Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Questions
  10. Schema
  11. Social Networks
  12. External Links
  13. Analytics And Tracking
  14. Libraries
  15. Hosting Providers
  16. CDN Services

We are analyzing https://www.nature.com/articles/nrc1819.

Title:
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis | Nature Reviews Cancer
Description:
Nature Reviews Cancer - Mutation or deletion of PTEN is found in many cancers — however, in others, deregulation of the PI3K–PTEN network occurs in the absence of PTEN mutation. This...
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
Estimations show Nature.com's display ad online revenue falls between $42,042 and $115,616 per month.

Keywords {🔍}

pubmed, google, scholar, cas, cancer, cell, nature, pten, kinase, central, pathway, growth, mtor, mutations, pathways, gene, mice, tsc, genes, article, tumor, multiple, signalling, breast, receptor, biol, sci, suppressor, access, clin, development, dev, oncol, usa, pik, tumorigenesis, ras, tumour, science, proc, natl, acad, content, levine, human, tumours, molecular, pikpten, survival, lung,

Topics {✒️}

permissions reprints nature portfolio privacy policy breast cancer research advertising small-cell lung cancer social media author correspondence pkb/akt-dependent cell survival nature cell biol sh2 domain/phosphoprotein association radiation-induced lymphoma development phosphotyrosine-sh2 domain interactions impaired akt1–gsk3β signaling pi3k–pten signalling network nature rev tumorigenesis megan cully computer-aided molecular design age-dependent motor deficits nature med ideal/intact gefitinib trials nature genet akt-1/protein kinase bα pkb/akt phosphorylates p27 signal transduction laboratory combating pi3k-dependent tumours postnatal brain development personal data protein interaction domains raf/mek/erk pathways springerlink instant access data protection nature 428 nature 370 nature 408 nature 436 permissions nature pkb/akt-mediated phosphorylation nf1 tumor suppressor human endometrial cancer rapamycin-sensitive pathway required tacc1 promotes survival mild growth deficiency normal drosophila development article cully nutrient-sensitive interaction phase ii study small mouse phenotype protein kinase akt2

Questions {❓}

  • Does the ribosome translate cancer?
  • How does the PI3K pathway integrate signals from numerous sources, and how can this information be used in the rational design of cancer therapies?
  • Selecting patients for epidermal growth factor receptor inhibitor treatment: a FISH story or a tale of mutations?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
         description: Mutation or deletion of PTEN is found in many cancers — however, in others, deregulation of the PI3K–PTEN network occurs in the absence of PTEN mutation. This review examines whether 'crosstalk' with other tumorigenic signalling pathways contributes to PI3K–PTEN deregulation. The tumour-suppressor phosphatase with tensin homology (PTEN) is the most important negative regulator of the cell-survival signalling pathway initiated by phosphatidylinositol 3-kinase (PI3K). Although PTEN is mutated or deleted in many tumours, deregulation of the PI3K–PTEN network also occurs through other mechanisms. Crosstalk between the PI3K pathways and other tumorigenic signalling pathways, such as those that involve Ras, p53, TOR (target of rapamycin) or DJ1, can contribute to this deregulation. How does the PI3K pathway integrate signals from numerous sources, and how can this information be used in the rational design of cancer therapies?
         datePublished:2006-02-02T00:00:00Z
         dateModified:2006-02-02T00:00:00Z
         pageStart:184
         pageEnd:192
         sameAs:https://doi.org/10.1038/nrc1819
         keywords:
            Biomedicine
            general
            Cancer Research
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1819/MediaObjects/41568_2006_Article_BFnrc1819_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1819/MediaObjects/41568_2006_Article_BFnrc1819_Figa_HTML.jpg
         isPartOf:
            name:Nature Reviews Cancer
            issn:
               1474-1768
               1474-175X
            volumeNumber:6
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Megan Cully
               affiliation:
                     name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto
                     address:
                        name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
                        type:PostalAddress
                     type:Organization
                     name:Cancer Research UK London Research Institute
                     address:
                        name:Signal Transduction Laboratory, Cancer Research UK London Research Institute, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Han You
               affiliation:
                     name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto
                     address:
                        name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Arnold J. Levine
               affiliation:
                     name:The Cancer Institute of New Jersey and the Institute for Advanced Study
                     address:
                        name:The Cancer Institute of New Jersey and the Institute for Advanced Study, New Jersey, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Tak W. Mak
               affiliation:
                     name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto
                     address:
                        name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
      description: Mutation or deletion of PTEN is found in many cancers — however, in others, deregulation of the PI3K–PTEN network occurs in the absence of PTEN mutation. This review examines whether 'crosstalk' with other tumorigenic signalling pathways contributes to PI3K–PTEN deregulation. The tumour-suppressor phosphatase with tensin homology (PTEN) is the most important negative regulator of the cell-survival signalling pathway initiated by phosphatidylinositol 3-kinase (PI3K). Although PTEN is mutated or deleted in many tumours, deregulation of the PI3K–PTEN network also occurs through other mechanisms. Crosstalk between the PI3K pathways and other tumorigenic signalling pathways, such as those that involve Ras, p53, TOR (target of rapamycin) or DJ1, can contribute to this deregulation. How does the PI3K pathway integrate signals from numerous sources, and how can this information be used in the rational design of cancer therapies?
      datePublished:2006-02-02T00:00:00Z
      dateModified:2006-02-02T00:00:00Z
      pageStart:184
      pageEnd:192
      sameAs:https://doi.org/10.1038/nrc1819
      keywords:
         Biomedicine
         general
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1819/MediaObjects/41568_2006_Article_BFnrc1819_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1819/MediaObjects/41568_2006_Article_BFnrc1819_Figa_HTML.jpg
      isPartOf:
         name:Nature Reviews Cancer
         issn:
            1474-1768
            1474-175X
         volumeNumber:6
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Megan Cully
            affiliation:
                  name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto
                  address:
                     name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
                     type:PostalAddress
                  type:Organization
                  name:Cancer Research UK London Research Institute
                  address:
                     name:Signal Transduction Laboratory, Cancer Research UK London Research Institute, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Han You
            affiliation:
                  name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto
                  address:
                     name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Arnold J. Levine
            affiliation:
                  name:The Cancer Institute of New Jersey and the Institute for Advanced Study
                  address:
                     name:The Cancer Institute of New Jersey and the Institute for Advanced Study, New Jersey, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tak W. Mak
            affiliation:
                  name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto
                  address:
                     name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Reviews Cancer
      issn:
         1474-1768
         1474-175X
      volumeNumber:6
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto
      address:
         name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
         type:PostalAddress
      name:Cancer Research UK London Research Institute
      address:
         name:Signal Transduction Laboratory, Cancer Research UK London Research Institute, London, UK
         type:PostalAddress
      name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto
      address:
         name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
         type:PostalAddress
      name:The Cancer Institute of New Jersey and the Institute for Advanced Study
      address:
         name:The Cancer Institute of New Jersey and the Institute for Advanced Study, New Jersey, USA
         type:PostalAddress
      name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto
      address:
         name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Megan Cully
      affiliation:
            name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto
            address:
               name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
               type:PostalAddress
            type:Organization
            name:Cancer Research UK London Research Institute
            address:
               name:Signal Transduction Laboratory, Cancer Research UK London Research Institute, London, UK
               type:PostalAddress
            type:Organization
      name:Han You
      affiliation:
            name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto
            address:
               name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Arnold J. Levine
      affiliation:
            name:The Cancer Institute of New Jersey and the Institute for Advanced Study
            address:
               name:The Cancer Institute of New Jersey and the Institute for Advanced Study, New Jersey, USA
               type:PostalAddress
            type:Organization
      name:Tak W. Mak
      affiliation:
            name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto
            address:
               name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
      name:Signal Transduction Laboratory, Cancer Research UK London Research Institute, London, UK
      name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
      name:The Cancer Institute of New Jersey and the Institute for Advanced Study, New Jersey, USA
      name:The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Canada
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

External Links {🔗}(245)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

4.54s.