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Title:
A human monoclonal antibody blocking SARS-CoV-2 infection | Nature Communications
Description:
The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19. Vaccines and targeted therapeutics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently lacking. Here, the authors report a human monoclonal antibody capable of neutralizing both authentic SARS-CoV and SARS-CoV-2 by targeting a common epitope.
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int/docs/default-source/coronaviruse/situation-reports/20200419-sitrep-90-covid-19 nature portfolio privacy policy cross-reactive nature editing advertising rabbit anti-sars-cov serum identify sars-cov-2-neutralizing antibodies sars-cov-neutralizing antibody cr3022 hrp-conjugated anti-strepmab social media research design research purposes solid-phase based assay life-threatening respiratory illness reprints cross-neutralize sars-cov-2 infection cross-neutralizing antibody targets open conformation half-maximum effective concentration japan nature 579 nature 426 nature 495 nature full-length spike proteins strep-tagged spike antigens thermo fisher scientific c-terminal trimerization motif bivalent spike-targeting nanobody exhibited cross-neutralizing activity anti-strep-tag mab anti-sarbecovirus activity iris low-level antibody responses emerging human coronavirus-emc mers-coronavirus spike glycoprotein human coronavirus sars-cov-2 rien van haperen berend-jan bosch naturally-acquired immune responses sars-cov-2 spike glycoprotein compromise spikeβreceptor interaction receptor-binding interface explains human monoclonal antibody cross-neutralize sars-cov elisa-based binding affinity cryo-electron microscopy structures source data file c-terminally tagged source data files
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headline:A human monoclonal antibody blocking SARS-CoV-2 infection
description:The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19. Vaccines and targeted therapeutics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently lacking. Here, the authors report a human monoclonal antibody capable of neutralizing both authentic SARS-CoV and SARS-CoV-2 by targeting a common epitope.
datePublished:2020-05-04T00:00:00Z
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headline:A human monoclonal antibody blocking SARS-CoV-2 infection
description:The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19. Vaccines and targeted therapeutics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently lacking. Here, the authors report a human monoclonal antibody capable of neutralizing both authentic SARS-CoV and SARS-CoV-2 by targeting a common epitope.
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