
NATURE . COM {
}
Title:
Ago–TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps | Nature Structural & Molecular Biology
Description:
miRNAs can repress transcripts through decay. Mammalian miRNA-mediated deadenylation is now shown to involve both the Pan2–Pan3 and the Ccr4–Caf1 deadenylases. Such deadenylation can be triggered by tethered Ago or TNRC6 and is followed by decapping of the reporter. MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly by promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear. Combining the approaches of transcriptional pulsing, RNA tethering, overexpression of dominant-negative mutants, and siRNA-mediated gene knockdown, we show that let-7 miRNA-induced silencing complexes (miRISCs), which contain the proteins Argonaute (Ago) and TNRC6 (also known as GW182), trigger very rapid mRNA decay by inducing accelerated biphasic deadenylation mediated by Pan2–Pan3 and Ccr4–Caf1 deadenylase complexes followed by Dcp1–Dcp2 complex–directed decapping in mammalian cells. When tethered to mRNAs, all four human Ago proteins and TNRC6C are each able to recapitulate the two deadenylation steps. Two conserved human Ago2 phenylalanines (Phe470 and Phe505) are critical for recruiting TNRC6 to promote deadenylation. These findings indicate that promotion of biphasic deadenylation to trigger mRNA decay is an intrinsic property of miRISCs.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Education
- Science
- Telecommunications
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.
Keywords {🔍}
article, google, scholar, cas, mrna, nature, cell, biol, rna, mammalian, deadenylation, decay, shyu, human, access, chen, micrornas, proteins, mol, protein, biology, cells, nat, repression, content, molecular, ago, microrna, cookies, gene, mrnas, translational, regulation, usa, privacy, data, micrornamediated, mirnamediated, silencing, argonaute, open, translation, science, cya, university, function, information, promoting, zheng, mirnas,
Topics {✒️}
nature portfolio permissions reprints privacy policy advertising social media author information authors nature 431 nature 433 nature 455 nature dcp1–dcp2 complex–directed decapping multiple gw-rich regions mirna-mediated gene silencing microrna-mediated gene silencing sirna-mediated gene knockdown ann-bin shyu author correspondence mirna-mediated translational repression microrna-mediated translational repression early-response-gene mrnas multiple argonaute-binding sites mammalian cell-free system springerlink instant access affect pabp-dependent deadenylation deadenylation steps chyi-ying p-body component gw182 permissions ccr4–caf1 deadenylase complexes personal data mirna-mediated decay au-rich elements molecular biology mammalian p-bodies mirna-mediated repression data protection analyzed data microrna-directed cleavage c-terminal half dcp2 decapping complexes mammalian mrna turnover protein synthesis induced human ago2 binds privacy microrna-dependent localization cold spring harbor purine-rich motifs c-terminal domains c-terminal domain rapid mrna decay cold spring harb
Questions {❓}
- Decoding ARE-mediated decay: is microRNA part of the equation?
- How do microRNAs regulate gene expression?
- Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
Schema {🗺️}
WebPage:
mainEntity:
headline:AgoâTNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps
description:miRNAs can repress transcripts through decay. Mammalian miRNA-mediated deadenylation is now shown to involve both the Pan2âPan3 and the Ccr4âCaf1 deadenylases. Such deadenylation can be triggered by tethered Ago or TNRC6 and is followed by decapping of the reporter. MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly by promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear. Combining the approaches of transcriptional pulsing, RNA tethering, overexpression of dominant-negative mutants, and siRNA-mediated gene knockdown, we show that let-7 miRNA-induced silencing complexes (miRISCs), which contain the proteins Argonaute (Ago) and TNRC6 (also known as GW182), trigger very rapid mRNA decay by inducing accelerated biphasic deadenylation mediated by Pan2âPan3 and Ccr4âCaf1 deadenylase complexes followed by Dcp1âDcp2 complexâdirected decapping in mammalian cells. When tethered to mRNAs, all four human Ago proteins and TNRC6C are each able to recapitulate the two deadenylation steps. Two conserved human Ago2 phenylalanines (Phe470 and Phe505) are critical for recruiting TNRC6 to promote deadenylation. These findings indicate that promotion of biphasic deadenylation to trigger mRNA decay is an intrinsic property of miRISCs.
datePublished:2009-10-18T00:00:00Z
dateModified:2009-10-18T00:00:00Z
pageStart:1160
pageEnd:1166
sameAs:https://doi.org/10.1038/nsmb.1709
keywords:
Life Sciences
general
Biochemistry
Protein Structure
Membrane Biology
Biological Microscopy
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig5_HTML.jpg
isPartOf:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:16
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Chyi-Ying A Chen
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Dinghai Zheng
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Zhenfang Xia
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Ann-Bin Shyu
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:AgoâTNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps
description:miRNAs can repress transcripts through decay. Mammalian miRNA-mediated deadenylation is now shown to involve both the Pan2âPan3 and the Ccr4âCaf1 deadenylases. Such deadenylation can be triggered by tethered Ago or TNRC6 and is followed by decapping of the reporter. MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly by promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear. Combining the approaches of transcriptional pulsing, RNA tethering, overexpression of dominant-negative mutants, and siRNA-mediated gene knockdown, we show that let-7 miRNA-induced silencing complexes (miRISCs), which contain the proteins Argonaute (Ago) and TNRC6 (also known as GW182), trigger very rapid mRNA decay by inducing accelerated biphasic deadenylation mediated by Pan2âPan3 and Ccr4âCaf1 deadenylase complexes followed by Dcp1âDcp2 complexâdirected decapping in mammalian cells. When tethered to mRNAs, all four human Ago proteins and TNRC6C are each able to recapitulate the two deadenylation steps. Two conserved human Ago2 phenylalanines (Phe470 and Phe505) are critical for recruiting TNRC6 to promote deadenylation. These findings indicate that promotion of biphasic deadenylation to trigger mRNA decay is an intrinsic property of miRISCs.
datePublished:2009-10-18T00:00:00Z
dateModified:2009-10-18T00:00:00Z
pageStart:1160
pageEnd:1166
sameAs:https://doi.org/10.1038/nsmb.1709
keywords:
Life Sciences
general
Biochemistry
Protein Structure
Membrane Biology
Biological Microscopy
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_Article_BFnsmb1709_Fig5_HTML.jpg
isPartOf:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:16
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Chyi-Ying A Chen
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Dinghai Zheng
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Zhenfang Xia
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Ann-Bin Shyu
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:16
Organization:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Chyi-Ying A Chen
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
name:Dinghai Zheng
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
name:Zhenfang Xia
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
name:Ann-Bin Shyu
affiliation:
name:The University of Texas Medical School
address:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
name:Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, USA
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(131)
- Check the income stats for https://link.springer.com/article/10.1038/nsmb.1709?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle
- What's the income generated by https://doi.org/10.1038%2Fnature02871 each month?
- Earnings of http://scholar.google.com/scholar_lookup?&title=The%20functions%20of%20animal%20microRNAs&journal=Nature&doi=10.1038%2Fnature02871&volume=431&pages=350-355&publication_year=2004&author=Ambros%2CV
- How much cash flow does https://doi.org/10.1146%2Fannurev.cellbio.23.090506.123406 have monthly?
- Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=microRNA%20functions&journal=Annu.%20Rev.%20Cell%20Dev.%20Biol.&doi=10.1146%2Fannurev.cellbio.23.090506.123406&volume=23&pages=175-205&publication_year=2007&author=Bushati%2CN&author=Cohen%2CSM
- How much does https://doi.org/10.1038%2Fnrg2290 pull in monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Mechanisms%20of%20post-transcriptional%20regulation%20by%20microRNAs%3A%20are%20the%20answers%20in%20sight%3F&journal=Nat.%20Rev.%20Genet.&doi=10.1038%2Fnrg2290&volume=9&pages=102-114&publication_year=2008&author=Filipowicz%2CW&author=Bhattacharyya%2CSN&author=Sonenberg%2CN pull in?
- Revenue of https://doi.org/10.1126%2Fstke.3672007re1
- How much money does http://scholar.google.com/scholar_lookup?&title=How%20do%20microRNAs%20regulate%20gene%20expression%3F&journal=Sci.%20STKE&doi=10.1126%2Fstke.3672007re1&volume=2007&publication_year=2007&author=Jackson%2CRJ&author=Standart%2CN make?
- How much does https://doi.org/10.1261%2Frna.1072808 pull in monthly?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Computational%20analysis%20of%20miRNA-mediated%20repression%20of%20translation%3A%20Implications%20for%20models%20of%20translation%20initiation%20inhibition&journal=RNA&doi=10.1261%2Frna.1072808&volume=14&pages=1480-1491&publication_year=2008&author=Nissan%2CT&author=Parker%2CR generate?
- How much income is https://doi.org/10.1016%2Fj.cell.2005.07.031 earning monthly?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Regulation%20by%20let-7%20and%20lin-4%20miRNAs%20results%20in%20target%20mRNA%20degradation&journal=Cell&doi=10.1016%2Fj.cell.2005.07.031&volume=122&pages=553-563&publication_year=2005&author=Bagga%2CS bring in?
- What's the financial intake of https://doi.org/10.1038%2Fnature03315?
- http://scholar.google.com/scholar_lookup?&title=Microarray%20analysis%20shows%20that%20some%20microRNAs%20downregulate%20large%20numbers%20of%20target%20mRNAs&journal=Nature&doi=10.1038%2Fnature03315&volume=433&pages=769-773&publication_year=2005&author=Lim%2CLP's revenue stream
- Income figures for https://doi.org/10.1038%2Fnature07242
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=The%20impact%20of%20microRNAs%20on%20protein%20output&journal=Nature&doi=10.1038%2Fnature07242&volume=455&pages=64-71&publication_year=2008&author=Baek%2CD?
- What's the financial intake of https://doi.org/10.1038%2Fnature07228?
- How much does http://scholar.google.com/scholar_lookup?&title=Widespread%20changes%20in%20protein%20synthesis%20induced%20by%20microRNAs&journal=Nature&doi=10.1038%2Fnature07228&volume=455&pages=58-63&publication_year=2008&author=Selbach%2CM rake in every month?
- What's the monthly income of https://doi.org/10.1101%2Fgad.1424106?
- See how much http://scholar.google.com/scholar_lookup?&title=mRNA%20degradation%20by%20miRNAs%20and%20GW182%20requires%20both%20CCR4%3ANOT%20deadenylase%20and%20DCP1%3ADCP2%20decapping%20complexes&journal=Genes%20Dev.&doi=10.1101%2Fgad.1424106&volume=20&pages=1885-1898&publication_year=2006&author=Behm-Ansmant%2CI makes per month
- How much does https://doi.org/10.1126%2Fscience.1122689 rake in every month?
- Find out how much http://scholar.google.com/scholar_lookup?&title=Zebrafish%20MiR-430%20promotes%20deadenylation%20and%20clearance%20of%20maternal%20mRNAs&journal=Science&doi=10.1126%2Fscience.1122689&volume=312&pages=75-79&publication_year=2006&author=Giraldez%2CAJ earns monthly
- What's https://doi.org/10.1073%2Fpnas.0510928103's gross income?
- Income figures for http://scholar.google.com/scholar_lookup?&title=MicroRNAs%20direct%20rapid%20deadenylation%20of%20mRNA&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0510928103&volume=103&pages=4034-4039&publication_year=2006&author=Wu%2CL&author=Fan%2CJ&author=Belasco%2CJG
- How much does https://doi.org/10.1126%2Fscience.1073827 pull in monthly?
- What's the income of http://scholar.google.com/scholar_lookup?&title=A%20microRNA%20in%20a%20multiple-turnover%20RNAi%20enzyme%20complex&journal=Science&doi=10.1126%2Fscience.1073827&volume=297&pages=2056-2060&publication_year=2002&author=Hutv%C3%A1gner%2CG&author=Zamore%2CPD?
- How much revenue does https://doi.org/10.1126%2Fscience.1097434 produce monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=MicroRNA-directed%20cleavage%20of%20HOXB8%20mRNA&journal=Science&doi=10.1126%2Fscience.1097434&volume=304&pages=594-596&publication_year=2004&author=Yekta%2CS&author=Shih%2CIH&author=Bartel%2CDP generate monthly?
- Check the income stats for https://doi.org/10.1093%2Fnar%2Fgkm1080
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=Epstein-Barr%20virus-encoded%20microRNA%20miR-BART2%20down-regulates%20the%20viral%20DNA%20polymerase%20BALF5&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkm1080&volume=36&pages=666-675&publication_year=2008&author=Barth%2CS
- How much revenue does https://doi.org/10.1101%2Fsqb.2006.71.013 produce monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=MicroRNAs%20silence%20gene%20expression%20by%20repressing%20protein%20expression%20and%2For%20by%20promoting%20mRNA%20decay&journal=Cold%20Spring%20Harb.%20Symp.%20Quant.%20Biol.&doi=10.1101%2Fsqb.2006.71.013&volume=71&pages=523-530&publication_year=2006&author=Behm-Ansmant%2CI&author=Rehwinkel%2CJ&author=Izaurralde%2CE pull in monthly?
- Revenue of https://doi.org/10.1038%2Fnsmb.1405
- http://scholar.google.com/scholar_lookup?&title=GW182%20interaction%20with%20Argonaute%20is%20essential%20for%20miRNA-mediated%20translational%20repression%20and%20mRNA%20decay&journal=Nat.%20Struct.%20Mol.%20Biol.&doi=10.1038%2Fnsmb.1405&volume=15&pages=346-353&publication_year=2008&author=Eulalio%2CA&author=Huntzinger%2CE&author=Izaurralde%2CE income
- How much does https://doi.org/10.1016%2Fj.cell.2007.12.024 gross monthly?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Getting%20to%20the%20root%20of%20miRNA-mediated%20gene%20silencing&journal=Cell&doi=10.1016%2Fj.cell.2007.12.024&volume=132&pages=9-14&publication_year=2008&author=Eulalio%2CA&author=Huntzinger%2CE&author=Izaurralde%2CE?
- Income figures for https://doi.org/10.1101%2Fgad.1566707
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Let-7%20microRNA-mediated%20mRNA%20deadenylation%20and%20translational%20repression%20in%20a%20mammalian%20cell-free%20system&journal=Genes%20Dev.&doi=10.1101%2Fgad.1566707&volume=21&pages=1857-1862&publication_year=2007&author=Wakiyama%2CM&author=Takimoto%2CK&author=Ohara%2CO&author=Yokoyama%2CS?
- Learn about the earnings of https://doi.org/10.1016%2Fj.tcb.2007.06.003
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=GW182%20family%20proteins%20are%20crucial%20for%20microRNA-mediated%20gene%20silencing&journal=Trends%20Cell%20Biol.&doi=10.1016%2Fj.tcb.2007.06.003&volume=17&pages=411-416&publication_year=2007&author=Ding%2CL&author=Han%2CM?
- Financial intake of https://doi.org/10.1038%2Fncb1334
- How much does http://scholar.google.com/scholar_lookup?&title=Disruption%20of%20GW%20bodies%20impairs%20mammalian%20RNA%20interference&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb1334&volume=8&pages=1267-1274&publication_year=2005&author=Jakymiw%2CA pull in?
- See how much https://doi.org/10.1038%2Fncb1333 makes per month
- How much revenue does http://scholar.google.com/scholar_lookup?&title=A%20role%20for%20the%20P-body%20component%20GW182%20in%20microRNA%20function&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb1333&volume=7&pages=1261-1266&publication_year=2005&author=Liu%2CJ produce monthly?
- What's the monthly money flow for https://doi.org/10.1016%2Fj.cub.2005.10.048?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Identificiation%20of%20novel%20argonaute-associated%20proteins&journal=Curr.%20Biol.&doi=10.1016%2Fj.cub.2005.10.048&volume=15&pages=2149-2155&publication_year=2005&author=Meister%2CG have monthly?
- What's the income of https://doi.org/10.1371%2Fjournal.pbio.0040210?
- Find out how much http://scholar.google.com/scholar_lookup?&title=Translation%20repression%20in%20human%20cells%20by%20microRNA-induced%20gene%20silencing%20requires%20RCK%2Fp54&journal=PLoS%20Biol.&doi=10.1371%2Fjournal.pbio.0040210&volume=4&publication_year=2006&author=Chu%2CC-Y&author=Rana%2CTM earns monthly
- How much does https://doi.org/10.1261%2Frna.1351608 net monthly?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Molecular%20characterization%20of%20human%20Argonaute-containing%20ribonucleoprotein%20complexes%20and%20their%20bound%20target%20mRNAs&journal=RNA&doi=10.1261%2Frna.1351608&volume=14&pages=2580-2596&publication_year=2008&author=Landthaler%2CM?
- Discover the revenue of https://doi.org/10.1261%2Frna.1606309
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=The%20C-terminal%20domains%20of%20human%20TNRC6A%2C%20TNRC6B%2C%20and%20TNRC6C%20silence%20bound%20transcripts%20independently%20of%20Argonaute%20proteins&journal=RNA&doi=10.1261%2Frna.1606309&volume=15&pages=1059-1066&publication_year=2009&author=Lazzaretti%2CD&author=Tournier%2CI&author=Izaurralde%2CE
- Discover the revenue of https://doi.org/10.1261%2Frna.1229409
- How much does http://scholar.google.com/scholar_lookup?&title=The%20C-terminal%20half%20of%20human%20Ago2%20binds%20to%20multiple%20GW-rich%20regions%20of%20GW182%20and%20requires%20GW182%20to%20mediate%20silencing&journal=RNA&doi=10.1261%2Frna.1229409&volume=15&pages=804-813&publication_year=2009&author=Lian%2CSL rake in every month?
- What's the financial intake of https://doi.org/10.1261%2Frna.1363109?
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=Mammalian%20GW182%20contains%20multiple%20Argonaute-binding%20sites%20and%20functions%20in%20microRNA-mediated%20translational%20repression&journal=RNA&doi=10.1261%2Frna.1363109&volume=15&pages=1078-1089&publication_year=2009&author=Takimoto%2CK&author=Wakiyama%2CM&author=Yokoyama%2CS is on a monthly basis
- Revenue of https://doi.org/10.1261%2Frna.1448009
- How much does http://scholar.google.com/scholar_lookup?&title=Importance%20of%20the%20C-terminal%20domain%20of%20the%20human%20GW182%20protein%20TNRC6C%20for%20translational%20repression&journal=RNA&doi=10.1261%2Frna.1448009&volume=15&pages=781-793&publication_year=2009&author=Zipprich%2CJT&author=Bhattacharyya%2CS&author=Mathys%2CH&author=Filipowicz%2CW bring in each month?
- How much money does https://doi.org/10.1038%2Fncb1274 make?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=MicroRNA-dependent%20localization%20of%20targeted%20mRNAs%20to%20mammalian%20P-bodies&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb1274&volume=7&pages=719-723&publication_year=2005&author=Liu%2CJ&author=Valencia-Sanchez%2CMA&author=Hannon%2CGJ&author=Parker%2CR?
- What's the monthly income of https://doi.org/10.1016%2Fj.cell.2007.05.016?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=An%20mRNA%20m7G%20cap%20binding-like%20motif%20within%20human%20Ago2%20represses%20translation&journal=Cell&doi=10.1016%2Fj.cell.2007.05.016&volume=129&pages=1141-1151&publication_year=2007&author=Kiriakidou%2CM?
- What's the financial outcome of https://doi.org/10.1016%2FS0076-6879%2808%2902617-7?
- Find out how much http://scholar.google.com/scholar_lookup?&title=Messenger%20RNA%20half-life%20measuremments%20in%20mammalian%20cells&journal=Methods%20Enzymol.&doi=10.1016%2FS0076-6879%2808%2902617-7&volume=448&pages=335-357&publication_year=2008&author=Chen%2CAC-Y&author=Ezzeddine%2CN&author=Shyu%2CAB earns monthly
- How much profit is https://doi.org/10.1038%2Fnsmb1016 making per month?
- Revenue of http://scholar.google.com/scholar_lookup?&title=Concerted%20action%20of%20poly%28A%29%20nucleases%20and%20decapping%20enzyme%20in%20mammalian%20mRNA%20turnover&journal=Nat.%20Struct.%20Mol.%20Biol.&doi=10.1038%2Fnsmb1016&volume=12&pages=1054-1063&publication_year=2005&author=Yamashita%2CA
- Find out how much https://doi.org/10.1083%2Fjcb.200801196 earns monthly
- What's http://scholar.google.com/scholar_lookup?&title=Deadenylation%20is%20prerequisite%20for%20P-body%20formation%20and%20mRNA%20decay%20in%20mammalian%20cells&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.200801196&volume=182&pages=89-101&publication_year=2008&author=Zheng%2CD's gross income?
- Check the income stats for https://doi.org/10.1126%2Fscience.1115079
- Income figures for http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20translational%20initiation%20by%20let-7%20micro-RNA%20in%20human%20cells&journal=Science&doi=10.1126%2Fscience.1115079&volume=309&pages=1573-1576&publication_year=2005&author=Pillai%2CRS
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14770003 pull in?
- http://scholar.google.com/scholar_lookup?&title=Using%20the%20lambda%20N%20peptide%20to%20tether%20proteins%20to%20RNAs&journal=Methods%20Mol.%20Biol.&volume=257&pages=135-154&publication_year=2004&author=Baron-Benhamou%2CJ&author=Gehring%2CNH&author=Kulozik%2CAE&author=Hentze%2CMW's revenue stream
- What's the monthly money flow for https://doi.org/10.1261%2Frna.7131604?
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=Tethering%20of%20human%20Ago%20proteins%20to%20mRNA%20mimics%20the%20miRNA-mediated%20repression%20of%20protein%20synthesis&journal=RNA&doi=10.1261%2Frna.7131604&volume=10&pages=1518-1525&publication_year=2004&author=Pillai%2CRS&author=Artus%2CCG&author=Filipowicz%2CW?
- What is the monthly revenue of https://doi.org/10.1126%2Fscience.1102513?
- Revenue of http://scholar.google.com/scholar_lookup?&title=Argonaute2%20Is%20the%20Catalytic%20Engine%20of%20Mammalian%20RNAi&journal=Science&doi=10.1126%2Fscience.1102513&volume=305&pages=1437-1441&publication_year=2004&author=Liu%2CJ
- How much profit does https://doi.org/10.1093%2Fnar%2F26.2.558 generate?
- Find out how much http://scholar.google.com/scholar_lookup?&title=A%20broader%20role%20for%20AU-rich%20element-mediated%20mRNA%20turnover%20revealed%20by%20a%20new%20transcriptional%20pulse%20strategy&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2F26.2.558&volume=26&pages=558-565&publication_year=1998&author=Xu%2CN&author=Loflin%2CP&author=Chen%2CC-YA&author=Shyu%2CA-B earns monthly
- Find out how much https://doi.org/10.1128%2FMCB.23.14.4805-4813.2003 earns monthly
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Rapid%20deadenylation%20triggered%20by%20a%20nonsense%20codon%20precedes%20decay%20of%20the%20RNA%20body%20in%20a%20mammalian%20cytoplasmic%20nonsense-mediated%20decay%20pathway&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.23.14.4805-4813.2003&volume=23&pages=4805-4813&publication_year=2003&author=Chen%2CC-YA&author=Shyu%2CA-B bring in?
- How much does https://doi.org/10.1128%2FMCB.14.12.8471 rake in every month?
- What's the income of http://scholar.google.com/scholar_lookup?&title=Selective%20degradation%20of%20early-response-gene%20mRNAs%3A%20functional%20analyses%20of%20sequence%20features%20of%20the%20AU-rich%20elements&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.14.12.8471&volume=14&pages=8471-8482&publication_year=1994&author=Chen%2CC-YA&author=Shyu%2CA-B?
- How much income is https://doi.org/10.1016%2FS0968-0004%2800%2989102-1 earning monthly?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=AU-rich%20elements%3A%20characterization%20and%20importance%20in%20mRNA%20degradation&journal=Trends%20Biochem.%20Sci.&doi=10.1016%2FS0968-0004%2800%2989102-1&volume=20&pages=465-470&publication_year=1995&author=Chen%2CC-YA&author=Shyu%2CA-B?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7565413 pull in?
- Revenue of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC239368
- http://scholar.google.com/scholar_lookup?&title=mRNA%20stability%20in%20mammalian%20cells&journal=Microbiol.%20Rev.&volume=59&pages=423-450&publication_year=1995&author=Ross%2CJ's revenue stream
- How much does https://doi.org/10.1016%2FS0092-8674%2800%2900102-1 generate monthly?
- Revenue of http://scholar.google.com/scholar_lookup?&title=A%20mechanism%20for%20translationally%20coupled%20mRNA%20turnover%3A%20interaction%20between%20the%20poly%28A%29%20tail%20and%20a%20c-fos%20RNA%20coding%20determinant%20via%20a%20protein%20complex&journal=Cell&doi=10.1016%2FS0092-8674%2800%2900102-1&volume=103&pages=29-40&publication_year=2000&author=Grosset%2CC
- Learn about the earnings of https://doi.org/10.1016%2Fj.cell.2009.02.006
- How much income is http://scholar.google.com/scholar_lookup?&title=Evolution%20and%20functions%20of%20long%20noncoding%20RNAs&journal=Cell&doi=10.1016%2Fj.cell.2009.02.006&volume=136&pages=629-641&publication_year=2009&author=Ponting%2CCP&author=Oliver%2CPL&author=Reik%2CW earning monthly?
- What's the financial intake of https://doi.org/10.1038%2Fsj.emboj.7601977?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Messenger%20RNA%20regulation%3A%20to%20translate%20or%20to%20degrad&journal=EMBO%20J.&doi=10.1038%2Fsj.emboj.7601977&volume=27&pages=471-481&publication_year=2008&author=Shyu%2CAB&author=Wilkinson%2CMF&author=van%20Hoof%2CA?
- Monthly income for https://doi.org/10.1261%2Frna.1399509
- How much money does http://scholar.google.com/scholar_lookup?&title=Deadenylation%20is%20a%20widespread%20effect%20of%20miRNA%20regulation&journal=RNA&doi=10.1261%2Frna.1399509&volume=15&pages=21-32&publication_year=2009&author=Eulalio%2CA make?
- How much money does https://doi.org/10.1128%2FMCB.00380-09 make?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Functional%20dissection%20of%20the%20human%20TNRC6%20%28GW182-related%29%20family%20of%20proteins&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.00380-09&volume=29&pages=4144-4155&publication_year=2009&author=Baillat%2CD&author=Shiekhattar%2CR?
- How profitable is https://doi.org/10.1016%2Fj.molcel.2007.09.014?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Systematic%20identification%20of%20C.%20elegans%20miRISC%20proteins%2C%20miRNAs%2C%20and%20mRNA%20targets%20by%20their%20interactions%20with%20GW182%20proteins%20AIN-1%20and%20AIN-2&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2007.09.014&volume=28&pages=598-613&publication_year=2007&author=Zhang%2CL?
- What's the profit of https://doi.org/10.1016%2Fj.molcel.2009.08.004?
- Revenue of http://scholar.google.com/scholar_lookup?&title=Mammalian%20miRNA%20RISC%20recruits%20CAF1%20and%20PABP%20to%20affect%20PABP-dependent%20deadenylation&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2009.08.004&volume=35&pages=868-880&publication_year=2009&author=Fabian%2CMR
- What's the financial intake of https://doi.org/10.1083%2Fjcb.200712054?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Decoding%20ARE-mediated%20decay%3A%20is%20microRNA%20part%20of%20the%20equation%3F&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.200712054&volume=181&pages=189-194&publication_year=2008&author=von%20Roretz%2CC&author=Gallouzi%2CI-E
- How much does https://doi.org/10.1073%2Fpnas.192445599 pull in monthly?
- Find out how much http://scholar.google.com/scholar_lookup?&title=The%20hDcp2%20protein%20is%20a%20mammalian%20mRNA%20decapping%20enzyme&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.192445599&volume=99&pages=12663-12668&publication_year=2002&author=Wang%2CZ&author=Jiao%2CX&author=Carr-Schmid%2CA&author=Kiledjian%2CM earns monthly
- https://doi.org/10.1101%2Fgad.5.2.221 income
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=Two%20distinct%20destabilizing%20elements%20in%20the%20c-fos%20message%20trigger%20deadenylation%20as%20a%20first%20step%20in%20rapid%20mRNA%20decay&journal=Genes%20Dev.&doi=10.1101%2Fgad.5.2.221&volume=5&pages=221-231&publication_year=1991&author=Shyu%2CA-B&author=Belasco%2CJG&author=Greenberg%2CMG?
- What's the monthly money flow for https://doi.org/10.1093%2Femboj%2F17.12.3461?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=RNA%20stabilization%20by%20the%20AU-rich%20element%20binding%20protein%2C%20HuR%2C%20an%20ELAV%20protein&journal=EMBO%20J.&doi=10.1093%2Femboj%2F17.12.3461&volume=17&pages=3461-3470&publication_year=1998&author=Peng%2CS-S&author=Chen%2CC-YA&author=Xu%2CN&author=Shyu%2CA-B
- What's the financial intake of https://citation-needed.springer.com/v2/references/10.1038/nsmb.1709?format=refman&flavour=references?
- How much cash flow does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chyi-Ying%20A%20Chen have monthly?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chyi-Ying%20A%20Chen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in?
- Get to know what's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dinghai%20Zheng
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Dinghai%20Zheng%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's revenue stream
- Learn how profitable https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Zhenfang%20Xia is on a monthly basis
- How much profit is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Zhenfang%20Xia%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en making per month?
- What's the income generated by https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ann-Bin%20Shyu each month?
- Get to know https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ann-Bin%20Shyu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's earnings
- Financial intake of https://static-content.springer.com/esm/art%3A10.1038%2Fnsmb.1709/MediaObjects/41594_2009_BFnsmb1709_MOESM14_ESM.pdf
- What's the financial outcome of https://s100.copyright.com/AppDispatchServlet?title=Ago%E2%80%93TNRC6%20triggers%20microRNA-mediated%20decay%20by%20promoting%20two%20deadenylation%20steps&author=Chyi-Ying%20A%20Chen%20et%20al&contentID=10.1038%2Fnsmb.1709©right=Springer%20Nature%20America%2C%20Inc.&publication=1545-9993&publicationDate=2009-10-18&publisherName=SpringerNature&orderBeanReset=true?
- How much does https://citation-needed.springer.com/v2/references/10.1038/nsmb.1709?format=refman&flavour=citation net monthly?
- What are the total earnings of https://doi.org/10.1186/s13059-023-02871-7?
- How much revenue does https://doi.org/10.1186/s13019-021-01613-9 generate?
- How much profit does https://doi.org/10.1038/s41598-021-86665-6 generate?
- How much does https://doi.org/10.1186/s13059-019-1857-2 pull in?
- How much does https://doi.org/10.1038/s41580-018-0045-7 bring in each month?
- How much profit is https://www.protocols.io/ making per month?
- How much revenue does https://www.natureindex.com/ bring in?
- How much does http://www.naturechina.com rake in every month?
- How much income is https://www.natureasia.com/ja-jp earning monthly?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref