NATURE . COM {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Nature.com Make Money
How Much Does Nature.com Make
Keywords
Topics
Questions
Schema
Social Networks
External Links
Analytics And Tracking
Libraries
Hosting Providers
CDN Services

We are analyzing https://www.nature.com/articles/nrmicro.2015.14.

Title:
CRISPR–Cas adaptation: insights into the mechanism of action | Nature Reviews Microbiology
Description:
Although the mechanisms of CRISPR–Cas interference have largely been elucidated, how new sequence memories are stored had remained unknown. In this Progress article, Amitai and Sorek discuss recent advances in the study of this adaptation stage of CRISPR immunity. Since the first demonstration that CRISPR–Cas systems provide bacteria and archaea with adaptive immunity against phages and plasmids, numerous studies have yielded key insights into the molecular mechanisms governing how these systems attack and degrade foreign DNA. However, the molecular mechanisms underlying the adaptation stage, in which new immunological memory is formed, have until recently represented a major unresolved question. In this Progress article, we discuss recent discoveries that have shown both how foreign DNA is identified by the CRISPR–Cas adaptation machinery and the molecular basis for its integration into the chromosome to form an immunological memory. Furthermore, we describe the roles of each of the specific CRISPR–Cas components that are involved in memory formation, and consider current models for their evolutionary origin.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

Education
Science
Animals & Wildlife

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)

google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)

conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.

Keywords {🔍}

pubmed, cas, google, scholar, central, crisprcas, nature, systems, crispr, dna, mol, biol, immunity, microbiol, article, adaptation, adaptive, system, acquisition, res, access, protein, nucleic, acids, nat, rev, coli, structure, cell, rna, immune, spacer, content, escherichia, repeats, makarova, bacterial, cookies, microbiology, sorek, molecular, mechanisms, foreign, memory, regularly, short, science, koonin, evolution, privacy,

Topics {✒️}

nature portfolio permissions reprints european research council privacy policy provide additional tools research excellence advertising pam-dependent spacer acquisition double-stranded endonuclease activity crispr/cas spacer acquisition social media double-stranded dna breaks crispr-cas immune system crispr-cas protein complex specific crispr–cas components crispr-cas immune systems integrase-mediated spacer acquisition crispr-cas surveillance complexes prokaryotic crispr-cas immunity nature 471 nature 519 nature 527 nature 520 nature crispr–cas adaptation machinery author information authors crispr–cas adaptive immunity single rna-guided endonuclease crispr-mediated genome defense author correspondence double-strand breaks host-derived crispr spacers trans-encoded small rna vivo-generated cruciform structures crispr–cas system crispr/cas system crispr–cas systems crispr-cas systems progress article personal data spacer integration intermediates crispr–cas adaptation springerlink instant access data protection permissions adaptive immune systems cas1 integrase directs anti-phage immunity mechanisms cas protein families single-strand interruptions

Questions {❓}

Self-targeting by CRISPR: gene regulation or autoimmunity?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:CRISPRâCas adaptation: insights into the mechanism of action
         description:Although the mechanisms of CRISPRâCas interference have largely been elucidated, how new sequence memories are stored had remained unknown. In this Progress article, Amitai and Sorek discuss recent advances in the study of this adaptation stage of CRISPR immunity. Since the first demonstration that CRISPRâCas systems provide bacteria and archaea with adaptive immunity against phages and plasmids, numerous studies have yielded key insights into the molecular mechanisms governing how these systems attack and degrade foreign DNA. However, the molecular mechanisms underlying the adaptation stage, in which new immunological memory is formed, have until recently represented a major unresolved question. In this Progress article, we discuss recent discoveries that have shown both how foreign DNA is identified by the CRISPRâCas adaptation machinery and the molecular basis for its integration into the chromosome to form an immunological memory. Furthermore, we describe the roles of each of the specific CRISPRâCas components that are involved in memory formation, and consider current models for their evolutionary origin.
         datePublished:2016-01-11T00:00:00Z
         dateModified:2016-01-11T00:00:00Z
         pageStart:67
         pageEnd:76
         sameAs:https://doi.org/10.1038/nrmicro.2015.14
         keywords:
            Bacterial evolution
            CRISPR-Cas systems
            Molecular biology
            Life Sciences
            general
            Microbiology
            Medical Microbiology
            Parasitology
            Infectious Diseases
            Virology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrmicro.2015.14/MediaObjects/41579_2016_Article_BFnrmicro201514_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrmicro.2015.14/MediaObjects/41579_2016_Article_BFnrmicro201514_Figa_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrmicro.2015.14/MediaObjects/41579_2016_Article_BFnrmicro201514_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrmicro.2015.14/MediaObjects/41579_2016_Article_BFnrmicro201514_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrmicro.2015.14/MediaObjects/41579_2016_Article_BFnrmicro201514_Figb_HTML.jpg
         isPartOf:
            name:Nature Reviews Microbiology
            issn:
               1740-1534
               1740-1526
            volumeNumber:14
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Gil Amitai
               affiliation:
                     name:Weizmann Institute of Science
                     address:
                        name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rotem Sorek
               affiliation:
                     name:Weizmann Institute of Science
                     address:
                        name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:CRISPRâCas adaptation: insights into the mechanism of action
      description:Although the mechanisms of CRISPRâCas interference have largely been elucidated, how new sequence memories are stored had remained unknown. In this Progress article, Amitai and Sorek discuss recent advances in the study of this adaptation stage of CRISPR immunity. Since the first demonstration that CRISPRâCas systems provide bacteria and archaea with adaptive immunity against phages and plasmids, numerous studies have yielded key insights into the molecular mechanisms governing how these systems attack and degrade foreign DNA. However, the molecular mechanisms underlying the adaptation stage, in which new immunological memory is formed, have until recently represented a major unresolved question. In this Progress article, we discuss recent discoveries that have shown both how foreign DNA is identified by the CRISPRâCas adaptation machinery and the molecular basis for its integration into the chromosome to form an immunological memory. Furthermore, we describe the roles of each of the specific CRISPRâCas components that are involved in memory formation, and consider current models for their evolutionary origin.
      datePublished:2016-01-11T00:00:00Z
      dateModified:2016-01-11T00:00:00Z
      pageStart:67
      pageEnd:76
      sameAs:https://doi.org/10.1038/nrmicro.2015.14
      keywords:
         Bacterial evolution
         CRISPR-Cas systems
         Molecular biology
         Life Sciences
         general
         Microbiology
         Medical Microbiology
         Parasitology
         Infectious Diseases
         Virology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrmicro.2015.14/MediaObjects/41579_2016_Article_BFnrmicro201514_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrmicro.2015.14/MediaObjects/41579_2016_Article_BFnrmicro201514_Figa_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrmicro.2015.14/MediaObjects/41579_2016_Article_BFnrmicro201514_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrmicro.2015.14/MediaObjects/41579_2016_Article_BFnrmicro201514_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrmicro.2015.14/MediaObjects/41579_2016_Article_BFnrmicro201514_Figb_HTML.jpg
      isPartOf:
         name:Nature Reviews Microbiology
         issn:
            1740-1534
            1740-1526
         volumeNumber:14
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Gil Amitai
            affiliation:
                  name:Weizmann Institute of Science
                  address:
                     name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rotem Sorek
            affiliation:
                  name:Weizmann Institute of Science
                  address:
                     name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Reviews Microbiology
      issn:
         1740-1534
         1740-1526
      volumeNumber:14
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Weizmann Institute of Science
      address:
         name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
         type:PostalAddress
      name:Weizmann Institute of Science
      address:
         name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Gil Amitai
      affiliation:
            name:Weizmann Institute of Science
            address:
               name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
               type:PostalAddress
            type:Organization
      name:Rotem Sorek
      affiliation:
            name:Weizmann Institute of Science
            address:
               name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
      name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(1)

https://www.facebook.com/NatureReviews

External Links {🔗}(231)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Prism.js
Zoom.js

Emails and Hosting {✉️}

Mail Servers:

mxa-002c5801.gslb.pphosted.com
mxb-002c5801.gslb.pphosted.com

Name Servers:

pdns1.ultradns.net
pdns2.ultradns.net
pdns3.ultradns.org
pdns4.ultradns.org
pdns5.ultradns.info
pdns6.ultradns.co.uk

CDN Services {📦}

Crossref

5.65s.