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We are analyzing https://www.nature.com/articles/nrmicro.2017.42.

Title:
Persistent bacterial infections and persister cells | Nature Reviews Microbiology
Description:
Many bacteria can infect and persist inside their hosts for long periods of time. In this Review, Fisher, Gollan and Helaine discuss recent developments in our understanding of bacterial persisters and their potential implications for the treatment of persistent infections. Many bacteria can infect and persist inside their hosts for long periods of time. This can be due to immunosuppression of the host, immune evasion by the pathogen and/or ineffective killing by antibiotics. Bacteria can survive antibiotic treatment if they are resistant or tolerant to a drug. Persisters are a subpopulation of transiently antibiotic-tolerant bacterial cells that are often slow-growing or growth-arrested, and are able to resume growth after a lethal stress. The formation of persister cells establishes phenotypic heterogeneity within a bacterial population and has been hypothesized to be important for increasing the chances of successfully adapting to environmental change. The presence of persister cells can result in the recalcitrance and relapse of persistent bacterial infections, and it has been linked to an increase in the risk of the emergence of antibiotic resistance during treatment. If the mechanisms of the formation and regrowth of these antibiotic-tolerant cells were better understood, it could lead to the development of new approaches for the eradication of persistent bacterial infections. In this Review, we discuss recent developments in our understanding of bacterial persisters and their potential implications for the treatment of persistent infections.
Website Age:
30 years and 10 months (reg. 1994-08-11).

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Keywords {🔍}

pubmed, google, scholar, cas, central, bacterial, microbiol, antibiotic, persistence, nature, cell, cells, infections, coli, persister, tolerance, escherichia, nat, persisters, formation, toxinantitoxin, rev, mol, host, gerdes, persistent, response, infection, protein, article, resistance, lewis, dna, sci, treatment, bacteria, system, growth, access, proc, natl, acad, usa, helaine, stress, aureus, biol, salmonella, toxin, content,

Topics {✒️}

nature portfolio journals permissions reprints nature portfolio privacy policy advertising broad-host-range plasmid rk2 disrupts toxin–antitoxin–promoter interactions hokb–sokb toxin–antitoxin system social media agr quorum-sensing system van den bergh bridget gollan & sophie helaine single-gene knockout mutants author information authors atp-dependent persister formation hipba–promoter structures reveal nature+ nature 513 nature 524 nature 503 nature 473 nature 427 nature 527 nature macrophage-induced efflux mechanism rele–homologous mrna interferases author correspondence multiple toxin–antitoxin systems microbial bet-hedging strategy mazef toxin–antitoxin module lethal double-stranded breaks stress-response sigma factor engineering persister-specific antibiotics highly efficient antibacterial drug-induced tolerant persisters personal data antibiotic-tolerant persister cells low-copy-number plasmids toxin–antitoxin modules data protection permissions mhc ii molecules springerlink instant access growth-arrested persisters regrow toxin–antitoxin activity toxin–antitoxin loci long-term impacts mhc class ii single metabolic stress toxin–antitoxin systems

Questions {❓}

  • What role does the quorum-sensing accessory gene regulator system play during Staphylococcus aureus bacteremia?

Schema {🗺️}

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