NATURE . COM {
}
Title:
Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages | Nature Immunology
Description:
CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (TH1) or TH2 lineages and instead favor the idea of a distinct effector lineage we call
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Education
- Science
- Telecommunications
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$63,100 per month
Our estimates place Nature.com's monthly online earnings from display ads at $42,042 to $115,616.
Keywords {🔍}
article, cas, google, scholar, cells, nature, immunol, murphy, cell, interleukin, autoimmune, immunity, development, stat, tbet, access, mice, cytokine, content, immunology, helper, ifnγ, lineage, distinct, exp, med, inflammation, cookies, naive, nat, expression, science, privacy, data, effector, type, role, rev, responses, differentiation, production, encephalomyelitis, induction, receptor, information, producing, weaver, interferonγ, signaling, critical,
Topics {✒️}
nature portfolio permissions reprints privacy policy th17 cell-derived tgf-β1 advertising social media nature 421 nature author information authors jak-stat signaling pathway tlr-activated dendritic cells author correspondence proximal ifn-gamma promoter t-helper 1 development–resolved silencing t-bet defines disrupted interferon-γ genes disrupted ifn-γ gene delayed-type hypersensitivity responses cd4+cd8+tcrlo thymocytes data protection promote ifn-γ production springerlink instant access permissions il-12p35-deficient mice counting antigen-specific cd8 personal data rocaglamide promotes infiltration il-4-independent mechanism joint autoimmune inflammation th1 development mediated present data experimental autoimmune encephalomyelitis induces autoimmune inflammation enhanced th1 development th17 cell heterogeneity biological activities similar privacy transcription factor gata-3 il-26+ th17 intermediates competing financial interests il-17-producing cells shared developmental pathway issue learn il-12-dependent selection ifn-γ plays ifn-α signal ifn-γ production interleukin-23 promotes independent mechanisms european economic area
Schema {🗺️}
WebPage:
mainEntity:
headline:Interleukin 17âproducing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
description:CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (TH1) or TH2 lineages and instead favor the idea of a distinct effector lineage we call 'TH-17'. The development of TH-17 cells from naive precursor cells was potently inhibited by interferon-γ (IFN-γ) and IL-4, whereas committed TH-17 cells were resistant to suppression by TH1 or TH2 cytokines. In the absence of IFN-γ and IL-4, IL-23 induced naive precursor cells to differentiate into TH-17 cells independently of the transcription factors STAT1, T-bet, STAT4 and STAT6. These findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
datePublished:2005-10-02T00:00:00Z
dateModified:2005-10-02T00:00:00Z
pageStart:1123
pageEnd:1132
sameAs:https://doi.org/10.1038/ni1254
keywords:
Biomedicine
general
Immunology
Infectious Diseases
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig6_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig7_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig8_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig9_HTML.jpg
isPartOf:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:6
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Laurie E Harrington
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Robin D Hatton
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Paul R Mangan
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Henrietta Turner
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Theresa L Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
type:Person
name:Kenneth M Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
type:Person
name:Casey T Weaver
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Interleukin 17âproducing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
description:CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (TH1) or TH2 lineages and instead favor the idea of a distinct effector lineage we call 'TH-17'. The development of TH-17 cells from naive precursor cells was potently inhibited by interferon-γ (IFN-γ) and IL-4, whereas committed TH-17 cells were resistant to suppression by TH1 or TH2 cytokines. In the absence of IFN-γ and IL-4, IL-23 induced naive precursor cells to differentiate into TH-17 cells independently of the transcription factors STAT1, T-bet, STAT4 and STAT6. These findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
datePublished:2005-10-02T00:00:00Z
dateModified:2005-10-02T00:00:00Z
pageStart:1123
pageEnd:1132
sameAs:https://doi.org/10.1038/ni1254
keywords:
Biomedicine
general
Immunology
Infectious Diseases
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig6_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig7_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig8_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_Article_BFni1254_Fig9_HTML.jpg
isPartOf:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:6
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Laurie E Harrington
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Robin D Hatton
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Paul R Mangan
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Henrietta Turner
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Theresa L Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
type:Person
name:Kenneth M Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
type:Person
name:Casey T Weaver
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:6
Organization:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Laurie E Harrington
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
name:Robin D Hatton
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
name:Paul R Mangan
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
name:Henrietta Turner
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
name:Theresa L Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
name:Kenneth M Murphy
affiliation:
name:Howard Hughes Medical Institute, Washington University School of Medicine
address:
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
name:Casey T Weaver
affiliation:
name:University of Alabama at Birmingham
address:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
name:Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, USA
name:Department of Pathology, University of Alabama at Birmingham, Birmingham, USA
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(127)
- Income figures for https://link.springer.com/article/10.1038/ni1254?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle
- What are the earnings of https://doi.org/10.1146%2Fannurev.iy.07.040189.001045?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Th1%20and%20Th2%20cells%3A%20Different%20patterns%20of%20lymphokine%20secretion%20leads%20to%20different%20functional%20properties&journal=Annu.%20Rev.%20Immunol.&doi=10.1146%2Fannurev.iy.07.040189.001045&volume=7&pages=145-173&publication_year=1989&author=Mosmann%2CT&author=Coffman%2CR?
- Revenue of https://doi.org/10.1016%2F0167-5699%2888%2991308-4
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=A%20functional%20dichotomy%20in%20CD4%2B%20T%20lymphocytes&journal=Immunol.%20Today&doi=10.1016%2F0167-5699%2888%2991308-4&volume=9&pages=268-277&publication_year=1988&author=Bottomly%2CK?
- https://doi.org/10.1038%2Fnri954's revenue stream
- What's http://scholar.google.com/scholar_lookup?&title=The%20lineage%20decisions%20of%20helper%20T%20cells&journal=Nat.%20Rev.%20Immunol.&doi=10.1038%2Fnri954&volume=2&pages=933-944&publication_year=2002&author=Murphy%2CKM&author=Reiner%2CSL's gross income?
- How much revenue does https://doi.org/10.1016%2FS1074-7613%2802%2900331-X generate?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Further%20checkpoints%20in%20Th1%20development&journal=Immunity&doi=10.1016%2FS1074-7613%2802%2900331-X&volume=16&pages=755-758&publication_year=2002&author=Robinson%2CDS&author=O%27Garra%2CA generate?
- How much profit does https://doi.org/10.1146%2Fannurev.immunol.21.120601.140942 make?
- Income figures for http://scholar.google.com/scholar_lookup?&title=Molecular%20mechanisms%20regulating%20Th1%20immune%20responses&journal=Annu.%20Rev.%20Immunol.&doi=10.1146%2Fannurev.immunol.21.120601.140942&volume=21&pages=713-758&publication_year=2003&author=Szabo%2CSJ&author=Sullivan%2CBM&author=Peng%2CSL&author=Glimcher%2CLH
- How much money does https://doi.org/10.1038%2Fni0703-616 generate?
- What's http://scholar.google.com/scholar_lookup?&title=An%20epigenetic%20view%20of%20helper%20T%20cell%20differentiation&journal=Nat.%20Immunol.&doi=10.1038%2Fni0703-616&volume=4&pages=616-623&publication_year=2003&author=Ansel%2CKM&author=Lee%2CDU&author=Rao%2CA's gross income?
- How much does https://doi.org/10.1084%2Fjem.185.5.817 make?
- How much does http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20the%20interleukin%20%28IL%29-12R%CE%B22%20subunit%20expression%20in%20developing%20T%20helper%201%20%28Th1%29%20and%20Th2%20cells&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.185.5.817&volume=185&pages=817-824&publication_year=1997&author=Szabo%2CSJ&author=Dighe%2CAS&author=Gubler%2CU&author=Murphy%2CKM net monthly?
- What's the total monthly financial gain of https://doi.org/10.1016%2FS1074-7613%2800%2980671-8?
- How much does http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20Th1%20development%20mediated%20by%20GATA-3%20through%20an%20IL-4-independent%20mechanism&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980671-8&volume=9&pages=745-755&publication_year=1998&author=Ouyang%2CW generate monthly?
- What's the income of https://doi.org/10.1016%2FS1074-7613%2802%2900324-2?
- How much income is http://scholar.google.com/scholar_lookup?&title=IL-27%2C%20a%20heterodimeric%20cytokine%20composed%20of%20EBI3%20and%20p28%20protein%2C%20induces%20proliferation%20of%20naive%20CD4%2B%20T%20cells&journal=Immunity&doi=10.1016%2FS1074-7613%2802%2900324-2&volume=16&pages=779-790&publication_year=2002&author=Pflanz%2CS earning monthly?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=The%20transcription%20factor%20GATA-3%20is%20necessary%20and%20sufficient%20for%20Th2%20cytokine%20gene%20expression%20in%20CD4%20T%20cells&journal=Cell&volume=89&pages=587-596&publication_year=1997&author=Zheng%2CW&author=Flavell%2CRA?
- What's the monthly money flow for https://doi.org/10.1016%2FS1074-7613%2800%2980156-9?
- http://scholar.google.com/scholar_lookup?&title=Stat6-independent%20GATA-3%20autoactivation%20directs%20IL-4-independent%20Th2%20development%20and%20commitment&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980156-9&volume=12&pages=27-37&publication_year=2000&author=Ouyang%2CW's revenue stream
- How profitable is https://doi.org/10.1084%2Fjem.20041257?
- What's the income of http://scholar.google.com/scholar_lookup?&title=IL-23%20drives%20a%20pathogenic%20T%20cell%20population%20that%20induces%20autoimmune%20inflammation&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20041257&volume=201&pages=233-240&publication_year=2005&author=Langrish%2CCL?
- How much does https://doi.org/10.1038%2Fnature01355 bring in each month?
- How much does http://scholar.google.com/scholar_lookup?&title=Interleukin-23%20rather%20than%20interleukin-12%20is%20the%20critical%20cytokine%20for%20autoimmune%20inflammation%20of%20the%20brain&journal=Nature&doi=10.1038%2Fnature01355&volume=421&pages=744-748&publication_year=2003&author=Cua%2CDJ gross monthly?
- What's the total monthly financial gain of https://doi.org/10.1084%2Fjem.20030896?
- Earnings of http://scholar.google.com/scholar_lookup?&title=Divergent%20pro-%20and%20antiinflammatory%20roles%20for%20IL-23%20and%20IL-12%20in%20joint%20autoimmune%20inflammation&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20030896&volume=198&pages=1951-1957&publication_year=2003&author=Murphy%2CCA
- How much does https://doi.org/10.1074%2Fjbc.M207577200 make?
- See how much http://scholar.google.com/scholar_lookup?&title=Interleukin-23%20promotes%20a%20distinct%20CD4%20T%20cell%20activation%20state%20characterized%20by%20the%20production%20of%20interleukin-17&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M207577200&volume=278&pages=1910-1914&publication_year=2003&author=Aggarwal%2CS&author=Ghilardi%2CN&author=Xie%2CMH&author=de%20Sauvage%2CFJ&author=Gurney%2CAL makes per month
- Discover the revenue of https://doi.org/10.4049%2Fjimmunol.169.12.7104
- How much income is http://scholar.google.com/scholar_lookup?&title=IL-12p35-deficient%20mice%20are%20susceptible%20to%20experimental%20autoimmune%20encephalomyelitis%3A%20evidence%20for%20redundancy%20in%20the%20IL-12%20system%20in%20the%20induction%20of%20central%20nervous%20system%20autoimmune%20demyelination&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.169.12.7104&volume=169&pages=7104-7110&publication_year=2002&author=Gran%2CB earning monthly?
- What's the financial outcome of https://doi.org/10.1084%2Fjem.20042279?
- Find out how much http://scholar.google.com/scholar_lookup?&title=IL-12-%20and%20IL-23-induced%20T%20helper%20cell%20subsets%3A%20birds%20of%20the%20same%20feather%20flock%20together&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20042279&volume=201&pages=169-171&publication_year=2005&author=Bettelli%2CE&author=Kuchroo%2CVK earns monthly
- https://doi.org/10.1016%2FS1074-7613%2800%2900070-4's revenue stream
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Novel%20p19%20protein%20engages%20IL-12p40%20to%20form%20a%20cytokine%2C%20IL-23%2C%20with%20biological%20activities%20similar%20as%20well%20as%20distinct%20from%20IL-12&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2900070-4&volume=13&pages=715-725&publication_year=2000&author=Oppmann%2CB?
- https://doi.org/10.4049%2Fjimmunol.168.11.5699's financial summary
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=A%20receptor%20for%20the%20heterodimeric%20cytokine%20IL-23%20is%20composed%20of%20IL-12Rbeta1%20and%20a%20novel%20cytokine%20receptor%20subunit%2C%20IL-23R&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.168.11.5699&volume=168&pages=5699-5708&publication_year=2002&author=Parham%2CC?
- How much does https://doi.org/10.1111%2Fj.0105-2896.2004.00214.x net monthly?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=IL-12%20and%20IL-23%3A%20master%20regulators%20of%20innate%20and%20adaptive%20immunity&journal=Immunol.%20Rev.&doi=10.1111%2Fj.0105-2896.2004.00214.x&volume=202&pages=96-105&publication_year=2004&author=Langrish%2CCL have monthly?
- How much does https://doi.org/10.1073%2Fpnas.2536517100 make?
- Revenue of http://scholar.google.com/scholar_lookup?&title=IL-27%20regulates%20IL-12%20responsiveness%20of%20naive%20CD4%2B%20T%20cells%20through%20Stat1-dependent%20and%20-independent%20mechanisms&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.2536517100&volume=100&pages=15047-15052&publication_year=2003&author=Lucas%2CS&author=Ghilardi%2CN&author=Li%2CJ&author=de%20Sauvage%2CFJ
- How much profit does https://doi.org/10.1089%2F10799900360708632 make?
- How much income does http://scholar.google.com/scholar_lookup?&title=IL-27%20and%20IFN-%CE%B1%20signal%20via%20Stat1%20and%20Stat3%20and%20induce%20T-Bet%20and%20IL-12R%CE%B22%20in%20naive%20T%20cells&journal=J.%20Interferon%20Cytokine%20Res.&doi=10.1089%2F10799900360708632&volume=23&pages=513-522&publication_year=2003&author=Hibbert%2CL&author=Pflanz%2CS&author=De%20Waal%20Malefyt%2CR&author=Kastelein%2CRA have?
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Mice%20with%20a%20disrupted%20IFN-%CE%B3%20gene%20are%20susceptible%20to%20the%20induction%20of%20experimental%20autoimmune%20encephalomyelitis%20%28EAE%29&journal=J.%20Immunol.&volume=156&pages=5-7&publication_year=1996&author=Ferber%2CIA
- How much revenue does http://scholar.google.com/scholar_lookup?&title=IFN-%CE%B3%20plays%20a%20critical%20down-regulatory%20role%20in%20the%20induction%20and%20effector%20phase%20of%20myelin%20oligodendrocyte%20glycoprotein-induced%20autoimmune%20encephalomyelitis&journal=J.%20Immunol.&volume=157&pages=3223-3227&publication_year=1996&author=Willenborg%2CDO&author=Fordham%2CS&author=Bernard%2CCC&author=Cowden%2CWB&author=Ramshaw%2CIA produce monthly?
- Monthly income for https://doi.org/10.1016%2Fj.immuni.2004.08.018
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Interleukin-17%20family%20members%20and%20inflammation&journal=Immunity&doi=10.1016%2Fj.immuni.2004.08.018&volume=21&pages=467-476&publication_year=2004&author=Kolls%2CJK&author=Linden%2CA bring in?
- What is the monthly revenue of https://doi.org/10.1126%2Fscience.8456301?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Immune%20response%20in%20mice%20that%20lack%20the%20interferon-%CE%B3%20receptor&journal=Science&doi=10.1126%2Fscience.8456301&volume=259&pages=1742-1745&publication_year=1993&author=Huang%2CS?
- https://doi.org/10.1126%2Fscience.8456300's total income per month
- Find out how much http://scholar.google.com/scholar_lookup?&title=Multiple%20defects%20of%20immune%20cell%20function%20in%20mice%20with%20disrupted%20interferon-%CE%B3%20genes&journal=Science&doi=10.1126%2Fscience.8456300&volume=259&pages=1739-1742&publication_year=1993&author=Dalton%2CDK earns monthly
- How profitable is https://doi.org/10.1016%2FS0092-8674%2800%2980702-3?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=A%20novel%20transcription%20factor%2C%20T-bet%2C%20directs%20Th1%20lineage%20commitment&journal=Cell&doi=10.1016%2FS0092-8674%2800%2980702-3&volume=100&pages=655-669&publication_year=2000&author=Szabo%2CSJ?
- How much does https://doi.org/10.1073%2Fpnas.261570598 pull in?
- Get to know http://scholar.google.com/scholar_lookup?&title=T-bet%20is%20rapidly%20induced%20by%20interferon-%CE%B3%20in%20lymphoid%20and%20myeloid%20cells&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.261570598&volume=98&pages=15137-15142&publication_year=2001&author=Lighvani%2CAA's earnings
- How much does https://doi.org/10.1126%2Fscience.1059835 pull in monthly?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Role%20of%20T-bet%20in%20commitment%20of%20TH1%20cells%20before%20IL-12-dependent%20selection&journal=Science&doi=10.1126%2Fscience.1059835&volume=292&pages=1907-1910&publication_year=2001&author=Mullen%2CAC
- What's the financial intake of https://doi.org/10.1038%2Fni794?
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=T-bet%20is%20a%20STAT1-induced%20regulator%20of%20IL-12R%20expression%20in%20naive%20CD4%2B%20T%20cells&journal=Nat.%20Immunol.&doi=10.1038%2Fni794&volume=3&pages=549-557&publication_year=2002&author=Afkarian%2CM?
- Learn about the earnings of https://doi.org/10.1093%2Fintimm%2Fdxg113
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Identification%20of%20cooperative%20monomeric%20Brachyury%20sites%20conferring%20T-bet%20responsiveness%20to%20the%20proximal%20IFN-gamma%20promoter&journal=Int.%20Immunol.&doi=10.1093%2Fintimm%2Fdxg113&volume=15&pages=1149-1160&publication_year=2003&author=Cho%2CJY&author=Grigura%2CV&author=Murphy%2CTL&author=Murphy%2CK?
- What's the income generated by https://doi.org/10.1126%2Fscience.1065543 each month?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Distinct%20effects%20of%20T-bet%20in%20TH1%20lineage%20commitment%20and%20IFN-%CE%B3%20production%20in%20CD4%20and%20CD8%20T%20cells&journal=Science&doi=10.1126%2Fscience.1065543&volume=295&pages=338-342&publication_year=2002&author=Szabo%2CSJ?
- What's the financial intake of https://doi.org/10.1084%2Fjem.183.3.901?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Reversibility%20of%20T%20helper%201%20and%202%20populations%20is%20lost%20after%20long-term%20stimulation&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.183.3.901&volume=183&pages=901-913&publication_year=1996&author=Murphy%2CE?
- How much does https://doi.org/10.1111%2Fj.0105-2896.2004.00208.x bring in each month?
- How much income is http://scholar.google.com/scholar_lookup?&title=Issues%20in%20T-helper%201%20development%E2%80%93resolved%20and%20unresolved&journal=Immunol.%20Rev.&doi=10.1111%2Fj.0105-2896.2004.00208.x&volume=202&pages=157-174&publication_year=2004&author=Berenson%2CLS&author=Ota%2CN&author=Murphy%2CKM earning monthly?
- How much money does https://doi.org/10.1038%2Fni1032 make?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=N-domain-dependent%20nonphosphorylated%20STAT4%20dimers%20required%20for%20cytokine-driven%20activation&journal=Nat.%20Immunol.&doi=10.1038%2Fni1032&volume=5&pages=208-215&publication_year=2004&author=Ota%2CN&author=Brett%2CTJ&author=Murphy%2CTL&author=Fremont%2CDH&author=Murphy%2CKM?
- How much profit does https://doi.org/10.1084%2Fjem.20031819 make?
- How much does http://scholar.google.com/scholar_lookup?&title=Loss%20of%20T-bet%2C%20but%20not%20STAT1%2C%20prevents%20the%20development%20of%20experimental%20autoimmune%20encephalomyelitis&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20031819&volume=200&pages=79-87&publication_year=2004&author=Bettelli%2CE generate monthly?
- How much profit does https://doi.org/10.1172%2FJCI200112563 generate?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Effect%20of%20targeted%20disruption%20of%20STAT4%20and%20STAT6%20on%20the%20induction%20of%20experimental%20autoimmune%20encephalomyelitis&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI200112563&volume=108&pages=739-747&publication_year=2001&author=Chitnis%2CT?
- How much revenue does https://doi.org/10.1016%2Fj.immuni.2004.09.010 bring in?
- How much does http://scholar.google.com/scholar_lookup?&title=Silencing%20T-bet%20defines%20a%20critical%20role%20in%20the%20differentiation%20of%20autoreactive%20T%20lymphocytes&journal=Immunity&doi=10.1016%2Fj.immuni.2004.09.010&volume=21&pages=719-731&publication_year=2004&author=Lovett-Racke%2CAE make?
- What's the financial gain of https://doi.org/10.1016%2FS1074-7613%2802%2900391-6?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Antigen-specific%20T%20cell%20sensitization%20is%20impaired%20in%20IL-17-deficient%20mice%2C%20causing%20suppression%20of%20allergic%20cellular%20and%20humoral%20responses&journal=Immunity&doi=10.1016%2FS1074-7613%2802%2900391-6&volume=17&pages=375-387&publication_year=2002&author=Nakae%2CS bring in?
- Discover the revenue of https://doi.org/10.4049%2Fjimmunol.172.5.2827
- Profit of http://scholar.google.com/scholar_lookup?&title=Compromised%20humoral%20and%20delayed-type%20hypersensitivity%20responses%20in%20IL-23-deficient%20mice&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.172.5.2827&volume=172&pages=2827-2833&publication_year=2004&author=Ghilardi%2CN
- What are the earnings of https://doi.org/10.4049%2Fjimmunol.170.9.4432?
- How much does http://scholar.google.com/scholar_lookup?&title=Cutting%20edge%3A%20roles%20of%20Toll-like%20receptor%204%20and%20IL-23%20in%20IL-17%20expression%20in%20response%20to%20Klebsiella%20pneumoniae%20infection&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.170.9.4432&volume=170&pages=4432-4436&publication_year=2003&author=Happel%2CKI gross monthly?
- Check the income stats for https://doi.org/10.1084%2Fjem.194.4.519
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Requirement%20of%20interleukin%2017%20receptor%20signaling%20for%20lung%20CXC%20chemokine%20and%20granulocyte%20colony-stimulating%20factor%20expression%2C%20neutrophil%20recruitment%2C%20and%20host%20defense&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.194.4.519&volume=194&pages=519-527&publication_year=2001&author=Ye%2CP have monthly?
- How much cash flow does https://doi.org/10.1002%2Feji.200324815 have monthly?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Commensal%20Gram-negative%20bacteria%20prime%20human%20dendritic%20cells%20for%20enhanced%20IL-23%20and%20IL-27%20expression%20and%20enhanced%20Th1%20development&journal=Eur.%20J.%20Immunol.&doi=10.1002%2Feji.200324815&volume=34&pages=1371-1380&publication_year=2004&author=Smits%2CHH generate?
- How much cash flow does https://doi.org/10.1172%2FJCI118861 have monthly?
- How much money does http://scholar.google.com/scholar_lookup?&title=Enterocolitis%20and%20colon%20cancer%20in%20interleukin-10-deficient%20mice%20are%20associated%20with%20aberrant%20cytokine%20production%20and%20CD4%2B%20TH1-like%20responses&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI118861&volume=98&pages=1010-1020&publication_year=1996&author=Berg%2CDJ generate?
- What's the profit of https://doi.org/10.1016%2FS1074-7613%2800%2980413-6?
- What's http://scholar.google.com/scholar_lookup?&title=IL-12-deficient%20mice%20are%20defective%20in%20IFN-%CE%B3%20production%20and%20type%201%20cytokine%20responses&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980413-6&volume=4&pages=471-481&publication_year=1996&author=Magram%2CJ's gross income?
- How much income is https://doi.org/10.1126%2Fscience.8430336 earning monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Restoration%20of%20T%20cell%20development%20in%20RAG-2-deficient%20mice%20by%20functional%20TCR%20transgenes&journal=Science&doi=10.1126%2Fscience.8430336&volume=259&pages=822-825&publication_year=1993&author=Shinkai%2CY make?
- How much profit does https://doi.org/10.1126%2Fscience.2125367 generate?
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Induction%20by%20antigen%20of%20intrathymic%20apoptosis%20of%20CD4%2BCD8%2BTCRlo%20thymocytes%20in%20vivo&journal=Science&doi=10.1126%2Fscience.2125367&volume=250&pages=1720-1723&publication_year=1990&author=Murphy%2CKM&author=Heimberger%2CAB&author=Loh%2CDY?
- How much money does https://doi.org/10.1016%2FS0092-8674%2800%2981288-X generate?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Targeted%20disruption%20of%20the%20Stat1%20gene%20in%20mice%20reveals%20unexpected%20physiologic%20specificity%20in%20the%20JAK-STAT%20signaling%20pathway&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981288-X&volume=84&pages=431-442&publication_year=1996&author=Meraz%2CMA?
- How much profit does https://doi.org/10.1016%2FS1074-7613%2800%2980470-7 generate?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Counting%20antigen-specific%20CD8%20T%20cells%3A%20a%20reevaluation%20of%20bystander%20activation%20during%20viral%20infection&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980470-7&volume=8&pages=177-187&publication_year=1998&author=Murali-Krishna%2CK?
- What's the income generated by https://doi.org/10.4049%2Fjimmunol.173.12.7249 each month?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Regulatory%20T%20cell%20suppression%20and%20anergy%20are%20differentially%20regulated%20by%20proinflammatory%20cytokines%20produced%20by%20TLR-activated%20dendritic%20cells&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.173.12.7249&volume=173&pages=7249-7258&publication_year=2004&author=Kubo%2CT?
- Discover the revenue of https://citation-needed.springer.com/v2/references/10.1038/ni1254?format=refman&flavour=references
- How much profit is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Laurie%20E%20Harrington making per month?
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Laurie%20E%20Harrington%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Robin%20D%20Hatton generate?
- What's the monthly income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Robin%20D%20Hatton%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Income figures for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Paul%20R%20Mangan
- What is the monthly revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Paul%20R%20Mangan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What's the total monthly financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Henrietta%20Turner?
- Earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Henrietta%20Turner%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Explore the financials of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Theresa%20L%20Murphy
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Theresa%20L%20Murphy%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's financial summary
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kenneth%20M%20Murphy bring in?
- What are the total earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kenneth%20M%20Murphy%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Casey%20T%20Weaver gross monthly?
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Casey%20T%20Weaver%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- How much does https://static-content.springer.com/esm/art%3A10.1038%2Fni1254/MediaObjects/41590_2005_BFni1254_MOESM1_ESM.pdf gross monthly?
- Learn how profitable https://s100.copyright.com/AppDispatchServlet?title=Interleukin%2017%E2%80%93producing%20CD4%2B%20effector%20T%20cells%20develop%20via%20a%20lineage%20distinct%20from%20the%20T%20helper%20type%201%20and%202%20lineages&author=Laurie%20E%20Harrington%20et%20al&contentID=10.1038%2Fni1254©right=Springer%20Nature%20America%2C%20Inc.&publication=1529-2908&publicationDate=2005-10-02&publisherName=SpringerNature&orderBeanReset=true is on a monthly basis
- How much does https://citation-needed.springer.com/v2/references/10.1038/ni1254?format=refman&flavour=citation bring in each month?
- How much revenue does https://doi.org/10.1007/s00262-024-03706-5 bring in?
- What's the financial gain of https://doi.org/10.1038/s41467-023-39023-1?
- How much does https://doi.org/10.1038/s41467-023-36595-w earn?
- Profit of https://doi.org/10.1038/s41590-022-01387-9
- How much income is https://doi.org/10.1038/s41467-023-39484-4 earning monthly?
- Get to know what's the income of https://www.protocols.io/
- Get to know https://www.natureindex.com/'s earnings
- Check the income stats for http://www.naturechina.com
- https://www.natureasia.com/ja-jp's financial summary
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref