NATURE . COM {}

Matching Content Categories {📚}

• Education
• Science
• Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,194,993 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$531,700 per month
Our analysis indicates Nature.com generates between $354,480 and $974,820 monthly online from display ads.

Keywords {🔍}

article, google, scholar, cas, nature, oct, cells, cell, stem, expression, access, transcription, factor, mouse, gene, embryonic, content, niwa, development, differentiation, smith, pluripotent, embryo, dev, biol, cookies, privacy, selfrenewal, mammalian, open, binding, research, data, information, genetics, hitoshi, miyazaki, pou, pluripotency, role, schöler, expressed, proc, natl, acad, sci, usa, genes, mol, site,

Topics {✒️}

nature portfolio permissions reprints privacy policy genome research author information authors advertising social media nature s345 crispr/cas-based toolkit nature 344 nature 336 nature 343 nature time-lapse recording facilities vertebrate oct4/pou5 functions pou-domain transcription factor protein-protein interactions facilitated personal data japan data protection permissions springerlink instant access transcription factor expressed mouse development colin pluripotent stem cells factor binding sites embryonic stem cells specific spatial arrangement privacy oct-3/4 induces loss oct-4 transcription factor expand oct4 binding sustain stem-cell controls lineage commitment osteopontin preimplantation enhancer mouse embryonic cells early stem cells lif-deficient cells hybrid cell extinction extra-embryonic membranes content oct-4 european economic area institutional subscriptions read tetracycline-responsive promoters dicistronic targeting constructs endodermally derived tissues progressive lineage analysis neural crest derivatives signalling mechanisms regulating mitotic bookmarking redundancy

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
         description:Cell fate during development is defined by transcription factors that act as molecular switches to activate or repress specific gene expression programmes. The POU transcription factor Oct-3/4 (encoded by Pou5f1) is a candidate regulator in pluripotent and germline cells1,2,3,4 and is essential for the initial formation of a pluripotent founder cell population in the mammalian embryo5. Here we use conditional expression and repression in embryonic stem (ES) cells to determine requirements for Oct-3/4 in the maintenance of developmental potency. Although transcriptional determination has usually been considered as a binary on-off control system, we found that the precise level of Oct-3/4 governs three distinct fates of ES cells. A less than twofold increase in expression causes differentiation into primitive endoderm and mesoderm. In contrast, repression of Oct-3/4 induces loss of pluripotency and dedifferentiation to trophectoderm. Thus a critical amount of Oct-3/4 is required to sustain stem-cell self-renewal, and up- or downregulation induce divergent developmental programmes. Our findings establish a role for Oct-3/4 as a master regulator of pluripotency that controls lineage commitment and illustrate the sophistication of critical transcriptional regulators and the consequent importance of quantitative analyses.
         datePublished:
         dateModified:
         pageStart:372
         pageEnd:376
         sameAs:https://doi.org/10.1038/74199
         keywords:
            Biomedicine
            general
            Human Genetics
            Cancer Research
            Agriculture
            Gene Function
            Animal Genetics and Genomics
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F74199/MediaObjects/41588_2000_Article_BFng0400_372_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F74199/MediaObjects/41588_2000_Article_BFng0400_372_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F74199/MediaObjects/41588_2000_Article_BFng0400_372_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F74199/MediaObjects/41588_2000_Article_BFng0400_372_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F74199/MediaObjects/41588_2000_Article_BFng0400_372_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F74199/MediaObjects/41588_2000_Article_BFng0400_372_Fig6_HTML.gif
         isPartOf:
            name:Nature Genetics
            issn:
               1546-1718
               1061-4036
            volumeNumber:24
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Hitoshi Niwa
               affiliation:
                     name:Centre for Genome Research, The University of Edinburgh
                     address:
                        name:Centre for Genome Research, The University of Edinburgh, Edinburgh, UK
                        type:PostalAddress
                     type:Organization
                     name:Osaka University School of Medicine
                     address:
                        name:Department of Nutrition and Physiological Chemistry, Osaka University School of Medicine, Japan
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Jun-ichi Miyazaki
               affiliation:
                     name:Osaka University School of Medicine
                     address:
                        name:Department of Nutrition and Physiological Chemistry, Osaka University School of Medicine, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Austin G. Smith
               affiliation:
                     name:Centre for Genome Research, The University of Edinburgh
                     address:
                        name:Centre for Genome Research, The University of Edinburgh, Edinburgh, UK
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
      description:Cell fate during development is defined by transcription factors that act as molecular switches to activate or repress specific gene expression programmes. The POU transcription factor Oct-3/4 (encoded by Pou5f1) is a candidate regulator in pluripotent and germline cells1,2,3,4 and is essential for the initial formation of a pluripotent founder cell population in the mammalian embryo5. Here we use conditional expression and repression in embryonic stem (ES) cells to determine requirements for Oct-3/4 in the maintenance of developmental potency. Although transcriptional determination has usually been considered as a binary on-off control system, we found that the precise level of Oct-3/4 governs three distinct fates of ES cells. A less than twofold increase in expression causes differentiation into primitive endoderm and mesoderm. In contrast, repression of Oct-3/4 induces loss of pluripotency and dedifferentiation to trophectoderm. Thus a critical amount of Oct-3/4 is required to sustain stem-cell self-renewal, and up- or downregulation induce divergent developmental programmes. Our findings establish a role for Oct-3/4 as a master regulator of pluripotency that controls lineage commitment and illustrate the sophistication of critical transcriptional regulators and the consequent importance of quantitative analyses.
      datePublished:
      dateModified:
      pageStart:372
      pageEnd:376
      sameAs:https://doi.org/10.1038/74199
      keywords:
         Biomedicine
         general
         Human Genetics
         Cancer Research
         Agriculture
         Gene Function
         Animal Genetics and Genomics
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F74199/MediaObjects/41588_2000_Article_BFng0400_372_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F74199/MediaObjects/41588_2000_Article_BFng0400_372_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F74199/MediaObjects/41588_2000_Article_BFng0400_372_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F74199/MediaObjects/41588_2000_Article_BFng0400_372_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F74199/MediaObjects/41588_2000_Article_BFng0400_372_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F74199/MediaObjects/41588_2000_Article_BFng0400_372_Fig6_HTML.gif
      isPartOf:
         name:Nature Genetics
         issn:
            1546-1718
            1061-4036
         volumeNumber:24
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Hitoshi Niwa
            affiliation:
                  name:Centre for Genome Research, The University of Edinburgh
                  address:
                     name:Centre for Genome Research, The University of Edinburgh, Edinburgh, UK
                     type:PostalAddress
                  type:Organization
                  name:Osaka University School of Medicine
                  address:
                     name:Department of Nutrition and Physiological Chemistry, Osaka University School of Medicine, Japan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Jun-ichi Miyazaki
            affiliation:
                  name:Osaka University School of Medicine
                  address:
                     name:Department of Nutrition and Physiological Chemistry, Osaka University School of Medicine, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Austin G. Smith
            affiliation:
                  name:Centre for Genome Research, The University of Edinburgh
                  address:
                     name:Centre for Genome Research, The University of Edinburgh, Edinburgh, UK
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Genetics
      issn:
         1546-1718
         1061-4036
      volumeNumber:24
Organization:
      name:Nature Publishing Group US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Centre for Genome Research, The University of Edinburgh
      address:
         name:Centre for Genome Research, The University of Edinburgh, Edinburgh, UK
         type:PostalAddress
      name:Osaka University School of Medicine
      address:
         name:Department of Nutrition and Physiological Chemistry, Osaka University School of Medicine, Japan
         type:PostalAddress
      name:Osaka University School of Medicine
      address:
         name:Department of Nutrition and Physiological Chemistry, Osaka University School of Medicine, Japan
         type:PostalAddress
      name:Centre for Genome Research, The University of Edinburgh
      address:
         name:Centre for Genome Research, The University of Edinburgh, Edinburgh, UK
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Hitoshi Niwa
      affiliation:
            name:Centre for Genome Research, The University of Edinburgh
            address:
               name:Centre for Genome Research, The University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
            name:Osaka University School of Medicine
            address:
               name:Department of Nutrition and Physiological Chemistry, Osaka University School of Medicine, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jun-ichi Miyazaki
      affiliation:
            name:Osaka University School of Medicine
            address:
               name:Department of Nutrition and Physiological Chemistry, Osaka University School of Medicine, Japan
               type:PostalAddress
            type:Organization
      name:Austin G. Smith
      affiliation:
            name:Centre for Genome Research, The University of Edinburgh
            address:
               name:Centre for Genome Research, The University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Centre for Genome Research, The University of Edinburgh, Edinburgh, UK
      name:Department of Nutrition and Physiological Chemistry, Osaka University School of Medicine, Japan
      name:Department of Nutrition and Physiological Chemistry, Osaka University School of Medicine, Japan
      name:Centre for Genome Research, The University of Edinburgh, Edinburgh, UK
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/NatureGenet
• https://twitter.com/NatureGenet

External Links {🔗}(82)

• Monthly income for https://link.springer.com/article/10.1038/74199?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle
• How much does https://doi.org/10.1038%2F344435a0 make?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=New%20type%20of%20POU%20domain%20in%20germ%20line-specific%20protein%20Oct-4.&journal=Nature&doi=10.1038%2F344435a0&volume=344&pages=435-439&publication_year=1990&author=Sch%C3%B6ler%2CHR&author=Ruppert%2CS&author=Suzuki%2CN&author=Chowdhury%2CK&author=Gruss%2CP produce monthly?
• Get to know what's the income of https://doi.org/10.1038%2F345686a0
• See how much http://scholar.google.com/scholar_lookup?&title=A%20POU-domain%20transcription%20factor%20in%20early%20stem%20cells%20and%20germ%20cells%20of%20the%20mammalian%20embryo.&journal=Nature&doi=10.1038%2F345686a0&volume=s345&pages=686-692&publication_year=1990&author=Rosner%2CMH makes per month
• What's the monthly money flow for https://doi.org/10.1016%2F0092-8674%2890%2990597-8?
• How profitable is http://scholar.google.com/scholar_lookup?&title=A%20novel%20octamer%20binding%20transcription%20factor%20is%20differentially%20expressed%20in%20mouse%20embryonic%20cells.&journal=Cell&doi=10.1016%2F0092-8674%2890%2990597-8&volume=60&pages=461-472&publication_year=1990&author=Okamoto%2CK?
• How much does https://doi.org/10.1016%2FS0925-4773%2898%2900002-1 gross monthly?
• Revenue of http://scholar.google.com/scholar_lookup?&title=Differential%20expression%20of%20the%20Oct-4%20transcription%20factor%20during%20mouse%20germ%20cell%20differentiation.&journal=Mech.%20Dev.&doi=10.1016%2FS0925-4773%2898%2900002-1&volume=71&pages=89-98&publication_year=1998&author=Pesce%2CM&author=Wang%2CX&author=Wolgemuth%2CDJ&author=Scholer%2CH
• How much profit does https://doi.org/10.1016%2FS0092-8674%2800%2981769-9 generate?
• How much profit does http://scholar.google.com/scholar_lookup?&title=Formation%20of%20pluripotent%20stem%20cells%20in%20the%20mammalian%20embryo%20depends%20on%20the%20POU%20transcription%20factor%20Oct-4.&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981769-9&volume=95&pages=379-391&publication_year=1998&author=Nichols%2CJ generate?
• How much does https://doi.org/10.1073%2Fpnas.89.12.5547 make?
• What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Tight%20control%20of%20gene%20expression%20in%20mammalian%20cells%20by%20tetracycline-responsive%20promoters.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.89.12.5547&volume=89&pages=5547-5551&publication_year=1992&author=Gossen%2CM&author=Bujard%2CH?
• See how much https://doi.org/10.1073%2Fpnas.91.10.4303 makes per month
• Financial intake of http://scholar.google.com/scholar_lookup?&title=Dicistronic%20targeting%20constructs%3A%20reporters%20and%20modifiers%20of%20mammalian%20gene%20expression.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.91.10.4303&volume=91&pages=4303-4307&publication_year=1994&author=Mountford%2CP
• How much does https://doi.org/10.1073%2Fpnas.92.5.1292 gross monthly?
• What's the income generated by http://scholar.google.com/scholar_lookup?&title=Maintenance%20of%20an%20extrachromosomal%20plasmid%20vector%20in%20mouse%20embryonic%20stem%20cells.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.92.5.1292&volume=92&pages=1292-1296&publication_year=1995&author=Gassmann%2CM&author=Donoho%2CG&author=Berg%2CP each month?
• How much does https://doi.org/10.1101%2Fgad.12.13.2048 make?
• How much does http://scholar.google.com/scholar_lookup?&title=Self-renewal%20of%20pluripotent%20embryonic%20stem%20cells%20is%20mediated%20via%20activation%20of%20STAT3.&journal=Genes%20Dev.&doi=10.1101%2Fgad.12.13.2048&volume=12&pages=2048-2060&publication_year=1998&author=Niwa%2CH&author=Burdon%2CT&author=Chambers%2CI&author=Smith%2CAG rake in every month?
• Profit of https://doi.org/10.1038%2F336688a0
• http://scholar.google.com/scholar_lookup?&title=G.&journal=Nature&doi=10.1038%2F336688a0&volume=336&pages=688-690&publication_year=1988&author=Smith%2CA's revenue stream
• Learn about the earnings of https://doi.org/10.1046%2Fj.1365-2443.1996.d01-237.x
• Monthly income for http://scholar.google.com/scholar_lookup?&title=Identification%20of%20putative%20downstream%20genes%20of%20Oct-3%2C%20a%20pluripotent%20cell-specific%20transcription%20factor.&journal=Genes%20Cells&doi=10.1046%2Fj.1365-2443.1996.d01-237.x&volume=1&pages=239-252&publication_year=1996&author=Saijoh%2CY
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8455608's revenue stream
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC359544's total income per month
• How much does http://scholar.google.com/scholar_lookup?&title=Mouse%20GATA-4%3A%20a%20retinoic%20acid-inducible%20GATA-binding%20transcription%20factor%20expressed%20in%20endodermally%20derived%20tissues%20and%20heart.&journal=Mol.%20Cell.%20Biol.&volume=13&pages=2235-2246&publication_year=1993&author=Arceci%2CRJ&author=King%2CAA&author=Simon%2CMC&author=Orkin%2CSH&author=Wilson%2CDB make?
• https://doi.org/10.1038%2F343657a0's revenue stream
• How much does http://scholar.google.com/scholar_lookup?&title=Expression%20pattern%20of%20the%20mouse%20T%20gene%20and%20its%20role%20in%20mesoderm%20formation.&journal=Nature&doi=10.1038%2F343657a0&volume=343&pages=657-659&publication_year=1990&author=Wilkinson%2CDG&author=Bhatt%2CS&author=Herrmann%2CBG bring in each month?
• How much revenue does https://doi.org/10.1242%2Fdev.125.9.1747 bring in?
• http://scholar.google.com/scholar_lookup?&title=Progressive%20lineage%20analysis%20by%20cell%20sorting%20and%20culture%20identifies%20FLK1%2BVE-cadherin%2B%20cells%20at%20a%20diverging%20point%20of%20endothelial%20and%20hemopoietic%20lineages.&journal=Development&doi=10.1242%2Fdev.125.9.1747&volume=125&pages=1747-1757&publication_year=1998&author=Nishikawa%2CSI&author=Nishikawa%2CS&author=Hirashima%2CM&author=Matsuyoshi%2CN&author=Kodama%2CH income
• How much income does https://doi.org/10.1242%2Fdev.112.2.407 have?
• Earnings of http://scholar.google.com/scholar_lookup?&title=mRNA%20localization%20studies%20suggest%20that%20murine%20FGF-5%20plays%20a%20role%20in%20gastrulation.&journal=Development&doi=10.1242%2Fdev.112.2.407&volume=112&pages=407-415&publication_year=1991&author=Hebert%2CJM&author=Boyle%2CM&author=Martin%2CGR
• How much revenue does https://doi.org/10.1006%2Fdbio.1995.1245 bring in?
• Earnings of http://scholar.google.com/scholar_lookup?&title=Expression%20of%20the%20novel%20basic%20helix-loop-helix%20gene%20eHAND%20in%20neural%20crest%20derivatives%20and%20extraembryonic%20membranes%20during%20mouse%20development.&journal=Dev.%20Biol.&doi=10.1006%2Fdbio.1995.1245&volume=170&pages=664-678&publication_year=1995&author=Cserjesi%2CP&author=Brown%2CD&author=Lyons%2CGE&author=Olson%2CEN
• Monthly income for https://doi.org/10.1002%2Faja.1002040302
• http://scholar.google.com/scholar_lookup?&title=Expression%20of%20Cdx-2%20in%20the%20mouse%20embryo%20and%20placenta%3A%20possible%20role%20in%20patterning%20of%20the%20extra-embryonic%20membranes.&journal=Dev.%20Dyn.&doi=10.1002%2Faja.1002040302&volume=204&pages=219-227&publication_year=1995&author=Beck%2CF&author=Erler%2CT&author=Russell%2CA&author=James%2CR income
• Discover the revenue of https://doi.org/10.1073%2Fpnas.94.11.5709
• Earnings of http://scholar.google.com/scholar_lookup?&title=The%20origin%20and%20efficient%20derivation%20of%20embryonic%20stem%20cells%20in%20the%20mouse.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.94.11.5709&volume=94&pages=5709-5712&publication_year=1997&author=Brook%2CFA&author=Gardner%2CRL
• How much does https://doi.org/10.1242%2Fdev.105.4.733 pull in?
• Get to know http://scholar.google.com/scholar_lookup?&title=An%20assessment%20of%20the%20developmental%20potential%20of%20embryonic%20stem%20cells%20in%20the%20midgestation%20mouse%20embryo.&journal=Development&doi=10.1242%2Fdev.105.4.733&volume=105&pages=733-737&publication_year=1989&author=Beddington%2CRSP&author=Robertson%2CEJ's earnings
• What's the income of https://doi.org/10.1126%2Fscience.282.5396.2072?
• Monthly income for http://scholar.google.com/scholar_lookup?&title=Promotion%20of%20trophoblast%20stem%20cell%20proliferation%20by%20FGF-4.&journal=Science&doi=10.1126%2Fscience.282.5396.2072&volume=282&pages=2072-2075&publication_year=1998&author=Tanaka%2CS&author=Kunath%2CT&author=Hadjantonakis%2CA-K&author=Nagy%2CA&author=Rossant%2CJ
• https://doi.org/10.1128%2FMCB.17.11.6321's revenue stream
• What's the profit of http://scholar.google.com/scholar_lookup?&title=Synergistic%20activation%20of%20the%20fibroblast%20growth%20factor%204%20enhancer%20by%20sox2%20and%20oct-3%20depends%20on%20protein-protein%20interactions%20facilitated%20by%20a%20specific%20spatial%20arrangement%20of%20factor%20binding%20sites.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.17.11.6321&volume=17&pages=6321-6329&publication_year=1997&author=Ambrosetti%2CD-C&author=Basilico%2CC&author=Dailey%2CL?
• Earnings of https://doi.org/10.1128%2FMCB.19.8.5453
• Earnings of http://scholar.google.com/scholar_lookup?&title=The%20gene%20for%20the%20embryonic%20stem%20cell%20coactivator%20UTF1%20carries%20a%20regulatory%20element%20which%20selectively%20interacts%20with%20a%20complex%20composed%20of%20Oct-3%2F4%20and%20Sox-2.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.19.8.5453&volume=19&pages=5453-5465&publication_year=1999&author=Nishimoto%2CM&author=Fukushima%2CA&author=Okuda%2CA&author=Muramatsu%2CM
• Revenue of https://doi.org/10.1016%2F0092-8674%2891%2990619-A
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=Anexus%20between%20Oct-4%20and%20E1A%3A%20implications%20for%20gene%20regulation%20in%20embryonic%20stem%20cells.&journal=Cell&doi=10.1016%2F0092-8674%2891%2990619-A&volume=66&pages=291-304&publication_year=1991&author=Sch%C3%B6ler%2CHR&author=Ciesiolka%2CT&author=Gruss%2CP have monthly?
• How much profit does https://doi.org/10.1128%2FMCB.18.4.1866 generate?
• What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Rex-1%2C%20a%20gene%20encoding%20a%20transcription%20factor%20expressed%20in%20the%20early%20embryo%2C%20is%20regulated%20via%20Oct-3%2F4%20and%20Oct-6%20binding%20to%20an%20octamer%20site%20and%20a%20novel%20protein%2C%20Rox-1%2C%20binding%20to%20an%20adjacent%20site.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.18.4.1866&volume=18&pages=1666-1878&publication_year=1998&author=Ben-Shushan%2CE&author=Thompson%2CJR&author=Gudas%2CLJ&author=Bergman%2CY?
• What's the financial intake of https://doi.org/10.1101%2Fgad.12.13.2073?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=New%20POU%20dimer%20configuration%20mediates%20antagonistic%20control%20of%20an%20osteopontin%20preimplantation%20enhancer%20by%20Oct-4%20and%20Sox-2.&journal=Genes%20Dev.&doi=10.1101%2Fgad.12.13.2073&volume=12&pages=2073-2090&publication_year=1998&author=Botquin%2CV?
• How much does https://doi.org/10.1159%2F000016693 rake in every month?
• How profitable is http://scholar.google.com/scholar_lookup?&title=Signalling%20mechanisms%20regulating%20self-renewal%20and%20differentiation%20of%20pluripotent%20embryonic%20stem%20cells.&journal=Cells%20Tissues%20Organs&doi=10.1159%2F000016693&volume=165&pages=131-143&publication_year=1999&author=Burdon%2CT&author=Chambers%2CI&author=Niwa%2CH&author=Stracey%2CC&author=Smith%2CAG?
• Check the income stats for https://doi.org/10.1006%2Fdbio.1998.9026
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Paracrine%20induction%20of%20stem%20cell%20renewal%20by%20LIF-deficient%20cells%3A%20a%20new%20ES%20cell%20regulatory%20pathway.&journal=Dev.%20Biol.&doi=10.1006%2Fdbio.1998.9026&volume=203&pages=149-162&publication_year=1998&author=Dani%2CC?
• How much profit does https://doi.org/10.1006%2Fdbio.1994.1312 make?
• How much profit does http://scholar.google.com/scholar_lookup?&title=Oct-4%20transcription%20factor%20is%20differentially%20expressed%20in%20the%20mouse%20embryo%20during%20establishment%20of%20the%20first%20two%20extraembryonic%20cell%20lineages%20involved%20in%20implantation.&journal=Dev.%20Biol.&doi=10.1006%2Fdbio.1994.1312&volume=166&pages=259-267&publication_year=1994&author=Palmieri%2CSL&author=Peter%2CW&author=Hess%2CH&author=Sch%C3%B6ler%2CHR generate?
• What's https://doi.org/10.1016%2F0378-1119%2891%2990434-D's gross income?
• How much income does http://scholar.google.com/scholar_lookup?&title=Efficient%20selection%20for%20high-expression%20transfectants%20with%20a%20novel%20eukaryotic%20vector.&journal=Gene&doi=10.1016%2F0378-1119%2891%2990434-D&volume=108&pages=193-200&publication_year=1991&author=Niwa%2CH&author=Yamamura%2CK-I&author=Miyazaki%2CJ-I have?
• What's the profit of https://doi.org/10.1002%2Fj.1460-2075.1993.tb06138.x?
• What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Hybrid%20cell%20extinction%20and%20re-expression%20of%20Oct-3%20function%20correlates%20with%20differentiation%20potential.&journal=EMBO%20J.&doi=10.1002%2Fj.1460-2075.1993.tb06138.x&volume=12&pages=4489-4498&publication_year=1993&author=Shimazaki%2CT?
• How much does https://citation-needed.springer.com/v2/references/10.1038/74199?format=refman&flavour=references rake in every month?
• What's the financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hitoshi%20Niwa?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hitoshi%20Niwa%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en gross monthly?
• What is the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jun-ichi%20Miyazaki?
• See how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jun-ichi%20Miyazaki%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en makes per month
• Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Austin%20G.%20Smith
• Learn about the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Austin%20G.%20Smith%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• What's the monthly income of https://static-content.springer.com/esm/art%3A10.1038%2F74199/MediaObjects/41588_2000_BFng0400_372_MOESM1_ESM.pdf?
• What is the monthly revenue of https://static-content.springer.com/esm/art%3A10.1038%2F74199/MediaObjects/41588_2000_BFng0400_372_MOESM2_ESM.qt?
• How much income does https://s100.copyright.com/AppDispatchServlet?title=Quantitative%20expression%20of%20Oct-3%2F4%20defines%20differentiation%2C%20dedifferentiation%20or%20self-renewal%20of%20ES%20cells&author=Hitoshi%20Niwa%20et%20al&contentID=10.1038%2F74199©right=Nature%20America%20Inc.&publication=1061-4036&publicationDate=2000-04&publisherName=SpringerNature&orderBeanReset=true have?
• Get to know https://citation-needed.springer.com/v2/references/10.1038/74199?format=refman&flavour=citation's earnings
• How much revenue does https://doi.org/10.1038/s41594-023-01195-1 produce monthly?
• How much cash flow does https://doi.org/10.1038/s41594-024-01344-0 have monthly?
• How much money does https://doi.org/10.1038/s41540-023-00326-0 generate?
• What's the income generated by https://doi.org/10.1038/s41467-023-38909-4 each month?
• How much does https://doi.org/10.1038/s41598-023-27901-z make?
• See how much https://www.protocols.io/ makes per month
• How much profit does https://www.natureindex.com/ make?
• What's the total monthly financial gain of http://www.naturechina.com?
• What's the monthly money flow for https://www.natureasia.com/ja-jp?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref