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pubmed, google, scholar, wilms, tumor, cancer, cas, central, tumour, pediatr, renal, study, oncol, report, group, children, oncology, childhood, clin, blood, treatment, tumors, nat, nature, clinical, childrens, siop, syndrome, mutations, patients, pediatric, national, tumours, genet, international, rev, kidney, surg, disease, pritchardjones, research, eur, stage, health, med, analysis, article, risk, results, development,

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=2020&mode=population&mode_population=continents&population=900&populations=900&key=asr&sex=0&cancer=29&type=1&statistic=5&prevalence=0&population_group=0&ages_group%5b%5d=0&ages_group%5b%5d=2&nb_items=10&group_cancer=1&include_nmsc=1&include_nmsc_other=1&projection=natural-earth&color_palette=default&map_scale=quantile&map_nb_colors=5&continent=0&show_ranking=0&rotate=%255b10%252c0%255d org/wp-content/uploads/2020/04/treatment-guidelines-collaborative-wilms-tumour-africa-project-phase-ii-doc-v1 nature portfolio journals nature portfolio permissions reprints population-based registry study international population-based study privacy policy population-based study van den heuvel-eibrink national library east-asian children advertising wnt/β-catenin pathway modulators potential solutions author information authors open-label social media populations sex org/guidelines/guidelines-detail nature+ nature 343 nature fr/today/online-analysis-map end-stage renal disease key areas comprehensive genome-wide sequencing favorable-histology wilms tumor β-catenin/aldh axis setting research priorities term=nct04322318&draw=2&rank=1 author correspondence tumour-suppressor gene wt1 gov/ct2/show/nct04322318 patient-derived xenografts capture subtype-specific fbxw7 mutation geller theodor-boveri-institute strengthen data collection intermediate-risk wilms’ tumour zinc-finger gene identified t1-weighted imaging identifies risk-adapted therapeutic approach complex wilms tumour beta-catenin proto-oncogene international consensus statement improved evidence-based follow wt1-syndromic wilms tumor low-risk wilms tumor collaborative siop-rtsg

Questions {❓}

• From Wilms to kidney tumors: which ones require a biopsy?
• Is Wilms tumor a candidate neoplasia for treatment with WNT/β-catenin pathway modulators?
• Is radiotherapy required in first-line treatment of stage I diffuse anaplastic Wilms tumor?
• Review of phase I and II trials for Wilms’ tumour–can we optimise the search for novel agents?
• Technical considerations for nephron-sparing surgery in children: what is needed to preserve renal units?
• Why should survivors of childhood renal tumor and others with only one kidney be denied the chance to play contact sports?
• Wilms tumor and trisomy 18: is there an association?
• Fr/today/online-analysis-map?
• Gov/ct2/show/NCT04322318?
• Org/guidelines/guidelines-detail?

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            type:Organization
      name:Manfred Gessler
      url:http://orcid.org/0000-0002-7915-6045
      affiliation:
            name:University of Wuerzburg
            address:
               name:Theodor-Boveri-Institute, Developmental Biochemistry, and Comprehensive Cancer Center Mainfranken, University of Wuerzburg, Wuerzburg, Germany
               type:PostalAddress
            type:Organization
      name:Mariana Maschietto
      url:http://orcid.org/0000-0003-2589-3186
      affiliation:
            name:State University of Campinas
            address:
               name:Research Center, Boldrini Children’s Hospital, Genetics and Molecular Biology, Institute of Biology, State University of Campinas, Campinas, Brazil
               type:PostalAddress
            type:Organization
      name:Sam Behjati
      affiliation:
            name:Wellcome Sanger Institute
            address:
               name:Wellcome Sanger Institute, Hinxton, UK
               type:PostalAddress
            type:Organization
            name:Cambridge University Hospitals NHS Foundation Trust
            address:
               name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:University of Cambridge
            address:
               name:Department of Paediatrics, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Angela Polanco
      affiliation:
            name:National Cancer Research Institute Children’s Group Consumer Representative
            address:
               name:National Cancer Research Institute Children’s Group Consumer Representative, London, UK
               type:PostalAddress
            type:Organization
      name:Vivian Paintsil
      url:http://orcid.org/0000-0002-8965-0549
      affiliation:
            name:Kwame Nkrumah University of Science and Technology
            address:
               name:Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
               type:PostalAddress
            type:Organization
      name:Sandra Luna-Fineman
      url:http://orcid.org/0000-0003-0713-7651
      affiliation:
            name:University of Colorado
            address:
               name:Division of Hematology, Oncology and Bone Marrow Transplantation, Department of Paediatrics, University of Colorado, Aurora, USA
               type:PostalAddress
            type:Organization
      name:Kathy Pritchard-Jones
      url:http://orcid.org/0000-0002-2384-9475
      affiliation:
            name:University College London
            address:
               name:Developmental Biology and Cancer Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Medical Oncology and Hematology, Paediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
      name:Department of Paediatrics, IWK Health, Dalhousie University, Halifax, Canada
      name:Department of Paediatric Haematology and Oncology, Rigshospitalet, Copenhagen, Denmark
      name:Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan
      name:Department of Pathology, Sidra Medicine, Doha, Qatar
      name:Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Cincinnati, USA
      name:Theodor-Boveri-Institute, Developmental Biochemistry, and Comprehensive Cancer Center Mainfranken, University of Wuerzburg, Wuerzburg, Germany
      name:Research Center, Boldrini Children’s Hospital, Genetics and Molecular Biology, Institute of Biology, State University of Campinas, Campinas, Brazil
      name:Wellcome Sanger Institute, Hinxton, UK
      name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
      name:Department of Paediatrics, University of Cambridge, Cambridge, UK
      name:National Cancer Research Institute Children’s Group Consumer Representative, London, UK
      name:Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
      name:Division of Hematology, Oncology and Bone Marrow Transplantation, Department of Paediatrics, University of Colorado, Aurora, USA
      name:Developmental Biology and Cancer Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK
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