
NATURE . COM {
}
Title:
Ago–TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps | Nature Structural & Molecular Biology
Description:
miRNAs can repress transcripts through decay. Mammalian miRNA-mediated deadenylation is now shown to involve both the Pan2–Pan3 and the Ccr4–Caf1 deadenylases. Such deadenylation can be triggered by tethered Ago or TNRC6 and is followed by decapping of the reporter. MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly by promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear. Combining the approaches of transcriptional pulsing, RNA tethering, overexpression of dominant-negative mutants, and siRNA-mediated gene knockdown, we show that let-7 miRNA-induced silencing complexes (miRISCs), which contain the proteins Argonaute (Ago) and TNRC6 (also known as GW182), trigger very rapid mRNA decay by inducing accelerated biphasic deadenylation mediated by Pan2–Pan3 and Ccr4–Caf1 deadenylase complexes followed by Dcp1–Dcp2 complex–directed decapping in mammalian cells. When tethered to mRNAs, all four human Ago proteins and TNRC6C are each able to recapitulate the two deadenylation steps. Two conserved human Ago2 phenylalanines (Phe470 and Phe505) are critical for recruiting TNRC6 to promote deadenylation. These findings indicate that promotion of biphasic deadenylation to trigger mRNA decay is an intrinsic property of miRISCs.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Education
- Science
- Telecommunications
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$63,100 per month
According to our algorithms, Nature.com's monthly online income from display advertising ranges from $42,042 to $115,616.
Keywords {🔍}
article, google, scholar, cas, mrna, nature, cell, biol, rna, mammalian, deadenylation, decay, shyu, human, access, chen, micrornas, proteins, mol, protein, biology, cells, nat, repression, content, molecular, ago, microrna, cookies, gene, mrnas, translational, regulation, usa, privacy, data, micrornamediated, mirnamediated, silencing, argonaute, open, translation, science, cya, university, function, information, promoting, zheng, mirnas,
Topics {✒️}
nature portfolio permissions reprints privacy policy advertising social media author information authors nature 431 nature 433 nature 455 nature dcp1–dcp2 complex–directed decapping multiple gw-rich regions mirna-mediated gene silencing microrna-mediated gene silencing sirna-mediated gene knockdown ann-bin shyu author correspondence mirna-mediated translational repression microrna-mediated translational repression early-response-gene mrnas multiple argonaute-binding sites mammalian cell-free system springerlink instant access affect pabp-dependent deadenylation deadenylation steps chyi-ying p-body component gw182 permissions ccr4–caf1 deadenylase complexes personal data mirna-mediated decay au-rich elements molecular biology mammalian p-bodies mirna-mediated repression data protection analyzed data microrna-directed cleavage c-terminal half dcp2 decapping complexes mammalian mrna turnover protein synthesis induced human ago2 binds privacy microrna-dependent localization cold spring harbor purine-rich motifs c-terminal domains c-terminal domain rapid mrna decay cold spring harb
Questions {❓}
- Decoding ARE-mediated decay: is microRNA part of the equation?
- How do microRNAs regulate gene expression?
- Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
Schema {🗺️}
WebPage:
mainEntity:
headline:AgoâTNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps
description:miRNAs can repress transcripts through decay. Mammalian miRNA-mediated deadenylation is now shown to involve both the Pan2âPan3 and the Ccr4âCaf1 deadenylases. Such deadenylation can be triggered by tethered Ago or TNRC6 and is followed by decapping of the reporter. MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly by promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear. Combining the approaches of transcriptional pulsing, RNA tethering, overexpression of dominant-negative mutants, and siRNA-mediated gene knockdown, we show that let-7 miRNA-induced silencing complexes (miRISCs), which contain the proteins Argonaute (Ago) and TNRC6 (also known as GW182), trigger very rapid mRNA decay by inducing accelerated biphasic deadenylation mediated by Pan2âPan3 and Ccr4âCaf1 deadenylase complexes followed by Dcp1âDcp2 complexâdirected decapping in mammalian cells. When tethered to mRNAs, all four human Ago proteins and TNRC6C are each able to recapitulate the two deadenylation steps. Two conserved human Ago2 phenylalanines (Phe470 and Phe505) are critical for recruiting TNRC6 to promote deadenylation. These findings indicate that promotion of biphasic deadenylation to trigger mRNA decay is an intrinsic property of miRISCs.
datePublished:2009-10-18T00:00:00Z
dateModified:2009-10-18T00:00:00Z
pageStart:1160
pageEnd:1166
sameAs:https://doi.org/10.1038/nsmb.1709
keywords:
Life Sciences
general
Biochemistry
Protein Structure
Membrane Biology
Biological Microscopy
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig5_HTML.jpg
isPartOf:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:16
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Chyi-Ying A Chen
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Dinghai Zheng
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Zhenfang Xia
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Ann-Bin Shyu
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:AgoâTNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps
description:miRNAs can repress transcripts through decay. Mammalian miRNA-mediated deadenylation is now shown to involve both the Pan2âPan3 and the Ccr4âCaf1 deadenylases. Such deadenylation can be triggered by tethered Ago or TNRC6 and is followed by decapping of the reporter. MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly by promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear. Combining the approaches of transcriptional pulsing, RNA tethering, overexpression of dominant-negative mutants, and siRNA-mediated gene knockdown, we show that let-7 miRNA-induced silencing complexes (miRISCs), which contain the proteins Argonaute (Ago) and TNRC6 (also known as GW182), trigger very rapid mRNA decay by inducing accelerated biphasic deadenylation mediated by Pan2âPan3 and Ccr4âCaf1 deadenylase complexes followed by Dcp1âDcp2 complexâdirected decapping in mammalian cells. When tethered to mRNAs, all four human Ago proteins and TNRC6C are each able to recapitulate the two deadenylation steps. Two conserved human Ago2 phenylalanines (Phe470 and Phe505) are critical for recruiting TNRC6 to promote deadenylation. These findings indicate that promotion of biphasic deadenylation to trigger mRNA decay is an intrinsic property of miRISCs.
datePublished:2009-10-18T00:00:00Z
dateModified:2009-10-18T00:00:00Z
pageStart:1160
pageEnd:1166
sameAs:https://doi.org/10.1038/nsmb.1709
keywords:
Life Sciences
general
Biochemistry
Protein Structure
Membrane Biology
Biological Microscopy
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig5_HTML.jpg
isPartOf:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:16
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Chyi-Ying A Chen
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Dinghai Zheng
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Zhenfang Xia
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Ann-Bin Shyu
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:16
Organization:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Chyi-Ying A Chen
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
name:Dinghai Zheng
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
name:Zhenfang Xia
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
name:Ann-Bin Shyu
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(131)
- Find out how much https://link.springer.com/article/10.1038/nsmb.1709?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle earns monthly
- Find out how much https://doi.org/10.1038%2Fnature02871 earns monthly
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=The%20functions%20of%20animal%20microRNAs&journal=Nature&doi=10.1038%2Fnature02871&volume=431&pages=350-355&publication_year=2004&author=Ambros%2CV each month?
- Learn how profitable https://doi.org/10.1146%2Fannurev.cellbio.23.090506.123406 is on a monthly basis
- How much income does http://scholar.google.com/scholar_lookup?&title=microRNA%20functions&journal=Annu.%20Rev.%20Cell%20Dev.%20Biol.&doi=10.1146%2Fannurev.cellbio.23.090506.123406&volume=23&pages=175-205&publication_year=2007&author=Bushati%2CN&author=Cohen%2CSM have?
- How much does https://doi.org/10.1038%2Fnrg2290 pull in?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Mechanisms%20of%20post-transcriptional%20regulation%20by%20microRNAs%3A%20are%20the%20answers%20in%20sight%3F&journal=Nat.%20Rev.%20Genet.&doi=10.1038%2Fnrg2290&volume=9&pages=102-114&publication_year=2008&author=Filipowicz%2CW&author=Bhattacharyya%2CSN&author=Sonenberg%2CN?
- Discover the revenue of https://doi.org/10.1126%2Fstke.3672007re1
- How much revenue does http://scholar.google.com/scholar_lookup?&title=How%20do%20microRNAs%20regulate%20gene%20expression%3F&journal=Sci.%20STKE&doi=10.1126%2Fstke.3672007re1&volume=2007&publication_year=2007&author=Jackson%2CRJ&author=Standart%2CN generate?
- How much money does https://doi.org/10.1261%2Frna.1072808 generate?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Computational%20analysis%20of%20miRNA-mediated%20repression%20of%20translation%3A%20Implications%20for%20models%20of%20translation%20initiation%20inhibition&journal=RNA&doi=10.1261%2Frna.1072808&volume=14&pages=1480-1491&publication_year=2008&author=Nissan%2CT&author=Parker%2CR?
- Revenue of https://doi.org/10.1016%2Fj.cell.2005.07.031
- How much does http://scholar.google.com/scholar_lookup?&title=Regulation%20by%20let-7%20and%20lin-4%20miRNAs%20results%20in%20target%20mRNA%20degradation&journal=Cell&doi=10.1016%2Fj.cell.2005.07.031&volume=122&pages=553-563&publication_year=2005&author=Bagga%2CS bring in each month?
- Explore the financials of https://doi.org/10.1038%2Fnature03315
- What's http://scholar.google.com/scholar_lookup?&title=Microarray%20analysis%20shows%20that%20some%20microRNAs%20downregulate%20large%20numbers%20of%20target%20mRNAs&journal=Nature&doi=10.1038%2Fnature03315&volume=433&pages=769-773&publication_year=2005&author=Lim%2CLP's gross income?
- Get to know what's the income of https://doi.org/10.1038%2Fnature07242
- How much does http://scholar.google.com/scholar_lookup?&title=The%20impact%20of%20microRNAs%20on%20protein%20output&journal=Nature&doi=10.1038%2Fnature07242&volume=455&pages=64-71&publication_year=2008&author=Baek%2CD earn?
- How much does https://doi.org/10.1038%2Fnature07228 generate monthly?
- http://scholar.google.com/scholar_lookup?&title=Widespread%20changes%20in%20protein%20synthesis%20induced%20by%20microRNAs&journal=Nature&doi=10.1038%2Fnature07228&volume=455&pages=58-63&publication_year=2008&author=Selbach%2CM's revenue stream
- How much does https://doi.org/10.1101%2Fgad.1424106 generate monthly?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=mRNA%20degradation%20by%20miRNAs%20and%20GW182%20requires%20both%20CCR4%3ANOT%20deadenylase%20and%20DCP1%3ADCP2%20decapping%20complexes&journal=Genes%20Dev.&doi=10.1101%2Fgad.1424106&volume=20&pages=1885-1898&publication_year=2006&author=Behm-Ansmant%2CI?
- How much profit does https://doi.org/10.1126%2Fscience.1122689 generate?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Zebrafish%20MiR-430%20promotes%20deadenylation%20and%20clearance%20of%20maternal%20mRNAs&journal=Science&doi=10.1126%2Fscience.1122689&volume=312&pages=75-79&publication_year=2006&author=Giraldez%2CAJ each month?
- Discover the revenue of https://doi.org/10.1073%2Fpnas.0510928103
- Earnings of http://scholar.google.com/scholar_lookup?&title=MicroRNAs%20direct%20rapid%20deadenylation%20of%20mRNA&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0510928103&volume=103&pages=4034-4039&publication_year=2006&author=Wu%2CL&author=Fan%2CJ&author=Belasco%2CJG
- How much does https://doi.org/10.1126%2Fscience.1073827 earn?
- How much profit does http://scholar.google.com/scholar_lookup?&title=A%20microRNA%20in%20a%20multiple-turnover%20RNAi%20enzyme%20complex&journal=Science&doi=10.1126%2Fscience.1073827&volume=297&pages=2056-2060&publication_year=2002&author=Hutv%C3%A1gner%2CG&author=Zamore%2CPD generate?
- How much does https://doi.org/10.1126%2Fscience.1097434 earn?
- How much does http://scholar.google.com/scholar_lookup?&title=MicroRNA-directed%20cleavage%20of%20HOXB8%20mRNA&journal=Science&doi=10.1126%2Fscience.1097434&volume=304&pages=594-596&publication_year=2004&author=Yekta%2CS&author=Shih%2CIH&author=Bartel%2CDP pull in monthly?
- What's the monthly income of https://doi.org/10.1093%2Fnar%2Fgkm1080?
- http://scholar.google.com/scholar_lookup?&title=Epstein-Barr%20virus-encoded%20microRNA%20miR-BART2%20down-regulates%20the%20viral%20DNA%20polymerase%20BALF5&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkm1080&volume=36&pages=666-675&publication_year=2008&author=Barth%2CS's financial summary
- How much does https://doi.org/10.1101%2Fsqb.2006.71.013 pull in monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=MicroRNAs%20silence%20gene%20expression%20by%20repressing%20protein%20expression%20and%2For%20by%20promoting%20mRNA%20decay&journal=Cold%20Spring%20Harb.%20Symp.%20Quant.%20Biol.&doi=10.1101%2Fsqb.2006.71.013&volume=71&pages=523-530&publication_year=2006&author=Behm-Ansmant%2CI&author=Rehwinkel%2CJ&author=Izaurralde%2CE make?
- How much revenue does https://doi.org/10.1038%2Fnsmb.1405 bring in?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=GW182%20interaction%20with%20Argonaute%20is%20essential%20for%20miRNA-mediated%20translational%20repression%20and%20mRNA%20decay&journal=Nat.%20Struct.%20Mol.%20Biol.&doi=10.1038%2Fnsmb.1405&volume=15&pages=346-353&publication_year=2008&author=Eulalio%2CA&author=Huntzinger%2CE&author=Izaurralde%2CE
- How much profit is https://doi.org/10.1016%2Fj.cell.2007.12.024 making per month?
- How much does http://scholar.google.com/scholar_lookup?&title=Getting%20to%20the%20root%20of%20miRNA-mediated%20gene%20silencing&journal=Cell&doi=10.1016%2Fj.cell.2007.12.024&volume=132&pages=9-14&publication_year=2008&author=Eulalio%2CA&author=Huntzinger%2CE&author=Izaurralde%2CE generate monthly?
- What is the monthly revenue of https://doi.org/10.1101%2Fgad.1566707?
- http://scholar.google.com/scholar_lookup?&title=Let-7%20microRNA-mediated%20mRNA%20deadenylation%20and%20translational%20repression%20in%20a%20mammalian%20cell-free%20system&journal=Genes%20Dev.&doi=10.1101%2Fgad.1566707&volume=21&pages=1857-1862&publication_year=2007&author=Wakiyama%2CM&author=Takimoto%2CK&author=Ohara%2CO&author=Yokoyama%2CS's financial summary
- https://doi.org/10.1016%2Fj.tcb.2007.06.003 income
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=GW182%20family%20proteins%20are%20crucial%20for%20microRNA-mediated%20gene%20silencing&journal=Trends%20Cell%20Biol.&doi=10.1016%2Fj.tcb.2007.06.003&volume=17&pages=411-416&publication_year=2007&author=Ding%2CL&author=Han%2CM
- What's https://doi.org/10.1038%2Fncb1334's gross income?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Disruption%20of%20GW%20bodies%20impairs%20mammalian%20RNA%20interference&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb1334&volume=8&pages=1267-1274&publication_year=2005&author=Jakymiw%2CA?
- Learn about the earnings of https://doi.org/10.1038%2Fncb1333
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=A%20role%20for%20the%20P-body%20component%20GW182%20in%20microRNA%20function&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb1333&volume=7&pages=1261-1266&publication_year=2005&author=Liu%2CJ?
- How much income is https://doi.org/10.1016%2Fj.cub.2005.10.048 earning monthly?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Identificiation%20of%20novel%20argonaute-associated%20proteins&journal=Curr.%20Biol.&doi=10.1016%2Fj.cub.2005.10.048&volume=15&pages=2149-2155&publication_year=2005&author=Meister%2CG?
- How much profit is https://doi.org/10.1371%2Fjournal.pbio.0040210 making per month?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Translation%20repression%20in%20human%20cells%20by%20microRNA-induced%20gene%20silencing%20requires%20RCK%2Fp54&journal=PLoS%20Biol.&doi=10.1371%2Fjournal.pbio.0040210&volume=4&publication_year=2006&author=Chu%2CC-Y&author=Rana%2CTM have monthly?
- How much does https://doi.org/10.1261%2Frna.1351608 net monthly?
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Molecular%20characterization%20of%20human%20Argonaute-containing%20ribonucleoprotein%20complexes%20and%20their%20bound%20target%20mRNAs&journal=RNA&doi=10.1261%2Frna.1351608&volume=14&pages=2580-2596&publication_year=2008&author=Landthaler%2CM?
- How much revenue does https://doi.org/10.1261%2Frna.1606309 generate?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=The%20C-terminal%20domains%20of%20human%20TNRC6A%2C%20TNRC6B%2C%20and%20TNRC6C%20silence%20bound%20transcripts%20independently%20of%20Argonaute%20proteins&journal=RNA&doi=10.1261%2Frna.1606309&volume=15&pages=1059-1066&publication_year=2009&author=Lazzaretti%2CD&author=Tournier%2CI&author=Izaurralde%2CE
- How much does https://doi.org/10.1261%2Frna.1229409 pull in?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=The%20C-terminal%20half%20of%20human%20Ago2%20binds%20to%20multiple%20GW-rich%20regions%20of%20GW182%20and%20requires%20GW182%20to%20mediate%20silencing&journal=RNA&doi=10.1261%2Frna.1229409&volume=15&pages=804-813&publication_year=2009&author=Lian%2CSL have monthly?
- How much does https://doi.org/10.1261%2Frna.1363109 earn?
- How much profit is http://scholar.google.com/scholar_lookup?&title=Mammalian%20GW182%20contains%20multiple%20Argonaute-binding%20sites%20and%20functions%20in%20microRNA-mediated%20translational%20repression&journal=RNA&doi=10.1261%2Frna.1363109&volume=15&pages=1078-1089&publication_year=2009&author=Takimoto%2CK&author=Wakiyama%2CM&author=Yokoyama%2CS making per month?
- Monthly income for https://doi.org/10.1261%2Frna.1448009
- How much does http://scholar.google.com/scholar_lookup?&title=Importance%20of%20the%20C-terminal%20domain%20of%20the%20human%20GW182%20protein%20TNRC6C%20for%20translational%20repression&journal=RNA&doi=10.1261%2Frna.1448009&volume=15&pages=781-793&publication_year=2009&author=Zipprich%2CJT&author=Bhattacharyya%2CS&author=Mathys%2CH&author=Filipowicz%2CW bring in each month?
- What's the financial intake of https://doi.org/10.1038%2Fncb1274?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=MicroRNA-dependent%20localization%20of%20targeted%20mRNAs%20to%20mammalian%20P-bodies&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb1274&volume=7&pages=719-723&publication_year=2005&author=Liu%2CJ&author=Valencia-Sanchez%2CMA&author=Hannon%2CGJ&author=Parker%2CR produce monthly?
- How much does https://doi.org/10.1016%2Fj.cell.2007.05.016 make?
- How much profit does http://scholar.google.com/scholar_lookup?&title=An%20mRNA%20m7G%20cap%20binding-like%20motif%20within%20human%20Ago2%20represses%20translation&journal=Cell&doi=10.1016%2Fj.cell.2007.05.016&volume=129&pages=1141-1151&publication_year=2007&author=Kiriakidou%2CM generate?
- Earnings of https://doi.org/10.1016%2FS0076-6879%2808%2902617-7
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=Messenger%20RNA%20half-life%20measuremments%20in%20mammalian%20cells&journal=Methods%20Enzymol.&doi=10.1016%2FS0076-6879%2808%2902617-7&volume=448&pages=335-357&publication_year=2008&author=Chen%2CAC-Y&author=Ezzeddine%2CN&author=Shyu%2CAB
- What's the financial outcome of https://doi.org/10.1038%2Fnsmb1016?
- How much money does http://scholar.google.com/scholar_lookup?&title=Concerted%20action%20of%20poly%28A%29%20nucleases%20and%20decapping%20enzyme%20in%20mammalian%20mRNA%20turnover&journal=Nat.%20Struct.%20Mol.%20Biol.&doi=10.1038%2Fnsmb1016&volume=12&pages=1054-1063&publication_year=2005&author=Yamashita%2CA make?
- Financial intake of https://doi.org/10.1083%2Fjcb.200801196
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Deadenylation%20is%20prerequisite%20for%20P-body%20formation%20and%20mRNA%20decay%20in%20mammalian%20cells&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.200801196&volume=182&pages=89-101&publication_year=2008&author=Zheng%2CD bring in?
- What's the monthly income of https://doi.org/10.1126%2Fscience.1115079?
- Get to know http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20translational%20initiation%20by%20let-7%20micro-RNA%20in%20human%20cells&journal=Science&doi=10.1126%2Fscience.1115079&volume=309&pages=1573-1576&publication_year=2005&author=Pillai%2CRS's earnings
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14770003 net monthly?
- How much money does http://scholar.google.com/scholar_lookup?&title=Using%20the%20lambda%20N%20peptide%20to%20tether%20proteins%20to%20RNAs&journal=Methods%20Mol.%20Biol.&volume=257&pages=135-154&publication_year=2004&author=Baron-Benhamou%2CJ&author=Gehring%2CNH&author=Kulozik%2CAE&author=Hentze%2CMW generate?
- How much cash flow does https://doi.org/10.1261%2Frna.7131604 have monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Tethering%20of%20human%20Ago%20proteins%20to%20mRNA%20mimics%20the%20miRNA-mediated%20repression%20of%20protein%20synthesis&journal=RNA&doi=10.1261%2Frna.7131604&volume=10&pages=1518-1525&publication_year=2004&author=Pillai%2CRS&author=Artus%2CCG&author=Filipowicz%2CW pull in monthly?
- What's the total monthly financial gain of https://doi.org/10.1126%2Fscience.1102513?
- Get to know http://scholar.google.com/scholar_lookup?&title=Argonaute2%20Is%20the%20Catalytic%20Engine%20of%20Mammalian%20RNAi&journal=Science&doi=10.1126%2Fscience.1102513&volume=305&pages=1437-1441&publication_year=2004&author=Liu%2CJ's earnings
- What are the total earnings of https://doi.org/10.1093%2Fnar%2F26.2.558?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=A%20broader%20role%20for%20AU-rich%20element-mediated%20mRNA%20turnover%20revealed%20by%20a%20new%20transcriptional%20pulse%20strategy&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2F26.2.558&volume=26&pages=558-565&publication_year=1998&author=Xu%2CN&author=Loflin%2CP&author=Chen%2CC-YA&author=Shyu%2CA-B
- How much money does https://doi.org/10.1128%2FMCB.23.14.4805-4813.2003 make?
- Revenue of http://scholar.google.com/scholar_lookup?&title=Rapid%20deadenylation%20triggered%20by%20a%20nonsense%20codon%20precedes%20decay%20of%20the%20RNA%20body%20in%20a%20mammalian%20cytoplasmic%20nonsense-mediated%20decay%20pathway&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.23.14.4805-4813.2003&volume=23&pages=4805-4813&publication_year=2003&author=Chen%2CC-YA&author=Shyu%2CA-B
- How profitable is https://doi.org/10.1128%2FMCB.14.12.8471?
- How much money does http://scholar.google.com/scholar_lookup?&title=Selective%20degradation%20of%20early-response-gene%20mRNAs%3A%20functional%20analyses%20of%20sequence%20features%20of%20the%20AU-rich%20elements&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.14.12.8471&volume=14&pages=8471-8482&publication_year=1994&author=Chen%2CC-YA&author=Shyu%2CA-B make?
- Discover the revenue of https://doi.org/10.1016%2FS0968-0004%2800%2989102-1
- How much does http://scholar.google.com/scholar_lookup?&title=AU-rich%20elements%3A%20characterization%20and%20importance%20in%20mRNA%20degradation&journal=Trends%20Biochem.%20Sci.&doi=10.1016%2FS0968-0004%2800%2989102-1&volume=20&pages=465-470&publication_year=1995&author=Chen%2CC-YA&author=Shyu%2CA-B pull in monthly?
- How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7565413 generate?
- What is the monthly revenue of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC239368?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=mRNA%20stability%20in%20mammalian%20cells&journal=Microbiol.%20Rev.&volume=59&pages=423-450&publication_year=1995&author=Ross%2CJ
- How much does https://doi.org/10.1016%2FS0092-8674%2800%2900102-1 pull in monthly?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=A%20mechanism%20for%20translationally%20coupled%20mRNA%20turnover%3A%20interaction%20between%20the%20poly%28A%29%20tail%20and%20a%20c-fos%20RNA%20coding%20determinant%20via%20a%20protein%20complex&journal=Cell&doi=10.1016%2FS0092-8674%2800%2900102-1&volume=103&pages=29-40&publication_year=2000&author=Grosset%2CC have monthly?
- Earnings of https://doi.org/10.1016%2Fj.cell.2009.02.006
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Evolution%20and%20functions%20of%20long%20noncoding%20RNAs&journal=Cell&doi=10.1016%2Fj.cell.2009.02.006&volume=136&pages=629-641&publication_year=2009&author=Ponting%2CCP&author=Oliver%2CPL&author=Reik%2CW
- How much money does https://doi.org/10.1038%2Fsj.emboj.7601977 make?
- http://scholar.google.com/scholar_lookup?&title=Messenger%20RNA%20regulation%3A%20to%20translate%20or%20to%20degrad&journal=EMBO%20J.&doi=10.1038%2Fsj.emboj.7601977&volume=27&pages=471-481&publication_year=2008&author=Shyu%2CAB&author=Wilkinson%2CMF&author=van%20Hoof%2CA's financial summary
- What's the income generated by https://doi.org/10.1261%2Frna.1399509 each month?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Deadenylation%20is%20a%20widespread%20effect%20of%20miRNA%20regulation&journal=RNA&doi=10.1261%2Frna.1399509&volume=15&pages=21-32&publication_year=2009&author=Eulalio%2CA generate?
- What's the income of https://doi.org/10.1128%2FMCB.00380-09?
- How much money does http://scholar.google.com/scholar_lookup?&title=Functional%20dissection%20of%20the%20human%20TNRC6%20%28GW182-related%29%20family%20of%20proteins&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.00380-09&volume=29&pages=4144-4155&publication_year=2009&author=Baillat%2CD&author=Shiekhattar%2CR generate?
- What are the total earnings of https://doi.org/10.1016%2Fj.molcel.2007.09.014?
- How much does http://scholar.google.com/scholar_lookup?&title=Systematic%20identification%20of%20C.%20elegans%20miRISC%20proteins%2C%20miRNAs%2C%20and%20mRNA%20targets%20by%20their%20interactions%20with%20GW182%20proteins%20AIN-1%20and%20AIN-2&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2007.09.014&volume=28&pages=598-613&publication_year=2007&author=Zhang%2CL gross monthly?
- Learn about the earnings of https://doi.org/10.1016%2Fj.molcel.2009.08.004
- How much money does http://scholar.google.com/scholar_lookup?&title=Mammalian%20miRNA%20RISC%20recruits%20CAF1%20and%20PABP%20to%20affect%20PABP-dependent%20deadenylation&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2009.08.004&volume=35&pages=868-880&publication_year=2009&author=Fabian%2CMR generate?
- How much revenue does https://doi.org/10.1083%2Fjcb.200712054 generate?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Decoding%20ARE-mediated%20decay%3A%20is%20microRNA%20part%20of%20the%20equation%3F&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.200712054&volume=181&pages=189-194&publication_year=2008&author=von%20Roretz%2CC&author=Gallouzi%2CI-E
- What's the monthly money flow for https://doi.org/10.1073%2Fpnas.192445599?
- What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=The%20hDcp2%20protein%20is%20a%20mammalian%20mRNA%20decapping%20enzyme&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.192445599&volume=99&pages=12663-12668&publication_year=2002&author=Wang%2CZ&author=Jiao%2CX&author=Carr-Schmid%2CA&author=Kiledjian%2CM?
- https://doi.org/10.1101%2Fgad.5.2.221's total income per month
- How much does http://scholar.google.com/scholar_lookup?&title=Two%20distinct%20destabilizing%20elements%20in%20the%20c-fos%20message%20trigger%20deadenylation%20as%20a%20first%20step%20in%20rapid%20mRNA%20decay&journal=Genes%20Dev.&doi=10.1101%2Fgad.5.2.221&volume=5&pages=221-231&publication_year=1991&author=Shyu%2CA-B&author=Belasco%2CJG&author=Greenberg%2CMG net monthly?
- How much money does https://doi.org/10.1093%2Femboj%2F17.12.3461 generate?
- Income figures for http://scholar.google.com/scholar_lookup?&title=RNA%20stabilization%20by%20the%20AU-rich%20element%20binding%20protein%2C%20HuR%2C%20an%20ELAV%20protein&journal=EMBO%20J.&doi=10.1093%2Femboj%2F17.12.3461&volume=17&pages=3461-3470&publication_year=1998&author=Peng%2CS-S&author=Chen%2CC-YA&author=Xu%2CN&author=Shyu%2CA-B
- What's the financial intake of https://citation-needed.springer.com/v2/references/10.1038/nsmb.1709?format=refman&flavour=references?
- Get to know https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chyi-Ying%20A%20Chen's earnings
- What are the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chyi-Ying%20A%20Chen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dinghai%20Zheng make?
- How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Dinghai%20Zheng%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Zhenfang%20Xia rake in every month?
- Monthly income for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Zhenfang%20Xia%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ann-Bin%20Shyu
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ann-Bin%20Shyu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in?
- How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_BFnsmb1709_MOESM14_ESM.pdf make?
- How much money does https://s100.copyright.com/AppDispatchServlet?title=Ago%E2%80%93TNRC6%20triggers%20microRNA-mediated%20decay%20by%20promoting%20two%20deadenylation%20steps&author=Chyi-Ying%20A%20Chen%20et%20al&contentID=10.1038%2Fnsmb.1709©right=Springer%20Nature%20America%2C%20Inc.&publication=1545-9993&publicationDate=2009-10-18&publisherName=SpringerNature&orderBeanReset=true make?
- What is the earnings of https://citation-needed.springer.com/v2/references/10.1038/nsmb.1709?format=refman&flavour=citation?
- How much does https://doi.org/10.1186/s13059-023-02871-7 make?
- How much cash flow does https://doi.org/10.1186/s13019-021-01613-9 have monthly?
- https://doi.org/10.1038/s41598-021-86665-6's revenue stream
- How much does https://doi.org/10.1186/s13059-019-1857-2 bring in each month?
- What's the revenue for https://doi.org/10.1038/s41580-018-0045-7?
- Revenue of https://www.protocols.io/
- How much profit does https://www.natureindex.com/ make?
- Find out how much http://www.naturechina.com earns monthly
- Income figures for https://www.natureasia.com/ja-jp
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref