NATURE . COM {
}
Title:
Ago–TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps | Nature Structural & Molecular Biology
Description:
miRNAs can repress transcripts through decay. Mammalian miRNA-mediated deadenylation is now shown to involve both the Pan2–Pan3 and the Ccr4–Caf1 deadenylases. Such deadenylation can be triggered by tethered Ago or TNRC6 and is followed by decapping of the reporter. MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly by promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear. Combining the approaches of transcriptional pulsing, RNA tethering, overexpression of dominant-negative mutants, and siRNA-mediated gene knockdown, we show that let-7 miRNA-induced silencing complexes (miRISCs), which contain the proteins Argonaute (Ago) and TNRC6 (also known as GW182), trigger very rapid mRNA decay by inducing accelerated biphasic deadenylation mediated by Pan2–Pan3 and Ccr4–Caf1 deadenylase complexes followed by Dcp1–Dcp2 complex–directed decapping in mammalian cells. When tethered to mRNAs, all four human Ago proteins and TNRC6C are each able to recapitulate the two deadenylation steps. Two conserved human Ago2 phenylalanines (Phe470 and Phe505) are critical for recruiting TNRC6 to promote deadenylation. These findings indicate that promotion of biphasic deadenylation to trigger mRNA decay is an intrinsic property of miRISCs.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Education
- Science
- Telecommunications
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$63,100 per month
Our estimates place Nature.com's monthly online earnings from display ads at $42,042 to $115,616.
Keywords {🔍}
article, google, scholar, cas, mrna, nature, cell, biol, rna, mammalian, deadenylation, decay, shyu, human, access, chen, micrornas, proteins, mol, protein, biology, cells, nat, repression, content, molecular, ago, microrna, cookies, gene, mrnas, translational, regulation, usa, privacy, data, micrornamediated, mirnamediated, silencing, argonaute, open, translation, science, cya, university, function, information, promoting, zheng, mirnas,
Topics {✒️}
nature portfolio permissions reprints privacy policy advertising social media author information authors nature 431 nature 433 nature 455 nature dcp1–dcp2 complex–directed decapping multiple gw-rich regions mirna-mediated gene silencing microrna-mediated gene silencing sirna-mediated gene knockdown ann-bin shyu author correspondence mirna-mediated translational repression microrna-mediated translational repression early-response-gene mrnas multiple argonaute-binding sites mammalian cell-free system springerlink instant access affect pabp-dependent deadenylation deadenylation steps chyi-ying p-body component gw182 permissions ccr4–caf1 deadenylase complexes personal data mirna-mediated decay au-rich elements molecular biology mammalian p-bodies mirna-mediated repression data protection analyzed data microrna-directed cleavage c-terminal half dcp2 decapping complexes mammalian mrna turnover protein synthesis induced human ago2 binds privacy microrna-dependent localization cold spring harbor purine-rich motifs c-terminal domains c-terminal domain rapid mrna decay cold spring harb
Questions {❓}
- Decoding ARE-mediated decay: is microRNA part of the equation?
- How do microRNAs regulate gene expression?
- Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
Schema {🗺️}
WebPage:
mainEntity:
headline:AgoâTNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps
description:miRNAs can repress transcripts through decay. Mammalian miRNA-mediated deadenylation is now shown to involve both the Pan2âPan3 and the Ccr4âCaf1 deadenylases. Such deadenylation can be triggered by tethered Ago or TNRC6 and is followed by decapping of the reporter. MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly by promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear. Combining the approaches of transcriptional pulsing, RNA tethering, overexpression of dominant-negative mutants, and siRNA-mediated gene knockdown, we show that let-7 miRNA-induced silencing complexes (miRISCs), which contain the proteins Argonaute (Ago) and TNRC6 (also known as GW182), trigger very rapid mRNA decay by inducing accelerated biphasic deadenylation mediated by Pan2âPan3 and Ccr4âCaf1 deadenylase complexes followed by Dcp1âDcp2 complexâdirected decapping in mammalian cells. When tethered to mRNAs, all four human Ago proteins and TNRC6C are each able to recapitulate the two deadenylation steps. Two conserved human Ago2 phenylalanines (Phe470 and Phe505) are critical for recruiting TNRC6 to promote deadenylation. These findings indicate that promotion of biphasic deadenylation to trigger mRNA decay is an intrinsic property of miRISCs.
datePublished:2009-10-18T00:00:00Z
dateModified:2009-10-18T00:00:00Z
pageStart:1160
pageEnd:1166
sameAs:https://doi.org/10.1038/nsmb.1709
keywords:
Life Sciences
general
Biochemistry
Protein Structure
Membrane Biology
Biological Microscopy
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig5_HTML.jpg
isPartOf:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:16
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Chyi-Ying A Chen
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Dinghai Zheng
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Zhenfang Xia
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Ann-Bin Shyu
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:AgoâTNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps
description:miRNAs can repress transcripts through decay. Mammalian miRNA-mediated deadenylation is now shown to involve both the Pan2âPan3 and the Ccr4âCaf1 deadenylases. Such deadenylation can be triggered by tethered Ago or TNRC6 and is followed by decapping of the reporter. MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly by promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear. Combining the approaches of transcriptional pulsing, RNA tethering, overexpression of dominant-negative mutants, and siRNA-mediated gene knockdown, we show that let-7 miRNA-induced silencing complexes (miRISCs), which contain the proteins Argonaute (Ago) and TNRC6 (also known as GW182), trigger very rapid mRNA decay by inducing accelerated biphasic deadenylation mediated by Pan2âPan3 and Ccr4âCaf1 deadenylase complexes followed by Dcp1âDcp2 complexâdirected decapping in mammalian cells. When tethered to mRNAs, all four human Ago proteins and TNRC6C are each able to recapitulate the two deadenylation steps. Two conserved human Ago2 phenylalanines (Phe470 and Phe505) are critical for recruiting TNRC6 to promote deadenylation. These findings indicate that promotion of biphasic deadenylation to trigger mRNA decay is an intrinsic property of miRISCs.
datePublished:2009-10-18T00:00:00Z
dateModified:2009-10-18T00:00:00Z
pageStart:1160
pageEnd:1166
sameAs:https://doi.org/10.1038/nsmb.1709
keywords:
Life Sciences
general
Biochemistry
Protein Structure
Membrane Biology
Biological Microscopy
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig5_HTML.jpg
isPartOf:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:16
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Chyi-Ying A Chen
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Dinghai Zheng
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Zhenfang Xia
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Ann-Bin Shyu
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:16
Organization:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Chyi-Ying A Chen
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
name:Dinghai Zheng
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
name:Zhenfang Xia
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
name:Ann-Bin Shyu
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(131)
- Financial intake of https://link.springer.com/article/10.1038/nsmb.1709?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle
- What's the income of https://doi.org/10.1038%2Fnature02871?
- Profit of http://scholar.google.com/scholar_lookup?&title=The%20functions%20of%20animal%20microRNAs&journal=Nature&doi=10.1038%2Fnature02871&volume=431&pages=350-355&publication_year=2004&author=Ambros%2CV
- How much profit is https://doi.org/10.1146%2Fannurev.cellbio.23.090506.123406 making per month?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=microRNA%20functions&journal=Annu.%20Rev.%20Cell%20Dev.%20Biol.&doi=10.1146%2Fannurev.cellbio.23.090506.123406&volume=23&pages=175-205&publication_year=2007&author=Bushati%2CN&author=Cohen%2CSM have monthly?
- How much does https://doi.org/10.1038%2Fnrg2290 make?
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Mechanisms%20of%20post-transcriptional%20regulation%20by%20microRNAs%3A%20are%20the%20answers%20in%20sight%3F&journal=Nat.%20Rev.%20Genet.&doi=10.1038%2Fnrg2290&volume=9&pages=102-114&publication_year=2008&author=Filipowicz%2CW&author=Bhattacharyya%2CSN&author=Sonenberg%2CN?
- How much money does https://doi.org/10.1126%2Fstke.3672007re1 make?
- See how much http://scholar.google.com/scholar_lookup?&title=How%20do%20microRNAs%20regulate%20gene%20expression%3F&journal=Sci.%20STKE&doi=10.1126%2Fstke.3672007re1&volume=2007&publication_year=2007&author=Jackson%2CRJ&author=Standart%2CN makes per month
- How much does https://doi.org/10.1261%2Frna.1072808 bring in each month?
- Find out how much http://scholar.google.com/scholar_lookup?&title=Computational%20analysis%20of%20miRNA-mediated%20repression%20of%20translation%3A%20Implications%20for%20models%20of%20translation%20initiation%20inhibition&journal=RNA&doi=10.1261%2Frna.1072808&volume=14&pages=1480-1491&publication_year=2008&author=Nissan%2CT&author=Parker%2CR earns monthly
- How much profit is https://doi.org/10.1016%2Fj.cell.2005.07.031 making per month?
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Regulation%20by%20let-7%20and%20lin-4%20miRNAs%20results%20in%20target%20mRNA%20degradation&journal=Cell&doi=10.1016%2Fj.cell.2005.07.031&volume=122&pages=553-563&publication_year=2005&author=Bagga%2CS
- How much revenue does https://doi.org/10.1038%2Fnature03315 produce monthly?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Microarray%20analysis%20shows%20that%20some%20microRNAs%20downregulate%20large%20numbers%20of%20target%20mRNAs&journal=Nature&doi=10.1038%2Fnature03315&volume=433&pages=769-773&publication_year=2005&author=Lim%2CLP produce monthly?
- Profit of https://doi.org/10.1038%2Fnature07242
- How much profit does http://scholar.google.com/scholar_lookup?&title=The%20impact%20of%20microRNAs%20on%20protein%20output&journal=Nature&doi=10.1038%2Fnature07242&volume=455&pages=64-71&publication_year=2008&author=Baek%2CD generate?
- Learn how profitable https://doi.org/10.1038%2Fnature07228 is on a monthly basis
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=Widespread%20changes%20in%20protein%20synthesis%20induced%20by%20microRNAs&journal=Nature&doi=10.1038%2Fnature07228&volume=455&pages=58-63&publication_year=2008&author=Selbach%2CM
- Discover the revenue of https://doi.org/10.1101%2Fgad.1424106
- What's http://scholar.google.com/scholar_lookup?&title=mRNA%20degradation%20by%20miRNAs%20and%20GW182%20requires%20both%20CCR4%3ANOT%20deadenylase%20and%20DCP1%3ADCP2%20decapping%20complexes&journal=Genes%20Dev.&doi=10.1101%2Fgad.1424106&volume=20&pages=1885-1898&publication_year=2006&author=Behm-Ansmant%2CI's gross income?
- Learn how profitable https://doi.org/10.1126%2Fscience.1122689 is on a monthly basis
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Zebrafish%20MiR-430%20promotes%20deadenylation%20and%20clearance%20of%20maternal%20mRNAs&journal=Science&doi=10.1126%2Fscience.1122689&volume=312&pages=75-79&publication_year=2006&author=Giraldez%2CAJ?
- Check the income stats for https://doi.org/10.1073%2Fpnas.0510928103
- How much does http://scholar.google.com/scholar_lookup?&title=MicroRNAs%20direct%20rapid%20deadenylation%20of%20mRNA&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0510928103&volume=103&pages=4034-4039&publication_year=2006&author=Wu%2CL&author=Fan%2CJ&author=Belasco%2CJG generate monthly?
- How much money does https://doi.org/10.1126%2Fscience.1073827 generate?
- What's http://scholar.google.com/scholar_lookup?&title=A%20microRNA%20in%20a%20multiple-turnover%20RNAi%20enzyme%20complex&journal=Science&doi=10.1126%2Fscience.1073827&volume=297&pages=2056-2060&publication_year=2002&author=Hutv%C3%A1gner%2CG&author=Zamore%2CPD's gross income?
- What's the income generated by https://doi.org/10.1126%2Fscience.1097434 each month?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=MicroRNA-directed%20cleavage%20of%20HOXB8%20mRNA&journal=Science&doi=10.1126%2Fscience.1097434&volume=304&pages=594-596&publication_year=2004&author=Yekta%2CS&author=Shih%2CIH&author=Bartel%2CDP produce monthly?
- Check the income stats for https://doi.org/10.1093%2Fnar%2Fgkm1080
- How much does http://scholar.google.com/scholar_lookup?&title=Epstein-Barr%20virus-encoded%20microRNA%20miR-BART2%20down-regulates%20the%20viral%20DNA%20polymerase%20BALF5&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkm1080&volume=36&pages=666-675&publication_year=2008&author=Barth%2CS pull in?
- Explore the financials of https://doi.org/10.1101%2Fsqb.2006.71.013
- How much profit does http://scholar.google.com/scholar_lookup?&title=MicroRNAs%20silence%20gene%20expression%20by%20repressing%20protein%20expression%20and%2For%20by%20promoting%20mRNA%20decay&journal=Cold%20Spring%20Harb.%20Symp.%20Quant.%20Biol.&doi=10.1101%2Fsqb.2006.71.013&volume=71&pages=523-530&publication_year=2006&author=Behm-Ansmant%2CI&author=Rehwinkel%2CJ&author=Izaurralde%2CE make?
- Monthly income for https://doi.org/10.1038%2Fnsmb.1405
- Get to know http://scholar.google.com/scholar_lookup?&title=GW182%20interaction%20with%20Argonaute%20is%20essential%20for%20miRNA-mediated%20translational%20repression%20and%20mRNA%20decay&journal=Nat.%20Struct.%20Mol.%20Biol.&doi=10.1038%2Fnsmb.1405&volume=15&pages=346-353&publication_year=2008&author=Eulalio%2CA&author=Huntzinger%2CE&author=Izaurralde%2CE's earnings
- How much money does https://doi.org/10.1016%2Fj.cell.2007.12.024 make?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Getting%20to%20the%20root%20of%20miRNA-mediated%20gene%20silencing&journal=Cell&doi=10.1016%2Fj.cell.2007.12.024&volume=132&pages=9-14&publication_year=2008&author=Eulalio%2CA&author=Huntzinger%2CE&author=Izaurralde%2CE produce monthly?
- Revenue of https://doi.org/10.1101%2Fgad.1566707
- How much does http://scholar.google.com/scholar_lookup?&title=Let-7%20microRNA-mediated%20mRNA%20deadenylation%20and%20translational%20repression%20in%20a%20mammalian%20cell-free%20system&journal=Genes%20Dev.&doi=10.1101%2Fgad.1566707&volume=21&pages=1857-1862&publication_year=2007&author=Wakiyama%2CM&author=Takimoto%2CK&author=Ohara%2CO&author=Yokoyama%2CS pull in monthly?
- Financial intake of https://doi.org/10.1016%2Fj.tcb.2007.06.003
- Income figures for http://scholar.google.com/scholar_lookup?&title=GW182%20family%20proteins%20are%20crucial%20for%20microRNA-mediated%20gene%20silencing&journal=Trends%20Cell%20Biol.&doi=10.1016%2Fj.tcb.2007.06.003&volume=17&pages=411-416&publication_year=2007&author=Ding%2CL&author=Han%2CM
- https://doi.org/10.1038%2Fncb1334 income
- How much profit is http://scholar.google.com/scholar_lookup?&title=Disruption%20of%20GW%20bodies%20impairs%20mammalian%20RNA%20interference&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb1334&volume=8&pages=1267-1274&publication_year=2005&author=Jakymiw%2CA making per month?
- What's the income of https://doi.org/10.1038%2Fncb1333?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=A%20role%20for%20the%20P-body%20component%20GW182%20in%20microRNA%20function&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb1333&volume=7&pages=1261-1266&publication_year=2005&author=Liu%2CJ?
- What's the monthly money flow for https://doi.org/10.1016%2Fj.cub.2005.10.048?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Identificiation%20of%20novel%20argonaute-associated%20proteins&journal=Curr.%20Biol.&doi=10.1016%2Fj.cub.2005.10.048&volume=15&pages=2149-2155&publication_year=2005&author=Meister%2CG
- Explore the financials of https://doi.org/10.1371%2Fjournal.pbio.0040210
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Translation%20repression%20in%20human%20cells%20by%20microRNA-induced%20gene%20silencing%20requires%20RCK%2Fp54&journal=PLoS%20Biol.&doi=10.1371%2Fjournal.pbio.0040210&volume=4&publication_year=2006&author=Chu%2CC-Y&author=Rana%2CTM bring in?
- How much profit is https://doi.org/10.1261%2Frna.1351608 making per month?
- How much money does http://scholar.google.com/scholar_lookup?&title=Molecular%20characterization%20of%20human%20Argonaute-containing%20ribonucleoprotein%20complexes%20and%20their%20bound%20target%20mRNAs&journal=RNA&doi=10.1261%2Frna.1351608&volume=14&pages=2580-2596&publication_year=2008&author=Landthaler%2CM generate?
- https://doi.org/10.1261%2Frna.1606309 income
- Get to know http://scholar.google.com/scholar_lookup?&title=The%20C-terminal%20domains%20of%20human%20TNRC6A%2C%20TNRC6B%2C%20and%20TNRC6C%20silence%20bound%20transcripts%20independently%20of%20Argonaute%20proteins&journal=RNA&doi=10.1261%2Frna.1606309&volume=15&pages=1059-1066&publication_year=2009&author=Lazzaretti%2CD&author=Tournier%2CI&author=Izaurralde%2CE's earnings
- Income figures for https://doi.org/10.1261%2Frna.1229409
- How much revenue does http://scholar.google.com/scholar_lookup?&title=The%20C-terminal%20half%20of%20human%20Ago2%20binds%20to%20multiple%20GW-rich%20regions%20of%20GW182%20and%20requires%20GW182%20to%20mediate%20silencing&journal=RNA&doi=10.1261%2Frna.1229409&volume=15&pages=804-813&publication_year=2009&author=Lian%2CSL bring in?
- Check the income stats for https://doi.org/10.1261%2Frna.1363109
- How much does http://scholar.google.com/scholar_lookup?&title=Mammalian%20GW182%20contains%20multiple%20Argonaute-binding%20sites%20and%20functions%20in%20microRNA-mediated%20translational%20repression&journal=RNA&doi=10.1261%2Frna.1363109&volume=15&pages=1078-1089&publication_year=2009&author=Takimoto%2CK&author=Wakiyama%2CM&author=Yokoyama%2CS pull in?
- Income figures for https://doi.org/10.1261%2Frna.1448009
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Importance%20of%20the%20C-terminal%20domain%20of%20the%20human%20GW182%20protein%20TNRC6C%20for%20translational%20repression&journal=RNA&doi=10.1261%2Frna.1448009&volume=15&pages=781-793&publication_year=2009&author=Zipprich%2CJT&author=Bhattacharyya%2CS&author=Mathys%2CH&author=Filipowicz%2CW
- Monthly income for https://doi.org/10.1038%2Fncb1274
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=MicroRNA-dependent%20localization%20of%20targeted%20mRNAs%20to%20mammalian%20P-bodies&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb1274&volume=7&pages=719-723&publication_year=2005&author=Liu%2CJ&author=Valencia-Sanchez%2CMA&author=Hannon%2CGJ&author=Parker%2CR?
- How much does https://doi.org/10.1016%2Fj.cell.2007.05.016 earn?
- How much does http://scholar.google.com/scholar_lookup?&title=An%20mRNA%20m7G%20cap%20binding-like%20motif%20within%20human%20Ago2%20represses%20translation&journal=Cell&doi=10.1016%2Fj.cell.2007.05.016&volume=129&pages=1141-1151&publication_year=2007&author=Kiriakidou%2CM earn?
- See how much https://doi.org/10.1016%2FS0076-6879%2808%2902617-7 makes per month
- How profitable is http://scholar.google.com/scholar_lookup?&title=Messenger%20RNA%20half-life%20measuremments%20in%20mammalian%20cells&journal=Methods%20Enzymol.&doi=10.1016%2FS0076-6879%2808%2902617-7&volume=448&pages=335-357&publication_year=2008&author=Chen%2CAC-Y&author=Ezzeddine%2CN&author=Shyu%2CAB?
- Income figures for https://doi.org/10.1038%2Fnsmb1016
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=Concerted%20action%20of%20poly%28A%29%20nucleases%20and%20decapping%20enzyme%20in%20mammalian%20mRNA%20turnover&journal=Nat.%20Struct.%20Mol.%20Biol.&doi=10.1038%2Fnsmb1016&volume=12&pages=1054-1063&publication_year=2005&author=Yamashita%2CA?
- What's the income of https://doi.org/10.1083%2Fjcb.200801196?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Deadenylation%20is%20prerequisite%20for%20P-body%20formation%20and%20mRNA%20decay%20in%20mammalian%20cells&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.200801196&volume=182&pages=89-101&publication_year=2008&author=Zheng%2CD?
- How much does https://doi.org/10.1126%2Fscience.1115079 rake in every month?
- How much money does http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20translational%20initiation%20by%20let-7%20micro-RNA%20in%20human%20cells&journal=Science&doi=10.1126%2Fscience.1115079&volume=309&pages=1573-1576&publication_year=2005&author=Pillai%2CRS make?
- What is the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14770003?
- Get to know http://scholar.google.com/scholar_lookup?&title=Using%20the%20lambda%20N%20peptide%20to%20tether%20proteins%20to%20RNAs&journal=Methods%20Mol.%20Biol.&volume=257&pages=135-154&publication_year=2004&author=Baron-Benhamou%2CJ&author=Gehring%2CNH&author=Kulozik%2CAE&author=Hentze%2CMW's earnings
- https://doi.org/10.1261%2Frna.7131604 income
- How much money does http://scholar.google.com/scholar_lookup?&title=Tethering%20of%20human%20Ago%20proteins%20to%20mRNA%20mimics%20the%20miRNA-mediated%20repression%20of%20protein%20synthesis&journal=RNA&doi=10.1261%2Frna.7131604&volume=10&pages=1518-1525&publication_year=2004&author=Pillai%2CRS&author=Artus%2CCG&author=Filipowicz%2CW generate?
- What's the financial gain of https://doi.org/10.1126%2Fscience.1102513?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Argonaute2%20Is%20the%20Catalytic%20Engine%20of%20Mammalian%20RNAi&journal=Science&doi=10.1126%2Fscience.1102513&volume=305&pages=1437-1441&publication_year=2004&author=Liu%2CJ?
- What's the revenue for https://doi.org/10.1093%2Fnar%2F26.2.558?
- What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=A%20broader%20role%20for%20AU-rich%20element-mediated%20mRNA%20turnover%20revealed%20by%20a%20new%20transcriptional%20pulse%20strategy&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2F26.2.558&volume=26&pages=558-565&publication_year=1998&author=Xu%2CN&author=Loflin%2CP&author=Chen%2CC-YA&author=Shyu%2CA-B?
- What's the monthly income of https://doi.org/10.1128%2FMCB.23.14.4805-4813.2003?
- How much does http://scholar.google.com/scholar_lookup?&title=Rapid%20deadenylation%20triggered%20by%20a%20nonsense%20codon%20precedes%20decay%20of%20the%20RNA%20body%20in%20a%20mammalian%20cytoplasmic%20nonsense-mediated%20decay%20pathway&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.23.14.4805-4813.2003&volume=23&pages=4805-4813&publication_year=2003&author=Chen%2CC-YA&author=Shyu%2CA-B pull in?
- Earnings of https://doi.org/10.1128%2FMCB.14.12.8471
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Selective%20degradation%20of%20early-response-gene%20mRNAs%3A%20functional%20analyses%20of%20sequence%20features%20of%20the%20AU-rich%20elements&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.14.12.8471&volume=14&pages=8471-8482&publication_year=1994&author=Chen%2CC-YA&author=Shyu%2CA-B?
- https://doi.org/10.1016%2FS0968-0004%2800%2989102-1 income
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=AU-rich%20elements%3A%20characterization%20and%20importance%20in%20mRNA%20degradation&journal=Trends%20Biochem.%20Sci.&doi=10.1016%2FS0968-0004%2800%2989102-1&volume=20&pages=465-470&publication_year=1995&author=Chen%2CC-YA&author=Shyu%2CA-B?
- Find out how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7565413 earns monthly
- Discover the revenue of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC239368
- http://scholar.google.com/scholar_lookup?&title=mRNA%20stability%20in%20mammalian%20cells&journal=Microbiol.%20Rev.&volume=59&pages=423-450&publication_year=1995&author=Ross%2CJ's revenue stream
- Discover the revenue of https://doi.org/10.1016%2FS0092-8674%2800%2900102-1
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=A%20mechanism%20for%20translationally%20coupled%20mRNA%20turnover%3A%20interaction%20between%20the%20poly%28A%29%20tail%20and%20a%20c-fos%20RNA%20coding%20determinant%20via%20a%20protein%20complex&journal=Cell&doi=10.1016%2FS0092-8674%2800%2900102-1&volume=103&pages=29-40&publication_year=2000&author=Grosset%2CC?
- What's the financial outcome of https://doi.org/10.1016%2Fj.cell.2009.02.006?
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=Evolution%20and%20functions%20of%20long%20noncoding%20RNAs&journal=Cell&doi=10.1016%2Fj.cell.2009.02.006&volume=136&pages=629-641&publication_year=2009&author=Ponting%2CCP&author=Oliver%2CPL&author=Reik%2CW?
- What's the total monthly financial gain of https://doi.org/10.1038%2Fsj.emboj.7601977?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=Messenger%20RNA%20regulation%3A%20to%20translate%20or%20to%20degrad&journal=EMBO%20J.&doi=10.1038%2Fsj.emboj.7601977&volume=27&pages=471-481&publication_year=2008&author=Shyu%2CAB&author=Wilkinson%2CMF&author=van%20Hoof%2CA
- What are the total earnings of https://doi.org/10.1261%2Frna.1399509?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Deadenylation%20is%20a%20widespread%20effect%20of%20miRNA%20regulation&journal=RNA&doi=10.1261%2Frna.1399509&volume=15&pages=21-32&publication_year=2009&author=Eulalio%2CA?
- How much revenue does https://doi.org/10.1128%2FMCB.00380-09 generate?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Functional%20dissection%20of%20the%20human%20TNRC6%20%28GW182-related%29%20family%20of%20proteins&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.00380-09&volume=29&pages=4144-4155&publication_year=2009&author=Baillat%2CD&author=Shiekhattar%2CR
- How much does https://doi.org/10.1016%2Fj.molcel.2007.09.014 net monthly?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Systematic%20identification%20of%20C.%20elegans%20miRISC%20proteins%2C%20miRNAs%2C%20and%20mRNA%20targets%20by%20their%20interactions%20with%20GW182%20proteins%20AIN-1%20and%20AIN-2&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2007.09.014&volume=28&pages=598-613&publication_year=2007&author=Zhang%2CL?
- How much revenue does https://doi.org/10.1016%2Fj.molcel.2009.08.004 bring in?
- What's http://scholar.google.com/scholar_lookup?&title=Mammalian%20miRNA%20RISC%20recruits%20CAF1%20and%20PABP%20to%20affect%20PABP-dependent%20deadenylation&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2009.08.004&volume=35&pages=868-880&publication_year=2009&author=Fabian%2CMR's gross income?
- Learn how profitable https://doi.org/10.1083%2Fjcb.200712054 is on a monthly basis
- How profitable is http://scholar.google.com/scholar_lookup?&title=Decoding%20ARE-mediated%20decay%3A%20is%20microRNA%20part%20of%20the%20equation%3F&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.200712054&volume=181&pages=189-194&publication_year=2008&author=von%20Roretz%2CC&author=Gallouzi%2CI-E?
- How much does https://doi.org/10.1073%2Fpnas.192445599 gross monthly?
- How profitable is http://scholar.google.com/scholar_lookup?&title=The%20hDcp2%20protein%20is%20a%20mammalian%20mRNA%20decapping%20enzyme&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.192445599&volume=99&pages=12663-12668&publication_year=2002&author=Wang%2CZ&author=Jiao%2CX&author=Carr-Schmid%2CA&author=Kiledjian%2CM?
- What's https://doi.org/10.1101%2Fgad.5.2.221's gross income?
- How much does http://scholar.google.com/scholar_lookup?&title=Two%20distinct%20destabilizing%20elements%20in%20the%20c-fos%20message%20trigger%20deadenylation%20as%20a%20first%20step%20in%20rapid%20mRNA%20decay&journal=Genes%20Dev.&doi=10.1101%2Fgad.5.2.221&volume=5&pages=221-231&publication_year=1991&author=Shyu%2CA-B&author=Belasco%2CJG&author=Greenberg%2CMG pull in?
- How much does https://doi.org/10.1093%2Femboj%2F17.12.3461 gross monthly?
- How much money does http://scholar.google.com/scholar_lookup?&title=RNA%20stabilization%20by%20the%20AU-rich%20element%20binding%20protein%2C%20HuR%2C%20an%20ELAV%20protein&journal=EMBO%20J.&doi=10.1093%2Femboj%2F17.12.3461&volume=17&pages=3461-3470&publication_year=1998&author=Peng%2CS-S&author=Chen%2CC-YA&author=Xu%2CN&author=Shyu%2CA-B make?
- Find out how much https://citation-needed.springer.com/v2/references/10.1038/nsmb.1709?format=refman&flavour=references earns monthly
- What's the monthly money flow for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chyi-Ying%20A%20Chen?
- Revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chyi-Ying%20A%20Chen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dinghai%20Zheng have?
- See how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Dinghai%20Zheng%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en makes per month
- Profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Zhenfang%20Xia
- Get to know https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Zhenfang%20Xia%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's earnings
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ann-Bin%20Shyu gross monthly?
- How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ann-Bin%20Shyu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- Earnings of https://static-content.springer.com/esm/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_BFnsmb1709_MOESM14_ESM.pdf
- Discover the revenue of https://s100.copyright.com/AppDispatchServlet?title=Ago%E2%80%93TNRC6%20triggers%20microRNA-mediated%20decay%20by%20promoting%20two%20deadenylation%20steps&author=Chyi-Ying%20A%20Chen%20et%20al&contentID=10.1038%2Fnsmb.1709©right=Springer%20Nature%20America%2C%20Inc.&publication=1545-9993&publicationDate=2009-10-18&publisherName=SpringerNature&orderBeanReset=true
- What is the monthly revenue of https://citation-needed.springer.com/v2/references/10.1038/nsmb.1709?format=refman&flavour=citation?
- Monthly income for https://doi.org/10.1186/s13059-023-02871-7
- https://doi.org/10.1186/s13019-021-01613-9's total income per month
- What's the income generated by https://doi.org/10.1038/s41598-021-86665-6 each month?
- Explore the financials of https://doi.org/10.1186/s13059-019-1857-2
- What's the monthly income of https://doi.org/10.1038/s41580-018-0045-7?
- How much does https://www.protocols.io/ bring in each month?
- How much does https://www.natureindex.com/ pull in monthly?
- Earnings of http://www.naturechina.com
- What's the financial intake of https://www.natureasia.com/ja-jp?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref