
NATURE . COM {
}
Title:
Dual targeting of Nur77 and AMPKα by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo | International Journal of Obesity
Description:
Suppression of adipogenesis has been considered as a potential target for the prevention and treatment of obesity and associated metabolic disorders, and the nuclear receptor 4A1 (NR4A1/Nur77) and AMPKα are known to play important roles during early and intermediate stages of adipogenesis. Therefore, we hypothesized that dual targeting Nur77 and AMPKα would show strong inhibitory effect on adipogenesis. We screened a herbal medicine-based small molecule library to identify novel natural compounds dual targeting Nur77 and AMPKα, and the antiadipogenic effects and mechanisms of action of a “hit” compound were studied in 3T3-L1 cells. In vivo antiobesity effects of the compound were also investigated in high-fat diet (HFD)-induced obese mice. We identified isoalantolactone (ISO) as a new NR4A1 inactivator that also activates AMPKα in 3T3-L1 cells. ISO, as expected, inhibited adipogenic differentiation of 3T3-L1 preadipocytes, accompanied by reduced mitotic clonal expansion (MCE) which occurs in the early stage of adipogenesis and decreased expression of genes required for MCE and cell cycle markers including cyclin A, cyclin D1. Furthermore, ISO reduced body weight gain and fat mass (epididymal, subcutaneous, perirenal, and inguinal white adipose tissues) in the high-fat diet-fed C57BL/6 N mice. Serum levels of triglycerides, aspartate transaminase, and alanine transaminase and hepatic steatosis were also significantly improved in the ISO-treated group compared to the high-fat diet control group. These results suggest that ISO dual targeting Nur77 and AMPKα during adipogenesis represents a novel class of mechanism-based antiadipogenic agents for treatment of obesity and associated metabolic disorders, including hyperlipidemia and fatty liver.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Science
- Education
- Health & Fitness
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌆 Monumental Traffic: 20M - 50M visitors per month
Based on our best estimate, this website will receive around 42,555,829 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$536,300 per month
Our analysis indicates Nature.com generates between $357,511 and $983,155 monthly online from display ads.
Keywords {🔍}
article, google, scholar, cas, nature, adipogenesis, lee, obesity, nuclear, access, receptor, mice, adipose, content, ampkα, kim, cells, ampk, tissue, cancer, development, cookies, data, targeting, inhibits, fat, safe, chen, research, korea, privacy, journal, cell, dual, body, metabolic, highfat, preadipocytes, metab, endocrinol, orphan, physiol, republic, information, adipocyte, effects, diet, iso, differentiation, mitotic,
Topics {✒️}
nature portfolio permissions reprints privacy policy cooperative research program nature ccaat/enhancer-binding protein beta advertising portal theory social media high-fat diet-fed c57bl/6 hye-rin cho syng-ook lee amp-activated protein kinase mechanism-based antiadipogenic agents author information authors iso-treated group compared keuk-jun kim joung-hee kim vivo yeon-seop jung insulin-resistant black men orphan receptor tr3 3t3-l1 preadipocytes depends springerlink instant access rural development administration orphan nuclear receptors author correspondence permissions technology development [project adipocyte development nuclear receptor 4a1 nuclear receptor atlas white adipose tissue physiol cell physiol dual targeting nur77 high-fat diet endocr relat cancer personal data mitotic clonal expansion privacy nat cell biol arctiin inhibits adipogenesis pancreatic cancer cells visceral adipose tissue isoalantolactone inhibits adipogenesis 3t3-l1 cells proc nutr soc breast cancer chemotherapy data protection black adzuki bean explore content
Schema {🗺️}
WebPage:
mainEntity:
headline:Dual targeting of Nur77 and AMPKα by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo
description:Suppression of adipogenesis has been considered as a potential target for the prevention and treatment of obesity and associated metabolic disorders, and the nuclear receptor 4A1 (NR4A1/Nur77) and AMPKα are known to play important roles during early and intermediate stages of adipogenesis. Therefore, we hypothesized that dual targeting Nur77 and AMPKα would show strong inhibitory effect on adipogenesis. We screened a herbal medicine-based small molecule library to identify novel natural compounds dual targeting Nur77 and AMPKα, and the antiadipogenic effects and mechanisms of action of a âhitâ compound were studied in 3T3-L1 cells. In vivo antiobesity effects of the compound were also investigated in high-fat diet (HFD)-induced obese mice. We identified isoalantolactone (ISO) as a new NR4A1 inactivator that also activates AMPKα in 3T3-L1 cells. ISO, as expected, inhibited adipogenic differentiation of 3T3-L1 preadipocytes, accompanied by reduced mitotic clonal expansion (MCE) which occurs in the early stage of adipogenesis and decreased expression of genes required for MCE and cell cycle markers including cyclin A, cyclin D1. Furthermore, ISO reduced body weight gain and fat mass (epididymal, subcutaneous, perirenal, and inguinal white adipose tissues) in the high-fat diet-fed C57BL/6âN mice. Serum levels of triglycerides, aspartate transaminase, and alanine transaminase and hepatic steatosis were also significantly improved in the ISO-treated group compared to the high-fat diet control group. These results suggest that ISO dual targeting Nur77 and AMPKα during adipogenesis represents a novel class of mechanism-based antiadipogenic agents for treatment of obesity and associated metabolic disorders, including hyperlipidemia and fatty liver.
datePublished:2018-12-11T00:00:00Z
dateModified:2018-12-11T00:00:00Z
pageStart:952
pageEnd:962
sameAs:https://doi.org/10.1038/s41366-018-0276-x
keywords:
Obesity
Weight management
Medicine/Public Health
general
Public Health
Epidemiology
Internal Medicine
Metabolic Diseases
Health Promotion and Disease Prevention
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41366-018-0276-x/MediaObjects/41366_2018_276_Fig1_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41366-018-0276-x/MediaObjects/41366_2018_276_Fig2_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41366-018-0276-x/MediaObjects/41366_2018_276_Fig3_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41366-018-0276-x/MediaObjects/41366_2018_276_Fig4_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41366-018-0276-x/MediaObjects/41366_2018_276_Fig5_HTML.png
isPartOf:
name:International Journal of Obesity
issn:
1476-5497
0307-0565
volumeNumber:43
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Yeon-Seop Jung
affiliation:
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
type:Organization
name:Korea Institute of Toxicology
address:
name:Gyeongnam Biological Resource Research Center, Korea Institute of Toxicology, Jinju, Republic of Korea
type:PostalAddress
type:Organization
type:Person
name:Hyo-Seon Lee
affiliation:
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
type:Organization
type:Person
name:Hye-Rin Cho
affiliation:
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
type:Organization
type:Person
name:Keuk-Jun Kim
affiliation:
name:Daekyeung College
address:
name:Department of Biomedical Laboratory Science, Daekyeung College, Gyeongsan, Republic of Korea
type:PostalAddress
type:Organization
type:Person
name:Joung-Hee Kim
affiliation:
name:Daekyeung College
address:
name:Department of Biomedical Laboratory Science, Daekyeung College, Gyeongsan, Republic of Korea
type:PostalAddress
type:Organization
type:Person
name:Stephen Safe
url:http://orcid.org/0000-0002-2115-3060
affiliation:
name:Texas A&M University
address:
name:Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, USA
type:PostalAddress
type:Organization
type:Person
name:Syng-Ook Lee
affiliation:
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Dual targeting of Nur77 and AMPKα by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo
description:Suppression of adipogenesis has been considered as a potential target for the prevention and treatment of obesity and associated metabolic disorders, and the nuclear receptor 4A1 (NR4A1/Nur77) and AMPKα are known to play important roles during early and intermediate stages of adipogenesis. Therefore, we hypothesized that dual targeting Nur77 and AMPKα would show strong inhibitory effect on adipogenesis. We screened a herbal medicine-based small molecule library to identify novel natural compounds dual targeting Nur77 and AMPKα, and the antiadipogenic effects and mechanisms of action of a âhitâ compound were studied in 3T3-L1 cells. In vivo antiobesity effects of the compound were also investigated in high-fat diet (HFD)-induced obese mice. We identified isoalantolactone (ISO) as a new NR4A1 inactivator that also activates AMPKα in 3T3-L1 cells. ISO, as expected, inhibited adipogenic differentiation of 3T3-L1 preadipocytes, accompanied by reduced mitotic clonal expansion (MCE) which occurs in the early stage of adipogenesis and decreased expression of genes required for MCE and cell cycle markers including cyclin A, cyclin D1. Furthermore, ISO reduced body weight gain and fat mass (epididymal, subcutaneous, perirenal, and inguinal white adipose tissues) in the high-fat diet-fed C57BL/6âN mice. Serum levels of triglycerides, aspartate transaminase, and alanine transaminase and hepatic steatosis were also significantly improved in the ISO-treated group compared to the high-fat diet control group. These results suggest that ISO dual targeting Nur77 and AMPKα during adipogenesis represents a novel class of mechanism-based antiadipogenic agents for treatment of obesity and associated metabolic disorders, including hyperlipidemia and fatty liver.
datePublished:2018-12-11T00:00:00Z
dateModified:2018-12-11T00:00:00Z
pageStart:952
pageEnd:962
sameAs:https://doi.org/10.1038/s41366-018-0276-x
keywords:
Obesity
Weight management
Medicine/Public Health
general
Public Health
Epidemiology
Internal Medicine
Metabolic Diseases
Health Promotion and Disease Prevention
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41366-018-0276-x/MediaObjects/41366_2018_276_Fig1_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41366-018-0276-x/MediaObjects/41366_2018_276_Fig2_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41366-018-0276-x/MediaObjects/41366_2018_276_Fig3_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41366-018-0276-x/MediaObjects/41366_2018_276_Fig4_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41366-018-0276-x/MediaObjects/41366_2018_276_Fig5_HTML.png
isPartOf:
name:International Journal of Obesity
issn:
1476-5497
0307-0565
volumeNumber:43
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Yeon-Seop Jung
affiliation:
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
type:Organization
name:Korea Institute of Toxicology
address:
name:Gyeongnam Biological Resource Research Center, Korea Institute of Toxicology, Jinju, Republic of Korea
type:PostalAddress
type:Organization
type:Person
name:Hyo-Seon Lee
affiliation:
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
type:Organization
type:Person
name:Hye-Rin Cho
affiliation:
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
type:Organization
type:Person
name:Keuk-Jun Kim
affiliation:
name:Daekyeung College
address:
name:Department of Biomedical Laboratory Science, Daekyeung College, Gyeongsan, Republic of Korea
type:PostalAddress
type:Organization
type:Person
name:Joung-Hee Kim
affiliation:
name:Daekyeung College
address:
name:Department of Biomedical Laboratory Science, Daekyeung College, Gyeongsan, Republic of Korea
type:PostalAddress
type:Organization
type:Person
name:Stephen Safe
url:http://orcid.org/0000-0002-2115-3060
affiliation:
name:Texas A&M University
address:
name:Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, USA
type:PostalAddress
type:Organization
type:Person
name:Syng-Ook Lee
affiliation:
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:International Journal of Obesity
issn:
1476-5497
0307-0565
volumeNumber:43
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
name:Korea Institute of Toxicology
address:
name:Gyeongnam Biological Resource Research Center, Korea Institute of Toxicology, Jinju, Republic of Korea
type:PostalAddress
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
name:Daekyeung College
address:
name:Department of Biomedical Laboratory Science, Daekyeung College, Gyeongsan, Republic of Korea
type:PostalAddress
name:Daekyeung College
address:
name:Department of Biomedical Laboratory Science, Daekyeung College, Gyeongsan, Republic of Korea
type:PostalAddress
name:Texas A&M University
address:
name:Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, USA
type:PostalAddress
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Yeon-Seop Jung
affiliation:
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
type:Organization
name:Korea Institute of Toxicology
address:
name:Gyeongnam Biological Resource Research Center, Korea Institute of Toxicology, Jinju, Republic of Korea
type:PostalAddress
type:Organization
name:Hyo-Seon Lee
affiliation:
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
type:Organization
name:Hye-Rin Cho
affiliation:
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
type:Organization
name:Keuk-Jun Kim
affiliation:
name:Daekyeung College
address:
name:Department of Biomedical Laboratory Science, Daekyeung College, Gyeongsan, Republic of Korea
type:PostalAddress
type:Organization
name:Joung-Hee Kim
affiliation:
name:Daekyeung College
address:
name:Department of Biomedical Laboratory Science, Daekyeung College, Gyeongsan, Republic of Korea
type:PostalAddress
type:Organization
name:Stephen Safe
url:http://orcid.org/0000-0002-2115-3060
affiliation:
name:Texas A&M University
address:
name:Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, USA
type:PostalAddress
type:Organization
name:Syng-Ook Lee
affiliation:
name:Keimyung University
address:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
name:Gyeongnam Biological Resource Research Center, Korea Institute of Toxicology, Jinju, Republic of Korea
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
name:Department of Biomedical Laboratory Science, Daekyeung College, Gyeongsan, Republic of Korea
name:Department of Biomedical Laboratory Science, Daekyeung College, Gyeongsan, Republic of Korea
name:Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, USA
name:Department of Food Science and Technology, Keimyung University, Daegu, Republic of Korea
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(88)
- Financial intake of https://orcid.org/0000-0002-2115-3060
- How much revenue does https://link.springer.com/article/10.1038/s41366-018-0276-x?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle generate?
- What's the monthly income of https://doi.org/10.1159%2F000321319?
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Brown%20versus%20white%20adipose%20tissue%3A%20a%20mini-review&journal=Gerontology&doi=10.1159%2F000321319&volume=58&pages=15-23&publication_year=2012&author=Saely%2CCH&author=Geiger%2CK&author=Drexel%2CH?
- How much income is https://doi.org/10.1079%2FPNS200194 earning monthly?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Physiological%20role%20of%20adipose%20tissue%3A%20white%20adipose%20tissue%20as%20an%20endocrine%20and%20secretory%20organ&journal=Proc%20Nutr%20Soc&doi=10.1079%2FPNS200194&volume=60&pages=329-39&publication_year=2001&author=Trayhurn%2CP&author=Beattie%2CJH?
- How much does https://link.springer.com/doi/10.1007/s11154-014-9302-z earn?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=The%20update%20of%20anthocyanins%20on%20obesity%20and%20type%202%20diabetes%3A%20experimental%20evidence%20and%20clinical%20perspectives&journal=Rev%20Endocr%20Metab%20Disord&doi=10.1007%2Fs11154-014-9302-z&volume=16&pages=1-13&publication_year=2015&author=Guo%2CH&author=Ling%2CW?
- Learn about the earnings of https://doi.org/10.1016%2Fj.nutres.2016.07.004
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=Defatted%20safflower%20seed%20extract%20inhibits%20adipogenesis%20in%203T3-L1%20preadipocytes%20and%20improves%20lipid%20profiles%20in%20C57BL%2F6J%20ob%2Fob%20mice%20fed%20a%20high-fat%20diet&journal=Nutr%20Res&doi=10.1016%2Fj.nutres.2016.07.004&volume=36&pages=995-1003&publication_year=2016&author=Hwang%2CEY&author=Yu%2CMH&author=Jung%2CYS&author=Lee%2CSP&author=Shon%2CJH&author=Lee%2CSO is on a monthly basis
- What's the financial intake of https://doi.org/10.1210%2Fme.2004-0539?
- How much profit is http://scholar.google.com/scholar_lookup?&title=A%20Nuclear%20Receptor%20Atlas%3A%203T3-L1%20adipogenesis&journal=Mol%20Endocrinol&doi=10.1210%2Fme.2004-0539&volume=19&pages=2437-50&publication_year=2005&author=Fu%2CM&author=Sun%2CT&author=Bookout%2CAL&author=Downes%2CM&author=Yu%2CRT&author=Evans%2CRM making per month?
- How much does https://doi.org/10.1042%2FCS20120536 rake in every month?
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=Role%20of%20AMP-activated%20protein%20kinase%20in%20adipose%20tissue%20metabolism%20and%20inflammation&journal=Clin%20Sci&doi=10.1042%2FCS20120536&volume=124&pages=491-507&publication_year=2013&author=Bijland%2CS&author=Mancini%2CSJ&author=Salt%2CIP is on a monthly basis
- What's the financial outcome of https://doi.org/10.1093%2Fjb%2Fmvm018?
- How much does http://scholar.google.com/scholar_lookup?&title=Orphan%20nuclear%20receptor%20Nur77%20accelerates%20the%20initial%20phase%20of%20adipocyte%20differentiation%20in%203T3-L1%20cells%20by%20promoting%20mitotic%20clonal%20expansion&journal=J%20Biochem&doi=10.1093%2Fjb%2Fmvm018&volume=141&pages=181-92&publication_year=2007&author=Fumoto%2CT&author=Yamaguchi%2CT&author=Hirose%2CF&author=Osumi%2CT rake in every month?
- Profit of https://doi.org/10.1038%2Fncb2329
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=The%20AMPK%20signalling%20pathway%20coordinates%20cell%20growth%2C%20autophagy%20and%20metabolism&journal=Nat%20Cell%20Biol&doi=10.1038%2Fncb2329&volume=13&pages=1016-23&publication_year=2011&author=Mihaylova%2CMM&author=Shaw%2CRJ?
- What's the monthly money flow for https://doi.org/10.3892%2Fijmm.2013.1313?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Small-molecule%20COH-SR4%20inhibits%20adipocyte%20differentiation%20via%20AMPK%20activation&journal=Int%20J%20Mol%20Med&doi=10.3892%2Fijmm.2013.1313&volume=31&pages=1166-76&publication_year=2013&author=Figarola%2CJL&author=Rahbar%2CS bring in?
- How much profit is https://doi.org/10.3892%2Fmmr.2015.4453 making per month?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Substance%20P%20enhances%20the%20activation%20of%20AMPK%20and%20cellular%20lipid%20accumulation%20in%203T3L1%20cells%20in%20response%20to%20high%20levels%20of%20glucose&journal=Mol%20Med%20Rep&doi=10.3892%2Fmmr.2015.4453&volume=12&pages=8048-54&publication_year=2015&author=Dubon%2CMJ&author=Byeon%2CY&author=Park%2CKS make?
- Discover the revenue of https://doi.org/10.1038%2Fonc.2011.504
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=The%20nuclear%20receptor%20TR3%20regulates%20mTORC1%20signaling%20in%20lung%20cancer%20cells%20expressing%20wild-type%20p53&journal=Oncogene&doi=10.1038%2Fonc.2011.504&volume=31&pages=3265-76&publication_year=2012&author=Lee%2CSO&author=Andey%2CT&author=Jin%2CUH&author=Kim%2CK&author=Singh%2CM&author=Safe%2CS
- How much does https://doi.org/10.1152%2Fajpcell.00569.2004 gross monthly?
- What's http://scholar.google.com/scholar_lookup?&title=Antimitogenic%20effect%20of%20green%20tea%20%28-%29-epigallocatechin%20gallate%20on%203T3-L1%20preadipocytes%20depends%20on%20the%20ERK%20and%20Cdk2%20pathways&journal=Am%20J%20Physiol%20Cell%20Physiol&doi=10.1152%2Fajpcell.00569.2004&volume=288&pages=C1094-C1108&publication_year=2005&author=Hung%2CPF&author=Wu%2CBT&author=Chen%2CHC&author=Chen%2CYH&author=Chen%2CCL&author=Wu%2CMH's gross income?
- What's the monthly money flow for https://doi.org/10.1210%2Fen.2015-1215?
- Revenue of http://scholar.google.com/scholar_lookup?&title=Endogenous%20IGFBP-3%20mediates%20intrinsic%20apoptosis%20through%20modulation%20of%20Nur77%20phosphorylation%20and%20nuclear%20export&journal=Endocrinology&doi=10.1210%2Fen.2015-1215&volume=156&pages=4141-51&publication_year=2015&author=Agostini-Dreyer%2CA&author=Jetzt%2CAE&author=Stires%2CH&author=Cohick%2CWS
- How much revenue does https://doi.org/10.1016%2Fj.taap.2017.07.017 bring in?
- How much money does http://scholar.google.com/scholar_lookup?&title=Inactivation%20of%20the%20orphan%20nuclear%20receptor%20NR4A1%20contributes%20to%20apoptosis%20induction%20by%20fangchinoline%20in%20pancreatic%20cancer%20cells&journal=Toxicol%20Appl%20Pharmacol&doi=10.1016%2Fj.taap.2017.07.017&volume=332&pages=32-39&publication_year=2017&author=Lee%2CHS&author=Safe%2CS&author=Lee%2CSO make?
- Get to know https://doi.org/10.1016%2Fj.tem.2008.11.005's earnings
- How much does http://scholar.google.com/scholar_lookup?&title=New%20developments%20in%20adipogenesis&journal=Trends%20Endocrinol%20Metab&doi=10.1016%2Fj.tem.2008.11.005&volume=20&pages=107-14&publication_year=2009&author=Lefterova%2CMI&author=Lazar%2CMA earn?
- What's the revenue for https://doi.org/10.1016%2Fj.plefa.2005.04.004?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=The%20transcriptional%20basis%20of%20adipocyte%20development&journal=Prostaglandins%20Leukot%20Essent%20Fat%20Acids&doi=10.1016%2Fj.plefa.2005.04.004&volume=73&pages=31-34&publication_year=2005&author=Rosen%2CED?
- How much profit does https://doi.org/10.3390%2Fnu7010277 make?
- How much money does http://scholar.google.com/scholar_lookup?&title=Effects%20of%20black%20adzuki%20bean%20%28Vigna%20angularis%29%20extract%20on%20proliferation%20and%20differentiation%20of%203T3-L1%20preadipocytes%20into%20mature%20adipocytes&journal=Nutrients&doi=10.3390%2Fnu7010277&volume=7&pages=277-92&publication_year=2015&author=Kim%2CM&author=Park%2CJE&author=Song%2CSB&author=Cha%2CYS make?
- What's the profit of https://doi.org/10.1073%2Fpnas.0137044100?
- http://scholar.google.com/scholar_lookup?&title=Mitotic%20clonal%20expansion%3A%20a%20synchronous%20process%20required%20for%20adipogenesis&journal=Proc%20Natl%20Acad%20Sci%20USA&doi=10.1073%2Fpnas.0137044100&volume=100&pages=44-49&publication_year=2003&author=Tang%2CQQ&author=Otto%2CTC&author=Lane%2CMD's financial summary
- How much cash flow does https://doi.org/10.1016%2F0026-0495%2895%2990123-X have monthly?
- http://scholar.google.com/scholar_lookup?&title=Differential%20effects%20of%20fat%20and%20sucrose%20on%20the%20development%20of%20obesity%20and%20diabetes%20in%20C57BL%2F6J%20and%20A%2FJ%20mice&journal=Metabolism&doi=10.1016%2F0026-0495%2895%2990123-X&volume=44&pages=645-51&publication_year=1995&author=Surwit%2CRS&author=Feinglos%2CMN&author=Rodin%2CJ&author=Sutherland%2CA&author=Petro%2CAE&author=Opara%2CEC's financial summary
- https://doi.org/10.1152%2Fajpendo.00203.2004's total income per month
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Molecular%20evidence%20supporting%20the%20portal%20theory%3A%20a%20causative%20link%20between%20visceral%20adiposity%20and%20hepatic%20insulin%20resistance&journal=Am%20J%20Physiol%20Endocrinol%20Metab&doi=10.1152%2Fajpendo.00203.2004&volume=288&pages=E454-E461&publication_year=2005&author=Kabir%2CM&author=Catalano%2CKJ&author=Ananthnarayan%2CS&author=Kim%2CSP&author=Citters%2CGW&author=Dea%2CMK?
- See how much https://doi.org/10.1152%2Fajpgi.00460.2014 makes per month
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Impact%20of%20SCP-2%2FSCP-x%20gene%20ablation%20and%20dietary%20cholesterol%20on%20hepatic%20lipid%20accumulation&journal=Am%20J%20Physiol%20Gastrointest%20Liver%20Physiol&doi=10.1152%2Fajpgi.00460.2014&volume=309&pages=G387-G399&publication_year=2015&author=Klipsic%2CD&author=Landrock%2CD&author=Martin%2CGG&author=McIntosh%2CAL&author=Landrock%2CKK&author=Mackie%2CJT?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8963350's revenue stream
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Liver%20fat%2C%20serum%20triglycerides%20and%20visceral%20adipose%20tissue%20in%20insulin-sensitive%20and%20insulin-resistant%20black%20men%20with%20NIDDM&journal=Int%20J%20Obes%20Relat%20Metab%20Disord&volume=19&pages=846-50&publication_year=1995&author=Banerji%2CMA&author=Buckley%2CMC&author=Chaiken%2CRL&author=Gordon%2CD&author=Lebovitz%2CHE&author=Kral%2CJG have monthly?
- Profit of https://doi.org/10.1210%2Fme.2013-1291
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Minireview%3A%20role%20of%20orphan%20nuclear%20receptors%20in%20cancer%20and%20potential%20as%20drug%20targets&journal=Mol%20Endocrinol&doi=10.1210%2Fme.2013-1291&volume=28&pages=157-72&publication_year=2014&author=Safe%2CS&author=Jin%2CUH&author=Hedrick%2CE&author=Reeder%2CA&author=Lee%2CSO?
- https://doi.org/10.1016%2Fj.tem.2017.05.004 income
- How profitable is http://scholar.google.com/scholar_lookup?&title=AMPK%20as%20a%20therapeutic%20target%20for%20treating%20metabolic%20diseases&journal=Trends%20Endocrinol%20Metab&doi=10.1016%2Fj.tem.2017.05.004&volume=28&pages=545-60&publication_year=2017&author=Day%2CEA&author=Ford%2CRJ&author=Steinberg%2CGR?
- How much does https://doi.org/10.1073%2Fpnas.0337434100 net monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=CCAAT%2Fenhancer-binding%20protein%20beta%20is%20required%20for%20mitotic%20clonal%20expansion%20during%20adipogenesis&journal=Proc%20Natl%20Acad%20Sci%20USA&doi=10.1073%2Fpnas.0337434100&volume=100&pages=850-5&publication_year=2003&author=Tang%2CQQ&author=Otto%2CTC&author=Lane%2CMD gross monthly?
- Financial intake of https://doi.org/10.1038%2Fsj.emboj.7601435
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=p53%20mediates%20the%20negative%20regulation%20of%20MDM2%20by%20orphan%20receptor%20TR3&journal=EMBO%20J&doi=10.1038%2Fsj.emboj.7601435&volume=25&pages=5703-15&publication_year=2006&author=Zhao%2CBX&author=Chen%2CHZ&author=Lei%2CNZ&author=Li%2CGD&author=Zhao%2CWX&author=Zhan%2CYY
- What is the monthly revenue of https://doi.org/10.1530%2FERC-15-0063?
- How much does http://scholar.google.com/scholar_lookup?&title=Nuclear%20receptor%204A1%20as%20a%20drug%20target%20for%20breast%20cancer%20chemotherapy&journal=Endocr%20Relat%20Cancer&doi=10.1530%2FERC-15-0063&volume=22&pages=831-40&publication_year=2015&author=Hedrick%2CE&author=Lee%2CSO&author=Doddapaneni%2CR&author=Singh%2CM&author=Safe%2CS earn?
- How much money does https://doi.org/10.1038%2Fnchembio.1069 generate?
- How much does http://scholar.google.com/scholar_lookup?&title=The%20orphan%20nuclear%20receptor%20Nur77%20regulates%20LKB1%20localization%20and%20activates%20AMPK&journal=Nat%20Chem%20Biol&doi=10.1038%2Fnchembio.1069&volume=8&pages=897-904&publication_year=2012&author=Zhan%2CYY&author=Chen%2CY&author=Zhang%2CQ&author=Zhuang%2CJJ&author=Tian%2CM&author=Chen%2CHZ earn?
- Discover the revenue of https://doi.org/10.3945%2Fjn.114.200931
- What's the profit of http://scholar.google.com/scholar_lookup?&title=The%20green%20algal%20carotenoid%20siphonaxanthin%20inhibits%20adipogenesis%20in%203T3-L1%20preadipocytes%20and%20the%20accumulation%20of%20lipids%20in%20white%20adipose%20tissue%20of%20KK-Ay%20mice&journal=J%20Nutr&doi=10.3945%2Fjn.114.200931&volume=145&pages=490-8&publication_year=2015&author=Li%2CZS&author=Noda%2CK&author=Fujita%2CE&author=Manabe%2CY&author=Hirata%2CT&author=Sugawara%2CT?
- Check the income stats for https://doi.org/10.4162%2Fnrp.2014.8.6.655
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Arctiin%20inhibits%20adipogenesis%20in%203T3-L1%20cells%20and%20decreases%20adiposity%20and%20body%20weight%20in%20mice%20fed%20a%20high-fat%20diet&journal=Nutr%20Res%20Pract&doi=10.4162%2Fnrp.2014.8.6.655&volume=8&pages=655-61&publication_year=2014&author=Min%2CB&author=Lee%2CH&author=Song%2CJH&author=Han%2CMJ&author=Chung%2CJ?
- Financial intake of https://doi.org/10.1002%2Fhep.23280
- How much profit is http://scholar.google.com/scholar_lookup?&title=Obesity%20and%20nonalcoholic%20fatty%20liver%20disease%3A%20biochemical%2C%20metabolic%2C%20and%20clinical%20implications&journal=Hepatology&doi=10.1002%2Fhep.23280&volume=51&pages=679-89&publication_year=2010&author=Fabbrini%2CE&author=Sullivan%2CS&author=Klein%2CS making per month?
- What's the revenue for https://citation-needed.springer.com/v2/references/10.1038/s41366-018-0276-x?format=refman&flavour=references?
- Profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Yeon-Seop%20Jung
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Yeon-Seop%20Jung%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in monthly?
- Learn about the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hyo-Seon%20Lee
- Learn how profitable https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hyo-Seon%20Lee%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en is on a monthly basis
- Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hye-Rin%20Cho
- What's the financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hye-Rin%20Cho%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Get to know what's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Keuk-Jun%20Kim
- What's the profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Keuk-Jun%20Kim%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Joung-Hee%20Kim gross monthly?
- What's the financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Joung-Hee%20Kim%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Income figures for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Stephen%20Safe
- What's the financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Stephen%20Safe%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Check the income stats for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Syng-Ook%20Lee
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Syng-Ook%20Lee%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earn?
- How much revenue does https://static-content.springer.com/esm/art%3A10.1038%2Fs41366-018-0276-x/MediaObjects/41366_2018_276_MOESM1_ESM.docx generate?
- What are the earnings of https://s100.copyright.com/AppDispatchServlet?title=Dual%20targeting%20of%20Nur77%20and%20AMPK%CE%B1%20by%20isoalantolactone%20inhibits%20adipogenesis%20in%20vitro%20and%20decreases%20body%20fat%20mass%20in%20vivo&author=Yeon-Seop%20Jung%20et%20al&contentID=10.1038%2Fs41366-018-0276-x©right=Springer%20Nature%20Limited&publication=0307-0565&publicationDate=2018-12-11&publisherName=SpringerNature&orderBeanReset=true?
- Discover the revenue of https://crossmark.crossref.org/dialog/?doi=10.1038/s41366-018-0276-x
- https://citation-needed.springer.com/v2/references/10.1038/s41366-018-0276-x?format=refman&flavour=citation income
- How much does https://doi.org/10.1007/s10555-022-10068-w pull in monthly?
- How much does https://www.protocols.io/ pull in monthly?
- Get to know what's the income of https://www.natureindex.com/
- What's the revenue for http://www.naturechina.com?
- How much profit does https://www.natureasia.com/ja-jp make?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref