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Title:
12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy? | Scientific Reports
Description:
We have interrogated a 12-chemokine gene expression signature (GES) on genomic arrays of 14,492 distinct solid tumors and show broad distribution across different histologies. We hypothesized that this 12-chemokine GES might accurately predict a unique intratumoral immune reaction in stage IV (non-locoregional) melanoma metastases. The 12-chemokine GES predicted the presence of unique, lymph node-like structures, containing CD20+ B cell follicles with prominent areas of CD3+ T cells (both CD4+ and CD8+ subsets). CD86+, but not FoxP3+, cells were present within these unique structures as well. The direct correlation between the 12-chemokine GES score and the presence of unique, lymph nodal structures was also associated with better overall survival of the subset of melanoma patients. The use of this novel 12-chemokine GES may reveal basic information on in situ mechanisms of the anti-tumor immune response, potentially leading to improvements in the identification and selection of melanoma patients most suitable for immunotherapy.
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chemokine, melanoma, article, structures, cancer, lymph, cells, tumor, samples, signature, immune, patients, google, scholar, nature, expression, ges, gene, nodelike, cell, genes, ectopic, cas, analysis, data, patient, presence, response, ccl, figure, immunotherapy, solid, unique, score, tumors, clinical, survival, based, sets, tlelns, pca, information, metastases, human, shown, moffitt, high, probe, center, content,
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nature portfolio privacy policy functional immune nature author information authors functional nature advertising cancer research nature rev nature social media 0/ reprints receive immune-based therapies basler tri-linear-array creative commons attribution-noncommercial high-resolution microcapillary electrophoresis t-cell antitumor response avidin-biotin complex method profound anti-tumor activity ectopic b-cell clusters average z-score based anti-tumor immune response affymetrix hursta-2a520709 genechips chemokine-secreting dendritic cells gov/geo/query/acc ventana medical systems tumour microenvironment thorsten t-cell transfer immunotherapy references sarnaik representative tissue sections immune-based therapies skin cancers tumor-infiltrating immune cells ectopic lymph node gene expression signature gene expression signatures gene expression microarrays anti-ctla4 antibody deidentified clinical data random representative section ectopic lymph nodes mrna microarray analysis gene chip technology laser capture microdissection immune checkpoint proteins immune checkpoint inhibition privacy reveal basic information obtained descriptive information immune-related ges t-cell clonality
Questions {β}
- 12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?
- 12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?
- Biomarkers for immune checkpoint inhibition in sarcomas β are we close to clinical implementation?
- Chemokines: can effector cells be re-directed to the site of tumor?
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headline:12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?
description:We have interrogated a 12-chemokine gene expression signature (GES) on genomic arrays of 14,492 distinct solid tumors and show broad distribution across different histologies. We hypothesized that this 12-chemokine GES might accurately predict a unique intratumoral immune reaction in stage IV (non-locoregional) melanoma metastases. The 12-chemokine GES predicted the presence of unique, lymph node-like structures, containing CD20+ B cell follicles with prominent areas of CD3+ T cells (both CD4+ and CD8+ subsets). CD86+, but not FoxP3+, cells were present within these unique structures as well. The direct correlation between the 12-chemokine GES score and the presence of unique, lymph nodal structures was also associated with better overall survival of the subset of melanoma patients. The use of this novel 12-chemokine GES may reveal basic information on in situ mechanisms of the anti-tumor immune response, potentially leading to improvements in the identification and selection of melanoma patients most suitable for immunotherapy.
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headline:12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?
description:We have interrogated a 12-chemokine gene expression signature (GES) on genomic arrays of 14,492 distinct solid tumors and show broad distribution across different histologies. We hypothesized that this 12-chemokine GES might accurately predict a unique intratumoral immune reaction in stage IV (non-locoregional) melanoma metastases. The 12-chemokine GES predicted the presence of unique, lymph node-like structures, containing CD20+ B cell follicles with prominent areas of CD3+ T cells (both CD4+ and CD8+ subsets). CD86+, but not FoxP3+, cells were present within these unique structures as well. The direct correlation between the 12-chemokine GES score and the presence of unique, lymph nodal structures was also associated with better overall survival of the subset of melanoma patients. The use of this novel 12-chemokine GES may reveal basic information on in situ mechanisms of the anti-tumor immune response, potentially leading to improvements in the identification and selection of melanoma patients most suitable for immunotherapy.
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