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Title:
12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy? | Scientific Reports
Description:
We have interrogated a 12-chemokine gene expression signature (GES) on genomic arrays of 14,492 distinct solid tumors and show broad distribution across different histologies. We hypothesized that this 12-chemokine GES might accurately predict a unique intratumoral immune reaction in stage IV (non-locoregional) melanoma metastases. The 12-chemokine GES predicted the presence of unique, lymph node-like structures, containing CD20+ B cell follicles with prominent areas of CD3+ T cells (both CD4+ and CD8+ subsets). CD86+, but not FoxP3+, cells were present within these unique structures as well. The direct correlation between the 12-chemokine GES score and the presence of unique, lymph nodal structures was also associated with better overall survival of the subset of melanoma patients. The use of this novel 12-chemokine GES may reveal basic information on in situ mechanisms of the anti-tumor immune response, potentially leading to improvements in the identification and selection of melanoma patients most suitable for immunotherapy.
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chemokine, melanoma, article, structures, cancer, lymph, cells, tumor, samples, signature, immune, patients, google, scholar, nature, expression, ges, gene, nodelike, cell, genes, ectopic, cas, analysis, data, patient, presence, response, ccl, figure, immunotherapy, solid, unique, score, tumors, clinical, survival, based, sets, tlelns, pca, metastases, human, shown, moffitt, information, high, probe, center, content,
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nature portfolio privacy policy functional immune nature author information authors functional nature advertising cancer research nature rev nature social media 0/ reprints receive immune-based therapies basler tri-linear-array creative commons attribution-noncommercial high-resolution microcapillary electrophoresis t-cell antitumor response avidin-biotin complex method profound anti-tumor activity ectopic b-cell clusters average z-score based anti-tumor immune response affymetrix hursta-2a520709 genechips chemokine-secreting dendritic cells gov/geo/query/acc ventana medical systems tumour microenvironment thorsten t-cell transfer immunotherapy immune-based therapies permissions skin cancers tumor-infiltrating immune cells ectopic lymph node gene expression signature gene expression signatures gene expression microarrays anti-ctla4 antibody deidentified clinical data random representative section ectopic lymph nodes mrna microarray analysis gene chip technology laser capture microdissection immune checkpoint proteins immune checkpoint inhibition privacy immune-related ges t-cell clonality ovarian carcinomas competing financial interests immune-related biomarkers
Questions {β}
- 12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?
- 12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?
- Biomarkers for immune checkpoint inhibition in sarcomas β are we close to clinical implementation?
- Chemokines: can effector cells be re-directed to the site of tumor?
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headline:12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?
description:We have interrogated a 12-chemokine gene expression signature (GES) on genomic arrays of 14,492 distinct solid tumors and show broad distribution across different histologies. We hypothesized that this 12-chemokine GES might accurately predict a unique intratumoral immune reaction in stage IV (non-locoregional) melanoma metastases. The 12-chemokine GES predicted the presence of unique, lymph node-like structures, containing CD20+ B cell follicles with prominent areas of CD3+ T cells (both CD4+ and CD8+ subsets). CD86+, but not FoxP3+, cells were present within these unique structures as well. The direct correlation between the 12-chemokine GES score and the presence of unique, lymph nodal structures was also associated with better overall survival of the subset of melanoma patients. The use of this novel 12-chemokine GES may reveal basic information on in situ mechanisms of the anti-tumor immune response, potentially leading to improvements in the identification and selection of melanoma patients most suitable for immunotherapy.
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headline:12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?
description:We have interrogated a 12-chemokine gene expression signature (GES) on genomic arrays of 14,492 distinct solid tumors and show broad distribution across different histologies. We hypothesized that this 12-chemokine GES might accurately predict a unique intratumoral immune reaction in stage IV (non-locoregional) melanoma metastases. The 12-chemokine GES predicted the presence of unique, lymph node-like structures, containing CD20+ B cell follicles with prominent areas of CD3+ T cells (both CD4+ and CD8+ subsets). CD86+, but not FoxP3+, cells were present within these unique structures as well. The direct correlation between the 12-chemokine GES score and the presence of unique, lymph nodal structures was also associated with better overall survival of the subset of melanoma patients. The use of this novel 12-chemokine GES may reveal basic information on in situ mechanisms of the anti-tumor immune response, potentially leading to improvements in the identification and selection of melanoma patients most suitable for immunotherapy.
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