NATURE . COM {
}
Title:
Ago–TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps | Nature Structural & Molecular Biology
Description:
miRNAs can repress transcripts through decay. Mammalian miRNA-mediated deadenylation is now shown to involve both the Pan2–Pan3 and the Ccr4–Caf1 deadenylases. Such deadenylation can be triggered by tethered Ago or TNRC6 and is followed by decapping of the reporter. MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly by promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear. Combining the approaches of transcriptional pulsing, RNA tethering, overexpression of dominant-negative mutants, and siRNA-mediated gene knockdown, we show that let-7 miRNA-induced silencing complexes (miRISCs), which contain the proteins Argonaute (Ago) and TNRC6 (also known as GW182), trigger very rapid mRNA decay by inducing accelerated biphasic deadenylation mediated by Pan2–Pan3 and Ccr4–Caf1 deadenylase complexes followed by Dcp1–Dcp2 complex–directed decapping in mammalian cells. When tethered to mRNAs, all four human Ago proteins and TNRC6C are each able to recapitulate the two deadenylation steps. Two conserved human Ago2 phenylalanines (Phe470 and Phe505) are critical for recruiting TNRC6 to promote deadenylation. These findings indicate that promotion of biphasic deadenylation to trigger mRNA decay is an intrinsic property of miRISCs.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Education
- Science
- Telecommunications
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌆 Monumental Traffic: 20M - 50M visitors per month
Based on our best estimate, this website will receive around 42,555,829 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$536,300 per month
Our calculations suggest that Nature.com earns between $357,511 and $983,155 monthly online from display advertisements.
Keywords {🔍}
article, google, scholar, cas, mrna, nature, cell, biol, rna, mammalian, deadenylation, decay, shyu, human, access, chen, micrornas, proteins, mol, protein, biology, cells, nat, repression, content, molecular, ago, microrna, cookies, gene, mrnas, translational, regulation, usa, privacy, data, micrornamediated, mirnamediated, silencing, argonaute, open, translation, science, cya, university, function, information, promoting, zheng, mirnas,
Topics {✒️}
nature portfolio permissions reprints privacy policy advertising social media author information authors nature 431 nature 433 nature 455 nature dcp1–dcp2 complex–directed decapping multiple gw-rich regions mirna-mediated gene silencing microrna-mediated gene silencing sirna-mediated gene knockdown ann-bin shyu author correspondence mirna-mediated translational repression microrna-mediated translational repression early-response-gene mrnas multiple argonaute-binding sites mammalian cell-free system springerlink instant access affect pabp-dependent deadenylation deadenylation steps chyi-ying p-body component gw182 permissions ccr4–caf1 deadenylase complexes personal data mirna-mediated decay au-rich elements molecular biology mammalian p-bodies mirna-mediated repression data protection analyzed data microrna-directed cleavage c-terminal half dcp2 decapping complexes mammalian mrna turnover protein synthesis induced human ago2 binds privacy microrna-dependent localization cold spring harbor purine-rich motifs c-terminal domains c-terminal domain rapid mrna decay cold spring harb
Questions {❓}
- Decoding ARE-mediated decay: is microRNA part of the equation?
- How do microRNAs regulate gene expression?
- Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
Schema {🗺️}
WebPage:
mainEntity:
headline:AgoâTNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps
description:miRNAs can repress transcripts through decay. Mammalian miRNA-mediated deadenylation is now shown to involve both the Pan2âPan3 and the Ccr4âCaf1 deadenylases. Such deadenylation can be triggered by tethered Ago or TNRC6 and is followed by decapping of the reporter. MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly by promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear. Combining the approaches of transcriptional pulsing, RNA tethering, overexpression of dominant-negative mutants, and siRNA-mediated gene knockdown, we show that let-7 miRNA-induced silencing complexes (miRISCs), which contain the proteins Argonaute (Ago) and TNRC6 (also known as GW182), trigger very rapid mRNA decay by inducing accelerated biphasic deadenylation mediated by Pan2âPan3 and Ccr4âCaf1 deadenylase complexes followed by Dcp1âDcp2 complexâdirected decapping in mammalian cells. When tethered to mRNAs, all four human Ago proteins and TNRC6C are each able to recapitulate the two deadenylation steps. Two conserved human Ago2 phenylalanines (Phe470 and Phe505) are critical for recruiting TNRC6 to promote deadenylation. These findings indicate that promotion of biphasic deadenylation to trigger mRNA decay is an intrinsic property of miRISCs.
datePublished:2009-10-18T00:00:00Z
dateModified:2009-10-18T00:00:00Z
pageStart:1160
pageEnd:1166
sameAs:https://doi.org/10.1038/nsmb.1709
keywords:
Life Sciences
general
Biochemistry
Protein Structure
Membrane Biology
Biological Microscopy
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig5_HTML.jpg
isPartOf:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:16
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Chyi-Ying A Chen
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Dinghai Zheng
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Zhenfang Xia
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Ann-Bin Shyu
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:AgoâTNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps
description:miRNAs can repress transcripts through decay. Mammalian miRNA-mediated deadenylation is now shown to involve both the Pan2âPan3 and the Ccr4âCaf1 deadenylases. Such deadenylation can be triggered by tethered Ago or TNRC6 and is followed by decapping of the reporter. MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly by promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear. Combining the approaches of transcriptional pulsing, RNA tethering, overexpression of dominant-negative mutants, and siRNA-mediated gene knockdown, we show that let-7 miRNA-induced silencing complexes (miRISCs), which contain the proteins Argonaute (Ago) and TNRC6 (also known as GW182), trigger very rapid mRNA decay by inducing accelerated biphasic deadenylation mediated by Pan2âPan3 and Ccr4âCaf1 deadenylase complexes followed by Dcp1âDcp2 complexâdirected decapping in mammalian cells. When tethered to mRNAs, all four human Ago proteins and TNRC6C are each able to recapitulate the two deadenylation steps. Two conserved human Ago2 phenylalanines (Phe470 and Phe505) are critical for recruiting TNRC6 to promote deadenylation. These findings indicate that promotion of biphasic deadenylation to trigger mRNA decay is an intrinsic property of miRISCs.
datePublished:2009-10-18T00:00:00Z
dateModified:2009-10-18T00:00:00Z
pageStart:1160
pageEnd:1166
sameAs:https://doi.org/10.1038/nsmb.1709
keywords:
Life Sciences
general
Biochemistry
Protein Structure
Membrane Biology
Biological Microscopy
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig5_HTML.jpg
isPartOf:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:16
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Chyi-Ying A Chen
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Dinghai Zheng
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Zhenfang Xia
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Ann-Bin Shyu
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:16
Organization:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Chyi-Ying A Chen
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
name:Dinghai Zheng
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
name:Zhenfang Xia
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
name:Ann-Bin Shyu
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(131)
- Check the income stats for https://link.springer.com/article/10.1038/nsmb.1709?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle
- How profitable is https://doi.org/10.1038%2Fnature02871?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=The%20functions%20of%20animal%20microRNAs&journal=Nature&doi=10.1038%2Fnature02871&volume=431&pages=350-355&publication_year=2004&author=Ambros%2CV generate?
- What's the revenue for https://doi.org/10.1146%2Fannurev.cellbio.23.090506.123406?
- http://scholar.google.com/scholar_lookup?&title=microRNA%20functions&journal=Annu.%20Rev.%20Cell%20Dev.%20Biol.&doi=10.1146%2Fannurev.cellbio.23.090506.123406&volume=23&pages=175-205&publication_year=2007&author=Bushati%2CN&author=Cohen%2CSM's financial summary
- What's the financial outcome of https://doi.org/10.1038%2Fnrg2290?
- How much does http://scholar.google.com/scholar_lookup?&title=Mechanisms%20of%20post-transcriptional%20regulation%20by%20microRNAs%3A%20are%20the%20answers%20in%20sight%3F&journal=Nat.%20Rev.%20Genet.&doi=10.1038%2Fnrg2290&volume=9&pages=102-114&publication_year=2008&author=Filipowicz%2CW&author=Bhattacharyya%2CSN&author=Sonenberg%2CN make?
- Get to know https://doi.org/10.1126%2Fstke.3672007re1's earnings
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=How%20do%20microRNAs%20regulate%20gene%20expression%3F&journal=Sci.%20STKE&doi=10.1126%2Fstke.3672007re1&volume=2007&publication_year=2007&author=Jackson%2CRJ&author=Standart%2CN?
- Monthly income for https://doi.org/10.1261%2Frna.1072808
- How much money does http://scholar.google.com/scholar_lookup?&title=Computational%20analysis%20of%20miRNA-mediated%20repression%20of%20translation%3A%20Implications%20for%20models%20of%20translation%20initiation%20inhibition&journal=RNA&doi=10.1261%2Frna.1072808&volume=14&pages=1480-1491&publication_year=2008&author=Nissan%2CT&author=Parker%2CR generate?
- https://doi.org/10.1016%2Fj.cell.2005.07.031's financial summary
- Revenue of http://scholar.google.com/scholar_lookup?&title=Regulation%20by%20let-7%20and%20lin-4%20miRNAs%20results%20in%20target%20mRNA%20degradation&journal=Cell&doi=10.1016%2Fj.cell.2005.07.031&volume=122&pages=553-563&publication_year=2005&author=Bagga%2CS
- Income figures for https://doi.org/10.1038%2Fnature03315
- How much profit is http://scholar.google.com/scholar_lookup?&title=Microarray%20analysis%20shows%20that%20some%20microRNAs%20downregulate%20large%20numbers%20of%20target%20mRNAs&journal=Nature&doi=10.1038%2Fnature03315&volume=433&pages=769-773&publication_year=2005&author=Lim%2CLP making per month?
- How much revenue does https://doi.org/10.1038%2Fnature07242 bring in?
- How much does http://scholar.google.com/scholar_lookup?&title=The%20impact%20of%20microRNAs%20on%20protein%20output&journal=Nature&doi=10.1038%2Fnature07242&volume=455&pages=64-71&publication_year=2008&author=Baek%2CD bring in each month?
- What's the total monthly financial gain of https://doi.org/10.1038%2Fnature07228?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Widespread%20changes%20in%20protein%20synthesis%20induced%20by%20microRNAs&journal=Nature&doi=10.1038%2Fnature07228&volume=455&pages=58-63&publication_year=2008&author=Selbach%2CM each month?
- What's the monthly income of https://doi.org/10.1101%2Fgad.1424106?
- How much does http://scholar.google.com/scholar_lookup?&title=mRNA%20degradation%20by%20miRNAs%20and%20GW182%20requires%20both%20CCR4%3ANOT%20deadenylase%20and%20DCP1%3ADCP2%20decapping%20complexes&journal=Genes%20Dev.&doi=10.1101%2Fgad.1424106&volume=20&pages=1885-1898&publication_year=2006&author=Behm-Ansmant%2CI bring in each month?
- Find out how much https://doi.org/10.1126%2Fscience.1122689 earns monthly
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Zebrafish%20MiR-430%20promotes%20deadenylation%20and%20clearance%20of%20maternal%20mRNAs&journal=Science&doi=10.1126%2Fscience.1122689&volume=312&pages=75-79&publication_year=2006&author=Giraldez%2CAJ?
- What's the profit of https://doi.org/10.1073%2Fpnas.0510928103?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=MicroRNAs%20direct%20rapid%20deadenylation%20of%20mRNA&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0510928103&volume=103&pages=4034-4039&publication_year=2006&author=Wu%2CL&author=Fan%2CJ&author=Belasco%2CJG?
- What's the revenue for https://doi.org/10.1126%2Fscience.1073827?
- How much money does http://scholar.google.com/scholar_lookup?&title=A%20microRNA%20in%20a%20multiple-turnover%20RNAi%20enzyme%20complex&journal=Science&doi=10.1126%2Fscience.1073827&volume=297&pages=2056-2060&publication_year=2002&author=Hutv%C3%A1gner%2CG&author=Zamore%2CPD make?
- What are the total earnings of https://doi.org/10.1126%2Fscience.1097434?
- Earnings of http://scholar.google.com/scholar_lookup?&title=MicroRNA-directed%20cleavage%20of%20HOXB8%20mRNA&journal=Science&doi=10.1126%2Fscience.1097434&volume=304&pages=594-596&publication_year=2004&author=Yekta%2CS&author=Shih%2CIH&author=Bartel%2CDP
- How much revenue does https://doi.org/10.1093%2Fnar%2Fgkm1080 bring in?
- How much does http://scholar.google.com/scholar_lookup?&title=Epstein-Barr%20virus-encoded%20microRNA%20miR-BART2%20down-regulates%20the%20viral%20DNA%20polymerase%20BALF5&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkm1080&volume=36&pages=666-675&publication_year=2008&author=Barth%2CS bring in each month?
- What's the income generated by https://doi.org/10.1101%2Fsqb.2006.71.013 each month?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=MicroRNAs%20silence%20gene%20expression%20by%20repressing%20protein%20expression%20and%2For%20by%20promoting%20mRNA%20decay&journal=Cold%20Spring%20Harb.%20Symp.%20Quant.%20Biol.&doi=10.1101%2Fsqb.2006.71.013&volume=71&pages=523-530&publication_year=2006&author=Behm-Ansmant%2CI&author=Rehwinkel%2CJ&author=Izaurralde%2CE?
- Financial intake of https://doi.org/10.1038%2Fnsmb.1405
- How much money does http://scholar.google.com/scholar_lookup?&title=GW182%20interaction%20with%20Argonaute%20is%20essential%20for%20miRNA-mediated%20translational%20repression%20and%20mRNA%20decay&journal=Nat.%20Struct.%20Mol.%20Biol.&doi=10.1038%2Fnsmb.1405&volume=15&pages=346-353&publication_year=2008&author=Eulalio%2CA&author=Huntzinger%2CE&author=Izaurralde%2CE generate?
- How profitable is https://doi.org/10.1016%2Fj.cell.2007.12.024?
- How much money does http://scholar.google.com/scholar_lookup?&title=Getting%20to%20the%20root%20of%20miRNA-mediated%20gene%20silencing&journal=Cell&doi=10.1016%2Fj.cell.2007.12.024&volume=132&pages=9-14&publication_year=2008&author=Eulalio%2CA&author=Huntzinger%2CE&author=Izaurralde%2CE generate?
- How much does https://doi.org/10.1101%2Fgad.1566707 net monthly?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Let-7%20microRNA-mediated%20mRNA%20deadenylation%20and%20translational%20repression%20in%20a%20mammalian%20cell-free%20system&journal=Genes%20Dev.&doi=10.1101%2Fgad.1566707&volume=21&pages=1857-1862&publication_year=2007&author=Wakiyama%2CM&author=Takimoto%2CK&author=Ohara%2CO&author=Yokoyama%2CS?
- What's the income generated by https://doi.org/10.1016%2Fj.tcb.2007.06.003 each month?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=GW182%20family%20proteins%20are%20crucial%20for%20microRNA-mediated%20gene%20silencing&journal=Trends%20Cell%20Biol.&doi=10.1016%2Fj.tcb.2007.06.003&volume=17&pages=411-416&publication_year=2007&author=Ding%2CL&author=Han%2CM generate?
- What's the financial outcome of https://doi.org/10.1038%2Fncb1334?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Disruption%20of%20GW%20bodies%20impairs%20mammalian%20RNA%20interference&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb1334&volume=8&pages=1267-1274&publication_year=2005&author=Jakymiw%2CA?
- Find out how much https://doi.org/10.1038%2Fncb1333 earns monthly
- See how much http://scholar.google.com/scholar_lookup?&title=A%20role%20for%20the%20P-body%20component%20GW182%20in%20microRNA%20function&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb1333&volume=7&pages=1261-1266&publication_year=2005&author=Liu%2CJ makes per month
- How much does https://doi.org/10.1016%2Fj.cub.2005.10.048 generate monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Identificiation%20of%20novel%20argonaute-associated%20proteins&journal=Curr.%20Biol.&doi=10.1016%2Fj.cub.2005.10.048&volume=15&pages=2149-2155&publication_year=2005&author=Meister%2CG bring in each month?
- See how much https://doi.org/10.1371%2Fjournal.pbio.0040210 makes per month
- How much does http://scholar.google.com/scholar_lookup?&title=Translation%20repression%20in%20human%20cells%20by%20microRNA-induced%20gene%20silencing%20requires%20RCK%2Fp54&journal=PLoS%20Biol.&doi=10.1371%2Fjournal.pbio.0040210&volume=4&publication_year=2006&author=Chu%2CC-Y&author=Rana%2CTM pull in monthly?
- How much does https://doi.org/10.1261%2Frna.1351608 pull in?
- How much money does http://scholar.google.com/scholar_lookup?&title=Molecular%20characterization%20of%20human%20Argonaute-containing%20ribonucleoprotein%20complexes%20and%20their%20bound%20target%20mRNAs&journal=RNA&doi=10.1261%2Frna.1351608&volume=14&pages=2580-2596&publication_year=2008&author=Landthaler%2CM make?
- How much revenue does https://doi.org/10.1261%2Frna.1606309 produce monthly?
- How much profit is http://scholar.google.com/scholar_lookup?&title=The%20C-terminal%20domains%20of%20human%20TNRC6A%2C%20TNRC6B%2C%20and%20TNRC6C%20silence%20bound%20transcripts%20independently%20of%20Argonaute%20proteins&journal=RNA&doi=10.1261%2Frna.1606309&volume=15&pages=1059-1066&publication_year=2009&author=Lazzaretti%2CD&author=Tournier%2CI&author=Izaurralde%2CE making per month?
- Get to know what's the income of https://doi.org/10.1261%2Frna.1229409
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=The%20C-terminal%20half%20of%20human%20Ago2%20binds%20to%20multiple%20GW-rich%20regions%20of%20GW182%20and%20requires%20GW182%20to%20mediate%20silencing&journal=RNA&doi=10.1261%2Frna.1229409&volume=15&pages=804-813&publication_year=2009&author=Lian%2CSL?
- How much money does https://doi.org/10.1261%2Frna.1363109 make?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Mammalian%20GW182%20contains%20multiple%20Argonaute-binding%20sites%20and%20functions%20in%20microRNA-mediated%20translational%20repression&journal=RNA&doi=10.1261%2Frna.1363109&volume=15&pages=1078-1089&publication_year=2009&author=Takimoto%2CK&author=Wakiyama%2CM&author=Yokoyama%2CS produce monthly?
- See how much https://doi.org/10.1261%2Frna.1448009 makes per month
- Get to know http://scholar.google.com/scholar_lookup?&title=Importance%20of%20the%20C-terminal%20domain%20of%20the%20human%20GW182%20protein%20TNRC6C%20for%20translational%20repression&journal=RNA&doi=10.1261%2Frna.1448009&volume=15&pages=781-793&publication_year=2009&author=Zipprich%2CJT&author=Bhattacharyya%2CS&author=Mathys%2CH&author=Filipowicz%2CW's earnings
- Discover the revenue of https://doi.org/10.1038%2Fncb1274
- What's the profit of http://scholar.google.com/scholar_lookup?&title=MicroRNA-dependent%20localization%20of%20targeted%20mRNAs%20to%20mammalian%20P-bodies&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb1274&volume=7&pages=719-723&publication_year=2005&author=Liu%2CJ&author=Valencia-Sanchez%2CMA&author=Hannon%2CGJ&author=Parker%2CR?
- Get to know what's the income of https://doi.org/10.1016%2Fj.cell.2007.05.016
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=An%20mRNA%20m7G%20cap%20binding-like%20motif%20within%20human%20Ago2%20represses%20translation&journal=Cell&doi=10.1016%2Fj.cell.2007.05.016&volume=129&pages=1141-1151&publication_year=2007&author=Kiriakidou%2CM
- https://doi.org/10.1016%2FS0076-6879%2808%2902617-7's revenue stream
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=Messenger%20RNA%20half-life%20measuremments%20in%20mammalian%20cells&journal=Methods%20Enzymol.&doi=10.1016%2FS0076-6879%2808%2902617-7&volume=448&pages=335-357&publication_year=2008&author=Chen%2CAC-Y&author=Ezzeddine%2CN&author=Shyu%2CAB is on a monthly basis
- What's the total monthly financial gain of https://doi.org/10.1038%2Fnsmb1016?
- What's the income of http://scholar.google.com/scholar_lookup?&title=Concerted%20action%20of%20poly%28A%29%20nucleases%20and%20decapping%20enzyme%20in%20mammalian%20mRNA%20turnover&journal=Nat.%20Struct.%20Mol.%20Biol.&doi=10.1038%2Fnsmb1016&volume=12&pages=1054-1063&publication_year=2005&author=Yamashita%2CA?
- How much does https://doi.org/10.1083%2Fjcb.200801196 gross monthly?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Deadenylation%20is%20prerequisite%20for%20P-body%20formation%20and%20mRNA%20decay%20in%20mammalian%20cells&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.200801196&volume=182&pages=89-101&publication_year=2008&author=Zheng%2CD?
- What are the earnings of https://doi.org/10.1126%2Fscience.1115079?
- How much does http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20translational%20initiation%20by%20let-7%20micro-RNA%20in%20human%20cells&journal=Science&doi=10.1126%2Fscience.1115079&volume=309&pages=1573-1576&publication_year=2005&author=Pillai%2CRS net monthly?
- Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14770003's earnings
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Using%20the%20lambda%20N%20peptide%20to%20tether%20proteins%20to%20RNAs&journal=Methods%20Mol.%20Biol.&volume=257&pages=135-154&publication_year=2004&author=Baron-Benhamou%2CJ&author=Gehring%2CNH&author=Kulozik%2CAE&author=Hentze%2CMW?
- What's the financial intake of https://doi.org/10.1261%2Frna.7131604?
- How much money does http://scholar.google.com/scholar_lookup?&title=Tethering%20of%20human%20Ago%20proteins%20to%20mRNA%20mimics%20the%20miRNA-mediated%20repression%20of%20protein%20synthesis&journal=RNA&doi=10.1261%2Frna.7131604&volume=10&pages=1518-1525&publication_year=2004&author=Pillai%2CRS&author=Artus%2CCG&author=Filipowicz%2CW generate?
- How much profit does https://doi.org/10.1126%2Fscience.1102513 make?
- How much money does http://scholar.google.com/scholar_lookup?&title=Argonaute2%20Is%20the%20Catalytic%20Engine%20of%20Mammalian%20RNAi&journal=Science&doi=10.1126%2Fscience.1102513&volume=305&pages=1437-1441&publication_year=2004&author=Liu%2CJ make?
- How much income does https://doi.org/10.1093%2Fnar%2F26.2.558 have?
- http://scholar.google.com/scholar_lookup?&title=A%20broader%20role%20for%20AU-rich%20element-mediated%20mRNA%20turnover%20revealed%20by%20a%20new%20transcriptional%20pulse%20strategy&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2F26.2.558&volume=26&pages=558-565&publication_year=1998&author=Xu%2CN&author=Loflin%2CP&author=Chen%2CC-YA&author=Shyu%2CA-B's revenue stream
- How much revenue does https://doi.org/10.1128%2FMCB.23.14.4805-4813.2003 bring in?
- Profit of http://scholar.google.com/scholar_lookup?&title=Rapid%20deadenylation%20triggered%20by%20a%20nonsense%20codon%20precedes%20decay%20of%20the%20RNA%20body%20in%20a%20mammalian%20cytoplasmic%20nonsense-mediated%20decay%20pathway&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.23.14.4805-4813.2003&volume=23&pages=4805-4813&publication_year=2003&author=Chen%2CC-YA&author=Shyu%2CA-B
- What's the financial outcome of https://doi.org/10.1128%2FMCB.14.12.8471?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Selective%20degradation%20of%20early-response-gene%20mRNAs%3A%20functional%20analyses%20of%20sequence%20features%20of%20the%20AU-rich%20elements&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.14.12.8471&volume=14&pages=8471-8482&publication_year=1994&author=Chen%2CC-YA&author=Shyu%2CA-B?
- How much does https://doi.org/10.1016%2FS0968-0004%2800%2989102-1 bring in each month?
- How profitable is http://scholar.google.com/scholar_lookup?&title=AU-rich%20elements%3A%20characterization%20and%20importance%20in%20mRNA%20degradation&journal=Trends%20Biochem.%20Sci.&doi=10.1016%2FS0968-0004%2800%2989102-1&volume=20&pages=465-470&publication_year=1995&author=Chen%2CC-YA&author=Shyu%2CA-B?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7565413 gross monthly?
- Earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC239368
- Profit of http://scholar.google.com/scholar_lookup?&title=mRNA%20stability%20in%20mammalian%20cells&journal=Microbiol.%20Rev.&volume=59&pages=423-450&publication_year=1995&author=Ross%2CJ
- What's the financial gain of https://doi.org/10.1016%2FS0092-8674%2800%2900102-1?
- http://scholar.google.com/scholar_lookup?&title=A%20mechanism%20for%20translationally%20coupled%20mRNA%20turnover%3A%20interaction%20between%20the%20poly%28A%29%20tail%20and%20a%20c-fos%20RNA%20coding%20determinant%20via%20a%20protein%20complex&journal=Cell&doi=10.1016%2FS0092-8674%2800%2900102-1&volume=103&pages=29-40&publication_year=2000&author=Grosset%2CC's financial summary
- What is the monthly revenue of https://doi.org/10.1016%2Fj.cell.2009.02.006?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Evolution%20and%20functions%20of%20long%20noncoding%20RNAs&journal=Cell&doi=10.1016%2Fj.cell.2009.02.006&volume=136&pages=629-641&publication_year=2009&author=Ponting%2CCP&author=Oliver%2CPL&author=Reik%2CW each month?
- How much money does https://doi.org/10.1038%2Fsj.emboj.7601977 make?
- How much money does http://scholar.google.com/scholar_lookup?&title=Messenger%20RNA%20regulation%3A%20to%20translate%20or%20to%20degrad&journal=EMBO%20J.&doi=10.1038%2Fsj.emboj.7601977&volume=27&pages=471-481&publication_year=2008&author=Shyu%2CAB&author=Wilkinson%2CMF&author=van%20Hoof%2CA generate?
- How profitable is https://doi.org/10.1261%2Frna.1399509?
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=Deadenylation%20is%20a%20widespread%20effect%20of%20miRNA%20regulation&journal=RNA&doi=10.1261%2Frna.1399509&volume=15&pages=21-32&publication_year=2009&author=Eulalio%2CA
- How much does https://doi.org/10.1128%2FMCB.00380-09 rake in every month?
- How much income is http://scholar.google.com/scholar_lookup?&title=Functional%20dissection%20of%20the%20human%20TNRC6%20%28GW182-related%29%20family%20of%20proteins&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.00380-09&volume=29&pages=4144-4155&publication_year=2009&author=Baillat%2CD&author=Shiekhattar%2CR earning monthly?
- How much does https://doi.org/10.1016%2Fj.molcel.2007.09.014 make?
- How much does http://scholar.google.com/scholar_lookup?&title=Systematic%20identification%20of%20C.%20elegans%20miRISC%20proteins%2C%20miRNAs%2C%20and%20mRNA%20targets%20by%20their%20interactions%20with%20GW182%20proteins%20AIN-1%20and%20AIN-2&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2007.09.014&volume=28&pages=598-613&publication_year=2007&author=Zhang%2CL bring in each month?
- Monthly income for https://doi.org/10.1016%2Fj.molcel.2009.08.004
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Mammalian%20miRNA%20RISC%20recruits%20CAF1%20and%20PABP%20to%20affect%20PABP-dependent%20deadenylation&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2009.08.004&volume=35&pages=868-880&publication_year=2009&author=Fabian%2CMR
- What's the monthly income of https://doi.org/10.1083%2Fjcb.200712054?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Decoding%20ARE-mediated%20decay%3A%20is%20microRNA%20part%20of%20the%20equation%3F&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.200712054&volume=181&pages=189-194&publication_year=2008&author=von%20Roretz%2CC&author=Gallouzi%2CI-E?
- How profitable is https://doi.org/10.1073%2Fpnas.192445599?
- How much profit does http://scholar.google.com/scholar_lookup?&title=The%20hDcp2%20protein%20is%20a%20mammalian%20mRNA%20decapping%20enzyme&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.192445599&volume=99&pages=12663-12668&publication_year=2002&author=Wang%2CZ&author=Jiao%2CX&author=Carr-Schmid%2CA&author=Kiledjian%2CM generate?
- What's the monthly money flow for https://doi.org/10.1101%2Fgad.5.2.221?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Two%20distinct%20destabilizing%20elements%20in%20the%20c-fos%20message%20trigger%20deadenylation%20as%20a%20first%20step%20in%20rapid%20mRNA%20decay&journal=Genes%20Dev.&doi=10.1101%2Fgad.5.2.221&volume=5&pages=221-231&publication_year=1991&author=Shyu%2CA-B&author=Belasco%2CJG&author=Greenberg%2CMG
- Learn how profitable https://doi.org/10.1093%2Femboj%2F17.12.3461 is on a monthly basis
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=RNA%20stabilization%20by%20the%20AU-rich%20element%20binding%20protein%2C%20HuR%2C%20an%20ELAV%20protein&journal=EMBO%20J.&doi=10.1093%2Femboj%2F17.12.3461&volume=17&pages=3461-3470&publication_year=1998&author=Peng%2CS-S&author=Chen%2CC-YA&author=Xu%2CN&author=Shyu%2CA-B?
- https://citation-needed.springer.com/v2/references/10.1038/nsmb.1709?format=refman&flavour=references's financial summary
- What's the financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chyi-Ying%20A%20Chen?
- Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chyi-Ying%20A%20Chen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dinghai%20Zheng
- Check the income stats for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Dinghai%20Zheng%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Zhenfang%20Xia
- What is the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Zhenfang%20Xia%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ann-Bin%20Shyu make?
- What's the financial outcome of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ann-Bin%20Shyu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What's the monthly income of https://static-content.springer.com/esm/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_BFnsmb1709_MOESM14_ESM.pdf?
- Get to know what's the income of https://s100.copyright.com/AppDispatchServlet?title=Ago%E2%80%93TNRC6%20triggers%20microRNA-mediated%20decay%20by%20promoting%20two%20deadenylation%20steps&author=Chyi-Ying%20A%20Chen%20et%20al&contentID=10.1038%2Fnsmb.1709©right=Springer%20Nature%20America%2C%20Inc.&publication=1545-9993&publicationDate=2009-10-18&publisherName=SpringerNature&orderBeanReset=true
- See how much https://citation-needed.springer.com/v2/references/10.1038/nsmb.1709?format=refman&flavour=citation makes per month
- Monthly income for https://doi.org/10.1186/s13059-023-02871-7
- Check the income stats for https://doi.org/10.1186/s13019-021-01613-9
- How much does https://doi.org/10.1038/s41598-021-86665-6 bring in each month?
- See how much https://doi.org/10.1186/s13059-019-1857-2 makes per month
- How much revenue does https://doi.org/10.1038/s41580-018-0045-7 bring in?
- What's the financial intake of https://www.protocols.io/?
- What's the profit of https://www.natureindex.com/?
- How much cash flow does http://www.naturechina.com have monthly?
- https://www.natureasia.com/ja-jp's financial summary
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref