NATURE . COM {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Nature.com Make Money
How Much Does Nature.com Make
Keywords
Topics
Schema
Social Networks
External Links
Analytics And Tracking
Libraries
Hosting Providers
CDN Services

We are analyzing https://www.nature.com/articles/ng0897-358.

Title:
Bcl-2 and Bax function independently to regulate cell death | Nature Genetics
Description:
The BCL-2 family has various pairs of antagonist and agonist proteins that regulate apoptosis. Whether their function is interdependent is uncertain. Using a genetic approach to address this question, we utilized gain- and loss-of-function models of Bcl-2 and Bax and found that apoptosis and thymic hypoplasia characteristic of Bcl-2–deficient mice are largely absent in mice also deficient in Bax. A single copy of Bax promoted apoptosis in the absence of Bcl-2. In contrast, overexpression of Bcl-2 still repressed apoptosis in the absence of Bax. While an in vivo competition exists between fiaxand Bax and Bcl-2, each is able to regulate apoptosis independently.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

Education
Telecommunications
Science

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)

google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)

conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$63,100 per month
Our estimates place Nature.com's monthly online earnings from display ads at $42,042 to $115,616.

Keywords {🔍}

article, google, scholar, cas, cell, bcl, nature, death, apoptosis, korsmeyer, bax, access, mice, family, protein, usa, content, proc, atal, acad, sci, cookies, bclxl, privacy, function, pubmed, data, journal, regulate, knudson, proteins, cancer, open, development, science, survival, dev, activation, protease, advertising, information, subscribe, genetics, independently, institution, buy, human, chromosome, promotes, cells,

Topics {✒️}

nature portfolio permissions reprints privacy policy advertising social media nature 335 nature 369 nature 379 nature 356 nature 381 nature 348 nature amyloid beta1–42-induced apoptosis b-cell neoplasms result personal data bax-induced cell death data protection permissions springerlink instant access promotes thymocyte differentiation murine development bcl-xl function upstream fas-induced activation cell death pathway—bcl-2 mitochondrial membrane protein development privacy immature hematopoietic cells ice protease cascade promotes cell death bcl-2 protein family bcl-2 family proteins programmed cell death protein binding functions explore content subscription content michael knudson & stanley european economic area thymic hypoplasia characteristic institutional subscriptions read transcriptionally active locus distorted small intestine trophic factor deprivation cd4+cd8+ stage washington university school chicken manure amendment statistical experimental designs colon cancer gaber defined neuroprotective agent bcl-2 protein expression

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Bcl-2 and Bax function independently to regulate cell death
         description:The BCL-2 family has various pairs of antagonist and agonist proteins that regulate apoptosis. Whether their function is interdependent is uncertain. Using a genetic approach to address this question, we utilized gain- and loss-of-function models of Bcl-2 and Bax and found that apoptosis and thymic hypoplasia characteristic of Bcl-2âdeficient mice are largely absent in mice also deficient in Bax. A single copy of Bax promoted apoptosis in the absence of Bcl-2. In contrast, overexpression of Bcl-2 still repressed apoptosis in the absence of Bax. While an in vivo competition exists between fiaxand Bax and Bcl-2, each is able to regulate apoptosis independently.
         datePublished:
         dateModified:
         pageStart:358
         pageEnd:363
         sameAs:https://doi.org/10.1038/ng0897-358
         keywords:
            Biomedicine
            general
            Human Genetics
            Cancer Research
            Agriculture
            Gene Function
            Animal Genetics and Genomics
         image:
         isPartOf:
            name:Nature Genetics
            issn:
               1546-1718
               1061-4036
            volumeNumber:16
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:C. Michael Knudson
               affiliation:
                     name:Washington University School of Medicine
                     address:
                        name:The Howard Hughes Medical Institute and the Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Stanley J. Korsmeyer
               affiliation:
                     name:Washington University School of Medicine
                     address:
                        name:The Howard Hughes Medical Institute and the Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, USA
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Bcl-2 and Bax function independently to regulate cell death
      description:The BCL-2 family has various pairs of antagonist and agonist proteins that regulate apoptosis. Whether their function is interdependent is uncertain. Using a genetic approach to address this question, we utilized gain- and loss-of-function models of Bcl-2 and Bax and found that apoptosis and thymic hypoplasia characteristic of Bcl-2âdeficient mice are largely absent in mice also deficient in Bax. A single copy of Bax promoted apoptosis in the absence of Bcl-2. In contrast, overexpression of Bcl-2 still repressed apoptosis in the absence of Bax. While an in vivo competition exists between fiaxand Bax and Bcl-2, each is able to regulate apoptosis independently.
      datePublished:
      dateModified:
      pageStart:358
      pageEnd:363
      sameAs:https://doi.org/10.1038/ng0897-358
      keywords:
         Biomedicine
         general
         Human Genetics
         Cancer Research
         Agriculture
         Gene Function
         Animal Genetics and Genomics
      image:
      isPartOf:
         name:Nature Genetics
         issn:
            1546-1718
            1061-4036
         volumeNumber:16
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:C. Michael Knudson
            affiliation:
                  name:Washington University School of Medicine
                  address:
                     name:The Howard Hughes Medical Institute and the Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stanley J. Korsmeyer
            affiliation:
                  name:Washington University School of Medicine
                  address:
                     name:The Howard Hughes Medical Institute and the Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Genetics
      issn:
         1546-1718
         1061-4036
      volumeNumber:16
Organization:
      name:Nature Publishing Group US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Washington University School of Medicine
      address:
         name:The Howard Hughes Medical Institute and the Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, USA
         type:PostalAddress
      name:Washington University School of Medicine
      address:
         name:The Howard Hughes Medical Institute and the Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:C. Michael Knudson
      affiliation:
            name:Washington University School of Medicine
            address:
               name:The Howard Hughes Medical Institute and the Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, USA
               type:PostalAddress
            type:Organization
      name:Stanley J. Korsmeyer
      affiliation:
            name:Washington University School of Medicine
            address:
               name:The Howard Hughes Medical Institute and the Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:The Howard Hughes Medical Institute and the Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, USA
      name:The Howard Hughes Medical Institute and the Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

External Links {🔗}(96)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Prism.js
Zoom.js

Emails and Hosting {✉️}

Mail Servers:

mxa-002c5801.gslb.pphosted.com
mxb-002c5801.gslb.pphosted.com

Name Servers:

pdns1.ultradns.net
pdns2.ultradns.net
pdns3.ultradns.org
pdns4.ultradns.org
pdns5.ultradns.info
pdns6.ultradns.co.uk

CDN Services {📦}

Crossref

5.29s.