NATURE . COM {
}
Title:
Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages | Nature Immunology
Description:
CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (TH1) or TH2 lineages and instead favor the idea of a distinct effector lineage we call
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Education
- Science
- Telecommunications
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$63,100 per month
Our calculations suggest that Nature.com earns between $42,042 and $115,616 monthly online from display advertisements.
Keywords {🔍}
article, cas, google, scholar, cells, nature, immunol, murphy, cell, interleukin, autoimmune, immunity, development, stat, tbet, access, mice, cytokine, content, immunology, helper, ifnγ, lineage, distinct, exp, med, inflammation, cookies, naive, nat, expression, science, privacy, data, effector, type, role, rev, responses, differentiation, production, encephalomyelitis, induction, receptor, information, producing, weaver, interferonγ, signaling, critical,
Topics {✒️}
nature portfolio permissions reprints privacy policy th17 cell-derived tgf-β1 advertising social media nature 421 nature author information authors jak-stat signaling pathway tlr-activated dendritic cells author correspondence proximal ifn-gamma promoter t-helper 1 development–resolved silencing t-bet defines disrupted interferon-γ genes disrupted ifn-γ gene delayed-type hypersensitivity responses cd4+cd8+tcrlo thymocytes data protection promote ifn-γ production springerlink instant access permissions il-12p35-deficient mice counting antigen-specific cd8 personal data rocaglamide promotes infiltration il-4-independent mechanism joint autoimmune inflammation th1 development mediated present data experimental autoimmune encephalomyelitis induces autoimmune inflammation enhanced th1 development th17 cell heterogeneity biological activities similar privacy transcription factor gata-3 il-26+ th17 intermediates competing financial interests il-17-producing cells shared developmental pathway issue learn il-12-dependent selection ifn-γ plays ifn-α signal ifn-γ production interleukin-23 promotes independent mechanisms european economic area
Schema {🗺️}
WebPage:
mainEntity:
headline:Interleukin 17âproducing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
description:CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (TH1) or TH2 lineages and instead favor the idea of a distinct effector lineage we call 'TH-17'. The development of TH-17 cells from naive precursor cells was potently inhibited by interferon-γ (IFN-γ) and IL-4, whereas committed TH-17 cells were resistant to suppression by TH1 or TH2 cytokines. In the absence of IFN-γ and IL-4, IL-23 induced naive precursor cells to differentiate into TH-17 cells independently of the transcription factors STAT1, T-bet, STAT4 and STAT6. These findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
datePublished:2005-10-02T00:00:00Z
dateModified:2005-10-02T00:00:00Z
pageStart:1123
pageEnd:1132
sameAs:https://doi.org/10.1038/ni1254
keywords:
Biomedicine
general
Immunology
Infectious Diseases
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig6_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig7_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig8_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig9_HTML.jpg
isPartOf:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:6
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Laurie E Harrington
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Robin D Hatton
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Paul R Mangan
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Henrietta Turner
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Theresa L Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
type:Person
name:Kenneth M Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
type:Person
name:Casey T Weaver
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Interleukin 17âproducing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
description:CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (TH1) or TH2 lineages and instead favor the idea of a distinct effector lineage we call 'TH-17'. The development of TH-17 cells from naive precursor cells was potently inhibited by interferon-γ (IFN-γ) and IL-4, whereas committed TH-17 cells were resistant to suppression by TH1 or TH2 cytokines. In the absence of IFN-γ and IL-4, IL-23 induced naive precursor cells to differentiate into TH-17 cells independently of the transcription factors STAT1, T-bet, STAT4 and STAT6. These findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
datePublished:2005-10-02T00:00:00Z
dateModified:2005-10-02T00:00:00Z
pageStart:1123
pageEnd:1132
sameAs:https://doi.org/10.1038/ni1254
keywords:
Biomedicine
general
Immunology
Infectious Diseases
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig6_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig7_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig8_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig9_HTML.jpg
isPartOf:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:6
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Laurie E Harrington
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Robin D Hatton
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Paul R Mangan
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Henrietta Turner
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Theresa L Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
type:Person
name:Kenneth M Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
type:Person
name:Casey T Weaver
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:6
Organization:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Laurie E Harrington
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
name:Robin D Hatton
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
name:Paul R Mangan
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
name:Henrietta Turner
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
name:Theresa L Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
name:Kenneth M Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
name:Casey T Weaver
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(127)
- How much revenue does https://link.springer.com/article/10.1038/ni1254?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle produce monthly?
- What is the earnings of https://doi.org/10.1146%2Fannurev.iy.07.040189.001045?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Th1%20and%20Th2%20cells%3A%20Different%20patterns%20of%20lymphokine%20secretion%20leads%20to%20different%20functional%20properties&journal=Annu.%20Rev.%20Immunol.&doi=10.1146%2Fannurev.iy.07.040189.001045&volume=7&pages=145-173&publication_year=1989&author=Mosmann%2CT&author=Coffman%2CR?
- Explore the financials of https://doi.org/10.1016%2F0167-5699%2888%2991308-4
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=A%20functional%20dichotomy%20in%20CD4%2B%20T%20lymphocytes&journal=Immunol.%20Today&doi=10.1016%2F0167-5699%2888%2991308-4&volume=9&pages=268-277&publication_year=1988&author=Bottomly%2CK
- Learn how profitable https://doi.org/10.1038%2Fnri954 is on a monthly basis
- How much money does http://scholar.google.com/scholar_lookup?&title=The%20lineage%20decisions%20of%20helper%20T%20cells&journal=Nat.%20Rev.%20Immunol.&doi=10.1038%2Fnri954&volume=2&pages=933-944&publication_year=2002&author=Murphy%2CKM&author=Reiner%2CSL make?
- How much does https://doi.org/10.1016%2FS1074-7613%2802%2900331-X generate monthly?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Further%20checkpoints%20in%20Th1%20development&journal=Immunity&doi=10.1016%2FS1074-7613%2802%2900331-X&volume=16&pages=755-758&publication_year=2002&author=Robinson%2CDS&author=O%27Garra%2CA?
- How much does https://doi.org/10.1146%2Fannurev.immunol.21.120601.140942 pull in?
- Get to know http://scholar.google.com/scholar_lookup?&title=Molecular%20mechanisms%20regulating%20Th1%20immune%20responses&journal=Annu.%20Rev.%20Immunol.&doi=10.1146%2Fannurev.immunol.21.120601.140942&volume=21&pages=713-758&publication_year=2003&author=Szabo%2CSJ&author=Sullivan%2CBM&author=Peng%2CSL&author=Glimcher%2CLH's earnings
- Check the income stats for https://doi.org/10.1038%2Fni0703-616
- http://scholar.google.com/scholar_lookup?&title=An%20epigenetic%20view%20of%20helper%20T%20cell%20differentiation&journal=Nat.%20Immunol.&doi=10.1038%2Fni0703-616&volume=4&pages=616-623&publication_year=2003&author=Ansel%2CKM&author=Lee%2CDU&author=Rao%2CA's revenue stream
- Learn how profitable https://doi.org/10.1084%2Fjem.185.5.817 is on a monthly basis
- http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20the%20interleukin%20%28IL%29-12R%CE%B22%20subunit%20expression%20in%20developing%20T%20helper%201%20%28Th1%29%20and%20Th2%20cells&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.185.5.817&volume=185&pages=817-824&publication_year=1997&author=Szabo%2CSJ&author=Dighe%2CAS&author=Gubler%2CU&author=Murphy%2CKM income
- What's https://doi.org/10.1016%2FS1074-7613%2800%2980671-8's gross income?
- What's http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20Th1%20development%20mediated%20by%20GATA-3%20through%20an%20IL-4-independent%20mechanism&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980671-8&volume=9&pages=745-755&publication_year=1998&author=Ouyang%2CW's gross income?
- How much does https://doi.org/10.1016%2FS1074-7613%2802%2900324-2 gross monthly?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=IL-27%2C%20a%20heterodimeric%20cytokine%20composed%20of%20EBI3%20and%20p28%20protein%2C%20induces%20proliferation%20of%20naive%20CD4%2B%20T%20cells&journal=Immunity&doi=10.1016%2FS1074-7613%2802%2900324-2&volume=16&pages=779-790&publication_year=2002&author=Pflanz%2CS
- http://scholar.google.com/scholar_lookup?&title=The%20transcription%20factor%20GATA-3%20is%20necessary%20and%20sufficient%20for%20Th2%20cytokine%20gene%20expression%20in%20CD4%20T%20cells&journal=Cell&volume=89&pages=587-596&publication_year=1997&author=Zheng%2CW&author=Flavell%2CRA's revenue stream
- Discover the revenue of https://doi.org/10.1016%2FS1074-7613%2800%2980156-9
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Stat6-independent%20GATA-3%20autoactivation%20directs%20IL-4-independent%20Th2%20development%20and%20commitment&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980156-9&volume=12&pages=27-37&publication_year=2000&author=Ouyang%2CW?
- What's the financial gain of https://doi.org/10.1084%2Fjem.20041257?
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=IL-23%20drives%20a%20pathogenic%20T%20cell%20population%20that%20induces%20autoimmune%20inflammation&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20041257&volume=201&pages=233-240&publication_year=2005&author=Langrish%2CCL is on a monthly basis
- How much does https://doi.org/10.1038%2Fnature01355 bring in each month?
- How much profit is http://scholar.google.com/scholar_lookup?&title=Interleukin-23%20rather%20than%20interleukin-12%20is%20the%20critical%20cytokine%20for%20autoimmune%20inflammation%20of%20the%20brain&journal=Nature&doi=10.1038%2Fnature01355&volume=421&pages=744-748&publication_year=2003&author=Cua%2CDJ making per month?
- Get to know what's the income of https://doi.org/10.1084%2Fjem.20030896
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Divergent%20pro-%20and%20antiinflammatory%20roles%20for%20IL-23%20and%20IL-12%20in%20joint%20autoimmune%20inflammation&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20030896&volume=198&pages=1951-1957&publication_year=2003&author=Murphy%2CCA?
- Learn about the earnings of https://doi.org/10.1074%2Fjbc.M207577200
- Revenue of http://scholar.google.com/scholar_lookup?&title=Interleukin-23%20promotes%20a%20distinct%20CD4%20T%20cell%20activation%20state%20characterized%20by%20the%20production%20of%20interleukin-17&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M207577200&volume=278&pages=1910-1914&publication_year=2003&author=Aggarwal%2CS&author=Ghilardi%2CN&author=Xie%2CMH&author=de%20Sauvage%2CFJ&author=Gurney%2CAL
- https://doi.org/10.4049%2Fjimmunol.169.12.7104's financial summary
- Revenue of http://scholar.google.com/scholar_lookup?&title=IL-12p35-deficient%20mice%20are%20susceptible%20to%20experimental%20autoimmune%20encephalomyelitis%3A%20evidence%20for%20redundancy%20in%20the%20IL-12%20system%20in%20the%20induction%20of%20central%20nervous%20system%20autoimmune%20demyelination&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.169.12.7104&volume=169&pages=7104-7110&publication_year=2002&author=Gran%2CB
- How much does https://doi.org/10.1084%2Fjem.20042279 pull in?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=IL-12-%20and%20IL-23-induced%20T%20helper%20cell%20subsets%3A%20birds%20of%20the%20same%20feather%20flock%20together&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20042279&volume=201&pages=169-171&publication_year=2005&author=Bettelli%2CE&author=Kuchroo%2CVK each month?
- How much profit does https://doi.org/10.1016%2FS1074-7613%2800%2900070-4 generate?
- http://scholar.google.com/scholar_lookup?&title=Novel%20p19%20protein%20engages%20IL-12p40%20to%20form%20a%20cytokine%2C%20IL-23%2C%20with%20biological%20activities%20similar%20as%20well%20as%20distinct%20from%20IL-12&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2900070-4&volume=13&pages=715-725&publication_year=2000&author=Oppmann%2CB's financial summary
- Get to know what's the income of https://doi.org/10.4049%2Fjimmunol.168.11.5699
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=A%20receptor%20for%20the%20heterodimeric%20cytokine%20IL-23%20is%20composed%20of%20IL-12Rbeta1%20and%20a%20novel%20cytokine%20receptor%20subunit%2C%20IL-23R&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.168.11.5699&volume=168&pages=5699-5708&publication_year=2002&author=Parham%2CC?
- Monthly income for https://doi.org/10.1111%2Fj.0105-2896.2004.00214.x
- Find out how much http://scholar.google.com/scholar_lookup?&title=IL-12%20and%20IL-23%3A%20master%20regulators%20of%20innate%20and%20adaptive%20immunity&journal=Immunol.%20Rev.&doi=10.1111%2Fj.0105-2896.2004.00214.x&volume=202&pages=96-105&publication_year=2004&author=Langrish%2CCL earns monthly
- How much does https://doi.org/10.1073%2Fpnas.2536517100 generate monthly?
- Find out how much http://scholar.google.com/scholar_lookup?&title=IL-27%20regulates%20IL-12%20responsiveness%20of%20naive%20CD4%2B%20T%20cells%20through%20Stat1-dependent%20and%20-independent%20mechanisms&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.2536517100&volume=100&pages=15047-15052&publication_year=2003&author=Lucas%2CS&author=Ghilardi%2CN&author=Li%2CJ&author=de%20Sauvage%2CFJ earns monthly
- What are the total earnings of https://doi.org/10.1089%2F10799900360708632?
- How much money does http://scholar.google.com/scholar_lookup?&title=IL-27%20and%20IFN-%CE%B1%20signal%20via%20Stat1%20and%20Stat3%20and%20induce%20T-Bet%20and%20IL-12R%CE%B22%20in%20naive%20T%20cells&journal=J.%20Interferon%20Cytokine%20Res.&doi=10.1089%2F10799900360708632&volume=23&pages=513-522&publication_year=2003&author=Hibbert%2CL&author=Pflanz%2CS&author=De%20Waal%20Malefyt%2CR&author=Kastelein%2CRA make?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Mice%20with%20a%20disrupted%20IFN-%CE%B3%20gene%20are%20susceptible%20to%20the%20induction%20of%20experimental%20autoimmune%20encephalomyelitis%20%28EAE%29&journal=J.%20Immunol.&volume=156&pages=5-7&publication_year=1996&author=Ferber%2CIA?
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=IFN-%CE%B3%20plays%20a%20critical%20down-regulatory%20role%20in%20the%20induction%20and%20effector%20phase%20of%20myelin%20oligodendrocyte%20glycoprotein-induced%20autoimmune%20encephalomyelitis&journal=J.%20Immunol.&volume=157&pages=3223-3227&publication_year=1996&author=Willenborg%2CDO&author=Fordham%2CS&author=Bernard%2CCC&author=Cowden%2CWB&author=Ramshaw%2CIA
- Profit of https://doi.org/10.1016%2Fj.immuni.2004.08.018
- http://scholar.google.com/scholar_lookup?&title=Interleukin-17%20family%20members%20and%20inflammation&journal=Immunity&doi=10.1016%2Fj.immuni.2004.08.018&volume=21&pages=467-476&publication_year=2004&author=Kolls%2CJK&author=Linden%2CA's financial summary
- How much revenue does https://doi.org/10.1126%2Fscience.8456301 produce monthly?
- http://scholar.google.com/scholar_lookup?&title=Immune%20response%20in%20mice%20that%20lack%20the%20interferon-%CE%B3%20receptor&journal=Science&doi=10.1126%2Fscience.8456301&volume=259&pages=1742-1745&publication_year=1993&author=Huang%2CS's financial summary
- Discover the revenue of https://doi.org/10.1126%2Fscience.8456300
- How profitable is http://scholar.google.com/scholar_lookup?&title=Multiple%20defects%20of%20immune%20cell%20function%20in%20mice%20with%20disrupted%20interferon-%CE%B3%20genes&journal=Science&doi=10.1126%2Fscience.8456300&volume=259&pages=1739-1742&publication_year=1993&author=Dalton%2CDK?
- What are the earnings of https://doi.org/10.1016%2FS0092-8674%2800%2980702-3?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=A%20novel%20transcription%20factor%2C%20T-bet%2C%20directs%20Th1%20lineage%20commitment&journal=Cell&doi=10.1016%2FS0092-8674%2800%2980702-3&volume=100&pages=655-669&publication_year=2000&author=Szabo%2CSJ
- How profitable is https://doi.org/10.1073%2Fpnas.261570598?
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=T-bet%20is%20rapidly%20induced%20by%20interferon-%CE%B3%20in%20lymphoid%20and%20myeloid%20cells&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.261570598&volume=98&pages=15137-15142&publication_year=2001&author=Lighvani%2CAA
- What's the monthly income of https://doi.org/10.1126%2Fscience.1059835?
- How much money does http://scholar.google.com/scholar_lookup?&title=Role%20of%20T-bet%20in%20commitment%20of%20TH1%20cells%20before%20IL-12-dependent%20selection&journal=Science&doi=10.1126%2Fscience.1059835&volume=292&pages=1907-1910&publication_year=2001&author=Mullen%2CAC make?
- What's the revenue for https://doi.org/10.1038%2Fni794?
- How much does http://scholar.google.com/scholar_lookup?&title=T-bet%20is%20a%20STAT1-induced%20regulator%20of%20IL-12R%20expression%20in%20naive%20CD4%2B%20T%20cells&journal=Nat.%20Immunol.&doi=10.1038%2Fni794&volume=3&pages=549-557&publication_year=2002&author=Afkarian%2CM pull in?
- https://doi.org/10.1093%2Fintimm%2Fdxg113 income
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Identification%20of%20cooperative%20monomeric%20Brachyury%20sites%20conferring%20T-bet%20responsiveness%20to%20the%20proximal%20IFN-gamma%20promoter&journal=Int.%20Immunol.&doi=10.1093%2Fintimm%2Fdxg113&volume=15&pages=1149-1160&publication_year=2003&author=Cho%2CJY&author=Grigura%2CV&author=Murphy%2CTL&author=Murphy%2CK
- Explore the financials of https://doi.org/10.1126%2Fscience.1065543
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Distinct%20effects%20of%20T-bet%20in%20TH1%20lineage%20commitment%20and%20IFN-%CE%B3%20production%20in%20CD4%20and%20CD8%20T%20cells&journal=Science&doi=10.1126%2Fscience.1065543&volume=295&pages=338-342&publication_year=2002&author=Szabo%2CSJ?
- What's the revenue for https://doi.org/10.1084%2Fjem.183.3.901?
- How much does http://scholar.google.com/scholar_lookup?&title=Reversibility%20of%20T%20helper%201%20and%202%20populations%20is%20lost%20after%20long-term%20stimulation&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.183.3.901&volume=183&pages=901-913&publication_year=1996&author=Murphy%2CE bring in each month?
- Learn how profitable https://doi.org/10.1111%2Fj.0105-2896.2004.00208.x is on a monthly basis
- How much income does http://scholar.google.com/scholar_lookup?&title=Issues%20in%20T-helper%201%20development%E2%80%93resolved%20and%20unresolved&journal=Immunol.%20Rev.&doi=10.1111%2Fj.0105-2896.2004.00208.x&volume=202&pages=157-174&publication_year=2004&author=Berenson%2CLS&author=Ota%2CN&author=Murphy%2CKM have?
- What's the profit of https://doi.org/10.1038%2Fni1032?
- http://scholar.google.com/scholar_lookup?&title=N-domain-dependent%20nonphosphorylated%20STAT4%20dimers%20required%20for%20cytokine-driven%20activation&journal=Nat.%20Immunol.&doi=10.1038%2Fni1032&volume=5&pages=208-215&publication_year=2004&author=Ota%2CN&author=Brett%2CTJ&author=Murphy%2CTL&author=Fremont%2CDH&author=Murphy%2CKM's total income per month
- How much revenue does https://doi.org/10.1084%2Fjem.20031819 produce monthly?
- http://scholar.google.com/scholar_lookup?&title=Loss%20of%20T-bet%2C%20but%20not%20STAT1%2C%20prevents%20the%20development%20of%20experimental%20autoimmune%20encephalomyelitis&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20031819&volume=200&pages=79-87&publication_year=2004&author=Bettelli%2CE's total income per month
- What is the monthly revenue of https://doi.org/10.1172%2FJCI200112563?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Effect%20of%20targeted%20disruption%20of%20STAT4%20and%20STAT6%20on%20the%20induction%20of%20experimental%20autoimmune%20encephalomyelitis&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI200112563&volume=108&pages=739-747&publication_year=2001&author=Chitnis%2CT make?
- How much money does https://doi.org/10.1016%2Fj.immuni.2004.09.010 generate?
- How much money does http://scholar.google.com/scholar_lookup?&title=Silencing%20T-bet%20defines%20a%20critical%20role%20in%20the%20differentiation%20of%20autoreactive%20T%20lymphocytes&journal=Immunity&doi=10.1016%2Fj.immuni.2004.09.010&volume=21&pages=719-731&publication_year=2004&author=Lovett-Racke%2CAE make?
- How much profit is https://doi.org/10.1016%2FS1074-7613%2802%2900391-6 making per month?
- Get to know http://scholar.google.com/scholar_lookup?&title=Antigen-specific%20T%20cell%20sensitization%20is%20impaired%20in%20IL-17-deficient%20mice%2C%20causing%20suppression%20of%20allergic%20cellular%20and%20humoral%20responses&journal=Immunity&doi=10.1016%2FS1074-7613%2802%2900391-6&volume=17&pages=375-387&publication_year=2002&author=Nakae%2CS's earnings
- What's the financial outcome of https://doi.org/10.4049%2Fjimmunol.172.5.2827?
- See how much http://scholar.google.com/scholar_lookup?&title=Compromised%20humoral%20and%20delayed-type%20hypersensitivity%20responses%20in%20IL-23-deficient%20mice&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.172.5.2827&volume=172&pages=2827-2833&publication_year=2004&author=Ghilardi%2CN makes per month
- How much money does https://doi.org/10.4049%2Fjimmunol.170.9.4432 generate?
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=Cutting%20edge%3A%20roles%20of%20Toll-like%20receptor%204%20and%20IL-23%20in%20IL-17%20expression%20in%20response%20to%20Klebsiella%20pneumoniae%20infection&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.170.9.4432&volume=170&pages=4432-4436&publication_year=2003&author=Happel%2CKI is on a monthly basis
- How much does https://doi.org/10.1084%2Fjem.194.4.519 gross monthly?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Requirement%20of%20interleukin%2017%20receptor%20signaling%20for%20lung%20CXC%20chemokine%20and%20granulocyte%20colony-stimulating%20factor%20expression%2C%20neutrophil%20recruitment%2C%20and%20host%20defense&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.194.4.519&volume=194&pages=519-527&publication_year=2001&author=Ye%2CP make?
- Learn how profitable https://doi.org/10.1002%2Feji.200324815 is on a monthly basis
- What's the income of http://scholar.google.com/scholar_lookup?&title=Commensal%20Gram-negative%20bacteria%20prime%20human%20dendritic%20cells%20for%20enhanced%20IL-23%20and%20IL-27%20expression%20and%20enhanced%20Th1%20development&journal=Eur.%20J.%20Immunol.&doi=10.1002%2Feji.200324815&volume=34&pages=1371-1380&publication_year=2004&author=Smits%2CHH?
- How much revenue does https://doi.org/10.1172%2FJCI118861 generate?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Enterocolitis%20and%20colon%20cancer%20in%20interleukin-10-deficient%20mice%20are%20associated%20with%20aberrant%20cytokine%20production%20and%20CD4%2B%20TH1-like%20responses&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI118861&volume=98&pages=1010-1020&publication_year=1996&author=Berg%2CDJ?
- What's https://doi.org/10.1016%2FS1074-7613%2800%2980413-6's gross income?
- How profitable is http://scholar.google.com/scholar_lookup?&title=IL-12-deficient%20mice%20are%20defective%20in%20IFN-%CE%B3%20production%20and%20type%201%20cytokine%20responses&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980413-6&volume=4&pages=471-481&publication_year=1996&author=Magram%2CJ?
- How much profit is https://doi.org/10.1126%2Fscience.8430336 making per month?
- How much income does http://scholar.google.com/scholar_lookup?&title=Restoration%20of%20T%20cell%20development%20in%20RAG-2-deficient%20mice%20by%20functional%20TCR%20transgenes&journal=Science&doi=10.1126%2Fscience.8430336&volume=259&pages=822-825&publication_year=1993&author=Shinkai%2CY have?
- https://doi.org/10.1126%2Fscience.2125367's total income per month
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Induction%20by%20antigen%20of%20intrathymic%20apoptosis%20of%20CD4%2BCD8%2BTCRlo%20thymocytes%20in%20vivo&journal=Science&doi=10.1126%2Fscience.2125367&volume=250&pages=1720-1723&publication_year=1990&author=Murphy%2CKM&author=Heimberger%2CAB&author=Loh%2CDY generate?
- How much income is https://doi.org/10.1016%2FS0092-8674%2800%2981288-X earning monthly?
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=Targeted%20disruption%20of%20the%20Stat1%20gene%20in%20mice%20reveals%20unexpected%20physiologic%20specificity%20in%20the%20JAK-STAT%20signaling%20pathway&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981288-X&volume=84&pages=431-442&publication_year=1996&author=Meraz%2CMA
- https://doi.org/10.1016%2FS1074-7613%2800%2980470-7's total income per month
- See how much http://scholar.google.com/scholar_lookup?&title=Counting%20antigen-specific%20CD8%20T%20cells%3A%20a%20reevaluation%20of%20bystander%20activation%20during%20viral%20infection&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980470-7&volume=8&pages=177-187&publication_year=1998&author=Murali-Krishna%2CK makes per month
- How much profit does https://doi.org/10.4049%2Fjimmunol.173.12.7249 make?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=Regulatory%20T%20cell%20suppression%20and%20anergy%20are%20differentially%20regulated%20by%20proinflammatory%20cytokines%20produced%20by%20TLR-activated%20dendritic%20cells&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.173.12.7249&volume=173&pages=7249-7258&publication_year=2004&author=Kubo%2CT
- How much does https://citation-needed.springer.com/v2/references/10.1038/ni1254?format=refman&flavour=references net monthly?
- Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Laurie%20E%20Harrington
- Check the income stats for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Laurie%20E%20Harrington%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Find out how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Robin%20D%20Hatton earns monthly
- What's the total monthly financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Robin%20D%20Hatton%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Paul%20R%20Mangan bring in each month?
- Get to know https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Paul%20R%20Mangan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's earnings
- Learn about the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Henrietta%20Turner
- How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Henrietta%20Turner%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- See how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Theresa%20L%20Murphy makes per month
- How profitable is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Theresa%20L%20Murphy%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kenneth%20M%20Murphy have?
- Learn how profitable https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kenneth%20M%20Murphy%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en is on a monthly basis
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Casey%20T%20Weaver generate?
- What's the financial outcome of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Casey%20T%20Weaver%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What is the earnings of https://static-content.springer.com/esm/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_BFni1254_MOESM1_ESM.pdf?
- How profitable is https://s100.copyright.com/AppDispatchServlet?title=Interleukin%2017%E2%80%93producing%20CD4%2B%20effector%20T%20cells%20develop%20via%20a%20lineage%20distinct%20from%20the%20T%20helper%20type%201%20and%202%20lineages&author=Laurie%20E%20Harrington%20et%20al&contentID=10.1038%2Fni1254©right=Springer%20Nature%20America%2C%20Inc.&publication=1529-2908&publicationDate=2005-10-02&publisherName=SpringerNature&orderBeanReset=true?
- How much does https://citation-needed.springer.com/v2/references/10.1038/ni1254?format=refman&flavour=citation rake in every month?
- How profitable is https://doi.org/10.1007/s00262-024-03706-5?
- How much does https://doi.org/10.1038/s41467-023-39023-1 bring in each month?
- What are the earnings of https://doi.org/10.1038/s41467-023-36595-w?
- Income figures for https://doi.org/10.1038/s41590-022-01387-9
- What's the profit of https://doi.org/10.1038/s41467-023-39484-4?
- How much does https://www.protocols.io/ pull in monthly?
- https://www.natureindex.com/ income
- How much does http://www.naturechina.com pull in monthly?
- How much income is https://www.natureasia.com/ja-jp earning monthly?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref