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We are analyzing https://www.nature.com/articles/ni1497.

Title:
Development, cytokine profile and function of human interleukin 17–producing helper T cells | Nature Immunology
Description:
TH-17 cells are a distinct lineage of proinflammatory T helper cells that are essential for autoimmune disease. In mice, commitment to the TH-17 lineage is dependent on transforming growth factor-β and interleukin 6 (IL-6). Here we demonstrate that IL-23 and IL-1β induced the development of human TH-17 cells expressing IL-17A, IL-17F, IL-22, IL-26, interferon-γ, the chemokine CCL20 and transcription factor RORγt. In situ, TH-17 cells were identified by expression of the IL-23 receptor and the memory T cell marker CD45RO. Psoriatic skin lesions contained IL-23-producing dendritic cells and were enriched in the cytokines produced by human TH-17 cells that promote the production of antimicrobial peptides in human keratinocytes. Our data collectively indicate that human and mouse TH-17 cells require distinct factors during differentiation and that human TH-17 cells may regulate innate immunity in epithelial cells.
Website Age:
30 years and 10 months (reg. 1994-08-11).

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  • Science
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article, pubmed, google, scholar, cas, cells, nature, interleukin, immunol, human, med, cell, central, receptor, inflammation, exp, cytokine, helper, differentiation, access, nat, content, development, distinct, expression, antimicrobial, psoriasis, research, immunology, producing, immunity, cookies, autoimmune, induces, inflammatory, privacy, data, chan, waal, malefyt, lineage, proinflammatory, epithelial, role, biol, essential, information, boniface, chemokine, ilproducing,

Topics {✒️}

nature portfolio permissions reprints privacy policy advertising medical research council social media transforming growth factor-β nature 383 nature 445 nature 421 nature 441 nature discovery research dnax research cell–mediated tissue damage de waal malefyt author correspondence central nervous system data protection jean-claude lecron springerlink instant access content interleukins 1β transcription factor rorγt il-20r2-dependent mechanisms permissions personal data interferon-γ synergize inflammatory cell response data collectively lymphokine secretion lead biological activities similar cell-mediated colitis cc-chemokine receptor 6 universite de poitiers privacy induces autoimmune inflammation cell marker cd45ro issue learn lung cxc chemokine human β-defensins mediate autoimmune encephalomyelitis antimicrobial immune response il-1β induced joint autoimmune inflammation inflamed epithelial surfaces receptor complex composed european economic area institutional subscriptions read reciprocal developmental pathways cryptococcus neoformans infection

Schema {🗺️}

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      headline:Development, cytokine profile and function of human interleukin 17–producing helper T cells
      description:TH-17 cells are a distinct lineage of proinflammatory T helper cells that are essential for autoimmune disease. In mice, commitment to the TH-17 lineage is dependent on transforming growth factor-β and interleukin 6 (IL-6). Here we demonstrate that IL-23 and IL-1β induced the development of human TH-17 cells expressing IL-17A, IL-17F, IL-22, IL-26, interferon-γ, the chemokine CCL20 and transcription factor RORγt. In situ, TH-17 cells were identified by expression of the IL-23 receptor and the memory T cell marker CD45RO. Psoriatic skin lesions contained IL-23-producing dendritic cells and were enriched in the cytokines produced by human TH-17 cells that promote the production of antimicrobial peptides in human keratinocytes. Our data collectively indicate that human and mouse TH-17 cells require distinct factors during differentiation and that human TH-17 cells may regulate innate immunity in epithelial cells.
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      name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
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      name:Laboratoire Cytokines et Inflammation EA 3806, Universite de Poitiers, Centre Hospitalier Universitaire de Poitiers, Pole Biologie Sante, Pineau, Poitiers, France
      name:Laboratoire Cytokines et Inflammation EA 3806, Universite de Poitiers, Centre Hospitalier Universitaire de Poitiers, Pole Biologie Sante, Pineau, Poitiers, France
      name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
      name:Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, USA
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