Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Questions
  10. Schema
  11. Social Networks
  12. External Links
  13. Analytics And Tracking
  14. Libraries
  15. Hosting Providers
  16. CDN Services

We are analyzing https://www.nature.com/articles/nm.4452.

Title:
A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway | Nature Medicine
Description:
A proteolytically derived fragment of the epigenetic regulator HDAC4 protects the heart through transcriptional repression of the hexosamine biosynthetic pathway, thereby inhibiting protein O-GlcNAcylation and maintaining normal calcium handling and contractility of cardiomyocytes. The stress-responsive epigenetic repressor histone deacetylase 4 (HDAC4) regulates cardiac gene expression. Here we show that the levels of an N-terminal proteolytically derived fragment of HDAC4, termed HDAC4-NT, are lower in failing mouse hearts than in healthy control hearts. Virus-mediated transfer of the portion of the Hdac4 gene encoding HDAC4-NT into the mouse myocardium protected the heart from remodeling and failure; this was associated with decreased expression of Nr4a1, which encodes a nuclear orphan receptor, and decreased NR4A1-dependent activation of the hexosamine biosynthetic pathway (HBP). Conversely, exercise enhanced HDAC4-NT levels, and mice with a cardiomyocyte-specific deletion of Hdac4 show reduced exercise capacity, which was characterized by cardiac fatigue and increased expression of Nr4a1. Mechanistically, we found that NR4A1 negatively regulated contractile function in a manner that depended on the HBP and the calcium sensor STIM1. Our work describes a new regulatory axis in which epigenetic regulation of a metabolic pathway affects calcium handling. Activation of this axis during intermittent physiological stress promotes cardiac function, whereas its impairment in sustained pathological cardiac stress leads to heart failure.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Science

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.

Keywords {🔍}

google, scholar, cardiac, heart, nature, cell, germany, failure, mice, research, heidelberg, hypertrophy, gene, access, university, article, histone, calcium, stim, res, physiol, nat, mol, circ, department, content, medicine, expression, biol, deacetylase, pathway, michael, backs, hdac, remodeling, signaling, circulation, function, nra, receptor, regulation, olson, protein, cardiol, lhl, center, cookies, lehmann, kreusser, nuclear,

Topics {✒️}

nature portfolio journals β2-adrenergic receptor–gi-dependent manner nature portfolio permissions reprints o-linked β-n-acetylglucosamine transferase privacy policy pineda antibody service ca2+–calmodulin-dependent kinase ii advertising fast gapped-read alignment cell-type-specific chromatin immunoprecipitation store-operated calcium channels pressure-overload-induced cardiac hypertrophy pressure-overload-induced cardiac remodeling partner site hamburg/kiel/lübeck normal cardiac homeostasis career development fellowship nature+ nature 502 nature creb-dependent nur77 induction hdac4-nt gene therapy provided research support individualized aconitine-induced cardiotoxicity o-linked n-acetylglucosamine heidelberg research center muscle-specific transcription factors g13-mediated signaling pathway hdac4-nt-specific antibody institutional subscriptions read hypertrophy-related contractile dysfunction short-term pressure overload dim-c-p-phoh nuclear orphan receptor author correspondence social media decreased nr4a1-dependent activation myh6–cre transgenic mice mef2d expression constructs springerlink instant access increased o-glcnac levels received grant support cardiovascular research histone deacetylase signaling increased protein o-glcnac alter cardiac contractility calcium release channel mef2 transcription factor permissions cam kinase ii

Questions {❓}

  • Takotsubo syndrome: underdiagnosed, underestimated but understood?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway
         description:A proteolytically derived fragment of the epigenetic regulator HDAC4 protects the heart through transcriptional repression of the hexosamine biosynthetic pathway, thereby inhibiting protein O-GlcNAcylation and maintaining normal calcium handling and contractility of cardiomyocytes. The stress-responsive epigenetic repressor histone deacetylase 4 (HDAC4) regulates cardiac gene expression. Here we show that the levels of an N-terminal proteolytically derived fragment of HDAC4, termed HDAC4-NT, are lower in failing mouse hearts than in healthy control hearts. Virus-mediated transfer of the portion of the Hdac4 gene encoding HDAC4-NT into the mouse myocardium protected the heart from remodeling and failure; this was associated with decreased expression of Nr4a1, which encodes a nuclear orphan receptor, and decreased NR4A1-dependent activation of the hexosamine biosynthetic pathway (HBP). Conversely, exercise enhanced HDAC4-NT levels, and mice with a cardiomyocyte-specific deletion of Hdac4 show reduced exercise capacity, which was characterized by cardiac fatigue and increased expression of Nr4a1. Mechanistically, we found that NR4A1 negatively regulated contractile function in a manner that depended on the HBP and the calcium sensor STIM1. Our work describes a new regulatory axis in which epigenetic regulation of a metabolic pathway affects calcium handling. Activation of this axis during intermittent physiological stress promotes cardiac function, whereas its impairment in sustained pathological cardiac stress leads to heart failure.
         datePublished:2017-12-11T00:00:00Z
         dateModified:2017-12-11T00:00:00Z
         pageStart:62
         pageEnd:72
         sameAs:https://doi.org/10.1038/nm.4452
         keywords:
            Cardiomyopathies
            Epigenetics
            Heart failure
            Metabolism
            Biomedicine
            general
            Cancer Research
            Metabolic Diseases
            Infectious Diseases
            Molecular Medicine
            Neurosciences
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnm.4452/MediaObjects/41591_2018_BFnm4452_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnm.4452/MediaObjects/41591_2018_BFnm4452_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnm.4452/MediaObjects/41591_2018_BFnm4452_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnm.4452/MediaObjects/41591_2018_BFnm4452_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnm.4452/MediaObjects/41591_2018_BFnm4452_Fig5_HTML.jpg
         isPartOf:
            name:Nature Medicine
            issn:
               1546-170X
               1078-8956
            volumeNumber:24
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer New York
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Lorenz H Lehmann
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Heidelberg University
                     address:
                        name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zegeye H Jebessa
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Michael M Kreusser
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Heidelberg University
                     address:
                        name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Axel Horsch
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Tao He
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mariya Kronlage
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Heidelberg University
                     address:
                        name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Matthias Dewenter
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Viviana Sramek
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ulrike Oehl
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jutta Krebs-Haupenthal
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Albert H von der Lieth
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Andrea Schmidt
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qiang Sun
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Julia Ritterhoff
               affiliation:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Heidelberg University
                     address:
                        name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daniel Finke
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Heidelberg University
                     address:
                        name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mirko Völkers
               affiliation:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Heidelberg University
                     address:
                        name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Andreas Jungmann
               affiliation:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Heidelberg University
                     address:
                        name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sven W Sauer
               affiliation:
                     name:Center for Child and Adolescent Medicine, Heidelberg University
                     address:
                        name:Department I, Center for Child and Adolescent Medicine, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Christian Thiel
               affiliation:
                     name:Center for Child and Adolescent Medicine, Heidelberg University
                     address:
                        name:Department I, Center for Child and Adolescent Medicine, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alexander Nickel
               affiliation:
                     name:Saarland University Hospital
                     address:
                        name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
                        type:PostalAddress
                     type:Organization
                     name:University Hospital Würzburg
                     address:
                        name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Michael Kohlhaas
               affiliation:
                     name:Saarland University Hospital
                     address:
                        name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
                        type:PostalAddress
                     type:Organization
                     name:University Hospital Würzburg
                     address:
                        name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Michaela Schäfer
               affiliation:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University
                     address:
                        name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University, Neuherberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Carsten Sticht
               affiliation:
                     name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University
                     address:
                        name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Christoph Maack
               affiliation:
                     name:Saarland University Hospital
                     address:
                        name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
                        type:PostalAddress
                     type:Organization
                     name:University Hospital Würzburg
                     address:
                        name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Norbert Gretz
               affiliation:
                     name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University
                     address:
                        name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Michael Wagner
               affiliation:
                     name:Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
                     address:
                        name:Department of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ali El-Armouche
               affiliation:
                     name:Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
                     address:
                        name:Department of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lars S Maier
               affiliation:
                     name:University Hospital Regensburg
                     address:
                        name:Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Juan E Camacho Londoño
               affiliation:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Institute of Pharmacology, Heidelberg University
                     address:
                        name:Institute of Pharmacology, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Benjamin Meder
               affiliation:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Heidelberg University
                     address:
                        name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marc Freichel
               affiliation:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Institute of Pharmacology, Heidelberg University
                     address:
                        name:Institute of Pharmacology, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hermann-Josef Gröne
               affiliation:
                     name:German Cancer Research Center
                     address:
                        name:Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Patrick Most
               affiliation:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Heidelberg University
                     address:
                        name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Oliver J Müller
               url:http://orcid.org/0000-0001-8223-2638
               affiliation:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Heidelberg University
                     address:
                        name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University Hospital Würzburg
                     address:
                        name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Kiel
                     address:
                        name:Department of Internal Medicine III, University of Kiel, Kiel, Germany
                        type:PostalAddress
                     type:Organization
                     name:partner site Hamburg/Kiel/Lübeck
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Kiel, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Stephan Herzig
               affiliation:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University
                     address:
                        name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University, Neuherberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eileen E M Furlong
               url:http://orcid.org/0000-0002-9544-8339
               affiliation:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:European Molecular Biology Laboratory, Genome Biology Unit
                     address:
                        name:European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hugo A Katus
               affiliation:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Heidelberg University
                     address:
                        name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Johannes Backs
               url:http://orcid.org/0000-0002-2322-2699
               affiliation:
                     name:Heidelberg University
                     address:
                        name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                     address:
                        name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway
      description:A proteolytically derived fragment of the epigenetic regulator HDAC4 protects the heart through transcriptional repression of the hexosamine biosynthetic pathway, thereby inhibiting protein O-GlcNAcylation and maintaining normal calcium handling and contractility of cardiomyocytes. The stress-responsive epigenetic repressor histone deacetylase 4 (HDAC4) regulates cardiac gene expression. Here we show that the levels of an N-terminal proteolytically derived fragment of HDAC4, termed HDAC4-NT, are lower in failing mouse hearts than in healthy control hearts. Virus-mediated transfer of the portion of the Hdac4 gene encoding HDAC4-NT into the mouse myocardium protected the heart from remodeling and failure; this was associated with decreased expression of Nr4a1, which encodes a nuclear orphan receptor, and decreased NR4A1-dependent activation of the hexosamine biosynthetic pathway (HBP). Conversely, exercise enhanced HDAC4-NT levels, and mice with a cardiomyocyte-specific deletion of Hdac4 show reduced exercise capacity, which was characterized by cardiac fatigue and increased expression of Nr4a1. Mechanistically, we found that NR4A1 negatively regulated contractile function in a manner that depended on the HBP and the calcium sensor STIM1. Our work describes a new regulatory axis in which epigenetic regulation of a metabolic pathway affects calcium handling. Activation of this axis during intermittent physiological stress promotes cardiac function, whereas its impairment in sustained pathological cardiac stress leads to heart failure.
      datePublished:2017-12-11T00:00:00Z
      dateModified:2017-12-11T00:00:00Z
      pageStart:62
      pageEnd:72
      sameAs:https://doi.org/10.1038/nm.4452
      keywords:
         Cardiomyopathies
         Epigenetics
         Heart failure
         Metabolism
         Biomedicine
         general
         Cancer Research
         Metabolic Diseases
         Infectious Diseases
         Molecular Medicine
         Neurosciences
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnm.4452/MediaObjects/41591_2018_BFnm4452_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnm.4452/MediaObjects/41591_2018_BFnm4452_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnm.4452/MediaObjects/41591_2018_BFnm4452_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnm.4452/MediaObjects/41591_2018_BFnm4452_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnm.4452/MediaObjects/41591_2018_BFnm4452_Fig5_HTML.jpg
      isPartOf:
         name:Nature Medicine
         issn:
            1546-170X
            1078-8956
         volumeNumber:24
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Lorenz H Lehmann
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Heidelberg University
                  address:
                     name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zegeye H Jebessa
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michael M Kreusser
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Heidelberg University
                  address:
                     name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Axel Horsch
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tao He
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mariya Kronlage
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Heidelberg University
                  address:
                     name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Matthias Dewenter
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Viviana Sramek
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ulrike Oehl
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jutta Krebs-Haupenthal
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Albert H von der Lieth
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andrea Schmidt
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qiang Sun
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Julia Ritterhoff
            affiliation:
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Heidelberg University
                  address:
                     name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel Finke
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Heidelberg University
                  address:
                     name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mirko Völkers
            affiliation:
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Heidelberg University
                  address:
                     name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andreas Jungmann
            affiliation:
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Heidelberg University
                  address:
                     name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sven W Sauer
            affiliation:
                  name:Center for Child and Adolescent Medicine, Heidelberg University
                  address:
                     name:Department I, Center for Child and Adolescent Medicine, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christian Thiel
            affiliation:
                  name:Center for Child and Adolescent Medicine, Heidelberg University
                  address:
                     name:Department I, Center for Child and Adolescent Medicine, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alexander Nickel
            affiliation:
                  name:Saarland University Hospital
                  address:
                     name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
                     type:PostalAddress
                  type:Organization
                  name:University Hospital Würzburg
                  address:
                     name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michael Kohlhaas
            affiliation:
                  name:Saarland University Hospital
                  address:
                     name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
                     type:PostalAddress
                  type:Organization
                  name:University Hospital Würzburg
                  address:
                     name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michaela Schäfer
            affiliation:
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University
                  address:
                     name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University, Neuherberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carsten Sticht
            affiliation:
                  name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University
                  address:
                     name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christoph Maack
            affiliation:
                  name:Saarland University Hospital
                  address:
                     name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
                     type:PostalAddress
                  type:Organization
                  name:University Hospital Würzburg
                  address:
                     name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Norbert Gretz
            affiliation:
                  name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University
                  address:
                     name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michael Wagner
            affiliation:
                  name:Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
                  address:
                     name:Department of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ali El-Armouche
            affiliation:
                  name:Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
                  address:
                     name:Department of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lars S Maier
            affiliation:
                  name:University Hospital Regensburg
                  address:
                     name:Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Juan E Camacho Londoño
            affiliation:
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Institute of Pharmacology, Heidelberg University
                  address:
                     name:Institute of Pharmacology, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Benjamin Meder
            affiliation:
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Heidelberg University
                  address:
                     name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marc Freichel
            affiliation:
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Institute of Pharmacology, Heidelberg University
                  address:
                     name:Institute of Pharmacology, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hermann-Josef Gröne
            affiliation:
                  name:German Cancer Research Center
                  address:
                     name:Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Patrick Most
            affiliation:
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Heidelberg University
                  address:
                     name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Oliver J Müller
            url:http://orcid.org/0000-0001-8223-2638
            affiliation:
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Heidelberg University
                  address:
                     name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University Hospital Würzburg
                  address:
                     name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Kiel
                  address:
                     name:Department of Internal Medicine III, University of Kiel, Kiel, Germany
                     type:PostalAddress
                  type:Organization
                  name:partner site Hamburg/Kiel/Lübeck
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Kiel, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stephan Herzig
            affiliation:
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University
                  address:
                     name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University, Neuherberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eileen E M Furlong
            url:http://orcid.org/0000-0002-9544-8339
            affiliation:
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:European Molecular Biology Laboratory, Genome Biology Unit
                  address:
                     name:European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hugo A Katus
            affiliation:
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Heidelberg University
                  address:
                     name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Johannes Backs
            url:http://orcid.org/0000-0002-2322-2699
            affiliation:
                  name:Heidelberg University
                  address:
                     name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
                  address:
                     name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Medicine
      issn:
         1546-170X
         1078-8956
      volumeNumber:24
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:Center for Child and Adolescent Medicine, Heidelberg University
      address:
         name:Department I, Center for Child and Adolescent Medicine, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:Center for Child and Adolescent Medicine, Heidelberg University
      address:
         name:Department I, Center for Child and Adolescent Medicine, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:Saarland University Hospital
      address:
         name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
         type:PostalAddress
      name:University Hospital Würzburg
      address:
         name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
         type:PostalAddress
      name:Saarland University Hospital
      address:
         name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
         type:PostalAddress
      name:University Hospital Würzburg
      address:
         name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University
      address:
         name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University, Neuherberg, Germany
         type:PostalAddress
      name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University
      address:
         name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
         type:PostalAddress
      name:Saarland University Hospital
      address:
         name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
         type:PostalAddress
      name:University Hospital Würzburg
      address:
         name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
         type:PostalAddress
      name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University
      address:
         name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
         type:PostalAddress
      name:Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
      address:
         name:Department of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
         type:PostalAddress
      name:Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
      address:
         name:Department of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
         type:PostalAddress
      name:University Hospital Regensburg
      address:
         name:Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Institute of Pharmacology, Heidelberg University
      address:
         name:Institute of Pharmacology, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Institute of Pharmacology, Heidelberg University
      address:
         name:Institute of Pharmacology, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Cancer Research Center
      address:
         name:Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:University Hospital Würzburg
      address:
         name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
         type:PostalAddress
      name:University of Kiel
      address:
         name:Department of Internal Medicine III, University of Kiel, Kiel, Germany
         type:PostalAddress
      name:partner site Hamburg/Kiel/Lübeck
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Kiel, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University
      address:
         name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University, Neuherberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:European Molecular Biology Laboratory, Genome Biology Unit
      address:
         name:European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University
      address:
         name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
         type:PostalAddress
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
      address:
         name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Lorenz H Lehmann
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University
            address:
               name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Zegeye H Jebessa
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Michael M Kreusser
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University
            address:
               name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Axel Horsch
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Tao He
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Mariya Kronlage
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University
            address:
               name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Matthias Dewenter
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Viviana Sramek
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Ulrike Oehl
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Jutta Krebs-Haupenthal
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Albert H von der Lieth
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Andrea Schmidt
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Qiang Sun
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Julia Ritterhoff
      affiliation:
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University
            address:
               name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Daniel Finke
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University
            address:
               name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Mirko Völkers
      affiliation:
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University
            address:
               name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Andreas Jungmann
      affiliation:
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University
            address:
               name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Sven W Sauer
      affiliation:
            name:Center for Child and Adolescent Medicine, Heidelberg University
            address:
               name:Department I, Center for Child and Adolescent Medicine, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Christian Thiel
      affiliation:
            name:Center for Child and Adolescent Medicine, Heidelberg University
            address:
               name:Department I, Center for Child and Adolescent Medicine, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Alexander Nickel
      affiliation:
            name:Saarland University Hospital
            address:
               name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
               type:PostalAddress
            type:Organization
            name:University Hospital Würzburg
            address:
               name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
               type:PostalAddress
            type:Organization
      name:Michael Kohlhaas
      affiliation:
            name:Saarland University Hospital
            address:
               name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
               type:PostalAddress
            type:Organization
            name:University Hospital Würzburg
            address:
               name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
               type:PostalAddress
            type:Organization
      name:Michaela Schäfer
      affiliation:
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University
            address:
               name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University, Neuherberg, Germany
               type:PostalAddress
            type:Organization
      name:Carsten Sticht
      affiliation:
            name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University
            address:
               name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
               type:PostalAddress
            type:Organization
      name:Christoph Maack
      affiliation:
            name:Saarland University Hospital
            address:
               name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
               type:PostalAddress
            type:Organization
            name:University Hospital Würzburg
            address:
               name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
               type:PostalAddress
            type:Organization
      name:Norbert Gretz
      affiliation:
            name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University
            address:
               name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
               type:PostalAddress
            type:Organization
      name:Michael Wagner
      affiliation:
            name:Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
            address:
               name:Department of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
               type:PostalAddress
            type:Organization
      name:Ali El-Armouche
      affiliation:
            name:Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
            address:
               name:Department of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
               type:PostalAddress
            type:Organization
      name:Lars S Maier
      affiliation:
            name:University Hospital Regensburg
            address:
               name:Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
               type:PostalAddress
            type:Organization
      name:Juan E Camacho Londoño
      affiliation:
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Institute of Pharmacology, Heidelberg University
            address:
               name:Institute of Pharmacology, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Benjamin Meder
      affiliation:
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University
            address:
               name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Marc Freichel
      affiliation:
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Institute of Pharmacology, Heidelberg University
            address:
               name:Institute of Pharmacology, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Hermann-Josef Gröne
      affiliation:
            name:German Cancer Research Center
            address:
               name:Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Patrick Most
      affiliation:
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University
            address:
               name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Oliver J Müller
      url:http://orcid.org/0000-0001-8223-2638
      affiliation:
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University
            address:
               name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:University Hospital Würzburg
            address:
               name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
               type:PostalAddress
            type:Organization
            name:University of Kiel
            address:
               name:Department of Internal Medicine III, University of Kiel, Kiel, Germany
               type:PostalAddress
            type:Organization
            name:partner site Hamburg/Kiel/Lübeck
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Kiel, Germany
               type:PostalAddress
            type:Organization
      name:Stephan Herzig
      affiliation:
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University
            address:
               name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University, Neuherberg, Germany
               type:PostalAddress
            type:Organization
      name:Eileen E M Furlong
      url:http://orcid.org/0000-0002-9544-8339
      affiliation:
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:European Molecular Biology Laboratory, Genome Biology Unit
            address:
               name:European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Hugo A Katus
      affiliation:
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University
            address:
               name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Johannes Backs
      url:http://orcid.org/0000-0002-2322-2699
      affiliation:
            name:Heidelberg University
            address:
               name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
            address:
               name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
      name:Department I, Center for Child and Adolescent Medicine, Heidelberg University, Heidelberg, Germany
      name:Department I, Center for Child and Adolescent Medicine, Heidelberg University, Heidelberg, Germany
      name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
      name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
      name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
      name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University, Neuherberg, Germany
      name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
      name:Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
      name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
      name:Medical Research Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
      name:Department of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
      name:Department of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
      name:Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Institute of Pharmacology, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Institute of Pharmacology, Heidelberg University, Heidelberg, Germany
      name:Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
      name:Department of Translational Science, Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Würzburg, Germany
      name:Department of Internal Medicine III, University of Kiel, Kiel, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Kiel, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University, Neuherberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
      name:Department of Cardiology, Heidelberg University, Heidelberg, Germany
      name:Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(175)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

5.72s.