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Title:
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition | Oncogene
Description:
The term mitochondrial permeability transition (MPT) is commonly used to indicate an abrupt increase in the permeability of the inner mitochondrial membrane to low molecular weight solutes. Widespread MPT has catastrophic consequences for the cell, de facto marking the boundary between cellular life and death. MPT results indeed in the structural and functional collapse of mitochondria, an event that commits cells to suicide via regulated necrosis or apoptosis. MPT has a central role in the etiology of both acute and chronic diseases characterized by the loss of post-mitotic cells. Moreover, cancer cells are often relatively insensitive to the induction of MPT, underlying their increased resistance to potentially lethal cues. Thus, intense efforts have been dedicated not only at the understanding of MPT in mechanistic terms, but also at the development of pharmacological MPT modulators. In this setting, multiple mitochondrial and extramitochondrial proteins have been suspected to critically regulate the MPT. So far, however, only peptidylprolyl isomerase F (best known as cyclophilin D) appears to constitute a key component of the so-called permeability transition pore complex (PTPC), the supramolecular entity that is believed to mediate MPT. Here, after reviewing the structural and functional features of the PTPC, we summarize recent findings suggesting that another of its core components is represented by the c subunit of mitochondrial ATP synthase.
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Questions {❓}
- Is supercomplex organization of the respiratory chain required for optimal electron transfer activity?
- Modulation of the mitochondrial permeability transition by cyclophilin D: moving closer to F(0)-F(1) ATP synthase?
- The apoptotic pore on mitochondria: are we breaking through or still stuck?
- What is the mitochondrial permeability transition pore?
- What makes you can also break you, part II: mitochondrial permeability transition pore formation by dimers of the F1FO ATP-synthase?
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- What's the financial outcome of https://doi.org/10.1038/onc.2014.462?
- Income figures for https://link.springer.com/article/10.1038/onc.2014.96?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle
- Income figures for http://scholar.google.com/scholar_lookup?&title=Mitochondrial%20membrane%20permeabilization%20in%20cell%20death&journal=Physiol%20Rev&volume=87&pages=99-163&publication_year=2007&author=Kroemer%2CG&author=Galluzzi%2CL&author=Brenner%2CC
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Molecular%20definitions%20of%20cell%20death%20subroutines%3A%20recommendations%20of%20the%20Nomenclature%20Committee%20on%20Cell%20Death%202012&journal=Cell%20Death%20%26%20Differentiation&volume=19&issue=1&pages=107-120&publication_year=2011&author=Galluzzi%2CL&author=Vitale%2CI&author=Abrams%2CJ%20M&author=Alnemri%2CE%20S&author=Baehrecke%2CE%20H&author=Blagosklonny%2CM%20V&author=Dawson%2CT%20M&author=Dawson%2CV%20L&author=El-Deiry%2CW%20S&author=Fulda%2CS&author=Gottlieb%2CE&author=Green%2CD%20R&author=Hengartner%2CM%20O&author=Kepp%2CO&author=Knight%2CR%20A&author=Kumar%2CS&author=Lipton%2CS%20A&author=Lu%2CX&author=Madeo%2CF&author=Malorni%2CW&author=Mehlen%2CP&author=Nu%C3%B1ez%2CG&author=Peter%2CM%20E&author=Piacentini%2CM&author=Rubinsztein%2CD%20C&author=Shi%2CY&author=Simon%2CH-U&author=Vandenabeele%2CP&author=White%2CE&author=Yuan%2CJ&author=Zhivotovsky%2CB&author=Melino%2CG&author=Kroemer%2CG?
- How much does http://scholar.google.com/scholar_lookup?&title=The%20permeability%20transition%20pore%20complex%20in%20cancer%20cell%20death&journal=Oncogene&volume=25&pages=4744-4756&publication_year=2006&author=Brenner%2CC&author=Grimm%2CS earn?
- How much does http://scholar.google.com/scholar_lookup?&title=The%20Ca2%2B-induced%20membrane%20transition%20in%20mitochondria.%20I.%20The%20protective%20mechanisms&journal=Arch%20Biochem%20Biophys&volume=195&pages=453-459&publication_year=1979&author=Hunter%2CDR&author=Haworth%2CRA pull in?
- How much does http://scholar.google.com/scholar_lookup?&title=Sequential%20reduction%20of%20mitochondrial%20transmembrane%20potential%20and%20generation%20of%20reactive%20oxygen%20species%20in%20early%20programmed%20cell%20death&journal=J%20Exp%20Med&volume=182&pages=367-377&publication_year=1995&author=Zamzami%2CN&author=Marchetti%2CP&author=Castedo%2CM&author=Decaudin%2CD&author=Macho%2CA&author=Hirsch%2CT make?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Reduction%20in%20mitochondrial%20potential%20constitutes%20an%20early%20irreversible%20step%20of%20programmed%20lymphocyte%20death%20in%20vivo&journal=J%20Exp%20Med&volume=181&pages=1661-1672&publication_year=1995&author=Zamzami%2CN&author=Marchetti%2CP&author=Castedo%2CM&author=Zanin%2CC&author=Vayssiere%2CJL&author=Petit%2CPX?
- See how much http://scholar.google.com/scholar_lookup?&title=Mitochondria%20and%20the%20autophagy-inflammation-cell%20death%20axis%20in%20organismal%20aging&journal=Science&volume=333&pages=1109-1112&publication_year=2011&author=Green%2CDR&author=Galluzzi%2CL&author=Kroemer%2CG makes per month
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Molecular%20mechanisms%20of%20necroptosis%3A%20an%20ordered%20cellular%20explosion&journal=Nat%20Rev%20Mol%20Cell%20Biol&volume=11&pages=700-714&publication_year=2010&author=Vandenabeele%2CP&author=Galluzzi%2CL&author=Vanden%20Berghe%2CT&author=Kroemer%2CG generate?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=ATP%20synthesis%20and%20storage&journal=Purinergic%20Signal&volume=8&pages=343-357&publication_year=2012&author=Bonora%2CM&author=Patergnani%2CS&author=Rimessi%2CA&author=De%20Marchi%2CE&author=Suski%2CJM&author=Bononi%2CA bring in?
- How much does http://scholar.google.com/scholar_lookup?&title=Mitochondria%3A%20master%20regulators%20of%20danger%20signalling&journal=Nat%20Rev%20Mol%20Cell%20Biol&volume=13&pages=780-788&publication_year=2012&author=Galluzzi%2CL&author=Kepp%2CO&author=Kroemer%2CG make?
- Revenue of http://scholar.google.com/scholar_lookup?&title=Mitochondria%20and%20cell%20death%3A%20outer%20membrane%20permeabilization%20and%20beyond&journal=Nat%20Rev%20Mol%20Cell%20Biol&volume=11&pages=621-632&publication_year=2010&author=Tait%2CSW&author=Green%2CDR
- How much does http://scholar.google.com/scholar_lookup?&title=Different%20mitochondrial%20intermembrane%20space%20proteins%20are%20released%20during%20apoptosis%20in%20a%20manner%20that%20is%20coordinately%20initiated%20but%20can%20vary%20in%20duration&journal=Proc%20Natl%20Acad%20Sci%20USA&volume=103&pages=11573-11578&publication_year=2006&author=Munoz-Pinedo%2CC&author=Guio-Carrion%2CA&author=Goldstein%2CJC&author=Fitzgerald%2CP&author=Newmeyer%2CDD&author=Green%2CDR rake in every month?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Classification%20of%20cell%20death%3A%20recommendations%20of%20the%20Nomenclature%20Committee%20on%20Cell%20Death%202009&journal=Cell%20Death%20%26%20Differentiation&volume=16&issue=1&pages=3-11&publication_year=2008&author=Kroemer%2CG&author=Galluzzi%2CL&author=Vandenabeele%2CP&author=Abrams%2CJ&author=Alnemri%2CE%20S&author=Baehrecke%2CE%20H&author=Blagosklonny%2CM%20V&author=El-Deiry%2CW%20S&author=Golstein%2CP&author=Green%2CD%20R&author=Hengartner%2CM&author=Knight%2CR%20A&author=Kumar%2CS&author=Lipton%2CS%20A&author=Malorni%2CW&author=Nu%C3%B1ez%2CG&author=Peter%2CM%20E&author=Tschopp%2CJ&author=Yuan%2CJ&author=Piacentini%2CM&author=Zhivotovsky%2CB&author=Melino%2CG
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Apoptosis%3A%20controlled%20demolition%20at%20the%20cellular%20level&journal=Nat%20Rev%20Mol%20Cell%20Biol&volume=9&pages=231-241&publication_year=2008&author=Taylor%2CRC&author=Cullen%2CSP&author=Martin%2CSJ?
- How much does http://scholar.google.com/scholar_lookup?&title=Intracellular%20adenosine%20triphosphate%20%28ATP%29%20concentration%3A%20a%20switch%20in%20the%20decision%20between%20apoptosis%20and%20necrosis&journal=J%20Exp%20Med&volume=185&pages=1481-1486&publication_year=1997&author=Leist%2CM&author=Single%2CB&author=Castoldi%2CAF&author=Kuhnle%2CS&author=Nicotera%2CP gross monthly?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=S-nitrosylation%20of%20mitochondrial%20caspases&journal=J%20Cell%20Biol&volume=154&pages=1111-1116&publication_year=2001&author=Mannick%2CJB&author=Schonhoff%2CC&author=Papeta%2CN&author=Ghafourifar%2CP&author=Szibor%2CM&author=Fang%2CK
- http://scholar.google.com/scholar_lookup?&title=XIAP%20discriminates%20between%20type%20I%20and%20type%20II%20FAS-induced%20apoptosis&journal=Nature&volume=460&pages=1035-1039&publication_year=2009&author=Jost%2CPJ&author=Grabow%2CS&author=Gray%2CD&author=McKenzie%2CMD&author=Nachbur%2CU&author=Huang%2CDC's revenue stream
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Catalytic%20activity%20of%20the%20caspase-8-FLIP%28L%29%20complex%20inhibits%20RIPK3-dependent%20necrosis&journal=Nature&volume=471&pages=363-367&publication_year=2011&author=Oberst%2CA&author=Dillon%2CCP&author=Weinlich%2CR&author=McCormick%2CLL&author=Fitzgerald%2CP&author=Pop%2CC?
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=The%20apoptosis-necrosis%20paradox.%20Apoptogenic%20proteases%20activated%20after%20mitochondrial%20permeability%20transition%20determine%20the%20mode%20of%20cell%20death&journal=Oncogene&volume=15&pages=1573-1581&publication_year=1997&author=Hirsch%2CT&author=Marchetti%2CP&author=Susin%2CSA&author=Dallaporta%2CB&author=Zamzami%2CN&author=Marzo%2CI?
- http://scholar.google.com/scholar_lookup?&title=Cyclophilin%20D%20is%20a%20component%20of%20mitochondrial%20permeability%20transition%20and%20mediates%20neuronal%20cell%20death%20after%20focal%20cerebral%20ischemia&journal=Proc%20Natl%20Acad%20Sci%20USA&volume=102&pages=12005-12010&publication_year=2005&author=Schinzel%2CAC&author=Takeuchi%2CO&author=Huang%2CZ&author=Fisher%2CJK&author=Zhou%2CZ&author=Rubens%2CJ's revenue stream
- http://scholar.google.com/scholar_lookup?&title=Loss%20of%20cyclophilin%20D%20reveals%20a%20critical%20role%20for%20mitochondrial%20permeability%20transition%20in%20cell%20death&journal=Nature&volume=434&pages=658-662&publication_year=2005&author=Baines%2CCP&author=Kaiser%2CRA&author=Purcell%2CNH&author=Blair%2CNS&author=Osinska%2CH&author=Hambleton%2CMA's financial summary
- Income figures for http://scholar.google.com/scholar_lookup?&title=Cyclophilin%20D-dependent%20mitochondrial%20permeability%20transition%20regulates%20some%20necrotic%20but%20not%20apoptotic%20cell%20death&journal=Nature&volume=434&pages=652-658&publication_year=2005&author=Nakagawa%2CT&author=Shimizu%2CS&author=Watanabe%2CT&author=Yamaguchi%2CO&author=Otsu%2CK&author=Yamagata%2CH
- Earnings of http://scholar.google.com/scholar_lookup?&title=Bax%20regulates%20primary%20necrosis%20through%20mitochondrial%20dynamics&journal=Proc%20Natl%20Acad%20Sci%20USA&volume=109&pages=6566-6571&publication_year=2012&author=Whelan%2CRS&author=Konstantinidis%2CK&author=Wei%2CAC&author=Chen%2CY&author=Reyna%2CDE&author=Jha%2CS
- How much does http://scholar.google.com/scholar_lookup?&title=Two%20independent%20pathways%20of%20regulated%20necrosis%20mediate%20ischemia-reperfusion%20injury&journal=Proc%20Natl%20Acad%20Sci%20USA&volume=110&pages=12024-12029&publication_year=2013&author=Linkermann%2CA&author=Brasen%2CJH&author=Darding%2CM&author=Jin%2CMK&author=Sanz%2CAB&author=Heller%2CJO bring in each month?
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Mitochondrial%20permeability%20transition%20pore%20component%20cyclophilin%20D%20distinguishes%20nigrostriatal%20dopaminergic%20death%20paradigms%20in%20the%20MPTP%20mouse%20model%20of%20Parkinson%27s%20disease&journal=Antioxid%20Redox%20Signal&volume=16&pages=855-868&publication_year=2012&author=Thomas%2CB&author=Banerjee%2CR&author=Starkova%2CNN&author=Zhang%2CSF&author=Calingasan%2CNY&author=Yang%2CL?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=Cyclophilin%20D%20deficiency%20protects%20against%20acetaminophen-induced%20oxidant%20stress%20and%20liver%20injury&journal=Free%20Radic%20Res&volume=45&pages=156-164&publication_year=2011&author=Ramachandran%2CA&author=Lebofsky%2CM&author=Baines%2CCP&author=Lemasters%2CJJ&author=Jaeschke%2CH
- How much income is http://scholar.google.com/scholar_lookup?&title=Pharmacologic%20targeting%20or%20genetic%20deletion%20of%20mitochondrial%20cyclophilin%20D%20protects%20from%20NSAID-induced%20small%20intestinal%20ulceration%20in%20mice&journal=Toxicol%20Sci&volume=118&pages=276-285&publication_year=2010&author=LoGuidice%2CA&author=Ramirez-Alcantara%2CV&author=Proli%2CA&author=Gavillet%2CB&author=Boelsterli%2CUA earning monthly?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Mitochondrial%20permeability%20transition%20as%20a%20novel%20principle%20of%20hepatorenal%20toxicity%20in%20vivo&journal=Apoptosis&volume=7&pages=395-405&publication_year=2002&author=Haouzi%2CD&author=Cohen%2CI&author=Vieira%2CHL&author=Poncet%2CD&author=Boya%2CP&author=Castedo%2CM?
- How much does http://scholar.google.com/scholar_lookup?&title=Targeting%20cyclophilin%20D%20and%20the%20mitochondrial%20permeability%20transition%20enhances%20beta-cell%20survival%20and%20prevents%20diabetes%20in%20Pdx1%20deficiency&journal=Proc%20Natl%20Acad%20Sci%20USA&volume=107&pages=10214-10219&publication_year=2010&author=Fujimoto%2CK&author=Chen%2CY&author=Polonsky%2CKS&author=Dorn%2CGW make?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Genetic%20ablation%20of%20cyclophilin%20D%20rescues%20mitochondrial%20defects%20and%20prevents%20muscle%20apoptosis%20in%20collagen%20VI%20myopathic%20mice&journal=Hum%20Mol%20Genet&volume=18&pages=2024-2031&publication_year=2009&author=Palma%2CE&author=Tiepolo%2CT&author=Angelin%2CA&author=Sabatelli%2CP&author=Maraldi%2CNM&author=Basso%2CE?
- How much income does http://scholar.google.com/scholar_lookup?&title=Genetic%20and%20pharmacologic%20inhibition%20of%20mitochondrial-dependent%20necrosis%20attenuates%20muscular%20dystrophy&journal=Nat%20Med&volume=14&pages=442-447&publication_year=2008&author=Millay%2CDP&author=Sargent%2CMA&author=Osinska%2CH&author=Baines%2CCP&author=Barton%2CER&author=Vuagniaux%2CG have?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Molecular%20mechanisms%20of%20cisplatin%20resistance&journal=Oncogene&volume=31&pages=1869-1883&publication_year=2012&author=Galluzzi%2CL&author=Senovilla%2CL&author=Vitale%2CI&author=Michels%2CJ&author=Martins%2CI&author=Kepp%2CO generate?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Mechanism%20of%20apoptosis%20induction%20by%20inhibition%20of%20the%20anti-apoptotic%20BCL-2%20proteins&journal=Proc%20Natl%20Acad%20Sci%20USA&volume=105&pages=20327-20332&publication_year=2008&author=Chipuk%2CJE&author=Fisher%2CJC&author=Dillon%2CCP&author=Kriwacki%2CRW&author=Kuwana%2CT&author=Green%2CDR produce monthly?
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Targeting%20Bax%20interaction%20sites%20reveals%20that%20only%20homo-oligomerization%20sites%20are%20essential%20for%20its%20activation&journal=Cell%20Death%20Differ&volume=20&pages=744-754&publication_year=2013&author=Peng%2CR&author=Tong%2CJS&author=Li%2CH&author=Yue%2CB&author=Zou%2CF&author=Yu%2CJ?
- How much does http://scholar.google.com/scholar_lookup?&title=Mitochondrial%20membrane%20permeabilization%20in%20neuronal%20injury&journal=Nat%20Rev%20Neurosci&volume=10&pages=481-494&publication_year=2009&author=Galluzzi%2CL&author=Blomgren%2CK&author=Kroemer%2CG pull in?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Targeting%20mitochondria%20for%20cancer%20therapy&journal=Nat%20Rev%20Drug%20Discov&volume=9&pages=447-464&publication_year=2010&author=Fulda%2CS&author=Galluzzi%2CL&author=Kroemer%2CG
- Monthly income for http://scholar.google.com/scholar_lookup?&title=Mitochondria%20as%20therapeutic%20targets%20for%20cancer%20chemotherapy&journal=Oncogene&volume=25&pages=4812-4830&publication_year=2006&author=Galluzzi%2CL&author=Larochette%2CN&author=Zamzami%2CN&author=Kroemer%2CG
- Get to know http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20the%20mitochondrial%20permeability%20transition%20for%20cytoprotection%3A%20direct%20versus%20indirect%20Mechanisms&journal=Biochem%20Res%20Int&volume=2012&publication_year=2012&author=Martel%2CC&author=Huynh%20le%2CH&author=Garnier%2CA&author=Ventura-Clapier%2CR&author=Brenner%2CC's earnings
- How much does http://scholar.google.com/scholar_lookup?&title=Cell%20death%20assays%20for%20drug%20discovery&journal=Nat%20Rev%20Drug%20Discov&volume=10&pages=221-237&publication_year=2011&author=Kepp%2CO&author=Galluzzi%2CL&author=Lipinski%2CM&author=Yuan%2CJ&author=Kroemer%2CG net monthly?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Individuality%3A%20the%20barrier%20to%20optimal%20immunosuppression&journal=Nat%20Rev%20Immunol&volume=3&pages=831-838&publication_year=2003&author=Kahan%2CBD?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=The%20apoptotic%20pore%20on%20mitochondria%3A%20are%20we%20breaking%20through%20or%20still%20stuck%3F&journal=Cell%20Death%20Differ&volume=21&pages=187-191&publication_year=2014&author=Borner%2CC&author=Andrews%2CDW?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=The%20mitochondrial%20megachannel%20is%20the%20permeability%20transition%20pore&journal=J%20Bioenerg%20Biomembr&volume=24&pages=111-117&publication_year=1992&author=Szabo%2CI&author=Zoratti%2CM?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Modulation%20of%20the%20mitochondrial%20megachannel%20by%20divalent%20cations%20and%20protons&journal=J%20Biol%20Chem&volume=267&pages=2940-2946&publication_year=1992&author=Szabo%2CI&author=Bernardi%2CP&author=Zoratti%2CM bring in?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=The%20mitochondrial%20permeability%20transition%20pore%20may%20comprise%20VDAC%20molecules.%20I.%20Binary%20structure%20and%20voltage%20dependence%20of%20the%20pore&journal=FEBS%20Lett&volume=330&pages=201-205&publication_year=1993&author=Szabo%2CI&author=Zoratti%2CM have monthly?
- How much profit is http://scholar.google.com/scholar_lookup?&title=The%20mitochondrial%20permeability%20transition%20pore%20may%20comprise%20VDAC%20molecules.%20II.%20The%20electrophysiological%20properties%20of%20VDAC%20are%20compatible%20with%20those%20of%20the%20mitochondrial%20megachannel&journal=FEBS%20Lett&volume=330&pages=206-210&publication_year=1993&author=Szabo%2CI&author=De%20Pinto%2CV&author=Zoratti%2CM making per month?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Isolation%20of%20the%20mitochondrial%20benzodiazepine%20receptor%3A%20association%20with%20the%20voltage-dependent%20anion%20channel%20and%20the%20adenine%20nucleotide%20carrier&journal=Proc%20Natl%20Acad%20Sci%20USA&volume=89&pages=3170-3174&publication_year=1992&author=McEnery%2CMW&author=Snowman%2CAM&author=Trifiletti%2CRR&author=Snyder%2CSH have monthly?
- What's the income of http://scholar.google.com/scholar_lookup?&title=Complexes%20between%20kinases%2C%20mitochondrial%20porin%20and%20adenylate%20translocator%20in%20rat%20brain%20resemble%20the%20permeability%20transition%20pore&journal=FEBS%20Lett&volume=396&pages=189-195&publication_year=1996&author=Beutner%2CG&author=Ruck%2CA&author=Riede%2CB&author=Welte%2CW&author=Brdiczka%2CD?
- http://scholar.google.com/scholar_lookup?&title=Complexes%20between%20porin%2C%20hexokinase%2C%20mitochondrial%20creatine%20kinase%20and%20adenylate%20translocator%20display%20properties%20of%20the%20permeability%20transition%20pore.%20Implication%20for%20regulation%20of%20permeability%20transition%20by%20the%20kinases&journal=Biochim%20Biophys%20Acta&volume=1368&pages=7-18&publication_year=1998&author=Beutner%2CG&author=Ruck%2CA&author=Riede%2CB&author=Brdiczka%2CD income
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Cyclophilin-D%20binds%20strongly%20to%20complexes%20of%20the%20voltage-dependent%20anion%20channel%20and%20the%20adenine%20nucleotide%20translocase%20to%20form%20the%20permeability%20transition%20pore&journal=Eur%20J%20Biochem&volume=258&pages=729-735&publication_year=1998&author=Crompton%2CM&author=Virji%2CS&author=Ward%2CJM?
- See how much http://scholar.google.com/scholar_lookup?&title=Involvement%20of%20cyclophilin%20D%20in%20the%20activation%20of%20a%20mitochondrial%20pore%20by%20Ca2%2B%20and%20oxidant%20stress&journal=Eur%20J%20Biochem&volume=238&pages=166-172&publication_year=1996&author=Tanveer%2CA&author=Virji%2CS&author=Andreeva%2CL&author=Totty%2CNF&author=Hsuan%2CJJ&author=Ward%2CJM makes per month
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20Ca2%28%2B%29-induced%20large-amplitude%20swelling%20of%20liver%20and%20heart%20mitochondria%20by%20cyclosporin%20is%20probably%20caused%20by%20the%20inhibitor%20binding%20to%20mitochondrial-matrix%20peptidyl-prolyl%20cis-trans%20isomerase%20and%20preventing%20it%20interacting%20with%20the%20adenine%20nucleotide%20translocase&journal=Biochem%20J&volume=268&pages=153-160&publication_year=1990&author=Halestrap%2CAP&author=Davidson%2CAM
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Reconstituted%20adenine%20nucleotide%20translocase%20forms%20a%20channel%20for%20small%20molecules%20comparable%20to%20the%20mitochondrial%20permeability%20transition%20pore&journal=FEBS%20Lett&volume=426&pages=97-101&publication_year=1998&author=Ruck%2CA&author=Dolder%2CM&author=Wallimann%2CT&author=Brdiczka%2CD?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=The%20ADP%2FATP%20translocator%20is%20not%20essential%20for%20the%20mitochondrial%20permeability%20transition%20pore&journal=Nature&volume=427&pages=461-465&publication_year=2004&author=Kokoszka%2CJE&author=Waymire%2CKG&author=Levy%2CSE&author=Sligh%2CJE&author=Cai%2CJ&author=Jones%2CDP?
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- Financial intake of http://scholar.google.com/scholar_lookup?&title=Osmotic%20reversal%20of%20phosphate-induced%20mitochondrial%20swelling&journal=Biochim%20Biophys%20Acta&volume=104&pages=612-615&publication_year=1965&author=Tedeschi%2CH&author=Hegarty%2CHJ&author=James%2CJM
- How much profit does http://scholar.google.com/scholar_lookup?&title=The%20mitochondrial%20transporter%20family%20%28SLC25%29%3A%20physiological%20and%20pathological%20implications&journal=Pflugers%20Arch&volume=447&pages=689-709&publication_year=2004&author=Palmieri%2CF make?
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- How much profit does http://scholar.google.com/scholar_lookup?&title=Viral%20control%20of%20mitochondrial%20apoptosis&journal=PLoS%20Pathog&volume=4&publication_year=2008&author=Galluzzi%2CL&author=Brenner%2CC&author=Morselli%2CE&author=Touat%2CZ&author=Kroemer%2CG make?
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- Explore the financials of http://scholar.google.com/scholar_lookup?&title=The%20reversible%20antiport-uniport%20conversion%20of%20the%20phosphate%20carrier%20from%20yeast%20mitochondria%20depends%20on%20the%20presence%20of%20a%20single%20cysteine&journal=J%20Biol%20Chem&volume=272&pages=10558-10564&publication_year=1997&author=Schroers%2CA&author=Kramer%2CR&author=Wohlrab%2CH
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=The%20roles%20of%20phosphate%20and%20the%20phosphate%20carrier%20in%20the%20mitochondrial%20permeability%20transition%20pore&journal=Mitochondrion&volume=12&pages=120-125&publication_year=2012&author=Varanyuwatana%2CP&author=Halestrap%2CAP have monthly?
- How much income does http://scholar.google.com/scholar_lookup?&title=Unexpected%20role%20of%20the%20phosphate%20carrier%20in%20mitochondrial%20fragmentation&journal=Cell%20Death%20Differ&volume=15&pages=616-618&publication_year=2008&author=Pauleau%2CAL&author=Galluzzi%2CL&author=Scholz%2CSR&author=Larochette%2CN&author=Kepp%2CO&author=Kroemer%2CG have?
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- http://scholar.google.com/scholar_lookup?&title=Mitochondrial%20benzodiazepine%20receptors%20regulate%20steroid%20biosynthesis&journal=Proc%20Natl%20Acad%20Sci%20USA&volume=86&pages=9813-9816&publication_year=1989&author=Mukhin%2CAG&author=Papadopoulos%2CV&author=Costa%2CE&author=Krueger%2CKE income
- Profit of http://scholar.google.com/scholar_lookup?&title=Protoporphyrin%20IX%2C%20an%20endogenous%20ligand%20of%20the%20peripheral%20benzodiazepine%20receptor%2C%20potentiates%20induction%20of%20the%20mitochondrial%20permeability%20transition%20and%20the%20killing%20of%20cultured%20hepatocytes%20by%20rotenone&journal=J%20Biol%20Chem&volume=269&pages=31041-31046&publication_year=1994&author=Pastorino%2CJG&author=Simbula%2CG&author=Gilfor%2CE&author=Hoek%2CJB&author=Farber%2CJL
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=PK11195%2C%20a%20ligand%20of%20the%20mitochondrial%20benzodiazepine%20receptor%2C%20facilitates%20the%20induction%20of%20apoptosis%20and%20reverses%20Bcl-2-mediated%20cytoprotection&journal=Exp%20Cell%20Res&volume=241&pages=426-434&publication_year=1998&author=Hirsch%2CT&author=Decaudin%2CD&author=Susin%2CSA&author=Marchetti%2CP&author=Larochette%2CN&author=Resche-Rigon%2CM each month?
- How much does http://scholar.google.com/scholar_lookup?&title=Peripheral-type%20benzodiazepine%20receptor%20ligands%3A%20mitochondrial%20permeability%20transition%20induction%20in%20rat%20cardiac%20tissue&journal=Biochem%20Pharmacol&volume=61&pages=695-705&publication_year=2001&author=Chelli%2CB&author=Falleni%2CA&author=Salvetti%2CF&author=Gremigni%2CV&author=Lucacchini%2CA&author=Martini%2CC gross monthly?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=The%20peripheral-type%20benzodiazepine%20receptor%20is%20involved%20in%20control%20of%20Ca2%2B-induced%20permeability%20transition%20pore%20opening%20in%20rat%20brain%20mitochondria&journal=Cell%20Calcium&volume=42&pages=27-39&publication_year=2007&author=Azarashvili%2CT&author=Grachev%2CD&author=Krestinina%2CO&author=Evtodienko%2CY&author=Yurkov%2CI&author=Papadopoulos%2CV
- How profitable is http://scholar.google.com/scholar_lookup?&title=PK11195%2C%20a%20specific%20ligand%20of%20the%20peripheral%20benzodiazepine%20receptor%2C%20may%20protect%20pancreatic%20beta-cells%20from%20cytokine-induced%20cell%20death&journal=Artif%20Cells%20Blood%20Substit%20Immobil%20Biotechnol&volume=40&pages=56-61&publication_year=2012&author=Klaffschenkel%2CRA&author=Waidmann%2CM&author=Northoff%2CH&author=Mahmoud%2CAA&author=Lembert%2CN?
- How much does http://scholar.google.com/scholar_lookup?&title=Ligands%20of%20the%20mitochondrial%2018%E2%80%89kDa%20translocator%20protein%20attenuate%20apoptosis%20of%20human%20glioblastoma%20cells%20exposed%20to%20erucylphosphohomocholine&journal=Cell%20Oncol&volume=30&pages=435-450&publication_year=2008&author=Kugler%2CW&author=Veenman%2CL&author=Shandalov%2CY&author=Leschiner%2CS&author=Spanier%2CI&author=Lakomek%2CM bring in each month?
- How much does http://scholar.google.com/scholar_lookup?&title=The%20nitric%20oxide%20donor%20sodium%20nitroprusside%20requires%20the%2018%E2%80%89kDa%20Translocator%20Protein%20to%20induce%20cell%20death&journal=Apoptosis&volume=17&pages=647-665&publication_year=2012&author=Shargorodsky%2CL&author=Veenman%2CL&author=Caballero%2CB&author=Pe%27er%2CY&author=Leschiner%2CS&author=Bode%2CJ pull in monthly?
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- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Peripheral%20benzodiazepine%20receptor%20ligands%20reverse%20apoptosis%20resistance%20of%20cancer%20cells%20in%20vitro%20and%20in%20vivo&journal=Cancer%20Res&volume=62&pages=1388-1393&publication_year=2002&author=Decaudin%2CD&author=Castedo%2CM&author=Nemati%2CF&author=Beurdeley-Thomas%2CA&author=De%20Pinieux%2CG&author=Caron%2CA have monthly?
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- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Some%20new%20aspects%20of%20creatine%20kinase%20%28CK%29%3A%20compartmentation%2C%20structure%2C%20function%20and%20regulation%20for%20cellular%20and%20mitochondrial%20bioenergetics%20and%20physiology&journal=Biofactors&volume=8&pages=229-234&publication_year=1998&author=Wallimann%2CT&author=Dolder%2CM&author=Schlattner%2CU&author=Eder%2CM&author=Hornemann%2CT&author=O%27Gorman%2CE?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20the%20mitochondrial%20permeability%20transition%20by%20creatine%20kinase%20substrates.%20Requirement%20for%20microcompartmentation&journal=J%20Biol%20Chem&volume=278&pages=17760-17766&publication_year=2003&author=Dolder%2CM&author=Walzel%2CB&author=Speer%2CO&author=Schlattner%2CU&author=Wallimann%2CT
- How much does http://scholar.google.com/scholar_lookup?&title=Isozymes%20of%20mammalian%20hexokinase%3A%20structure%2C%20subcellular%20localization%20and%20metabolic%20function&journal=J%20Exp%20Biol&volume=206&pages=2049-2057&publication_year=2003&author=Wilson%2CJE generate monthly?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20hexokinase%20binding%20to%20VDAC&journal=J%20Bioenerg%20Biomembr&volume=40&pages=171-182&publication_year=2008&author=Pastorino%2CJG&author=Hoek%2CJB generate?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Hexokinase%20II%3A%20the%20integration%20of%20energy%20metabolism%20and%20control%20of%20apoptosis&journal=Curr%20Med%20Chem&volume=10&pages=1535-1551&publication_year=2003&author=Pastorino%2CJG&author=Hoek%2CJB
- How much does http://scholar.google.com/scholar_lookup?&title=Disruption%20of%20the%20hexokinase-VDAC%20complex%20for%20tumor%20therapy&journal=Oncogene&volume=27&pages=4633-4635&publication_year=2008&author=Galluzzi%2CL&author=Kepp%2CO&author=Tajeddine%2CN&author=Kroemer%2CG bring in each month?
- http://scholar.google.com/scholar_lookup?&title=Methyl%20jasmonate%20binds%20to%20and%20detaches%20mitochondria-bound%20hexokinase&journal=Oncogene&volume=27&pages=4636-4643&publication_year=2008&author=Goldin%2CN&author=Arzoine%2CL&author=Heyfets%2CA&author=Israelson%2CA&author=Zaslavsky%2CZ&author=Bravman%2CT's revenue stream
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Voltage-dependent%20anion%20channel%201-based%20peptides%20interact%20with%20hexokinase%20to%20prevent%20its%20anti-apoptotic%20activity&journal=J%20Biol%20Chem&volume=284&pages=3946-3955&publication_year=2009&author=Arzoine%2CL&author=Zilberberg%2CN&author=Ben-Romano%2CR&author=Shoshan-Barmatz%2CV
- How much does http://scholar.google.com/scholar_lookup?&title=Disruption%20of%20hexokinase%20II-mitochondrial%20binding%20blocks%20ischemic%20preconditioning%20and%20causes%20rapid%20cardiac%20necrosis&journal=Circ%20Res&volume=108&pages=1165-1169&publication_year=2011&author=Smeele%2CKM&author=Southworth%2CR&author=Wu%2CR&author=Xie%2CC&author=Nederlof%2CR&author=Warley%2CA pull in monthly?
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- How much does http://scholar.google.com/scholar_lookup?&title=Glucose%20phosphorylation%20and%20mitochondrial%20binding%20are%20required%20for%20the%20protective%20effects%20of%20hexokinases%20I%20and%20II&journal=Mol%20Cell%20Biol&volume=28&pages=1007-1017&publication_year=2008&author=Sun%2CL&author=Shukair%2CS&author=Naik%2CTJ&author=Moazed%2CF&author=Ardehali%2CH pull in?
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- Income figures for http://scholar.google.com/scholar_lookup?&title=Activation%20of%20glycogen%20synthase%20kinase%203beta%20disrupts%20the%20binding%20of%20hexokinase%20II%20to%20mitochondria%20by%20phosphorylating%20voltage-dependent%20anion%20channel%20and%20potentiates%20chemotherapy-induced%20cytotoxicity&journal=Cancer%20Res&volume=65&pages=10545-10554&publication_year=2005&author=Pastorino%2CJG&author=Hoek%2CJB&author=Shulga%2CN
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- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Modulation%20of%20the%20mitochondrial%20permeability%20transition%20pore%20complex%20in%20GSK-3beta-mediated%20myocardial%20protection&journal=J%20Mol%20Cell%20Cardiol&volume=43&pages=564-570&publication_year=2007&author=Nishihara%2CM&author=Miura%2CT&author=Miki%2CT&author=Tanno%2CM&author=Yano%2CT&author=Naitoh%2CK
- How much does http://scholar.google.com/scholar_lookup?&title=Chemotherapeutic%20induction%20of%20mitochondrial%20oxidative%20stress%20activates%20GSK-3alpha%2Fbeta%20and%20Bax%2C%20leading%20to%20permeability%20transition%20pore%20opening%20and%20tumor%20cell%20death&journal=Cell%20Death%20Dis&volume=3&publication_year=2012&author=Chiara%2CF&author=Gambalunga%2CA&author=Sciacovelli%2CM&author=Nicolli%2CA&author=Ronconi%2CL&author=Fregona%2CD generate monthly?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Activation%20of%20mitochondrial%20ERK%20protects%20cancer%20cells%20from%20death%20through%20inhibition%20of%20the%20permeability%20transition&journal=Proc%20Natl%20Acad%20Sci%20USA&volume=107&pages=726-731&publication_year=2010&author=Rasola%2CA&author=Sciacovelli%2CM&author=Chiara%2CF&author=Pantic%2CB&author=Brusilow%2CWS&author=Bernardi%2CP make?
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