NATURE . COM {}

Matching Content Categories {📚}

• Science
• Education
• Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,797,153 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$539,300 per month
Estimations show Nature.com's display ad online revenue falls between $359,538 and $988,730 per month.

Keywords {🔍}

sclc, egfr, cell, cancer, resistant, mgh, mutant, lung, expression, cells, article, nsclc, lines, fig, transformed, patient, google, scholar, cancers, resistance, supplementary, data, samples, patients, classical, cas, mutation, loss, tumours, nature, analysis, tumour, adenocarcinoma, mutations, gene, histology, treatment, transformation, performed, line, abt, dna, derived, massachusetts, revealed, cases, gefitinib, acquired, ihc, array,

Topics {✒️}

nature portfolio privacy policy thoracic oncology service research agreements advertising valuable tools scientific merit award universal nature 0/ reprints open label open-label constructs targeting gfp nature 462 nature 483 nature 376 nature 455 nature small-cell lung cancer small-cell lung cancer small-cell lung cancers small-cell lung cancers transit-lt1 transfection reagent tki-resistant cell lines egfr-mutant lung cancers egfr mutant-resistant cancers tyrosine kinase inhibitors nih/national cancer institute author correspondence patient-derived cell lines erlotinib-resistant cell lines alk-rearranged lung cancers paraffin-embedded tissue sections bonferroni post-hoc test celltiter-glo assay reagent full size image rb-deficient adenocarcinomas serves molecular details underlying tumour/cell line samples yield resistant cells/tumours removing low expressing cancer drug development exome-enriched gdna fragments advanced egfr mutation-positive cell lines established lose egfr expression cell viability assays alk kinase inhibitors small-cell carcinoma small-cell carcinoma squamous cell carcinoma

Schema {🗺️}

WebPage:
      mainEntity:
         headline:RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer
         description:Tyrosine kinase inhibitors are effective treatments for non-small-cell lung cancers (NSCLCs) with epidermal growth factor receptor (EGFR) mutations. However, relapse typically occurs after an average of 1 year of continuous treatment. A fundamental histological transformation from NSCLC to small-cell lung cancer (SCLC) is observed in a subset of the resistant cancers, but the molecular changes associated with this transformation remain unknown. Analysis of tumour samples and cell lines derived from resistant EGFR mutant patients revealed that Retinoblastoma (RB) is lost in 100% of these SCLC transformed cases, but rarely in those that remain NSCLC. Further, increased neuroendocrine marker and decreased EGFR expression as well as greater sensitivity to BCL2 family inhibition are observed in resistant SCLC transformed cancers compared with resistant NSCLCs. Together, these findings suggest that this subset of resistant cancers ultimately adopt many of the molecular and phenotypic characteristics of classical SCLC. Resistance to tyrosine kinase inhibitors occurs in treatments of non-small-cell lung cancers (NSCLCs) with EGFR mutations but the mechanisms underlying this acquired resistance are unknown. Here the authors examine the molecular changes that occur in resistant cancers that transition from NSCLC to small-cell lung cancer phenotype and implicate loss of retinoblastoma in this process.
         datePublished:2015-03-11T00:00:00Z
         dateModified:2015-03-11T00:00:00Z
         pageStart:1
         pageEnd:10
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/ncomms7377
         keywords:
            Lung cancer
            Oncogenesis
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms7377/MediaObjects/41467_2015_Article_BFncomms7377_Figa_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms7377/MediaObjects/41467_2015_Article_BFncomms7377_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms7377/MediaObjects/41467_2015_Article_BFncomms7377_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms7377/MediaObjects/41467_2015_Article_BFncomms7377_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms7377/MediaObjects/41467_2015_Article_BFncomms7377_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms7377/MediaObjects/41467_2015_Article_BFncomms7377_Fig5_HTML.jpg
         isPartOf:
            name:Nature Communications
            issn:
               2041-1723
            volumeNumber:6
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Matthew J. Niederst
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lecia V. Sequist
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:John T. Poirier
               affiliation:
                     name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service
                     address:
                        name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Craig H. Mermel
               affiliation:
                     name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group
                     address:
                        name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Massachusetts General Hospital Cancer Center
                     address:
                        name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Elizabeth L. Lockerman
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Angel R. Garcia
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ryohei Katayama
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Carlotta Costa
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kenneth N. Ross
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Teresa Moran
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Present address: Catalan Institute of Oncology, Avinguda de la Granvia de l’Hospitalet, 199-203, 08907 Barcelona, Spain
                     address:
                        name:Present address: Catalan Institute of Oncology, Avinguda de la Granvia de l’Hospitalet, 199-203, 08907 Barcelona, Spain,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Emily Howe
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Linnea E. Fulton
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hillary E. Mulvey
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lindsay A. Bernardo
               affiliation:
                     name:Massachusetts General Hospital Cancer Center
                     address:
                        name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Pathology, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Farhiya Mohamoud
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Norikatsu Miyoshi
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Paul A. VanderLaan
               affiliation:
                     name:Beth Israel Deaconess Medical Center, Harvard Medical School
                     address:
                        name:Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daniel B. Costa
               affiliation:
                     name:Beth Israel Deaconess Medical Center, Harvard Medical School
                     address:
                        name:Department of Medicine, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pasi A. Jänne
               affiliation:
                     name:Belfer Institute of Applied Science, Dana Farber Cancer Institute
                     address:
                        name:Department of Medical Oncology, Belfer Institute of Applied Science, Dana Farber Cancer Institute, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Brigham and Women’s Hospital and Harvard Medical School
                     address:
                        name:Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Darrell R. Borger
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sridhar Ramaswamy
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group
                     address:
                        name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Toshi Shioda
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anthony J. Iafrate
               affiliation:
                     name:Massachusetts General Hospital Cancer Center
                     address:
                        name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Pathology, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gad Getz
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group
                     address:
                        name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Massachusetts General Hospital Cancer Center
                     address:
                        name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Charles M. Rudin
               affiliation:
                     name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service
                     address:
                        name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mari Mino-Kenudson
               affiliation:
                     name:Massachusetts General Hospital Cancer Center
                     address:
                        name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Pathology, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jeffrey A. Engelman
               affiliation:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                     address:
                        name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer
      description:Tyrosine kinase inhibitors are effective treatments for non-small-cell lung cancers (NSCLCs) with epidermal growth factor receptor (EGFR) mutations. However, relapse typically occurs after an average of 1 year of continuous treatment. A fundamental histological transformation from NSCLC to small-cell lung cancer (SCLC) is observed in a subset of the resistant cancers, but the molecular changes associated with this transformation remain unknown. Analysis of tumour samples and cell lines derived from resistant EGFR mutant patients revealed that Retinoblastoma (RB) is lost in 100% of these SCLC transformed cases, but rarely in those that remain NSCLC. Further, increased neuroendocrine marker and decreased EGFR expression as well as greater sensitivity to BCL2 family inhibition are observed in resistant SCLC transformed cancers compared with resistant NSCLCs. Together, these findings suggest that this subset of resistant cancers ultimately adopt many of the molecular and phenotypic characteristics of classical SCLC. Resistance to tyrosine kinase inhibitors occurs in treatments of non-small-cell lung cancers (NSCLCs) with EGFR mutations but the mechanisms underlying this acquired resistance are unknown. Here the authors examine the molecular changes that occur in resistant cancers that transition from NSCLC to small-cell lung cancer phenotype and implicate loss of retinoblastoma in this process.
      datePublished:2015-03-11T00:00:00Z
      dateModified:2015-03-11T00:00:00Z
      pageStart:1
      pageEnd:10
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/ncomms7377
      keywords:
         Lung cancer
         Oncogenesis
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms7377/MediaObjects/41467_2015_Article_BFncomms7377_Figa_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms7377/MediaObjects/41467_2015_Article_BFncomms7377_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms7377/MediaObjects/41467_2015_Article_BFncomms7377_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms7377/MediaObjects/41467_2015_Article_BFncomms7377_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms7377/MediaObjects/41467_2015_Article_BFncomms7377_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms7377/MediaObjects/41467_2015_Article_BFncomms7377_Fig5_HTML.jpg
      isPartOf:
         name:Nature Communications
         issn:
            2041-1723
         volumeNumber:6
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Matthew J. Niederst
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lecia V. Sequist
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:John T. Poirier
            affiliation:
                  name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service
                  address:
                     name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Craig H. Mermel
            affiliation:
                  name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group
                  address:
                     name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Massachusetts General Hospital Cancer Center
                  address:
                     name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Elizabeth L. Lockerman
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Angel R. Garcia
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ryohei Katayama
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carlotta Costa
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kenneth N. Ross
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Teresa Moran
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Present address: Catalan Institute of Oncology, Avinguda de la Granvia de l’Hospitalet, 199-203, 08907 Barcelona, Spain
                  address:
                     name:Present address: Catalan Institute of Oncology, Avinguda de la Granvia de l’Hospitalet, 199-203, 08907 Barcelona, Spain,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Emily Howe
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Linnea E. Fulton
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hillary E. Mulvey
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lindsay A. Bernardo
            affiliation:
                  name:Massachusetts General Hospital Cancer Center
                  address:
                     name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Pathology, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Farhiya Mohamoud
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Norikatsu Miyoshi
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Paul A. VanderLaan
            affiliation:
                  name:Beth Israel Deaconess Medical Center, Harvard Medical School
                  address:
                     name:Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel B. Costa
            affiliation:
                  name:Beth Israel Deaconess Medical Center, Harvard Medical School
                  address:
                     name:Department of Medicine, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pasi A. Jänne
            affiliation:
                  name:Belfer Institute of Applied Science, Dana Farber Cancer Institute
                  address:
                     name:Department of Medical Oncology, Belfer Institute of Applied Science, Dana Farber Cancer Institute, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Brigham and Women’s Hospital and Harvard Medical School
                  address:
                     name:Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Darrell R. Borger
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sridhar Ramaswamy
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group
                  address:
                     name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Toshi Shioda
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anthony J. Iafrate
            affiliation:
                  name:Massachusetts General Hospital Cancer Center
                  address:
                     name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Pathology, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gad Getz
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group
                  address:
                     name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Massachusetts General Hospital Cancer Center
                  address:
                     name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Charles M. Rudin
            affiliation:
                  name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service
                  address:
                     name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mari Mino-Kenudson
            affiliation:
                  name:Massachusetts General Hospital Cancer Center
                  address:
                     name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Pathology, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jeffrey A. Engelman
            affiliation:
                  name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
                  address:
                     name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Nature Communications
      issn:
         2041-1723
      volumeNumber:6
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service
      address:
         name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service, New York, USA
         type:PostalAddress
      name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group
      address:
         name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center
      address:
         name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Present address: Catalan Institute of Oncology, Avinguda de la Granvia de l’Hospitalet, 199-203, 08907 Barcelona, Spain
      address:
         name:Present address: Catalan Institute of Oncology, Avinguda de la Granvia de l’Hospitalet, 199-203, 08907 Barcelona, Spain,
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center
      address:
         name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Pathology, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Beth Israel Deaconess Medical Center, Harvard Medical School
      address:
         name:Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Beth Israel Deaconess Medical Center, Harvard Medical School
      address:
         name:Department of Medicine, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Belfer Institute of Applied Science, Dana Farber Cancer Institute
      address:
         name:Department of Medical Oncology, Belfer Institute of Applied Science, Dana Farber Cancer Institute, Boston, USA
         type:PostalAddress
      name:Brigham and Women’s Hospital and Harvard Medical School
      address:
         name:Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group
      address:
         name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center
      address:
         name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Pathology, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group
      address:
         name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center
      address:
         name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
         type:PostalAddress
      name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service
      address:
         name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service, New York, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center
      address:
         name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Pathology, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
      address:
         name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Matthew J. Niederst
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Lecia V. Sequist
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:John T. Poirier
      affiliation:
            name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service
            address:
               name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service, New York, USA
               type:PostalAddress
            type:Organization
      name:Craig H. Mermel
      affiliation:
            name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group
            address:
               name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Massachusetts General Hospital Cancer Center
            address:
               name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
               type:PostalAddress
            type:Organization
      name:Elizabeth L. Lockerman
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Angel R. Garcia
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Ryohei Katayama
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Carlotta Costa
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Kenneth N. Ross
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Teresa Moran
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Present address: Catalan Institute of Oncology, Avinguda de la Granvia de l’Hospitalet, 199-203, 08907 Barcelona, Spain
            address:
               name:Present address: Catalan Institute of Oncology, Avinguda de la Granvia de l’Hospitalet, 199-203, 08907 Barcelona, Spain,
               type:PostalAddress
            type:Organization
      name:Emily Howe
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Linnea E. Fulton
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Hillary E. Mulvey
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Lindsay A. Bernardo
      affiliation:
            name:Massachusetts General Hospital Cancer Center
            address:
               name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Pathology, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Farhiya Mohamoud
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Norikatsu Miyoshi
      affiliation:
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
      name:Paul A. VanderLaan
      affiliation:
            name:Beth Israel Deaconess Medical Center, Harvard Medical School
            address:
               name:Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Daniel B. Costa
      affiliation:
            name:Beth Israel Deaconess Medical Center, Harvard Medical School
            address:
               name:Department of Medicine, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Pasi A. Jänne
      affiliation:
            name:Belfer Institute of Applied Science, Dana Farber Cancer Institute
            address:
               name:Department of Medical Oncology, Belfer Institute of Applied Science, Dana Farber Cancer Institute, Boston, USA
               type:PostalAddress
            type:Organization
            name:Brigham and Women’s Hospital and Harvard Medical School
            address:
               name:Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Darrell R. Borger
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Sridhar Ramaswamy
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group
            address:
               name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Toshi Shioda
      affiliation:
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
      name:Anthony J. Iafrate
      affiliation:
            name:Massachusetts General Hospital Cancer Center
            address:
               name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Pathology, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Gad Getz
      affiliation:
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group
            address:
               name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Massachusetts General Hospital Cancer Center
            address:
               name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
               type:PostalAddress
            type:Organization
      name:Charles M. Rudin
      affiliation:
            name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service
            address:
               name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service, New York, USA
               type:PostalAddress
            type:Organization
      name:Mari Mino-Kenudson
      affiliation:
            name:Massachusetts General Hospital Cancer Center
            address:
               name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Pathology, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Jeffrey A. Engelman
      affiliation:
            name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital
            address:
               name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service, New York, USA
      name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
      name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Present address: Catalan Institute of Oncology, Avinguda de la Granvia de l’Hospitalet, 199-203, 08907 Barcelona, Spain,
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
      name:Department of Pathology, Harvard Medical School, Boston, USA
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
      name:Department of Medicine, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
      name:Department of Medical Oncology, Belfer Institute of Applied Science, Dana Farber Cancer Institute, Boston, USA
      name:Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
      name:Department of Pathology, Harvard Medical School, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA
      name:Broad Institute of MIT and Harvard, Cancer Genome Comparative Analysis Group, Cambridge, USA
      name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
      name:Memorial Sloan Kettering Cancer Center, Thoracic Oncology Service, New York, USA
      name:Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, USA
      name:Department of Pathology, Harvard Medical School, Boston, USA
      name:Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, USA
      name:Department of Medicine, Harvard Medical School, Boston, USA

Social Networks {👍}(2)

• https://www.facebook.com/NatureCommunications
• https://twitter.com/NatureComms

External Links {🔗}(150)

• What's http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE64765's gross income?
• How much does http://www.broadinstitute.org/ccle/home bring in each month?
• How much revenue does http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE64322 bring in?
• How much profit is http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE64766 making per month?
• What's the income generated by https://doi.org/10.1056%2FNEJMoa0810699 each month?
• How much does http://scholar.google.com/scholar_lookup?&title=Gefitinib%20or%20carboplatin-paclitaxel%20in%20pulmonary%20adenocarcinoma&journal=New%20Engl.%20J.%20Med.&doi=10.1056%2FNEJMoa0810699&volume=361&pages=947-957&publication_year=2009&author=Mok%2CTS bring in each month?
• What is the earnings of https://doi.org/10.1016%2FS1470-2045%2809%2970364-X?
• How much money does http://scholar.google.com/scholar_lookup?&title=Gefitinib%20versus%20cisplatin%20plus%20docetaxel%20in%20patients%20with%20non-small-cell%20lung%20cancer%20harbouring%20mutations%20of%20the%20epidermal%20growth%20factor%20receptor%20%28WJTOG3405%29%3A%20an%20open%20label%2C%20randomised%20phase%203%20trial&journal=Lancet%20Oncol.&doi=10.1016%2FS1470-2045%2809%2970364-X&volume=11&pages=121-128&publication_year=2010&author=Mitsudomi%2CT make?
• How much does https://doi.org/10.1056%2FNEJMoa0909530 pull in monthly?
• What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Gefitinib%20or%20chemotherapy%20for%20non-small-cell%20lung%20cancer%20with%20mutated%20EGFR&journal=New%20Engl.%20J.%20Med.&doi=10.1056%2FNEJMoa0909530&volume=362&pages=2380-2388&publication_year=2010&author=Maemondo%2CM?
• How much does https://doi.org/10.1016%2FS1470-2045%2811%2970393-X pull in monthly?
• What's http://scholar.google.com/scholar_lookup?&title=Erlotinib%20versus%20standard%20chemotherapy%20as%20first-line%20treatment%20for%20European%20patients%20with%20advanced%20EGFR%20mutation-positive%20non-small-cell%20lung%20cancer%20%28EURTAC%29%3A%20a%20multicentre%2C%20open-label%2C%20randomised%20phase%203%20trial&journal=Lancet%20Oncol.&doi=10.1016%2FS1470-2045%2811%2970393-X&volume=13&pages=239-246&publication_year=2012&author=Rosell%2CR's gross income?
• What's the financial gain of https://doi.org/10.1200%2FJCO.2012.44.2806?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Phase%20III%20study%20of%20afatinib%20or%20cisplatin%20plus%20pemetrexed%20in%20patients%20with%20metastatic%20lung%20adenocarcinoma%20with%20EGFR%20mutations&journal=J.%20Clin.%20Oncol.&doi=10.1200%2FJCO.2012.44.2806&volume=31&pages=3327-3334&publication_year=2013&author=Sequist%2CLV generate?
• What's https://doi.org/10.1200%2FJCO.2012.43.3912's gross income?
• Profit of http://scholar.google.com/scholar_lookup?&title=Epidermal%20growth%20factor%20receptor%20tyrosine%20kinase%20inhibitor-resistant%20disease&journal=J.%20Clin.%20Oncol.&doi=10.1200%2FJCO.2012.43.3912&volume=31&pages=1070-1080&publication_year=2013&author=Ohashi%2CK&author=Maruvka%2CYE&author=Michor%2CF&author=Pao%2CW
• https://doi.org/10.1126%2Fscitranslmed.3002003's financial summary
• How much money does http://scholar.google.com/scholar_lookup?&title=Genotypic%20and%20histological%20evolution%20of%20lung%20cancers%20acquiring%20resistance%20to%20EGFR%20inhibitors&journal=Sci.%20Transl.%20Med.&doi=10.1126%2Fscitranslmed.3002003&volume=3&publication_year=2011&author=Sequist%2CLV make?
• What's the income of https://doi.org/10.1056%2FNEJMc053610?
• What is the earnings of http://scholar.google.com/scholar_lookup?&title=EGFR%20mutations%20in%20small-cell%20lung%20cancers%20in%20patients%20who%20have%20never%20smoked&journal=New%20Engl.%20J.%20Med.&doi=10.1056%2FNEJMc053610&volume=355&pages=213-215&publication_year=2006&author=Zakowski%2CMF&author=Ladanyi%2CM&author=Kris%2CMG?
• What is the earnings of https://doi.org/10.1016%2Fj.lungcan.2007.05.014?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Sequential%20occurrence%20of%20non-small%20cell%20and%20small%20cell%20lung%20cancer%20with%20the%20same%20EGFR%20mutation&journal=Lung%20Cancer&doi=10.1016%2Fj.lungcan.2007.05.014&volume=58&pages=411-413&publication_year=2007&author=Morinaga%2CR?
• How much does https://doi.org/10.1093%2Fannonc%2Fmdj114 pull in?
• See how much http://scholar.google.com/scholar_lookup?&title=EGFR%20mutation%20in%20gefitinib-responsive%20small-cell%20lung%20cancer&journal=Ann.%20Oncol.&doi=10.1093%2Fannonc%2Fmdj114&volume=17&pages=1028-1029&publication_year=2006&author=Okamoto%2CI makes per month
• What is the earnings of https://doi.org/10.1111%2Fj.1349-7006.2007.00600.x?
• What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Epidermal%20growth%20factor%20receptor%20mutation%20status%20and%20clinicopathological%20features%20of%20combined%20small%20cell%20carcinoma%20with%20adenocarcinoma%20of%20the%20lung&journal=Cancer%20Sci.&doi=10.1111%2Fj.1349-7006.2007.00600.x&volume=98&pages=1714-1719&publication_year=2007&author=Fukui%2CT?
• What's the financial outcome of https://doi.org/10.1158%2F1078-0432.CCR-08-0332?
• Find out how much http://scholar.google.com/scholar_lookup?&title=Epidermal%20growth%20factor%20receptor%20mutations%20in%20small%20cell%20lung%20cancer&journal=Clin.%20Cancer%20Res.&doi=10.1158%2F1078-0432.CCR-08-0332&volume=14&pages=6092-6096&publication_year=2008&author=Tatematsu%2CA earns monthly
• https://doi.org/10.1158%2F1078-0432.CCR-12-2246 income
• Monthly income for http://scholar.google.com/scholar_lookup?&title=Analysis%20of%20tumor%20specimens%20at%20the%20time%20of%20acquired%20resistance%20to%20EGFR-TKI%20therapy%20in%20155%20patients%20with%20EGFR-mutant%20lung%20cancers&journal=Clin.%20Cancer%20Res.&doi=10.1158%2F1078-0432.CCR-12-2246&volume=19&pages=2240-2247&publication_year=2013&author=Yu%2CHA
• What are the earnings of https://doi.org/10.1126%2Fscitranslmed.3003316?
• Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Mechanisms%20of%20acquired%20crizotinib%20resistance%20in%20ALK-rearranged%20lung%20Cancers&journal=Sci.%20Transl.%20Med.&doi=10.1126%2Fscitranslmed.3003316&volume=4&publication_year=2012&author=Katayama%2CR
• How much money does https://doi.org/10.1158%2F0008-5472.CAN-11-1340 generate?
• How much does http://scholar.google.com/scholar_lookup?&title=A%20novel%20ALK%20secondary%20mutation%20and%20EGFR%20signaling%20cause%20resistance%20to%20ALK%20kinase%20inhibitors&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-11-1340&volume=71&pages=6051-6060&publication_year=2011&author=Sasaki%2CT net monthly?
• See how much https://doi.org/10.1126%2Fscience.1254721 makes per month
• What's http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2014Sci...346.1480C's gross income?
• What are the earnings of http://scholar.google.com/scholar_lookup?&title=Patient-derived%20models%20of%20acquired%20resistance%20can%20identify%20effective%20drug%20combinations%20for%20cancer&journal=Science&doi=10.1126%2Fscience.1254721&volume=346&pages=1480-1486&publication_year=2014&author=Crystal%2CAS?
• How much does https://link.springer.com/doi/10.1186/1756-9966-29-75 pull in?
• Find out how much http://scholar.google.com/scholar_lookup?&title=MicroRNA%20expression%20distinguishes%20SCLC%20from%20NSCLC%20lung%20tumor%20cells%20and%20suggests%20a%20possible%20pathological%20relationship%20between%20SCLCs%20and%20NSCLCs&journal=J.%20Exp.%20Clin.%20Cancer%20Res.&doi=10.1186%2F1756-9966-29-75&volume=29&publication_year=2010&author=Du%2CL earns monthly
• Discover the revenue of https://doi.org/10.1016%2Fj.ccr.2010.12.021
• Get to know http://scholar.google.com/scholar_lookup?&title=A%20functional%20role%20for%20tumor%20cell%20heterogeneity%20in%20a%20mouse%20model%20of%20small%20cell%20lung%20cancer&journal=Cancer%20Cell&doi=10.1016%2Fj.ccr.2010.12.021&volume=19&pages=244-256&publication_year=2011&author=Calbo%2CJ's earnings
• Income figures for https://doi.org/10.1038%2Fnature08622
• How much revenue does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009Natur.462.1070Z produce monthly?
• How much does http://scholar.google.com/scholar_lookup?&title=Novel%20mutant-selective%20EGFR%20kinase%20inhibitors%20against%20EGFR%20T790M&journal=Nature&doi=10.1038%2Fnature08622&volume=462&pages=1070-1074&publication_year=2009&author=Zhou%2CW pull in monthly?
• Revenue of https://doi.org/10.1038%2Fnature11003
• Financial intake of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2012Natur.483..603B
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=The%20Cancer%20Cell%20Line%20Encyclopedia%20enables%20predictive%20modelling%20of%20anticancer%20drug%20sensitivity&journal=Nature&doi=10.1038%2Fnature11003&volume=483&pages=603-607&publication_year=2012&author=Barretina%2CJ
• What's the revenue for https://doi.org/10.1158%2F1078-0432.CCR-07-4622?
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=Activity%20of%20the%20Bcl-2%20family%20inhibitor%20ABT-263%20in%20a%20panel%20of%20small%20cell%20lung%20cancer%20xenograft%20models&journal=Clin.%20Cancer%20Res.&doi=10.1158%2F1078-0432.CCR-07-4622&volume=14&pages=3268-3277&publication_year=2008&author=Shoemaker%2CAR is on a monthly basis
• What's the profit of https://doi.org/10.1158%2F1078-0432.CCR-11-3090?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Phase%20II%20study%20of%20single-agent%20navitoclax%20%28ABT-263%29%20and%20biomarker%20correlates%20in%20patients%20with%20relapsed%20small%20cell%20lung%20cancer&journal=Clin.%20Cancer%20Res.&doi=10.1158%2F1078-0432.CCR-11-3090&volume=18&pages=3163-3169&publication_year=2012&author=Rudin%2CCM?
• What's the revenue for https://doi.org/10.1158%2F0008-5472.CAN-13-3460?
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=Rapamycin%20rescues%20ABT-737%20efficacy%20in%20small%20cell%20lung%20cancer&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-13-3460&volume=74&pages=2846-2856&publication_year=2014&author=Gardner%2CEE have monthly?
• Monthly income for https://doi.org/10.1038%2Fng.2405
• How much income is http://scholar.google.com/scholar_lookup?&title=Comprehensive%20genomic%20analysis%20identifies%20SOX2%20as%20a%20frequently%20amplified%20gene%20in%20small-cell%20lung%20cancer&journal=Nat.%20Genet.&doi=10.1038%2Fng.2405&volume=44&pages=1111-1116&publication_year=2012&author=Rudin%2CCM earning monthly?
• See how much https://doi.org/10.1038%2Fng.2396 makes per month
• Income figures for http://scholar.google.com/scholar_lookup?&title=Integrative%20genome%20analyses%20identify%20key%20somatic%20driver%20mutations%20of%20small-cell%20lung%20cancer&journal=Nat.%20Genet.&doi=10.1038%2Fng.2396&volume=44&pages=1104-1110&publication_year=2012&author=Peifer%2CM
• What's the financial gain of https://doi.org/10.1016%2FS0140-6736%2811%2960165-7?
• Find out how much http://scholar.google.com/scholar_lookup?&title=Small-cell%20lung%20cancer&journal=Lancet&doi=10.1016%2FS0140-6736%2811%2960165-7&volume=378&pages=1741-1755&publication_year=2011&author=van%20Meerbeeck%2CJP&author=Fennell%2CDA&author=De%20Ruysscher%2CDK earns monthly
• How much does https://doi.org/10.1038%2F376337a0 make?
• What is the earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1995Natur.376..337M?
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Epithelial%20immaturity%20and%20multiorgan%20failure%20in%20mice%20lacking%20epidermal%20growth%20factor%20receptor&journal=Nature&doi=10.1038%2F376337a0&volume=376&pages=337-341&publication_year=1995&author=Miettinen%2CPJ?
• Find out how much https://doi.org/10.1097%2FJTO.0b013e3181f94abb earns monthly
• Income figures for http://scholar.google.com/scholar_lookup?&title=Epidermal%20growth%20factor%20receptor%20mutations%20in%20small%20cell%20lung%20cancer%3A%20a%20brief%20report&journal=J.%20Thorac.%20Oncol.&doi=10.1097%2FJTO.0b013e3181f94abb&volume=6&pages=195-198&publication_year=2011&author=Shiao%2CTH
• Get to know https://doi.org/10.1158%2F2159-8290.CD-12-0112's earnings
• What is the earnings of http://scholar.google.com/scholar_lookup?&title=Proteomic%20profiling%20identifies%20dysregulated%20pathways%20in%20small%20cell%20lung%20cancer%20and%20novel%20therapeutic%20targets%20including%20PARP1&journal=Cancer%20Discov.&doi=10.1158%2F2159-8290.CD-12-0112&volume=2&pages=798-811&publication_year=2012&author=Byers%2CLA?
• What's the total monthly financial gain of https://doi.org/10.1093%2Fannonc%2Fmdu331.9?
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Updated%20safety%20and%20efficacy%20from%20a%20phase%20I%20study%20of%20AZD9291%20in%20patients%20%28PTS%29%20with%20EGFR-TKI-Resistant%20non-small%20cell%20lung%20cancer%20%28NSCLC%29&journal=EMSO%20Meet.%20Abstr.%20Ann.%20Oncol&doi=10.1093%2Fannonc%2Fmdu331.9&volume=25&publication_year=2014&author=Yang%2CJC
• Revenue of https://doi.org/10.1093%2Fannonc%2Fmdr489
• How much does http://scholar.google.com/scholar_lookup?&title=Implementing%20multiplexed%20genotyping%20of%20non-small-cell%20lung%20cancers%20into%20routine%20clinical%20practice&journal=Ann.%20Oncol.&doi=10.1093%2Fannonc%2Fmdr489&volume=22&pages=2616-2624&publication_year=2011&author=Sequist%2CLV net monthly?
• What's the financial intake of https://doi.org/10.1126%2Fscisignal.2001148?
• Earnings of http://scholar.google.com/scholar_lookup?&title=BRAF%20gene%20amplification%20can%20promote%20acquired%20resistance%20to%20MEK%20inhibitors%20in%20cancer%20cells%20harboring%20the%20BRAF%20V600E%20mutation&journal=Sci.%20Signal.&doi=10.1126%2Fscisignal.2001148&volume=3&publication_year=2010&author=Corcoran%2CRB
• https://doi.org/10.1038%2Fnature07310's financial summary
• What's the profit of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2008Natur.455..552M?
• What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=E2F1%20represses%20beta-catenin%20transcription%20and%20is%20antagonized%20by%20both%20pRB%20and%20CDK8&journal=Nature&doi=10.1038%2Fnature07310&volume=455&pages=552-556&publication_year=2008&author=Morris%2CEJ?
• https://doi.org/10.1126%2Fscience.1141478's revenue stream
• What's the income of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2007Sci...316.1039E?
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=MET%20amplification%20leads%20to%20gefitinib%20resistance%20in%20lung%20cancer%20by%20activating%20ERBB3%20signaling&journal=Science&doi=10.1126%2Fscience.1141478&volume=316&pages=1039-1043&publication_year=2007&author=Engelman%2CJA
• https://doi.org/10.1038%2Fnature11005's total income per month
• What's the income generated by http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2012Natur.483..570G each month?
• Income figures for http://scholar.google.com/scholar_lookup?&title=Systematic%20identification%20of%20genomic%20markers%20of%20drug%20sensitivity%20in%20cancer%20cells&journal=Nature&doi=10.1038%2Fnature11005&volume=483&pages=570-575&publication_year=2012&author=Garnett%2CMJ
• Get to know what's the income of https://citation-needed.springer.com/v2/references/10.1038/ncomms7377?format=refman&flavour=references
• How much profit is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Matthew%20J.%20Niederst making per month?
• Find out how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Matthew%20J.%20Niederst%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earns monthly
• What's the monthly money flow for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Lecia%20V.%20Sequist?
• What's https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Lecia%20V.%20Sequist%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's gross income?
• What's the financial outcome of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=John%20T.%20Poirier?
• How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22John%20T.%20Poirier%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
• Find out how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Craig%20H.%20Mermel earns monthly
• Revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Craig%20H.%20Mermel%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Elizabeth%20L.%20Lockerman rake in every month?
• See how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Elizabeth%20L.%20Lockerman%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en makes per month
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Angel%20R.%20Garcia's financial summary
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Angel%20R.%20Garcia%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earn?
• How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ryohei%20Katayama have?
• Learn about the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ryohei%20Katayama%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much income is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Carlotta%20Costa earning monthly?
• Get to know https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Carlotta%20Costa%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's earnings
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kenneth%20N.%20Ross's financial summary
• What's the total monthly financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kenneth%20N.%20Ross%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Teresa%20Moran bring in each month?
• How profitable is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Teresa%20Moran%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Emily%20Howe make?
• Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Emily%20Howe%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• What's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Linnea%20E.%20Fulton?
• What's the income generated by https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Linnea%20E.%20Fulton%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en each month?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hillary%20E.%20Mulvey make?
• What is the monthly revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hillary%20E.%20Mulvey%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Lindsay%20A.%20Bernardo
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Lindsay%20A.%20Bernardo%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• Find out how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Farhiya%20Mohamoud earns monthly
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Farhiya%20Mohamoud%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en produce monthly?
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Norikatsu%20Miyoshi's total income per month
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Norikatsu%20Miyoshi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• What's the profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Paul%20A.%20VanderLaan?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Paul%20A.%20VanderLaan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Daniel%20B.%20Costa bring in each month?
• Learn about the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Daniel%20B.%20Costa%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Pasi%20A.%20J%C3%A4nne generate?
• What's the total monthly financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Pasi%20A.%20J%C3%A4nne%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Darrell%20R.%20Borger make?
• What are the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Darrell%20R.%20Borger%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sridhar%20Ramaswamy produce monthly?
• Explore the financials of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sridhar%20Ramaswamy%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much income is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Toshi%20Shioda earning monthly?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Toshi%20Shioda%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Anthony%20J.%20Iafrate make?
• What is the monthly revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Anthony%20J.%20Iafrate%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What are the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Gad%20Getz?
• What's the financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Gad%20Getz%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What is the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Charles%20M.%20Rudin?
• How much income does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Charles%20M.%20Rudin%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have?
• What are the total earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Mari%20Mino-Kenudson?
• What is the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Mari%20Mino-Kenudson%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jeffrey%20A.%20Engelman have?
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jeffrey%20A.%20Engelman%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• Profit of https://static-content.springer.com/esm/art%3A10.1038%2Fncomms7377/MediaObjects/41467_2015_BFncomms7377_MOESM988_ESM.pdf
• http://creativecommons.org/licenses/by/4.0/'s total income per month
• How much does https://s100.copyright.com/AppDispatchServlet?title=RB%20loss%20in%20resistant%20EGFR%20mutant%20lung%20adenocarcinomas%20that%20transform%20to%20small-cell%20lung%20cancer&author=Matthew%20J.%20Niederst%20et%20al&contentID=10.1038%2Fncomms7377©right=The%20Author%28s%29&publication=2041-1723&publicationDate=2015-03-11&publisherName=SpringerNature&orderBeanReset=true&oa=CC%20BY pull in?
• How much does https://crossmark.crossref.org/dialog/?doi=10.1038/ncomms7377 net monthly?
• How much does https://citation-needed.springer.com/v2/references/10.1038/ncomms7377?format=refman&flavour=citation rake in every month?
• What's the monthly income of https://doi.org/10.1186/s12964-023-01260-8?
• What's the monthly money flow for https://doi.org/10.1038/s41698-023-00490-w?
• Monthly income for https://doi.org/10.1186/s12943-023-01892-x
• What's https://doi.org/10.1038/s44276-023-00015-9's gross income?
• How much does https://doi.org/10.1038/s41698-023-00464-y generate monthly?
• How much profit is https://www.protocols.io/ making per month?
• Learn about the earnings of https://www.natureindex.com/
• http://www.naturechina.com's financial summary
• How much revenue does https://www.natureasia.com/ja-jp generate?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref