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nature portfolio permissions reprints pkm2/stat1-mediated pd-l1 upregulation privacy policy cardiovascular translational research advertising author information authors medical research anti-hmgb1-neutralizing antibody nature 330 nature 418 nature 493 nature 496 nature 452 nature attenuate lps-induced il-1β full access kits japan development gel-pro analyzer software vesicle-mediated secretory pathway ifn-γ-induced hmgb1 release secretory lysosome-mediated exocytosis hypoxia-inducible factor 1α research real-time quantitative pcr metabolism-driven reprogramming dictates hypoxia inducible factor-1alpha enzyme-linked immunosorbant assay rate-limiting reaction step tumour necrosis factor-alpha autocrine hmgb1-dependent pathway peroxidase-conjugated secondary antibodies hypoxia regulates beta-enolase fulfill anti-inflammatory functions full size image tumour necrosis factor-α hif-1α-dependent transcription lps-induced glycolytic genes extracellular signal-regulated kinase targeting hypoxia-induced inflammation lps-induced hmgb1 acetylation pkm2-mediated hif1α activation gram-negative bacterial infection2 pro-inflammatory th17 cells33 bone marrow-derived macrophages growing evidence suggests aerobic glycolysis-related genes lps-induced lactate production

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