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cells, mutant, article, pubmed, cancer, google, scholar, cell, hcc, cas, transcripts, plcprf, pptm, transsplicing, expression, tumor, figure, wtp, repair, tumors, growth, apoptosis, genes, transfected, nature, gene, mutation, cycle, smart, human, rna, mice, adenovirus, hepatocellular, carcinoma, demonstrated, genetic, xenograft, pdefective, study, mutations, liver, rtpcr, central, function, protein, correction, supplementary, vitro, therapy,

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nature portfolio privacy policy providing pcmv-neo-bam wtp53 plasmid pcmv-neo-bam wtp53 hyper-igm x-linked immunodeficiency advertising diverse nature spliceosome-mediated rna trans-splicing nature reviews evaluate trans-splicing-mediated repair p53 pre-trans-splicing molecules nature 415 nature p53-ptm-e7-11 trans-activated social media trans-splicing ribozymes-mediate repair ad-p53ptm-e7-11 group manifested pre-established plc/prf/5 xenografts trans-spliced p53 rnas 0/ reprints adenovirus encoding p53-ptm p53 research p53-based cancer therapies trans-spliced p53 rna vectors expressing p53-ptm italy trans splicing-mediated revision pre-trans-splicing molecule providing pcyclinb-prom-luc pre-mrna trans-splicing wild-type p53 activity trans-splicing-mediated repair plasmid carrying p53-ptm wild-type human p53 trans-activate downstream genes sybr green qrt-pcr p53-dependent downstream genes restores wt-p53 activity defective target pre-mrna restored wt-p53 activities mature wt-p53 transcripts activating cyclin-dependent kinase blocking mdm2-induced degradation yeast branch-point consensus wild-type p53 function restore wt-p53 production p53-dependent target genes plc/prf/5 cells led induces wt-p53 production research

Questions {❓}

• Splicing out the West?
• P53 Isoforms: An Intracellular Microprocessor?
• P53-based cancer therapies: Is defective p53 the Achilles heel of the tumor?

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      headline:Trans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo
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