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         description:TH-17 cells are a distinct lineage of proinflammatory T helper cells that are essential for autoimmune disease. In mice, commitment to the TH-17 lineage is dependent on transforming growth factor-β and interleukin 6 (IL-6). Here we demonstrate that IL-23 and IL-1β induced the development of human TH-17 cells expressing IL-17A, IL-17F, IL-22, IL-26, interferon-γ, the chemokine CCL20 and transcription factor RORγt. In situ, TH-17 cells were identified by expression of the IL-23 receptor and the memory T cell marker CD45RO. Psoriatic skin lesions contained IL-23-producing dendritic cells and were enriched in the cytokines produced by human TH-17 cells that promote the production of antimicrobial peptides in human keratinocytes. Our data collectively indicate that human and mouse TH-17 cells require distinct factors during differentiation and that human TH-17 cells may regulate innate immunity in epithelial cells.
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      headline:Development, cytokine profile and function of human interleukin 17–producing helper T cells
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      name:Wendy M Blumenschein
      affiliation:
            name:Schering-Plough Biopharma (formerly DNAX Research)
            address:
               name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Jeanine D Mattson
      affiliation:
            name:Schering-Plough Biopharma (formerly DNAX Research)
            address:
               name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Beth Basham
      affiliation:
            name:Schering-Plough Biopharma (formerly DNAX Research)
            address:
               name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Kathleen Smith
      affiliation:
            name:Schering-Plough Biopharma (formerly DNAX Research)
            address:
               name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Taiying Chen
      affiliation:
            name:Schering-Plough Biopharma (formerly DNAX Research)
            address:
               name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Franck Morel
      affiliation:
            name:Laboratoire Cytokines et Inflammation EA 3806, Universite de Poitiers, Centre Hospitalier Universitaire de Poitiers, Pole Biologie Sante, Pineau
            address:
               name:Laboratoire Cytokines et Inflammation EA 3806, Universite de Poitiers, Centre Hospitalier Universitaire de Poitiers, Pole Biologie Sante, Pineau, Poitiers, France
               type:PostalAddress
            type:Organization
      name:Jean-Claude Lecron
      affiliation:
            name:Laboratoire Cytokines et Inflammation EA 3806, Universite de Poitiers, Centre Hospitalier Universitaire de Poitiers, Pole Biologie Sante, Pineau
            address:
               name:Laboratoire Cytokines et Inflammation EA 3806, Universite de Poitiers, Centre Hospitalier Universitaire de Poitiers, Pole Biologie Sante, Pineau, Poitiers, France
               type:PostalAddress
            type:Organization
      name:Robert A Kastelein
      affiliation:
            name:Schering-Plough Biopharma (formerly DNAX Research)
            address:
               name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Daniel J Cua
      affiliation:
            name:Schering-Plough Biopharma (formerly DNAX Research)
            address:
               name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Terrill K McClanahan
      affiliation:
            name:Schering-Plough Biopharma (formerly DNAX Research)
            address:
               name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Edward P Bowman
      affiliation:
            name:Schering-Plough Biopharma (formerly DNAX Research)
            address:
               name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Rene de Waal Malefyt
      affiliation:
            name:Schering-Plough Biopharma (formerly DNAX Research)
            address:
               name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Present address: Entelos, Foster City, California 94404, USA.,
      name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Laboratoire Cytokines et Inflammation EA 3806, Universite de Poitiers, Centre Hospitalier Universitaire de Poitiers, Pole Biologie Sante, Pineau, Poitiers, France
      name:Laboratoire Cytokines et Inflammation EA 3806, Universite de Poitiers, Centre Hospitalier Universitaire de Poitiers, Pole Biologie Sante, Pineau, Poitiers, France
      name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
WebPageElement:
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Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref