NATURE . COM {}

Matching Content Categories {📚}

• Education
• Science
• Video & Online Content

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,797,153 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$539,300 per month
According to our algorithms, Nature.com's monthly online income from display advertising ranges from $359,538 to $988,730.

Keywords {🔍}

cas, dna, cleavage, target, crrna, fret, article, fig, conformational, binding, google, scholar, tracrrna, casgrna, nature, rloop, conformation, complex, grnas, inactive, supplementary, singlemolecule, data, activity, min, time, nuclease, structure, state, casgrnadna, efficiency, states, crisprcas, sequences, end, pamdistal, ads, structural, kim, genome, results, open, guide, endonuclease, active, apocas, rna, fluorescence, formation, strand,

Topics {✒️}

nature portfolio privacy policy rna-related solutions national research foundation rna-programmed genome editing advertising short-lived open conformation γ=δ iacceptor/δ idonor=1 social media efficient genome editing research 0/ reprints nature 471 nature 507 nature 513 nature 527 nature ni-nta agarose beads single-molecule fluorescence spectroscopy seong keun kim rna-guided endonuclease utilizing genome editing water-immersion objective lens temperature-dependent circular dichroism open conformation resulted increased-fidelity spcas9 variants rna-directed adaptive immunity crrna–dna r-loop structure trans-encoded small rna single rna-guided cas9 single-molecule fret data synchronous single-molecule measurement watson–crick base pairing cas9 rna-guided endonuclease peltier-type temperature controller initiate large-scale conformational r-loop structure based entire rna–dna heteroduplex dna double-helix structures single-molecule time traces prevent urea-mediated denaturation author cas9–grna–dna ternary complex rna–dna base pairing single-molecule fret analysis single-molecule fret measurements pam-proximal bound complex home-built idl pre-incubation temperature increases permissions

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Structural roles of guide RNAs in the nuclease activity of Cas9 endonuclease
         description:The type II CRISPR-associated protein Cas9 recognizes and cleaves target DNA with the help of two guide RNAs (gRNAs; tracrRNA and crRNA). However, the detailed mechanisms and kinetics of these gRNAs in the Cas9 nuclease activity are unclear. Here, we investigate the structural roles of gRNAs in the CRISPR-Cas9 system by single-molecule spectroscopy and reveal a new conformation of inactive Cas9 that is thermodynamically more preferable than active apo-Cas9. We find that tracrRNA prevents Cas9 from changing into the inactive form and leads to the Cas9:gRNA complex. For the Cas9:gRNA complex, we identify sub-conformations of the RNA–DNA heteroduplex during R-loop expansion. Our single-molecule study indicates that the kinetics of the sub-conformations is controlled by the complementarity between crRNA and target DNA. We conclude that both tracrRNA and crRNA regulate the conformations and kinetics of the Cas9 complex, which are crucial in the DNA cleavage activity of the CRISPR-Cas9 system. In bacteria, CRISPR-Cas9 identifies and cleaves the target DNA with the assistance of a tracrRNA and a crRNA. Here the authors use single-molecule spectroscopy to investigate conformational changes and show that the tracrRNA keeps Cas9 in a functionally active form.
         datePublished:2016-11-02T00:00:00Z
         dateModified:2016-11-02T00:00:00Z
         pageStart:1
         pageEnd:8
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/ncomms13350
         keywords:
            Biological fluorescence
            CRISPR-Cas9 genome editing
            Enzyme mechanisms
            Structural biology
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Figa_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig5_HTML.jpg
         isPartOf:
            name:Nature Communications
            issn:
               2041-1723
            volumeNumber:7
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Youngbin Lim
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:So Young Bak
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Keewon Sung
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Euihwan Jeong
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Seung Hwan Lee
               affiliation:
                     name:Center for Genome Engineering, Institute for Basic Science
                     address:
                        name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jin-Soo Kim
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:Center for Genome Engineering, Institute for Basic Science
                     address:
                        name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sangsu Bae
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:Center for Genome Engineering, Institute for Basic Science
                     address:
                        name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea
                     address:
                        name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea,
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Seong Keun Kim
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Structural roles of guide RNAs in the nuclease activity of Cas9 endonuclease
      description:The type II CRISPR-associated protein Cas9 recognizes and cleaves target DNA with the help of two guide RNAs (gRNAs; tracrRNA and crRNA). However, the detailed mechanisms and kinetics of these gRNAs in the Cas9 nuclease activity are unclear. Here, we investigate the structural roles of gRNAs in the CRISPR-Cas9 system by single-molecule spectroscopy and reveal a new conformation of inactive Cas9 that is thermodynamically more preferable than active apo-Cas9. We find that tracrRNA prevents Cas9 from changing into the inactive form and leads to the Cas9:gRNA complex. For the Cas9:gRNA complex, we identify sub-conformations of the RNA–DNA heteroduplex during R-loop expansion. Our single-molecule study indicates that the kinetics of the sub-conformations is controlled by the complementarity between crRNA and target DNA. We conclude that both tracrRNA and crRNA regulate the conformations and kinetics of the Cas9 complex, which are crucial in the DNA cleavage activity of the CRISPR-Cas9 system. In bacteria, CRISPR-Cas9 identifies and cleaves the target DNA with the assistance of a tracrRNA and a crRNA. Here the authors use single-molecule spectroscopy to investigate conformational changes and show that the tracrRNA keeps Cas9 in a functionally active form.
      datePublished:2016-11-02T00:00:00Z
      dateModified:2016-11-02T00:00:00Z
      pageStart:1
      pageEnd:8
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/ncomms13350
      keywords:
         Biological fluorescence
         CRISPR-Cas9 genome editing
         Enzyme mechanisms
         Structural biology
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Figa_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig5_HTML.jpg
      isPartOf:
         name:Nature Communications
         issn:
            2041-1723
         volumeNumber:7
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Youngbin Lim
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:So Young Bak
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Keewon Sung
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Euihwan Jeong
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Seung Hwan Lee
            affiliation:
                  name:Center for Genome Engineering, Institute for Basic Science
                  address:
                     name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jin-Soo Kim
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Center for Genome Engineering, Institute for Basic Science
                  address:
                     name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sangsu Bae
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Center for Genome Engineering, Institute for Basic Science
                  address:
                     name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea
                  address:
                     name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea,
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Seong Keun Kim
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Nature Communications
      issn:
         2041-1723
      volumeNumber:7
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Seoul National University
      address:
         name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Center for Genome Engineering, Institute for Basic Science
      address:
         name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Center for Genome Engineering, Institute for Basic Science
      address:
         name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Center for Genome Engineering, Institute for Basic Science
      address:
         name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
         type:PostalAddress
      name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea
      address:
         name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea,
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Youngbin Lim
      affiliation:
            name:Seoul National University
            address:
               name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:So Young Bak
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Keewon Sung
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Euihwan Jeong
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Seung Hwan Lee
      affiliation:
            name:Center for Genome Engineering, Institute for Basic Science
            address:
               name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Jin-Soo Kim
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:Center for Genome Engineering, Institute for Basic Science
            address:
               name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Sangsu Bae
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:Center for Genome Engineering, Institute for Basic Science
            address:
               name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea
            address:
               name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea,
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Seong Keun Kim
      affiliation:
            name:Seoul National University
            address:
               name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
      name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
      name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
      name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
      name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
      name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
      name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
      name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
      name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
      name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea,
      name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
      name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea

Social Networks {👍}(2)

• https://www.facebook.com/NatureCommunications
• https://twitter.com/NatureComms

External Links {🔗}(102)

• Monthly income for https://cplc.illinois.edu/software
• How much income does https://doi.org/10.1046%2Fj.1365-2958.2002.02839.x have?
• Monthly income for http://scholar.google.com/scholar_lookup?&title=Identification%20of%20genes%20that%20are%20associated%20with%20DNA%20repeats%20in%20prokaryotes&journal=Mol.%20Microbiol.&doi=10.1046%2Fj.1365-2958.2002.02839.x&volume=43&pages=1565-1575&publication_year=2002&author=Jansen%2CR&author=van%20Embden%2CJDA&author=Gaastra%2CW&author=Schouls%2CLM
• https://doi.org/10.1099%2Fmic.0.28048-0 income
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=Clustered%20regularly%20interspaced%20short%20palindrome%20repeats%20%28CRISPRs%29%20have%20spacers%20of%20extrachromosomal%20origin&journal=Microbiology&doi=10.1099%2Fmic.0.28048-0&volume=151&pages=2551-2561&publication_year=2005&author=Bolotin%2CA&author=Quinquis%2CB&author=Sorokin%2CA&author=Ehrlich%2CSD
• How much does https://doi.org/10.1038%2Fnrg2749 pull in monthly?
• Monthly income for http://scholar.google.com/scholar_lookup?&title=CRISPR%20interference%3A%20RNA-directed%20adaptive%20immunity%20in%20bacteria%20and%20archaea&journal=Nat.%20Rev.%20Genet.&doi=10.1038%2Fnrg2749&volume=11&pages=181-190&publication_year=2010&author=Marraffini%2CLA&author=Sontheimer%2CEJ
• How much does https://doi.org/10.1126%2Fscience.1138140 pull in monthly?
• Discover the revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2007Sci...315.1709B
• How much profit does http://scholar.google.com/scholar_lookup?&title=CRISPR%20provides%20acquired%20resistance%20against%20viruses%20in%20prokaryotes&journal=Science&doi=10.1126%2Fscience.1138140&volume=315&pages=1709-1712&publication_year=2007&author=Barrangou%2CR make?
• What are the total earnings of https://doi.org/10.1038%2Fnature09886?
• Discover the revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2011Natur.471..602D
• How profitable is http://scholar.google.com/scholar_lookup?&title=CRISPR%20RNA%20maturation%20by%20trans-encoded%20small%20RNA%20and%20host%20factor%20RNase%20III&journal=Nature&doi=10.1038%2Fnature09886&volume=471&pages=602-607&publication_year=2011&author=Deltcheva%2CE?
• How much does https://doi.org/10.1038%2Fnrg3686 rake in every month?
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=A%20guide%20to%20genome%20engineering%20with%20programmable%20nucleases&journal=Nat.%20Rev.%20Genet.&doi=10.1038%2Fnrg3686&volume=15&pages=321-334&publication_year=2014&author=Kim%2CH&author=Kim%2CJS?
• What's the monthly money flow for https://doi.org/10.1038%2Fnrmicro2577?
• http://scholar.google.com/scholar_lookup?&title=Evolution%20and%20classification%20of%20the%20CRISPR-Cas%20systems&journal=Nat.%20Rev.%20Microbiol.&doi=10.1038%2Fnrmicro2577&volume=9&pages=467-477&publication_year=2011&author=Makarova%2CKS's total income per month
• Earnings of https://doi.org/10.1099%2Fmic.0.023960-0
• What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Short%20motif%20sequences%20determine%20the%20targets%20of%20the%20prokaryotic%20CRISPR%20defence%20system&journal=Microbiology&doi=10.1099%2Fmic.0.023960-0&volume=155&pages=733-740&publication_year=2009&author=Mojica%2CFJM&author=Diez-Villasenor%2CC&author=Garcia-Martinez%2CJ&author=Almendros%2CC?
• https://doi.org/10.1128%2FJB.01412-07's revenue stream
• What is the earnings of http://scholar.google.com/scholar_lookup?&title=Phage%20response%20to%20CRISPR-encoded%20resistance%20in%20Streptococcus%20thermophilus&journal=J.%20Bacteriol.&doi=10.1128%2FJB.01412-07&volume=190&pages=1390-1400&publication_year=2008&author=Deveau%2CH?
• How much income does https://doi.org/10.1126%2Fscience.1225829 have?
• Discover the revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2012Sci...337..816J
• Income figures for http://scholar.google.com/scholar_lookup?&title=A%20programmable%20dual-RNA-guided%20DNA%20endonuclease%20in%20adaptive%20bacterial%20immunity&journal=Science&doi=10.1126%2Fscience.1225829&volume=337&pages=816-821&publication_year=2012&author=Jinek%2CM
• https://doi.org/10.1126%2Fscience.1231143's revenue stream
• What's the financial intake of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2013Sci...339..819C?
• http://scholar.google.com/scholar_lookup?&title=Multiplex%20genome%20engineering%20using%20CRISPR%2FCas%20systems&journal=Science&doi=10.1126%2Fscience.1231143&volume=339&pages=819-823&publication_year=2013&author=Cong%2CL's total income per month
• Monthly income for https://doi.org/10.7554%2FeLife.00471
• How much does http://scholar.google.com/scholar_lookup?&title=RNA-programmed%20genome%20editing%20in%20human%20cells&journal=Elife&doi=10.7554%2FeLife.00471&volume=2&publication_year=2013&author=Jinek%2CM make?
• How much does https://doi.org/10.1038%2Fnbt.2507 generate monthly?
• How much does http://scholar.google.com/scholar_lookup?&title=Targeted%20genome%20engineering%20in%20human%20cells%20with%20the%20Cas9%20RNA-guided%20endonuclease&journal=Nat.%20Biotechnol.&doi=10.1038%2Fnbt.2507&volume=31&pages=230-232&publication_year=2013&author=Cho%2CSW&author=Kim%2CS&author=Kim%2CJM&author=Kim%2CJS pull in?
• How much does https://doi.org/10.1126%2Fscience.1232033 generate monthly?
• Financial intake of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2013Sci...339..823M
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=RNA-guided%20human%20genome%20engineering%20via%20Cas9&journal=Science&doi=10.1126%2Fscience.1232033&volume=339&pages=823-826&publication_year=2013&author=Mali%2CP
• How much money does https://doi.org/10.1038%2Fnature13011 generate?
• What's the financial outcome of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2014Natur.507...62S?
• http://scholar.google.com/scholar_lookup?&title=DNA%20interrogation%20by%20the%20CRISPR%20RNA-guided%20endonuclease%20Cas9&journal=Nature&doi=10.1038%2Fnature13011&volume=507&pages=62-67&publication_year=2014&author=Sternberg%2CSH&author=Redding%2CS&author=Jinek%2CM&author=Greene%2CEC&author=Doudna%2CJA income
• How profitable is https://doi.org/10.1038%2Fnature13579?
• Discover the revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2014Natur.513..569A
• How much does http://scholar.google.com/scholar_lookup?&title=Structural%20basis%20of%20PAM-dependent%20target%20DNA%20recognition%20by%20the%20Cas9%20endonuclease&journal=Nature&doi=10.1038%2Fnature13579&volume=513&pages=569-573&publication_year=2014&author=Anders%2CC&author=Niewoehner%2CO&author=Duerst%2CA&author=Jinek%2CM rake in every month?
• Explore the financials of https://doi.org/10.1016%2Fj.cell.2014.02.001
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=Crystal%20structure%20of%20Cas9%20in%20complex%20with%20guide%20RNA%20and%20target%20DNA&journal=Cell&doi=10.1016%2Fj.cell.2014.02.001&volume=156&pages=935-949&publication_year=2014&author=Nishimasu%2CH is on a monthly basis
• How much does https://doi.org/10.1126%2Fscience.aab1452 bring in each month?
• How profitable is http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2015Sci...348.1477J?
• What's the revenue for http://scholar.google.com/scholar_lookup?&title=Structural%20biology.%20A%20Cas9-guide%20RNA%20complex%20preorganized%20for%20target%20DNA%20recognition&journal=Science&doi=10.1126%2Fscience.aab1452&volume=348&pages=1477-1481&publication_year=2015&author=Jiang%2CF&author=Zhou%2CK&author=Ma%2CL&author=Gressel%2CS&author=Doudna%2CJA?
• What's the income generated by https://doi.org/10.1126%2Fscience.1247997 each month?
• Monthly income for http://scholar.google.com/scholar_lookup?&title=Structures%20of%20Cas9%20endonucleases%20reveal%20RNA-mediated%20conformational%20activation&journal=Science&doi=10.1126%2Fscience.1247997&volume=343&publication_year=2014&author=Jinek%2CM
• How much does https://doi.org/10.1126%2Fscience.aad8282 earn?
• How much cash flow does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2016Sci...351..867J have monthly?
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=Structures%20of%20a%20CRISPR-Cas9%20R-loop%20complex%20primed%20for%20DNA%20cleavage&journal=Science&doi=10.1126%2Fscience.aad8282&volume=351&pages=867-871&publication_year=2016&author=Jiang%2CF have monthly?
• Get to know https://doi.org/10.1038%2Fnbt.2808's earnings
• How much does http://scholar.google.com/scholar_lookup?&title=Improving%20CRISPR-Cas%20nuclease%20specificity%20using%20truncated%20guide%20RNAs&journal=Nat.%20Biotechnol.&doi=10.1038%2Fnbt.2808&volume=32&pages=279-284&publication_year=2014&author=Fu%2CYF&author=Sander%2CJD&author=Reyon%2CD&author=Cascio%2CVM&author=Joung%2CJK rake in every month?
• Discover the revenue of https://doi.org/10.1126%2Fscience.aad5227
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2016Sci...351...84S gross monthly?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Rationally%20engineered%20Cas9%20nucleases%20with%20improved%20specificity&journal=Science&doi=10.1126%2Fscience.aad5227&volume=351&pages=84-88&publication_year=2016&author=Slaymaker%2CIM bring in?
• Revenue of https://doi.org/10.1038%2Fnbt.2889
• How much does http://scholar.google.com/scholar_lookup?&title=Genome-wide%20binding%20of%20the%20CRISPR%20endonuclease%20Cas9%20in%20mammalian%20cells&journal=Nat.%20Biotechnol.&doi=10.1038%2Fnbt.2889&volume=32&pages=670-676&publication_year=2014&author=Wu%2CXB pull in monthly?
• How much does https://doi.org/10.1073%2Fpnas.1402597111 make?
• How much income is http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2014PNAS..111.9798S earning monthly?
• http://scholar.google.com/scholar_lookup?&title=Direct%20observation%20of%20R-loop%20formation%20by%20single%20RNA-guided%20Cas9%20and%20Cascade%20effector%20complexes&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.1402597111&volume=111&pages=9798-9803&publication_year=2014&author=Szczelkun%2CMD income
• What's the total monthly financial gain of https://doi.org/10.1038%2Fnature15544?
• What's the revenue for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2015Natur.527..110S?
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Conformational%20control%20of%20DNA%20target%20cleavage%20by%20CRISPR-Cas9&journal=Nature&doi=10.1038%2Fnature15544&volume=527&pages=110-113&publication_year=2015&author=Sternberg%2CSH&author=LaFrance%2CB&author=Kaplan%2CM&author=Doudna%2CJA
• Learn about the earnings of https://doi.org/10.1038%2Fnmeth.1208
• How much money does http://scholar.google.com/scholar_lookup?&title=A%20practical%20guide%20to%20single-molecule%20FRET&journal=Nat.%20Methods&doi=10.1038%2Fnmeth.1208&volume=5&pages=507-516&publication_year=2008&author=Roy%2CR&author=Hohng%2CS&author=Ha%2CT generate?
• How much does https://doi.org/10.1021%2Fnn301895c bring in each month?
• How much does http://scholar.google.com/scholar_lookup?&title=Enzymatic%20oxygen%20scavenging%20for%20photostability%20without%20pH%20drop%20in%20single-molecule%20experiments&journal=ACS%20Nano&doi=10.1021%2Fnn301895c&volume=6&pages=6364-6369&publication_year=2012&author=Swoboda%2CM make?
• What's the total monthly financial gain of https://doi.org/10.1016%2Fj.bpj.2009.09.031?
• Get to know http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009BpJ....97.3196B's earnings
• How much profit does http://scholar.google.com/scholar_lookup?&title=Learning%20rates%20and%20states%20from%20biophysical%20time%20series%3A%20a%20Bayesian%20approach%20to%20model%20selection%20and%20single-molecule%20FRET%20data&journal=Biophys.%20J.&doi=10.1016%2Fj.bpj.2009.09.031&volume=97&pages=3196-3205&publication_year=2009&author=Bronson%2CJE&author=Fei%2CJY&author=Hofman%2CJM&author=Gonzalez%2CRL&author=Wiggins%2CCH make?
• How much revenue does https://citation-needed.springer.com/v2/references/10.1038/ncomms13350?format=refman&flavour=references generate?
• What's the monthly income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Youngbin%20Lim?
• Learn about the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Youngbin%20Lim%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=So%20Young%20Bak have?
• Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22So%20Young%20Bak%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Keewon%20Sung make?
• Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Keewon%20Sung%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Euihwan%20Jeong's financial summary
• How much profit is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Euihwan%20Jeong%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en making per month?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Seung%20Hwan%20Lee rake in every month?
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Seung%20Hwan%20Lee%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's total income per month
• Explore the financials of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jin-Soo%20Kim
• What's the financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jin-Soo%20Kim%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sangsu%20Bae's financial summary
• How much income does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sangsu%20Bae%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have?
• What are the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Seong%20Keun%20Kim?
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Seong%20Keun%20Kim%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• How much revenue does https://static-content.springer.com/esm/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_BFncomms13350_MOESM1164_ESM.pdf generate?
• What are the total earnings of https://static-content.springer.com/esm/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_BFncomms13350_MOESM1165_ESM.pdf?
• How much income is http://creativecommons.org/licenses/by/4.0/ earning monthly?
• How much does https://s100.copyright.com/AppDispatchServlet?title=Structural%20roles%20of%20guide%20RNAs%20in%20the%20nuclease%20activity%20of%20Cas9%20endonuclease&author=Youngbin%20Lim%20et%20al&contentID=10.1038%2Fncomms13350©right=The%20Author%28s%29&publication=2041-1723&publicationDate=2016-11-02&publisherName=SpringerNature&orderBeanReset=true&oa=CC%20BY net monthly?
• What's the revenue for https://crossmark.crossref.org/dialog/?doi=10.1038/ncomms13350?
• What's https://citation-needed.springer.com/v2/references/10.1038/ncomms13350?format=refman&flavour=citation's gross income?
• How profitable is https://doi.org/10.1038/s41467-023-41393-5?
• How much does https://doi.org/10.1186/s12967-022-03738-4 net monthly?
• What's the profit of https://doi.org/10.1038/s41467-022-29604-x?
• https://doi.org/10.1038/s41598-021-93685-9's revenue stream
• How much does https://doi.org/10.1007/s10142-021-00782-z gross monthly?
• How much does https://www.protocols.io/ bring in each month?
• How much does https://www.natureindex.com/ earn?
• How much revenue does http://www.naturechina.com generate?
• How much money does https://www.natureasia.com/ja-jp make?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref