NATURE . COM {
}
Title:
Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages | Nature Immunology
Description:
CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (TH1) or TH2 lineages and instead favor the idea of a distinct effector lineage we call
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Education
- Science
- Telecommunications
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🚀🌠 Tremendous Traffic: 10M - 20M visitors per month
Based on our best estimate, this website will receive around 16,942,715 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$213,500 per month
Our calculations suggest that Nature.com earns between $142,361 and $391,492 monthly online from display advertisements.
Keywords {🔍}
article, cas, google, scholar, cells, nature, immunol, murphy, cell, interleukin, autoimmune, immunity, development, stat, tbet, access, mice, cytokine, content, immunology, helper, ifnγ, lineage, distinct, exp, med, inflammation, cookies, naive, nat, expression, science, privacy, data, effector, type, role, rev, responses, differentiation, production, encephalomyelitis, induction, receptor, information, producing, weaver, interferonγ, signaling, critical,
Topics {✒️}
nature portfolio permissions reprints privacy policy th17 cell-derived tgf-β1 advertising social media nature 421 nature author information authors jak-stat signaling pathway tlr-activated dendritic cells author correspondence proximal ifn-gamma promoter t-helper 1 development–resolved silencing t-bet defines disrupted interferon-γ genes disrupted ifn-γ gene delayed-type hypersensitivity responses cd4+cd8+tcrlo thymocytes data protection promote ifn-γ production springerlink instant access permissions il-12p35-deficient mice counting antigen-specific cd8 personal data rocaglamide promotes infiltration il-4-independent mechanism joint autoimmune inflammation th1 development mediated present data experimental autoimmune encephalomyelitis induces autoimmune inflammation enhanced th1 development th17 cell heterogeneity biological activities similar privacy transcription factor gata-3 il-26+ th17 intermediates competing financial interests il-17-producing cells shared developmental pathway issue learn il-12-dependent selection ifn-γ plays ifn-α signal ifn-γ production interleukin-23 promotes independent mechanisms european economic area
Schema {🗺️}
WebPage:
mainEntity:
headline:Interleukin 17âproducing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
description:CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (TH1) or TH2 lineages and instead favor the idea of a distinct effector lineage we call 'TH-17'. The development of TH-17 cells from naive precursor cells was potently inhibited by interferon-γ (IFN-γ) and IL-4, whereas committed TH-17 cells were resistant to suppression by TH1 or TH2 cytokines. In the absence of IFN-γ and IL-4, IL-23 induced naive precursor cells to differentiate into TH-17 cells independently of the transcription factors STAT1, T-bet, STAT4 and STAT6. These findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
datePublished:2005-10-02T00:00:00Z
dateModified:2005-10-02T00:00:00Z
pageStart:1123
pageEnd:1132
sameAs:https://doi.org/10.1038/ni1254
keywords:
Biomedicine
general
Immunology
Infectious Diseases
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig6_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig7_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig8_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig9_HTML.jpg
isPartOf:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:6
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Laurie E Harrington
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Robin D Hatton
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Paul R Mangan
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Henrietta Turner
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Theresa L Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
type:Person
name:Kenneth M Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
type:Person
name:Casey T Weaver
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Interleukin 17âproducing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
description:CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (TH1) or TH2 lineages and instead favor the idea of a distinct effector lineage we call 'TH-17'. The development of TH-17 cells from naive precursor cells was potently inhibited by interferon-γ (IFN-γ) and IL-4, whereas committed TH-17 cells were resistant to suppression by TH1 or TH2 cytokines. In the absence of IFN-γ and IL-4, IL-23 induced naive precursor cells to differentiate into TH-17 cells independently of the transcription factors STAT1, T-bet, STAT4 and STAT6. These findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
datePublished:2005-10-02T00:00:00Z
dateModified:2005-10-02T00:00:00Z
pageStart:1123
pageEnd:1132
sameAs:https://doi.org/10.1038/ni1254
keywords:
Biomedicine
general
Immunology
Infectious Diseases
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig6_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig7_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig8_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig9_HTML.jpg
isPartOf:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:6
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Laurie E Harrington
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Robin D Hatton
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Paul R Mangan
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Henrietta Turner
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Theresa L Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
type:Person
name:Kenneth M Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
type:Person
name:Casey T Weaver
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:6
Organization:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Laurie E Harrington
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
name:Robin D Hatton
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
name:Paul R Mangan
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
name:Henrietta Turner
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
name:Theresa L Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
name:Kenneth M Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
name:Casey T Weaver
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(127)
- Revenue of https://link.springer.com/article/10.1038/ni1254?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle
- How much cash flow does https://doi.org/10.1146%2Fannurev.iy.07.040189.001045 have monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Th1%20and%20Th2%20cells%3A%20Different%20patterns%20of%20lymphokine%20secretion%20leads%20to%20different%20functional%20properties&journal=Annu.%20Rev.%20Immunol.&doi=10.1146%2Fannurev.iy.07.040189.001045&volume=7&pages=145-173&publication_year=1989&author=Mosmann%2CT&author=Coffman%2CR pull in monthly?
- How much does https://doi.org/10.1016%2F0167-5699%2888%2991308-4 pull in?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=A%20functional%20dichotomy%20in%20CD4%2B%20T%20lymphocytes&journal=Immunol.%20Today&doi=10.1016%2F0167-5699%2888%2991308-4&volume=9&pages=268-277&publication_year=1988&author=Bottomly%2CK?
- Get to know what's the income of https://doi.org/10.1038%2Fnri954
- What's the profit of http://scholar.google.com/scholar_lookup?&title=The%20lineage%20decisions%20of%20helper%20T%20cells&journal=Nat.%20Rev.%20Immunol.&doi=10.1038%2Fnri954&volume=2&pages=933-944&publication_year=2002&author=Murphy%2CKM&author=Reiner%2CSL?
- How profitable is https://doi.org/10.1016%2FS1074-7613%2802%2900331-X?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Further%20checkpoints%20in%20Th1%20development&journal=Immunity&doi=10.1016%2FS1074-7613%2802%2900331-X&volume=16&pages=755-758&publication_year=2002&author=Robinson%2CDS&author=O%27Garra%2CA produce monthly?
- Explore the financials of https://doi.org/10.1146%2Fannurev.immunol.21.120601.140942
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Molecular%20mechanisms%20regulating%20Th1%20immune%20responses&journal=Annu.%20Rev.%20Immunol.&doi=10.1146%2Fannurev.immunol.21.120601.140942&volume=21&pages=713-758&publication_year=2003&author=Szabo%2CSJ&author=Sullivan%2CBM&author=Peng%2CSL&author=Glimcher%2CLH?
- How much revenue does https://doi.org/10.1038%2Fni0703-616 bring in?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=An%20epigenetic%20view%20of%20helper%20T%20cell%20differentiation&journal=Nat.%20Immunol.&doi=10.1038%2Fni0703-616&volume=4&pages=616-623&publication_year=2003&author=Ansel%2CKM&author=Lee%2CDU&author=Rao%2CA
- Discover the revenue of https://doi.org/10.1084%2Fjem.185.5.817
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20the%20interleukin%20%28IL%29-12R%CE%B22%20subunit%20expression%20in%20developing%20T%20helper%201%20%28Th1%29%20and%20Th2%20cells&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.185.5.817&volume=185&pages=817-824&publication_year=1997&author=Szabo%2CSJ&author=Dighe%2CAS&author=Gubler%2CU&author=Murphy%2CKM produce monthly?
- How much does https://doi.org/10.1016%2FS1074-7613%2800%2980671-8 bring in each month?
- How much money does http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20Th1%20development%20mediated%20by%20GATA-3%20through%20an%20IL-4-independent%20mechanism&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980671-8&volume=9&pages=745-755&publication_year=1998&author=Ouyang%2CW generate?
- https://doi.org/10.1016%2FS1074-7613%2802%2900324-2 income
- How much income is http://scholar.google.com/scholar_lookup?&title=IL-27%2C%20a%20heterodimeric%20cytokine%20composed%20of%20EBI3%20and%20p28%20protein%2C%20induces%20proliferation%20of%20naive%20CD4%2B%20T%20cells&journal=Immunity&doi=10.1016%2FS1074-7613%2802%2900324-2&volume=16&pages=779-790&publication_year=2002&author=Pflanz%2CS earning monthly?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=The%20transcription%20factor%20GATA-3%20is%20necessary%20and%20sufficient%20for%20Th2%20cytokine%20gene%20expression%20in%20CD4%20T%20cells&journal=Cell&volume=89&pages=587-596&publication_year=1997&author=Zheng%2CW&author=Flavell%2CRA
- How much does https://doi.org/10.1016%2FS1074-7613%2800%2980156-9 generate monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Stat6-independent%20GATA-3%20autoactivation%20directs%20IL-4-independent%20Th2%20development%20and%20commitment&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980156-9&volume=12&pages=27-37&publication_year=2000&author=Ouyang%2CW pull in monthly?
- Discover the revenue of https://doi.org/10.1084%2Fjem.20041257
- How much profit does http://scholar.google.com/scholar_lookup?&title=IL-23%20drives%20a%20pathogenic%20T%20cell%20population%20that%20induces%20autoimmune%20inflammation&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20041257&volume=201&pages=233-240&publication_year=2005&author=Langrish%2CCL make?
- What are the earnings of https://doi.org/10.1038%2Fnature01355?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Interleukin-23%20rather%20than%20interleukin-12%20is%20the%20critical%20cytokine%20for%20autoimmune%20inflammation%20of%20the%20brain&journal=Nature&doi=10.1038%2Fnature01355&volume=421&pages=744-748&publication_year=2003&author=Cua%2CDJ
- Get to know https://doi.org/10.1084%2Fjem.20030896's earnings
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Divergent%20pro-%20and%20antiinflammatory%20roles%20for%20IL-23%20and%20IL-12%20in%20joint%20autoimmune%20inflammation&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20030896&volume=198&pages=1951-1957&publication_year=2003&author=Murphy%2CCA?
- How much income is https://doi.org/10.1074%2Fjbc.M207577200 earning monthly?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Interleukin-23%20promotes%20a%20distinct%20CD4%20T%20cell%20activation%20state%20characterized%20by%20the%20production%20of%20interleukin-17&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M207577200&volume=278&pages=1910-1914&publication_year=2003&author=Aggarwal%2CS&author=Ghilardi%2CN&author=Xie%2CMH&author=de%20Sauvage%2CFJ&author=Gurney%2CAL each month?
- How profitable is https://doi.org/10.4049%2Fjimmunol.169.12.7104?
- How much money does http://scholar.google.com/scholar_lookup?&title=IL-12p35-deficient%20mice%20are%20susceptible%20to%20experimental%20autoimmune%20encephalomyelitis%3A%20evidence%20for%20redundancy%20in%20the%20IL-12%20system%20in%20the%20induction%20of%20central%20nervous%20system%20autoimmune%20demyelination&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.169.12.7104&volume=169&pages=7104-7110&publication_year=2002&author=Gran%2CB make?
- Income figures for https://doi.org/10.1084%2Fjem.20042279
- How much profit is http://scholar.google.com/scholar_lookup?&title=IL-12-%20and%20IL-23-induced%20T%20helper%20cell%20subsets%3A%20birds%20of%20the%20same%20feather%20flock%20together&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20042279&volume=201&pages=169-171&publication_year=2005&author=Bettelli%2CE&author=Kuchroo%2CVK making per month?
- How much does https://doi.org/10.1016%2FS1074-7613%2800%2900070-4 make?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Novel%20p19%20protein%20engages%20IL-12p40%20to%20form%20a%20cytokine%2C%20IL-23%2C%20with%20biological%20activities%20similar%20as%20well%20as%20distinct%20from%20IL-12&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2900070-4&volume=13&pages=715-725&publication_year=2000&author=Oppmann%2CB generate?
- Learn about the earnings of https://doi.org/10.4049%2Fjimmunol.168.11.5699
- See how much http://scholar.google.com/scholar_lookup?&title=A%20receptor%20for%20the%20heterodimeric%20cytokine%20IL-23%20is%20composed%20of%20IL-12Rbeta1%20and%20a%20novel%20cytokine%20receptor%20subunit%2C%20IL-23R&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.168.11.5699&volume=168&pages=5699-5708&publication_year=2002&author=Parham%2CC makes per month
- What's https://doi.org/10.1111%2Fj.0105-2896.2004.00214.x's gross income?
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=IL-12%20and%20IL-23%3A%20master%20regulators%20of%20innate%20and%20adaptive%20immunity&journal=Immunol.%20Rev.&doi=10.1111%2Fj.0105-2896.2004.00214.x&volume=202&pages=96-105&publication_year=2004&author=Langrish%2CCL
- Get to know https://doi.org/10.1073%2Fpnas.2536517100's earnings
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=IL-27%20regulates%20IL-12%20responsiveness%20of%20naive%20CD4%2B%20T%20cells%20through%20Stat1-dependent%20and%20-independent%20mechanisms&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.2536517100&volume=100&pages=15047-15052&publication_year=2003&author=Lucas%2CS&author=Ghilardi%2CN&author=Li%2CJ&author=de%20Sauvage%2CFJ
- What's the revenue for https://doi.org/10.1089%2F10799900360708632?
- How much does http://scholar.google.com/scholar_lookup?&title=IL-27%20and%20IFN-%CE%B1%20signal%20via%20Stat1%20and%20Stat3%20and%20induce%20T-Bet%20and%20IL-12R%CE%B22%20in%20naive%20T%20cells&journal=J.%20Interferon%20Cytokine%20Res.&doi=10.1089%2F10799900360708632&volume=23&pages=513-522&publication_year=2003&author=Hibbert%2CL&author=Pflanz%2CS&author=De%20Waal%20Malefyt%2CR&author=Kastelein%2CRA generate monthly?
- http://scholar.google.com/scholar_lookup?&title=Mice%20with%20a%20disrupted%20IFN-%CE%B3%20gene%20are%20susceptible%20to%20the%20induction%20of%20experimental%20autoimmune%20encephalomyelitis%20%28EAE%29&journal=J.%20Immunol.&volume=156&pages=5-7&publication_year=1996&author=Ferber%2CIA's revenue stream
- How profitable is http://scholar.google.com/scholar_lookup?&title=IFN-%CE%B3%20plays%20a%20critical%20down-regulatory%20role%20in%20the%20induction%20and%20effector%20phase%20of%20myelin%20oligodendrocyte%20glycoprotein-induced%20autoimmune%20encephalomyelitis&journal=J.%20Immunol.&volume=157&pages=3223-3227&publication_year=1996&author=Willenborg%2CDO&author=Fordham%2CS&author=Bernard%2CCC&author=Cowden%2CWB&author=Ramshaw%2CIA?
- How much money does https://doi.org/10.1016%2Fj.immuni.2004.08.018 make?
- How much does http://scholar.google.com/scholar_lookup?&title=Interleukin-17%20family%20members%20and%20inflammation&journal=Immunity&doi=10.1016%2Fj.immuni.2004.08.018&volume=21&pages=467-476&publication_year=2004&author=Kolls%2CJK&author=Linden%2CA rake in every month?
- What's the financial intake of https://doi.org/10.1126%2Fscience.8456301?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Immune%20response%20in%20mice%20that%20lack%20the%20interferon-%CE%B3%20receptor&journal=Science&doi=10.1126%2Fscience.8456301&volume=259&pages=1742-1745&publication_year=1993&author=Huang%2CS?
- What's the monthly income of https://doi.org/10.1126%2Fscience.8456300?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Multiple%20defects%20of%20immune%20cell%20function%20in%20mice%20with%20disrupted%20interferon-%CE%B3%20genes&journal=Science&doi=10.1126%2Fscience.8456300&volume=259&pages=1739-1742&publication_year=1993&author=Dalton%2CDK?
- What's the financial gain of https://doi.org/10.1016%2FS0092-8674%2800%2980702-3?
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=A%20novel%20transcription%20factor%2C%20T-bet%2C%20directs%20Th1%20lineage%20commitment&journal=Cell&doi=10.1016%2FS0092-8674%2800%2980702-3&volume=100&pages=655-669&publication_year=2000&author=Szabo%2CSJ
- How much does https://doi.org/10.1073%2Fpnas.261570598 net monthly?
- Revenue of http://scholar.google.com/scholar_lookup?&title=T-bet%20is%20rapidly%20induced%20by%20interferon-%CE%B3%20in%20lymphoid%20and%20myeloid%20cells&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.261570598&volume=98&pages=15137-15142&publication_year=2001&author=Lighvani%2CAA
- Monthly income for https://doi.org/10.1126%2Fscience.1059835
- How profitable is http://scholar.google.com/scholar_lookup?&title=Role%20of%20T-bet%20in%20commitment%20of%20TH1%20cells%20before%20IL-12-dependent%20selection&journal=Science&doi=10.1126%2Fscience.1059835&volume=292&pages=1907-1910&publication_year=2001&author=Mullen%2CAC?
- What's the revenue for https://doi.org/10.1038%2Fni794?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=T-bet%20is%20a%20STAT1-induced%20regulator%20of%20IL-12R%20expression%20in%20naive%20CD4%2B%20T%20cells&journal=Nat.%20Immunol.&doi=10.1038%2Fni794&volume=3&pages=549-557&publication_year=2002&author=Afkarian%2CM?
- See how much https://doi.org/10.1093%2Fintimm%2Fdxg113 makes per month
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Identification%20of%20cooperative%20monomeric%20Brachyury%20sites%20conferring%20T-bet%20responsiveness%20to%20the%20proximal%20IFN-gamma%20promoter&journal=Int.%20Immunol.&doi=10.1093%2Fintimm%2Fdxg113&volume=15&pages=1149-1160&publication_year=2003&author=Cho%2CJY&author=Grigura%2CV&author=Murphy%2CTL&author=Murphy%2CK produce monthly?
- Monthly income for https://doi.org/10.1126%2Fscience.1065543
- Find out how much http://scholar.google.com/scholar_lookup?&title=Distinct%20effects%20of%20T-bet%20in%20TH1%20lineage%20commitment%20and%20IFN-%CE%B3%20production%20in%20CD4%20and%20CD8%20T%20cells&journal=Science&doi=10.1126%2Fscience.1065543&volume=295&pages=338-342&publication_year=2002&author=Szabo%2CSJ earns monthly
- https://doi.org/10.1084%2Fjem.183.3.901's financial summary
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Reversibility%20of%20T%20helper%201%20and%202%20populations%20is%20lost%20after%20long-term%20stimulation&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.183.3.901&volume=183&pages=901-913&publication_year=1996&author=Murphy%2CE?
- Learn how profitable https://doi.org/10.1111%2Fj.0105-2896.2004.00208.x is on a monthly basis
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=Issues%20in%20T-helper%201%20development%E2%80%93resolved%20and%20unresolved&journal=Immunol.%20Rev.&doi=10.1111%2Fj.0105-2896.2004.00208.x&volume=202&pages=157-174&publication_year=2004&author=Berenson%2CLS&author=Ota%2CN&author=Murphy%2CKM is on a monthly basis
- How much does https://doi.org/10.1038%2Fni1032 generate monthly?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=N-domain-dependent%20nonphosphorylated%20STAT4%20dimers%20required%20for%20cytokine-driven%20activation&journal=Nat.%20Immunol.&doi=10.1038%2Fni1032&volume=5&pages=208-215&publication_year=2004&author=Ota%2CN&author=Brett%2CTJ&author=Murphy%2CTL&author=Fremont%2CDH&author=Murphy%2CKM?
- How much does https://doi.org/10.1084%2Fjem.20031819 pull in?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Loss%20of%20T-bet%2C%20but%20not%20STAT1%2C%20prevents%20the%20development%20of%20experimental%20autoimmune%20encephalomyelitis&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20031819&volume=200&pages=79-87&publication_year=2004&author=Bettelli%2CE?
- What are the total earnings of https://doi.org/10.1172%2FJCI200112563?
- How much does http://scholar.google.com/scholar_lookup?&title=Effect%20of%20targeted%20disruption%20of%20STAT4%20and%20STAT6%20on%20the%20induction%20of%20experimental%20autoimmune%20encephalomyelitis&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI200112563&volume=108&pages=739-747&publication_year=2001&author=Chitnis%2CT make?
- See how much https://doi.org/10.1016%2Fj.immuni.2004.09.010 makes per month
- Get to know http://scholar.google.com/scholar_lookup?&title=Silencing%20T-bet%20defines%20a%20critical%20role%20in%20the%20differentiation%20of%20autoreactive%20T%20lymphocytes&journal=Immunity&doi=10.1016%2Fj.immuni.2004.09.010&volume=21&pages=719-731&publication_year=2004&author=Lovett-Racke%2CAE's earnings
- How much income is https://doi.org/10.1016%2FS1074-7613%2802%2900391-6 earning monthly?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Antigen-specific%20T%20cell%20sensitization%20is%20impaired%20in%20IL-17-deficient%20mice%2C%20causing%20suppression%20of%20allergic%20cellular%20and%20humoral%20responses&journal=Immunity&doi=10.1016%2FS1074-7613%2802%2900391-6&volume=17&pages=375-387&publication_year=2002&author=Nakae%2CS have monthly?
- Revenue of https://doi.org/10.4049%2Fjimmunol.172.5.2827
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Compromised%20humoral%20and%20delayed-type%20hypersensitivity%20responses%20in%20IL-23-deficient%20mice&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.172.5.2827&volume=172&pages=2827-2833&publication_year=2004&author=Ghilardi%2CN?
- Check the income stats for https://doi.org/10.4049%2Fjimmunol.170.9.4432
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=Cutting%20edge%3A%20roles%20of%20Toll-like%20receptor%204%20and%20IL-23%20in%20IL-17%20expression%20in%20response%20to%20Klebsiella%20pneumoniae%20infection&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.170.9.4432&volume=170&pages=4432-4436&publication_year=2003&author=Happel%2CKI?
- What's https://doi.org/10.1084%2Fjem.194.4.519's gross income?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Requirement%20of%20interleukin%2017%20receptor%20signaling%20for%20lung%20CXC%20chemokine%20and%20granulocyte%20colony-stimulating%20factor%20expression%2C%20neutrophil%20recruitment%2C%20and%20host%20defense&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.194.4.519&volume=194&pages=519-527&publication_year=2001&author=Ye%2CP
- https://doi.org/10.1002%2Feji.200324815's total income per month
- How much does http://scholar.google.com/scholar_lookup?&title=Commensal%20Gram-negative%20bacteria%20prime%20human%20dendritic%20cells%20for%20enhanced%20IL-23%20and%20IL-27%20expression%20and%20enhanced%20Th1%20development&journal=Eur.%20J.%20Immunol.&doi=10.1002%2Feji.200324815&volume=34&pages=1371-1380&publication_year=2004&author=Smits%2CHH gross monthly?
- What are the earnings of https://doi.org/10.1172%2FJCI118861?
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=Enterocolitis%20and%20colon%20cancer%20in%20interleukin-10-deficient%20mice%20are%20associated%20with%20aberrant%20cytokine%20production%20and%20CD4%2B%20TH1-like%20responses&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI118861&volume=98&pages=1010-1020&publication_year=1996&author=Berg%2CDJ is on a monthly basis
- What's the income generated by https://doi.org/10.1016%2FS1074-7613%2800%2980413-6 each month?
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=IL-12-deficient%20mice%20are%20defective%20in%20IFN-%CE%B3%20production%20and%20type%201%20cytokine%20responses&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980413-6&volume=4&pages=471-481&publication_year=1996&author=Magram%2CJ?
- What's the revenue for https://doi.org/10.1126%2Fscience.8430336?
- Get to know http://scholar.google.com/scholar_lookup?&title=Restoration%20of%20T%20cell%20development%20in%20RAG-2-deficient%20mice%20by%20functional%20TCR%20transgenes&journal=Science&doi=10.1126%2Fscience.8430336&volume=259&pages=822-825&publication_year=1993&author=Shinkai%2CY's earnings
- How much cash flow does https://doi.org/10.1126%2Fscience.2125367 have monthly?
- See how much http://scholar.google.com/scholar_lookup?&title=Induction%20by%20antigen%20of%20intrathymic%20apoptosis%20of%20CD4%2BCD8%2BTCRlo%20thymocytes%20in%20vivo&journal=Science&doi=10.1126%2Fscience.2125367&volume=250&pages=1720-1723&publication_year=1990&author=Murphy%2CKM&author=Heimberger%2CAB&author=Loh%2CDY makes per month
- https://doi.org/10.1016%2FS0092-8674%2800%2981288-X's total income per month
- Monthly income for http://scholar.google.com/scholar_lookup?&title=Targeted%20disruption%20of%20the%20Stat1%20gene%20in%20mice%20reveals%20unexpected%20physiologic%20specificity%20in%20the%20JAK-STAT%20signaling%20pathway&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981288-X&volume=84&pages=431-442&publication_year=1996&author=Meraz%2CMA
- What's the revenue for https://doi.org/10.1016%2FS1074-7613%2800%2980470-7?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Counting%20antigen-specific%20CD8%20T%20cells%3A%20a%20reevaluation%20of%20bystander%20activation%20during%20viral%20infection&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980470-7&volume=8&pages=177-187&publication_year=1998&author=Murali-Krishna%2CK each month?
- How much revenue does https://doi.org/10.4049%2Fjimmunol.173.12.7249 generate?
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=Regulatory%20T%20cell%20suppression%20and%20anergy%20are%20differentially%20regulated%20by%20proinflammatory%20cytokines%20produced%20by%20TLR-activated%20dendritic%20cells&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.173.12.7249&volume=173&pages=7249-7258&publication_year=2004&author=Kubo%2CT
- How much does https://citation-needed.springer.com/v2/references/10.1038/ni1254?format=refman&flavour=references earn?
- Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Laurie%20E%20Harrington
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Laurie%20E%20Harrington%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's total income per month
- Learn how profitable https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Robin%20D%20Hatton is on a monthly basis
- How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Robin%20D%20Hatton%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- Check the income stats for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Paul%20R%20Mangan
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Paul%20R%20Mangan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en income
- Profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Henrietta%20Turner
- What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Henrietta%20Turner%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What is the monthly revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Theresa%20L%20Murphy?
- What's the income generated by https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Theresa%20L%20Murphy%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en each month?
- Learn how profitable https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kenneth%20M%20Murphy is on a monthly basis
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kenneth%20M%20Murphy%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- What's the total monthly financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Casey%20T%20Weaver?
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Casey%20T%20Weaver%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's financial summary
- What's the monthly income of https://static-content.springer.com/esm/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_BFni1254_MOESM1_ESM.pdf?
- How much does https://s100.copyright.com/AppDispatchServlet?title=Interleukin%2017%E2%80%93producing%20CD4%2B%20effector%20T%20cells%20develop%20via%20a%20lineage%20distinct%20from%20the%20T%20helper%20type%201%20and%202%20lineages&author=Laurie%20E%20Harrington%20et%20al&contentID=10.1038%2Fni1254©right=Springer%20Nature%20America%2C%20Inc.&publication=1529-2908&publicationDate=2005-10-02&publisherName=SpringerNature&orderBeanReset=true net monthly?
- What's the financial intake of https://citation-needed.springer.com/v2/references/10.1038/ni1254?format=refman&flavour=citation?
- Income figures for https://doi.org/10.1007/s00262-024-03706-5
- How much does https://doi.org/10.1038/s41467-023-39023-1 make?
- What's the financial gain of https://doi.org/10.1038/s41467-023-36595-w?
- How much does https://doi.org/10.1038/s41590-022-01387-9 bring in each month?
- How much revenue does https://doi.org/10.1038/s41467-023-39484-4 bring in?
- Find out how much https://www.protocols.io/ earns monthly
- How much income is https://www.natureindex.com/ earning monthly?
- What's the monthly money flow for http://www.naturechina.com?
- How profitable is https://www.natureasia.com/ja-jp?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref