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tumor, mutations, pubmed, cancer, cell, article, samples, google, scholar, data, tumors, number, immunoediting, line, cas, model, mice, immune, wildtype, neoantigens, cells, analysis, supplementary, central, fig, mouse, expressed, nature, checkpoint, genome, rag, blockade, crc, sequencing, evolution, immunotherapy, clonal, neutral, heterogeneity, system, figure, copy, pdpdl, showed, genomic, study, control, subclonal, pathway, human,

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}\ast {\mathrm{ccf}}/\left[ {{\mathrm{cn}}_{\mathrm{ nature portfolio n-nitroso-n-methylurethane-induced balb/ }\ast {\mathrm{cn}}_{\mathrm{ privacy policy author information authors thermo fisher scientific mammalian swi/snf-related complexes prevent dc/t-cell aggregates advertising pd-1/pd-l1 pathway induces basic research studies pd-1/pd-l1 pathway renders computational genomics tools anti-pd-1/-pd-l1 antibodies pd-1/pd-l1 blockade therapy37 resulting libraries anti-pd-l1 blocking antibodies pd-1/pd-l1 pathway showed io/picard t-cell-dependent immunoselection sculpting t-cell-dependent immunoselection process cancer research anti-pd-l1-treated sample natascha hermann-kleiter anti-pd-l1-treated samples clinical research supplementary information files wild-type c57bl/6n mice reprints original author immunogenic nature dynamic nature pd-1/pd-l1 pathway pd-1/pd-l1 axis anti-pd-l1 antibodies anti pd-l1 antibodies references burnet anti-pd-l1 treated gene-editing technologies research t-cell-dependent immunoediting anti-mouse pd-l1 t-cell-independent immunoselection genotype-immunophenotype relationships t-cell-dependent mechanism anti-pd-l1 therapy advanced bioinformatics tools nature 410 nature 482

Questions {❓}

• However, as neither longitudinal samples of wild-type or immunodeficient mice nor checkpoint blockade was applied, two major questions remain unanswered: (1) To what extent is T-cell-dependent immunoselection sculpting the cancer genome?

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