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Title:
Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog | Nature Medicine
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In considering tumorigenesis, much attention is paid to genome instability and mutation rates. While reflecting on the circumstances that have led to this emphasis on mutation rates, Ian Tomlinson and Walter Bodmer point out that an increased mutation rate does not necessarily cause a tumor to grow and that selection is in fact the mechanism that drives the cellular, somatic evolution that leads to cancer.
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nature portfolio permissions reprints privacy policy advertising nature med nature genet social media nature 255 nature 392 nature 386 nature springerlink instant access personal data methylation kinetics data protection permissions richard boland … natalia walter bodmer point privacy tumor cell populations programmed cell death hereditary colorectal cancer simple mathematical models explore content subscription content mismatch repair occur mismatch repair deficiency cancer–susceptibility genes article tomlinson european economic area ian tomlinson institutional subscriptions read john radcliffe hospital hierarchical clustering identifies accepting optional cookies mathematical modelling sporadic colorectal tumors journals search log access conditional mutator phenotypes manage preferences molecular medicine content genomic instability occurs population genetics laboratory clonal selection advantage increased mutation rate article purchase january 1999 selection article cite
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In considering tumorigenesis, much attention is paid to genome instability and mutation rates. While reflecting on the circumstances that have led to this emphasis on mutation rates, Ian Tomlinson and Walter Bodmer point out that an increased mutation rate does not necessarily cause a tumor to grow and that selection is in fact the mechanism that drives the cellular, somatic evolution that leads to cancer.
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In considering tumorigenesis, much attention is paid to genome instability and mutation rates. While reflecting on the circumstances that have led to this emphasis on mutation rates, Ian Tomlinson and Walter Bodmer point out that an increased mutation rate does not necessarily cause a tumor to grow and that selection is in fact the mechanism that drives the cellular, somatic evolution that leads to cancer.
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