM%3A%20a%20new%20graphical%20interface%20for%20diffraction-image%20processing%20with%20MOSFLM&journal=Acta%20Crystallogr%20D%20Biol%20Crystallogr&doi=10.1107%2FS0907444910048675&volume=67&pages=271-81&publication_year=2011&author=Battye%2CTG&author=Kontogiannis%2CL&author=Johnson%2CO&author=Powell%2CHR&author=Leslie%2CAG
• What's the income generated by https://doi.org/10.1107%2FS0021889807021206 each month?
• What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Phaser%20crystallographic%20software&journal=J%20Appl%20Crystallogr&doi=10.1107%2FS0021889807021206&volume=40&pages=658-674&publication_year=2007&author=McCoy%2CAJ?
• Revenue of https://doi.org/10.1107%2FS0907444904019158
• How much does http://scholar.google.com/scholar_lookup?&title=Coot%3A%20model-building%20tools%20for%20molecular%20graphics&journal=Acta%20Crystallogr%20D%20Biol%20Crystallogr&doi=10.1107%2FS0907444904019158&volume=60&pages=2126-32&publication_year=2004&author=Emsley%2CP&author=Cowtan%2CK pull in monthly?
• How much income is https://doi.org/10.1107%2FS0907444909052925 earning monthly?
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=PHENIX%3A%20a%20comprehensive%20Python-based%20system%20for%20macromolecular%20structure%20solution&journal=Acta%20Crystallogr%20D%20Biol%20Crystallogr&doi=10.1107%2FS0907444909052925&volume=66&pages=213-21&publication_year=2010&author=Adams%2CPD?
• How much does https://citation-needed.springer.com/v2/references/10.1038/srep13293?format=refman&flavour=references rake in every month?
• What's the financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jamie%20E.%20Marshall?
• Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jamie%20E.%20Marshall%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Bayan%20H.%20A.%20Faraj bring in each month?
• What's the financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Bayan%20H.%20A.%20Faraj%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Alexandre%20R.%20Gingras income
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Alexandre%20R.%20Gingras%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in monthly?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Rana%20Lonnen pull in?
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Rana%20Lonnen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Md.%20Arif%20Sheikh
• Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Md.%20Arif%20Sheikh%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much income is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Mohammed%20El-Mezgueldi earning monthly?
• Discover the revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Mohammed%20El-Mezgueldi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Peter%20C.%20E.%20Moody
• How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Peter%20C.%20E.%20Moody%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
• See how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Peter%20W.%20Andrew makes per month
• How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Peter%20W.%20Andrew%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
• Learn how profitable https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Russell%20Wallis is on a monthly basis
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Russell%20Wallis%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• What's the income of http://creativecommons.org/licenses/by/4.0/?
• What's the financial outcome of https://s100.copyright.com/AppDispatchServlet?title=The%20Crystal%20Structure%20of%20Pneumolysin%20at%202.0%20%C3%85%20Resolution%20Reveals%20the%20Molecular%20Packing%20of%20the%20Pre-pore%20Complex&author=Jamie%20E.%20Marshall%20et%20al&contentID=10.1038%2Fsrep13293©right=The%20Author%28s%29&publication=2045-2322&publicationDate=2015-09-03&publisherName=SpringerNature&orderBeanReset=true&oa=CC%20BY?
• Discover the revenue of https://crossmark.crossref.org/dialog/?doi=10.1038/srep13293
• https://citation-needed.springer.com/v2/references/10.1038/srep13293?format=refman&flavour=citation income
• What's the monthly money flow for https://doi.org/10.1038/s41467-024-47741-3?
• How much does https://doi.org/10.1038/s41467-022-32757-4 rake in every month?
• How much money does https://doi.org/10.1038/s41598-020-60348-0 generate?
• How much profit does https://doi.org/10.1007/s12551-018-0448-x make?
• What's the income generated by https://www.protocols.io/ each month?
• Explore the financials of https://www.natureindex.com/
• How much does http://www.naturechina.com pull in monthly?
• Earnings of https://www.natureasia.com/ja-jp

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref