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nature portfolio permissions reprints privacy policy cell-culture-adapted sars-cov-2 virus rna extraction kits advertising early development rabbit anti-sars-cov-2 nucleocapsid sars-cov s1/s2 junction tools regulate sars-cov-2 entry nature https china attenuated sars-cov-2 variants sars-cov-2prra variants emergent sars-cov-2 lineage emergent-sars-cov-2-lineage sars-cov-2 spike protein infra-red secondary antibodies nature 579 nature 426 nature efficient serine-protease-dependent entry c-terminal flag-tag sars-cov-2 spike variants closely related sars-cov research excellence grant wider sars-related coronaviruses sequential proteolytic cleavage thermo fisher scientific mda-5-dependent interferon response codon-optimized spike proteins rabbit anti-fragilis/ifitm3 sars-cov-2 spike glycoprotein blocking sars-cov-2 replication s1/s2 cleavage site mixed sars-cov-2 population sars-cov-2 animal models20 multiple sars-cov-2 variants sars-cov-2 strain england/2/2020 sars-cov-2 spike mutants endosomal/endolysosomal ifitm proteins sars-cov-2 virus lacking sars-cov-2 overlay medium sars-cov wt spike furin-cleavable spike proteins world health organization1 δcs mutant sars-cov-2 s1/s2 cs predicted peer review

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            name:Imperial College London
            address:
               name:Department of Infectious Diseases, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
      name:Ruthiran Kugathasan
      affiliation:
            name:Imperial College London
            address:
               name:Department of Infectious Diseases, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
      name:Rebecca Penn
      affiliation:
            name:Imperial College London
            address:
               name:Department of Infectious Diseases, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
      name:Jonathan C. Brown
      affiliation:
            name:Imperial College London
            address:
               name:Department of Infectious Diseases, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
      name:Raul Y. Sanchez-David
      affiliation:
            name:Imperial College London
            address:
               name:Department of Infectious Diseases, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
      name:Luca Braga
      affiliation:
            name:King’s College London
            address:
               name:British Hearth Foundation Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King’s College London, London, UK
               type:PostalAddress
            type:Organization
      name:Maia Kavanagh Williamson
      affiliation:
            name:University of Bristol
            address:
               name:School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK
               type:PostalAddress
            type:Organization
      name:Jack A. Hassard
      affiliation:
            name:Imperial College London
            address:
               name:Department of Infectious Diseases, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
      name:Ecco Staller
      affiliation:
            name:Imperial College London
            address:
               name:Department of Infectious Diseases, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
      name:Brian Hanley
      affiliation:
            name:Northwest London Pathology, Imperial College London NHS Trust
            address:
               name:Department of Cellular Pathology, Northwest London Pathology, Imperial College London NHS Trust, London, UK
               type:PostalAddress
            type:Organization
      name:Michael Osborn
      affiliation:
            name:Northwest London Pathology, Imperial College London NHS Trust
            address:
               name:Department of Cellular Pathology, Northwest London Pathology, Imperial College London NHS Trust, London, UK
               type:PostalAddress
            type:Organization
      name:Mauro Giacca
      url:http://orcid.org/0000-0003-2927-7225
      affiliation:
            name:King’s College London
            address:
               name:British Hearth Foundation Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King’s College London, London, UK
               type:PostalAddress
            type:Organization
      name:Andrew D. Davidson
      affiliation:
            name:University of Bristol
            address:
               name:School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK
               type:PostalAddress
            type:Organization
      name:David A. Matthews
      url:http://orcid.org/0000-0003-4611-8795
      affiliation:
            name:University of Bristol
            address:
               name:School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK
               type:PostalAddress
            type:Organization
      name:Wendy S. Barclay
      url:http://orcid.org/0000-0002-3948-0895
      affiliation:
            name:Imperial College London
            address:
               name:Department of Infectious Diseases, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Infectious Diseases, Imperial College London, London, UK
      name:Department of Infectious Diseases, Imperial College London, London, UK
      name:Department of Infectious Diseases, Imperial College London, London, UK
      name:Department of Infectious Diseases, Imperial College London, London, UK
      name:Department of Infectious Diseases, Imperial College London, London, UK
      name:Department of Infectious Diseases, Imperial College London, London, UK
      name:Department of Infectious Diseases, Imperial College London, London, UK
      name:Department of Infectious Diseases, Imperial College London, London, UK
      name:Department of Infectious Diseases, Imperial College London, London, UK
      name:Department of Infectious Diseases, Imperial College London, London, UK
      name:British Hearth Foundation Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King’s College London, London, UK
      name:School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK
      name:Department of Infectious Diseases, Imperial College London, London, UK
      name:Department of Infectious Diseases, Imperial College London, London, UK
      name:Department of Cellular Pathology, Northwest London Pathology, Imperial College London NHS Trust, London, UK
      name:Department of Cellular Pathology, Northwest London Pathology, Imperial College London NHS Trust, London, UK
      name:British Hearth Foundation Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King’s College London, London, UK
      name:School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK
      name:School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK
      name:Department of Infectious Diseases, Imperial College London, London, UK

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